Themis (thymocyte selection associated) - Rat Genome Database

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Pathways
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Gene: Themis (thymocyte selection associated) Mus musculus
Analyze
Symbol: Themis
Name: thymocyte selection associated
RGD ID: 1623011
MGI Page MGI
Description: Involved in T cell receptor signaling pathway; negative T cell selection; and positive T cell selection. Located in cell-cell junction; cytoplasm; and nucleus. Part of COP9 signalosome. Is expressed in lymph node; spleen; and thymus. Orthologous to human THEMIS (thymocyte selection associated).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A430108D01; BB160712; E430004N04Rik; G; Gasp; grb2-associating protein; signaling phosphoprotein specific for T cells; Spot; thylex; thymocyte selection pathway associated; thymocyte-expressed molecule involved in selection; thymus lymphocyte exclusively expressed; Ts; Tsepa
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391028,544,356 - 28,759,816 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1028,544,356 - 28,759,814 (+)EnsemblGRCm39 Ensembl
GRCm381028,668,360 - 28,883,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1028,668,360 - 28,883,818 (+)EnsemblGRCm38mm10GRCm38
MGSCv371028,388,201 - 28,602,555 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361028,357,811 - 28,572,165 (+)NCBIMGSCv36mm8
Celera1029,586,196 - 29,816,300 (+)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1016.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell-cell junction  (IDA)
COP9 signalosome  (IDA)
cytoplasm  (IBA,IDA)
nucleus  (IBA,IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD4-positive T cell differentiation  (IEA)
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology  (IEA)
abnormal CD8-positive, alpha-beta T cell differentiation  (IAGP)
abnormal lymphocyte morphology  (IEA)
abnormal memory T cell morphology  (IAGP)
abnormal negative T cell selection  (IAGP)
abnormal positive T cell selection  (IAGP)
abnormal regulatory T cell morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal thymus medulla morphology  (IAGP)
arrested T cell differentiation  (IAGP)
decreased alpha-beta T cell number  (IEA)
decreased B-1a cell number  (IEA)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IEA)
decreased CD8-positive, alpha-beta memory T cell number  (IEA)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased regulatory T cell number  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased splenocyte number  (IAGP)
decreased T cell number  (IEA)
decreased T cell proliferation  (IAGP)
decreased thymocyte number  (IAGP)
impaired hematopoiesis  (IEA)
impaired humoral immune response  (IEA)
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IEA)
increased CD8-positive, alpha-beta memory T cell number  (IEA)
increased CD8-positive, alpha-beta T cell number  (IEA)
increased central memory CD4-positive, alpha-beta T cell number  (IEA)
increased central memory CD8 positive, alpha-beta T cell number  (IEA)
increased double-positive T cell number  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased memory T cell number  (IAGP)
increased NK T cell number  (IEA)
increased T cell proliferation  (IAGP)
small thymus medulla  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease. Chabod M, etal., PLoS Genet. 2012 Jan;8(1):e1002461. doi: 10.1371/journal.pgen.1002461. Epub 2012 Jan 19.
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:19597497   PMID:19597498   PMID:19597499  
PMID:19620281   PMID:19805304   PMID:21189249   PMID:21267068   PMID:21873635   PMID:22561606   PMID:22732588   PMID:23460737   PMID:23793062   PMID:24226767   PMID:24586531   PMID:24935457  
PMID:25452553   PMID:25535246   PMID:27188442   PMID:28250424   PMID:28373295   PMID:28877990   PMID:30413615   PMID:31316154   PMID:31591574   PMID:31932808   PMID:32004441   PMID:32513716  
PMID:33897691   PMID:35167340   PMID:35857631   PMID:36977779   PMID:37067793   PMID:37739454  


Genomics

Comparative Map Data
Themis
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391028,544,356 - 28,759,816 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1028,544,356 - 28,759,814 (+)EnsemblGRCm39 Ensembl
GRCm381028,668,360 - 28,883,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1028,668,360 - 28,883,818 (+)EnsemblGRCm38mm10GRCm38
MGSCv371028,388,201 - 28,602,555 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361028,357,811 - 28,572,165 (+)NCBIMGSCv36mm8
Celera1029,586,196 - 29,816,300 (+)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1016.06NCBI
THEMIS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386127,696,628 - 127,918,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6127,708,072 - 127,918,631 (-)EnsemblGRCh38hg38GRCh38
GRCh376128,029,339 - 128,239,740 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366128,071,038 - 128,281,435 (-)NCBINCBI36Build 36hg18NCBI36
Celera6128,771,575 - 128,982,019 (-)NCBICelera
Cytogenetic Map6q22.33NCBI
HuRef6125,605,605 - 125,816,711 (-)NCBIHuRef
CHM1_16128,293,828 - 128,504,020 (-)NCBICHM1_1
T2T-CHM13v2.06128,897,128 - 129,107,550 (-)NCBIT2T-CHM13v2.0
Themis
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2116,433,906 - 16,623,889 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl116,432,631 - 16,664,329 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0117,152,973 - 17,378,225 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl117,171,631 - 17,378,047 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0118,308,043 - 18,532,366 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4117,032,677 - 17,226,924 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera114,851,097 - 15,078,338 (-)NCBICelera
Cytogenetic Map1p12NCBI
Themis
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554368,743,835 - 8,909,040 (-)NCBIChiLan1.0ChiLan1.0
THEMIS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan16145,596,428 - 145,800,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06125,489,491 - 125,685,995 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16129,601,170 - 129,814,542 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6129,601,176 - 129,797,112 (-)Ensemblpanpan1.1panPan2
THEMIS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1166,363,172 - 66,540,272 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl166,363,125 - 66,540,327 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha167,190,331 - 67,279,926 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0166,571,969 - 66,748,404 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,571,954 - 66,748,440 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,494,735 - 66,676,345 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0166,282,091 - 66,458,649 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,921,859 - 67,104,609 (-)NCBIUU_Cfam_GSD_1.0
Themis
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946116,589,828 - 116,679,894 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366391,739,380 - 1,915,560 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366391,739,380 - 1,915,545 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THEMIS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl135,333,465 - 35,519,870 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1135,333,210 - 35,530,710 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2138,931,867 - 38,999,233 (+)NCBISscrofa10.2Sscrofa10.2susScr3
THEMIS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11345,665,494 - 45,886,672 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1345,682,663 - 45,884,856 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604017,911,702 - 18,107,125 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Themis
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247532,214,779 - 2,292,936 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Themis
8181 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2474
Count of miRNA genes:773
Interacting mature miRNAs:1008
Transcripts:ENSMUST00000056097, ENSMUST00000060409, ENSMUST00000105516, ENSMUST00000159927, ENSMUST00000161345, ENSMUST00000162202, ENSMUST00000162343
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10852500342525126Mouse
1301796Mop2_mmorphine preference 2 (mouse)Not determined10928911929028424Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined10989026443890391Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined10989026443890391Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined10989026443890391Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1558857Igan1_mIgA nephropathy 1 (mouse)Not determined101771831329704155Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
10755518Chol16_mcholesterol 16 (mouse)101891504352915043Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102028318556031223Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
26884394Humsd3_mhumerus midshaft diameter 3, 10 week (mouse)102237589951076096Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
4142209Psrs1_mpsoriasis susceptibility 1 (mouse)Not determined102689026446720483Mouse

Markers in Region
BB160712  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381028,881,358 - 28,881,468UniSTSGRCm38
MGSCv371028,601,164 - 28,601,274UniSTSGRCm37
Celera1029,814,909 - 29,815,019UniSTS
Cytogenetic Map10A4UniSTS
Whitehead/MRC_RH10340.17UniSTS
BB165335  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381028,731,622 - 28,731,764UniSTSGRCm38
MGSCv371028,451,428 - 28,451,570UniSTSGRCm37
Celera1029,660,131 - 29,660,268UniSTS
Celera1029,649,005 - 29,649,147UniSTS
Cytogenetic Map10A4UniSTS
Whitehead/MRC_RH10310.54UniSTS
AI449547  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381028,793,867 - 28,794,019UniSTSGRCm38
MGSCv371028,513,673 - 28,513,825UniSTSGRCm37
Celera1029,725,069 - 29,725,221UniSTS
Cytogenetic Map10A4UniSTS
Whitehead/MRC_RH10323.36UniSTS
UniSTS:224833  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381028,841,723 - 28,841,900UniSTSGRCm38
MGSCv371028,561,529 - 28,561,706UniSTSGRCm37
Celera1029,775,274 - 29,775,451UniSTS
Cytogenetic Map10A4UniSTS
GDB:1318196  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371028,453,970 - 28,454,285UniSTSGRCm37
Celera1029,651,547 - 29,651,862UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001305663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001374699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_178666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_131208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006512643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA967480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB509340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC152983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC153798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB638055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000056097   ⟹   ENSMUSP00000060129
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1028,544,356 - 28,759,811 (+)Ensembl
GRCm38.p6 Ensembl1028,668,360 - 28,883,815 (+)Ensembl
RefSeq Acc Id: ENSMUST00000060409   ⟹   ENSMUSP00000055315
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1028,544,356 - 28,665,916 (+)Ensembl
GRCm38.p6 Ensembl1028,668,360 - 28,789,920 (+)Ensembl
RefSeq Acc Id: ENSMUST00000105516   ⟹   ENSMUSP00000101155
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1028,544,393 - 28,673,812 (+)Ensembl
GRCm38.p6 Ensembl1028,668,397 - 28,797,816 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159927   ⟹   ENSMUSP00000123919
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1028,544,623 - 28,759,814 (+)Ensembl
GRCm38.p6 Ensembl1028,668,627 - 28,883,818 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161345   ⟹   ENSMUSP00000123894
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1028,544,629 - 28,658,042 (+)Ensembl
GRCm38.p6 Ensembl1028,668,633 - 28,782,046 (+)Ensembl
RefSeq Acc Id: ENSMUST00000162202   ⟹   ENSMUSP00000124451
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1028,544,629 - 28,615,302 (+)Ensembl
GRCm38.p6 Ensembl1028,668,633 - 28,739,306 (+)Ensembl
RefSeq Acc Id: ENSMUST00000162343
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1028,544,391 - 28,640,035 (+)Ensembl
GRCm38.p6 Ensembl1028,668,395 - 28,764,039 (+)Ensembl
RefSeq Acc Id: ENSMUST00000219119
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1028,613,421 - 28,616,881 (+)Ensembl
GRCm38.p6 Ensembl1028,737,425 - 28,740,885 (+)Ensembl
RefSeq Acc Id: NM_001305663   ⟹   NP_001292592
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391028,544,356 - 28,759,814 (+)NCBI
GRCm381028,668,360 - 28,883,818 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001374699   ⟹   NP_001361628
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391028,544,391 - 28,673,812 (+)NCBI
GRCm381028,668,395 - 28,797,816 (+)NCBI
Sequence:
RefSeq Acc Id: NM_178666   ⟹   NP_848781
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391028,544,356 - 28,759,814 (+)NCBI
GRCm381028,668,360 - 28,883,818 (+)NCBI
MGSCv371028,388,201 - 28,602,555 (+)RGD
Celera1029,586,196 - 29,816,300 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_131208
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391028,544,356 - 28,615,302 (+)NCBI
GRCm381028,668,360 - 28,739,306 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006512643   ⟹   XP_006512706
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391028,629,446 - 28,759,816 (+)NCBI
GRCm381028,753,450 - 28,883,820 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_848781   ⟸   NM_178666
- Peptide Label: isoform 1
- UniProtKB: Q8BGP0 (UniProtKB/Swiss-Prot),   Q3UU76 (UniProtKB/Swiss-Prot),   Q3TEM0 (UniProtKB/Swiss-Prot),   Q059Y0 (UniProtKB/Swiss-Prot),   Q8C9S6 (UniProtKB/Swiss-Prot),   Q8BGW0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006512706   ⟸   XM_006512643
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001292592   ⟸   NM_001305663
- Peptide Label: isoform 2
- UniProtKB: Q8BGW0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001361628   ⟸   NM_001374699
- Peptide Label: isoform 4
RefSeq Acc Id: ENSMUSP00000123919   ⟸   ENSMUST00000159927
RefSeq Acc Id: ENSMUSP00000101155   ⟸   ENSMUST00000105516
RefSeq Acc Id: ENSMUSP00000060129   ⟸   ENSMUST00000056097
RefSeq Acc Id: ENSMUSP00000055315   ⟸   ENSMUST00000060409
RefSeq Acc Id: ENSMUSP00000124451   ⟸   ENSMUST00000162202
RefSeq Acc Id: ENSMUSP00000123894   ⟸   ENSMUST00000161345
Protein Domains
CABIT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BGW0-F1-model_v2 AlphaFold Q8BGW0 1-636 view protein structure

Promoters
RGD ID:6820036
Promoter ID:MM_KWN:3813
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:ENSMUST00000060409,   ENSMUST00000105515,   ENSMUST00000105516,   NM_178666,   UC007ESO.1,   UC007ESQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361028,387,896 - 28,388,396 (+)MPROMDB
RGD ID:8671714
Promoter ID:EPDNEW_M13888
Type:multiple initiation site
Name:Themis_1
Description:Mus musculus thymocyte selection associated , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13889  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381028,668,395 - 28,668,455EPDNEW
RGD ID:8671716
Promoter ID:EPDNEW_M13889
Type:single initiation site
Name:Themis_2
Description:Mus musculus thymocyte selection associated , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13888  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381028,695,338 - 28,695,398EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2443552 AgrOrtholog
Ensembl Genes ENSMUSG00000049109 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000056097 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000060409 UniProtKB/Swiss-Prot
  ENSMUST00000105516 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000159927.8 UniProtKB/TrEMBL
  ENSMUST00000161345.2 UniProtKB/TrEMBL
  ENSMUST00000162202 ENTREZGENE
  ENSMUST00000162202.8 UniProtKB/TrEMBL
InterPro CABIT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THEMIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:210757 UniProtKB/Swiss-Prot
MGD MGI:2443552 ENTREZGENE
NCBI Gene 210757 ENTREZGENE
PANTHER PROTEIN THEMIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15215 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CABIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Themis PhenoGen
UniProt E0CY68_MOUSE UniProtKB/TrEMBL
  E0CYT7_MOUSE UniProtKB/TrEMBL
  Q059Y0 ENTREZGENE
  Q3TEM0 ENTREZGENE
  Q3UU76 ENTREZGENE
  Q8BGP0 ENTREZGENE
  Q8BGW0 ENTREZGENE
  Q8C9S6 ENTREZGENE
  THMS1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q059Y0 UniProtKB/Swiss-Prot
  Q3TEM0 UniProtKB/Swiss-Prot
  Q3UU76 UniProtKB/Swiss-Prot
  Q8BGP0 UniProtKB/Swiss-Prot
  Q8C9S6 UniProtKB/Swiss-Prot