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Gene: Polr2h (polymerase (RNA) II (DNA directed) polypeptide H) Mus musculus

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Symbol:

Polr2h

Name:

polymerase (RNA) II (DNA directed) polypeptide H

RGD ID:

1622909

MGI Page

MGI

Description:

Predicted to enable single-stranded DNA binding activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of nuclear DNA-directed RNA polymerase complex and protein-DNA complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human POLR2H (RNA polymerase II, I and III subunit H).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

DNA-directed RNA polymerase II subunit H; DNA-directed RNA polymerases I, II, and III subunit RPABC3; MGC103049; MGC8248; MGC:8248; RNA polymerases I, II, and III subunit ABC3; RPB17; RPB8 homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	POLR2H (RNA polymerase II, I and III subunit H)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Polr2h (RNA polymerase II, I and III subunit H)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Polr2h (RNA polymerase II, I and III subunit H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	POLR2H (RNA polymerase II, I and III subunit H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	POLR2H (RNA polymerase II, I and III subunit H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Polr2h (RNA polymerase II, I and III subunit H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	POLR2H (RNA polymerase II, I and III subunit H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	POLR2H (RNA polymerase II, I and III subunit H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Polr2h (RNA polymerase II, I and III subunit H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	POLR2H (RNA polymerase II, I and III subunit H)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Polr2h (RNA polymerase II, I and III subunit H)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	polr2h (info polymerase (RNA) II (DNA directed) polypeptide H)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Caenorhabditis elegans (roundworm):	rpb-8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RPB8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Rpb8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	polr2h	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	20,536,552 - 20,541,015 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	20,536,415 - 20,541,017 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	20,717,826 - 20,722,272 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	20,717,665 - 20,722,267 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	20,717,899 - 20,722,338 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	20,631,369 - 20,635,808 (+)	NCBI		MGSCv36	mm8
Celera	16	21,283,180 - 21,287,619 (+)	NCBI		Celera
Cytogenetic Map	16	B1	NCBI
cM Map	16	12.5	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-methylcrotonyl-CoA carboxylase 1 deficiency (ISO)

congenital disorder of glycosylation Id (ISO)

Currarino syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (EXP)

1,2-dimethylhydrazine (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

6-propyl-2-thiouracil (ISO)

acrylamide (ISO)

actinomycin D (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (ISO)

antimycin A (ISO)

apigenin (EXP)

Aroclor 1254 (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (EXP)

bisphenol A (ISO)

bisphenol AF (ISO)

bisphenol F (EXP)

butanal (ISO)

carbon nanotube (EXP)

chlorpyrifos (EXP)

chromium(6+) (EXP)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

deguelin (ISO)

dextran sulfate (EXP)

Dibutyl phosphate (ISO)

dioxygen (EXP)

endosulfan (ISO)

epoxiconazole (EXP)

Evodiamine (EXP)

folic acid (EXP)

gentamycin (ISO)

ivermectin (ISO)

methylseleninic acid (ISO)

N-nitrosodiethylamine (ISO)

Nutlin-3 (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (EXP)

perfluorooctane-1-sulfonic acid (EXP)

perfluorooctanoic acid (EXP)

permethrin (ISO)

phenobarbital (ISO)

picoxystrobin (ISO)

pirinixic acid (EXP,ISO)

pyrimidifen (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tebufenpyrad (ISO)

tetrachloromethane (EXP,ISO)

thiram (ISO)

titanium dioxide (EXP)

versicolorin A (ISO)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

transcription by RNA polymerase II (ISO,ISS)

Cellular Component

nucleoplasm (TAS)

nucleus (ISO,ISS)

protein-DNA complex (IEA,ISO)

RNA polymerase I complex (IBA,IEA,ISO)

RNA polymerase II, core complex (IBA,ISO,ISS)

RNA polymerase III complex (IBA,IEA,ISO)

Molecular Function

DNA-directed 5'-3' RNA polymerase activity (IEA)

obsolete RNA polymerase I activity (IBA)

obsolete RNA polymerase II activity (IBA)

obsolete RNA polymerase III activity (IBA)

single-stranded DNA binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Huntington's disease pathway (IEA)

purine metabolic pathway (IEA)

pyrimidine metabolic pathway (IEA)

RNA polymerase I transcription pathway (ISO)

RNA polymerase II transcription pathway (ISO)

RNA polymerase III transcription pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased circulating iron level (IEA)

decreased circulating sodium level (IEA)

embryonic lethality prior to organogenesis (IEA)

embryonic lethality prior to tooth bud stage (IEA)

increased circulating free fatty acids level (IEA)

preweaning lethality, complete penetrance (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription.	Dumay-Odelot H, etal., Cell Cycle. 2010 Sep 15;9(18):3687-99. Epub 2010 Sep 1.
2.	Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.	Hu P, etal., Mol Cell Biol. 2002 Nov;22(22):8044-55.
3.	TFIIB-related factors in RNA polymerase I transcription.	Knutson BA and Hahn S, Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):265-73. doi: 10.1016/j.bbagrm.2012.08.003. Epub 2012 Aug 30.
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation.	Schneider DA Gene. 2012 Feb 10;493(2):176-84. doi: 10.1016/j.gene.2011.08.006. Epub 2011 Aug 26.
8.	Conservation between the RNA polymerase I, II, and III transcription initiation machineries.	Vannini A and Cramer P, Mol Cell. 2012 Feb 24;45(4):439-46. doi: 10.1016/j.molcel.2012.01.023.

Additional References at PubMed

PMID:10349636	PMID:10725249	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12466851	PMID:12477932	PMID:14610273	PMID:14681479	PMID:15489334	PMID:16141072
PMID:16141073	PMID:18799693	PMID:20059953	PMID:21267068	PMID:21589869	PMID:21677750	PMID:21873635	PMID:24194600	PMID:24457600	PMID:25737280	PMID:27626380	PMID:32098917
PMID:32325033	PMID:38355793

Genomics

Comparative Map Data

Polr2h
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	20,536,552 - 20,541,015 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	20,536,415 - 20,541,017 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	20,717,826 - 20,722,272 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	20,717,665 - 20,722,267 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	20,717,899 - 20,722,338 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	20,631,369 - 20,635,808 (+)	NCBI		MGSCv36	mm8
Celera	16	21,283,180 - 21,287,619 (+)	NCBI		Celera
Cytogenetic Map	16	B1	NCBI
cM Map	16	12.5	NCBI

POLR2H
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	184,361,710 - 184,368,591 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	184,361,710 - 184,368,596 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	184,079,498 - 184,086,379 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	185,563,888 - 185,569,057 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	185,563,895 - 185,569,065	NCBI
Celera	3	182,522,093 - 182,527,333 (+)	NCBI		Celera
Cytogenetic Map	3	q27.1	NCBI
HuRef	3	181,485,934 - 181,492,918 (+)	NCBI		HuRef
CHM1_1	3	184,043,961 - 184,050,843 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	187,170,978 - 187,177,848 (+)	NCBI		T2T-CHM13v2.0

Polr2h
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	93,696,423 - 93,701,902 (-)	NCBI		GRCr8
mRatBN7.2	11	80,192,017 - 80,197,468 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	104,855,233 - 104,855,685 (-)	Ensembl		mRatBN7.2 Ensembl
mRatBN7.2 Ensembl	11	80,192,032 - 80,197,515 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	88,914,729 - 88,919,176 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	81,568,145 - 81,572,593 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	80,629,207 - 80,633,655 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	83,877,760 - 83,882,208 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	83,878,006 - 83,882,117 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	11	82,856,529 - 82,860,977 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	86,949,678 - 86,954,126 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	82,421,657 - 82,426,105 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	11	79,031,758 - 79,036,206 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

Polr2h
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	23,131,297 - 23,136,800 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	23,132,053 - 23,136,954 (-)	NCBI	ChiLan1.0	ChiLan1.0

POLR2H
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	182,235,029 - 182,241,579 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	182,239,731 - 182,246,243 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	181,399,136 - 181,405,680 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	189,881,152 - 189,887,608 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	189,881,594 - 189,887,608 (+)	Ensembl	panpan1.1		panPan2

POLR2H
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	17,240,604 - 17,244,907 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	17,240,624 - 17,244,904 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	21,326,156 - 21,330,472 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	17,148,082 - 17,152,412 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	17,148,113 - 17,152,408 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	17,184,969 - 17,189,285 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	17,181,038 - 17,185,353 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	17,410,010 - 17,414,320 (+)	NCBI		UU_Cfam_GSD_1.0

Polr2h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	119,427,628 - 119,436,559 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936578	5,519,462 - 5,523,744 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936578	5,519,482 - 5,528,355 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

POLR2H
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	122,250,020 - 122,256,195 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	122,250,087 - 122,256,201 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	131,741,139 - 131,745,977 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

POLR2H
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	5,051,705 - 5,056,497 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	5,051,712 - 5,056,413 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	13,829,647 - 13,834,279 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Polr2h
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	72,221,964 - 72,228,616 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	72,221,964 - 72,228,133 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Polr2h
94 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	251
Count of miRNA genes:	176
Interacting mature miRNAs:	187
Transcripts:	ENSMUST00000021405, ENSMUST00000161038
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301970	Heal11_m	wound healing/regeneration 11 (mouse)			Not determined		16	1	24263853	Mouse
26884376	Skwq4_m	skull length QTL 4, 5 week (mouse)					16	8417864	90896888	Mouse
1301841	Lrnx9_m	learning-contextual 9 (mouse)			Not determined		16	12225360	46225471	Mouse
4142460	Nilac10_m	nicotine induced locomotor activity 10 (mouse)			Not determined		16	7136906	29225471	Mouse
38501069	Tip4_m	tuberculosis immunophenotype 4, IFN-g level (mouse)					16	4317864	44520363	Mouse
26884432	Zlq7_m	zygomatic length QTL 7, 10 week (mouse)					16	3817864	64620363	Mouse
1300632	Loca2_m	locomotor activity 2 (mouse)			Not determined		16	1	22500574	Mouse
11565820	Vasr1_m	variability in acoustic startle response 1 (mouse)					16	19698657	26368664	Mouse
1301086	Lprm5_m	lymphoproliferation modifier 5 (mouse)			Not determined		16	11848824	45848923	Mouse
27226768	Tibl9_m	tibia length 9, 5 week (mouse)					16	3317864	51420363	Mouse
1301443	Mopkd2_m	modifier of polycystic kidney disease progression 2 (mouse)			Not determined		16	4646314	38646414	Mouse
10043978	Obq35_m	obesity QTL 35 (mouse)			Not determined		16	9881631	43881631	Mouse
1301575	Tanidd3_m	tally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)			Not determined		16	1	22897739	Mouse
1357763	Lp1_m	lymphocyte proliferation 1 (mouse)			Not determined		16	6542979	65466552	Mouse
1357517	Bwtn1_m	body weight at necropsy 1 (mouse)			Not determined		16	20019329	85600826	Mouse
1301384	Dice1_m	determination of interleukin 4 commitment 1 (mouse)			Not determined		16	1	28434358	Mouse
1300943	Skts9_m	skin tumor susceptibility 9 (mouse)			Not determined		16	5775252	39775440	Mouse
10402497	Lmr23_m	leishmaniasis resistance 23 (mouse)			Not determined		16	1	29674200	Mouse
10412289	Ppsl_m	plasma P-selectin levels (mouse)			Not determined		16	1	30814572	Mouse
4141468	Nhdlq10_m	non-HDL QTL 10 (mouse)			Not determined		16	1	24263853	Mouse
1300656	Bgeq15_m	body growth early QTL 15 (mouse)			Not determined		16	5775252	39775440	Mouse
4142236	Pstc4_m	periosteal circumference 4 (mouse)			Not determined		16	15522909	49523112	Mouse
1301559	Bbaa19_m	B.burgdorferi-associated arthritis 19 (mouse)			Not determined		16	1	30066977	Mouse
11251724	Ewc6_m	ethanol withdrawal and consumption 6 (mouse)					16	8226052	42226052	Mouse
1300987	Skull23_m	skull morphology 23 (mouse)			Not determined		16	5775252	39775440	Mouse
1301945	Skl7_m	skeletal size (tail length) 7 (mouse)			Not determined		16	5775252	39775440	Mouse
4141010	Bbq1_m	brain and behavior QTL 1 (mouse)			Not determined		16	6477009	35021216	Mouse
10045614	Rapop6_m	radiation-induced apoptosis 6 (mouse)			Not determined		16	14802921	48803032	Mouse
27095908	Scvln7_m	sacral vertebrae length 2, 5 week (mouse)					16	3317864	39820362	Mouse
4141060	Pbwg19_m	postnatal body weight growth 19 (mouse)			Not determined		16	1	20780888	Mouse
10043879	Adip25_m	adiposity 25 (mouse)			Not determined		16	1	22520318	Mouse
27226785	Feml12_m	femur length 12, 5 week (mouse)					16	3317864	64620363	Mouse

Markers in Region

UniSTS:236846

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	16	20,721,939 - 20,722,146	UniSTS	GRCm38
GRCm38	12	55,067,630 - 55,067,837	UniSTS	GRCm38
MGSCv37	16	20,722,012 - 20,722,219	UniSTS	GRCm37
MGSCv37	12	56,168,617 - 56,168,824	UniSTS	GRCm37
Celera	16	21,287,293 - 21,287,500	UniSTS
Celera	12	56,358,230 - 56,358,437	UniSTS
Cytogenetic Map	12	C1	UniSTS
Cytogenetic Map	16	B1	UniSTS

UniSTS:236847

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	16	20,718,891 - 20,719,081	UniSTS	GRCm38
GRCm38	12	55,067,954 - 55,068,061	UniSTS	GRCm38
MGSCv37	16	20,718,964 - 20,719,154	UniSTS	GRCm37
MGSCv37	12	56,168,941 - 56,169,048	UniSTS	GRCm37
Celera	16	21,284,245 - 21,284,435	UniSTS
Celera	12	56,358,554 - 56,358,661	UniSTS
Cytogenetic Map	12	C1	UniSTS
Cytogenetic Map	16	B1	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001356423	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001417237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001417238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_145632	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_184434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_184435	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK146429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK161617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC002306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC092087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC125612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC125638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT010490	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000021405 ⟹ ENSMUSP00000021405

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	20,536,415 - 20,541,017 (+)	Ensembl
GRCm38.p6 Ensembl	16	20,717,665 - 20,722,267 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000161038 ⟹ ENSMUSP00000155920

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	20,536,922 - 20,540,757 (+)	Ensembl
GRCm38.p6 Ensembl	16	20,718,172 - 20,722,007 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000231392 ⟹ ENSMUSP00000155967

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	20,536,856 - 20,541,014 (+)	Ensembl
GRCm38.p6 Ensembl	16	20,718,106 - 20,722,264 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000231656 ⟹ ENSMUSP00000155895

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	20,536,580 - 20,541,015 (+)	Ensembl
GRCm38.p6 Ensembl	16	20,717,830 - 20,722,265 (+)	Ensembl

RefSeq Acc Id:

NM_001356423 ⟹ NP_001343352

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	16	20,536,861 - 20,541,015 (+)	NCBI
GRCm38	16	20,718,177 - 20,722,265 (+)	NCBI

Sequence:

show sequence

CTTAGCTGGGTGCTGGCATACCCCTGGGAACCTTTCTAACTCCCTACACAGTTATTATGTGCTC
TACCGTGCTCTGAACTTTATTCTTGGAAAAAGTAGATGGTGCCTTATCTCTTTTGTTACCCCAG
GTCTTGCAGCGAGTTACCTACCTGCCTTCCTAACCAATAATTTTGTATTAGCCTAAGAACAAGT
TAGCTCTTTCCGAAGCTCTCTGAATTTCATTCAGTTGACCGCTTGGTGTATTTATTTTCCCAAC
GATCCGGAAGTTGTTTCTTCTTGGTGTCGCTTAGCCTGGAGGCAAATGTCTTAAGACAGATGTC
AGTTTTGAATACATCCCTCAGATTCCCTCAGCAGTGTCTCCTGCTAGAAAGAGGAAGTCTCAGG
ACCAGTGAGACTCTAGTCTAAATCATCCAGGCGTTTTTAGTTAGAGCCTGGAGACTGGCCACTG
CTGGAGGAGCTTTGCCGCTTGCTTGGGACCCTGTCACTTGCTGAGTATCCCGGCTGCACTGTGA
GAGTGAATCTTTCAAGATGGACCTCATCTTAGATGTAAACATTCAGATTTACCCTGTGGACTTA
GGTGACAAGTTCCGGTTGGTTATAGCTAGTACTTTGTATGAAGATGGTACCTTGGATGATGGTG
AATACAACCCCACAGATGACAGGCCTTCCAGGGCTGACCAGTTTGAGTATGTCATGTATGGGAA
AGTGTACAGGATCGAAGGGGATGAGACCTCCACTGAAGCAGCCACACGCCTCTCTGCGTACGTG
TCCTATGGGGGCCTGCTCATGAGGCTTCAGGGTGATGCCAACAACCTGCATGGATTTGAGGTGG
ACTCCAGAGTTTATCTGCTGATGAAGAAGCTGGCCTTCTGAACTTCGTGGGAAACCAGACTTGC
TGCTTAGTCACTCATGTCATGGACACTGTTCAAGGCTGTGTAGAAGCTGTCGGTGTTAGCCTGT
AAAAGGGGCGGAACTCTGTCCACTGTGGGGACGTCTTCAGTTTGTCTGAATGCAGTGGAAAACC
GACTCTCCCTCTCGGAAGGCCGAGAGGGAGAACTTAGCATGAACCTGAAGTTGTATATGATTTT
TTTTATTAAAGTTTTCTTTTTCA

hide sequence

RefSeq Acc Id:

NM_001417237 ⟹ NP_001404166

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	16	20,536,861 - 20,541,015 (+)	NCBI

RefSeq Acc Id:

NM_001417238 ⟹ NP_001404167

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	16	20,536,552 - 20,541,015 (+)	NCBI

RefSeq Acc Id:

NM_145632 ⟹ NP_663607

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	16	20,536,552 - 20,541,015 (+)	NCBI
GRCm38	16	20,717,826 - 20,722,265 (+)	NCBI
MGSCv37	16	20,717,899 - 20,722,338 (+)	RGD
Celera	16	21,283,180 - 21,287,619 (+)	RGD
cM Map	16		ENTREZGENE

Sequence:

show sequence

CTCTGCCCTGTCTTACTTTTCTCCACGTGAGGGGGTGCGCGAATCCCCAGTGGTGGCCGCGCGC
TCACATCCTCTGCAGCTTTCGTGCCCTTCGCGATGGCGGGCATCCTGTTCGAGGATATTTTCGA
TGTGAAAGACATCGACCCAGAAGGCAAGAAATTTGACCGAGTATCCCGGCTGCACTGTGAGAGT
GAATCTTTCAAGATGGACCTCATCTTAGATGTAAACATTCAGATTTACCCTGTGGACTTAGGTG
ACAAGTTCCGGTTGGTTATAGCTAGTACTTTGTATGAAGATGGTACCTTGGATGATGGTGAATA
CAACCCCACAGATGACAGGCCTTCCAGGGCTGACCAGTTTGAGTATGTCATGTATGGGAAAGTG
TACAGGATCGAAGGGGATGAGACCTCCACTGAAGCAGCCACACGCCTCTCTGCGTACGTGTCCT
ATGGGGGCCTGCTCATGAGGCTTCAGGGTGATGCCAACAACCTGCATGGATTTGAGGTGGACTC
CAGAGTTTATCTGCTGATGAAGAAGCTGGCCTTCTGAACTTCGTGGGAAACCAGACTTGCTGCT
TAGTCACTCATGTCATGGACACTGTTCAAGGCTGTGTAGAAGCTGTCGGTGTTAGCCTGTAAAA
GGGGCGGAACTCTGTCCACTGTGGGGACGTCTTCAGTTTGTCTGAATGCAGTGGAAAACCGACT
CTCCCTCTCGGAAGGCCGAGAGGGAGAACTTAGCATGAACCTGAAGTTGTATATGATTTTTTTT
ATTAAAGTTTTCTTTTTCA

hide sequence

RefSeq Acc Id:

NR_184434

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	16	20,536,552 - 20,541,015 (+)	NCBI

RefSeq Acc Id:

NR_184435

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	16	20,536,552 - 20,541,015 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001343352	(Get FASTA)	NCBI Sequence Viewer
	NP_001404166	(Get FASTA)	NCBI Sequence Viewer
	NP_001404167	(Get FASTA)	NCBI Sequence Viewer
	NP_663607	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH02306	(Get FASTA)	NCBI Sequence Viewer
	AAH92087	(Get FASTA)	NCBI Sequence Viewer
	AAI25613	(Get FASTA)	NCBI Sequence Viewer
	AAI25639	(Get FASTA)	NCBI Sequence Viewer
	BAE27163	(Get FASTA)	NCBI Sequence Viewer
	BAE36495	(Get FASTA)	NCBI Sequence Viewer
	EDK97591	(Get FASTA)	NCBI Sequence Viewer
	EDK97592	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000021405
	ENSMUSP00000021405.8
	ENSMUSP00000155895
	ENSMUSP00000155895.2
	ENSMUSP00000155920
	ENSMUSP00000155920.2
	ENSMUSP00000155967.2
GenBank Protein	Q923G2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_663607 ⟸ NM_145632
- Peptide Label:	isoform 1
- UniProtKB:	Q923G2 (UniProtKB/Swiss-Prot), Q3TT30 (UniProtKB/Swiss-Prot), A0A338P6I2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTL YEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGGLLMRLQGD ANNLHGFEVDSRVYLLMKKLAF hide sequence

RefSeq Acc Id:	NP_001343352 ⟸ NM_001356423
- Peptide Label:	isoform 2
- UniProtKB:	A0A338P6B4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSMUSP00000155895 ⟸ ENSMUST00000231656

Ensembl Acc Id:

ENSMUSP00000155967 ⟸ ENSMUST00000231392

Ensembl Acc Id:

ENSMUSP00000021405 ⟸ ENSMUST00000021405

Ensembl Acc Id:

ENSMUSP00000155920 ⟸ ENSMUST00000161038

RefSeq Acc Id:	NP_001404167 ⟸ NM_001417238
- Peptide Label:	isoform 3
- UniProtKB:	A0A338P6M3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001404166 ⟸ NM_001417237
- Peptide Label:	isoform 2
- UniProtKB:	A0A338P6B4 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q923G2-F1-model_v2	AlphaFold	Q923G2	1-150	view protein structure

Promoters

RGD ID:

6827370

Promoter ID:

MM_KWN:20501

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

ENSMUST00000021405, ENSMUST00000120099, OTTMUST00000070706, OTTMUST00000070725, OTTMUST00000070726, OTTMUST00000070727, UC007YQY.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	16	20,716,056 - 20,718,422 (+)	MPROMDB

RGD ID:

8685772

Promoter ID:

EPDNEW_M20917

Type:

initiation region

Name:

Polr2h_1

Description:

Mus musculus polymerase II polypeptide H , transcript variant1, mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	16	20,717,874 - 20,717,934	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2384309	AgrOrtholog
Ensembl Genes	ENSMUSG00000021018	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000021405	ENTREZGENE
	ENSMUST00000021405.8	UniProtKB/Swiss-Prot
	ENSMUST00000161038	ENTREZGENE
	ENSMUST00000161038.2	UniProtKB/TrEMBL
	ENSMUST00000231392.2	UniProtKB/TrEMBL
	ENSMUST00000231656	ENTREZGENE
	ENSMUST00000231656.2	UniProtKB/TrEMBL
Gene3D-CATH	2.40.50.140	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	NA-bd_OB-fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RNA_pol_Rpb8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:245841	UniProtKB/Swiss-Prot
MGD	MGI:2384309	ENTREZGENE
NCBI Gene	Polr2h	ENTREZGENE
PANTHER	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10917	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	RNA_pol_Rpb8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Polr2h	PhenoGen
PIRSF	RNA_pol_Rpb8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	RPOL8c	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF50249	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A338P6B4	ENTREZGENE, UniProtKB/TrEMBL
	A0A338P6I2	ENTREZGENE, UniProtKB/TrEMBL
	A0A338P6M3	ENTREZGENE, UniProtKB/TrEMBL
	Q3TT30	ENTREZGENE
	Q923G2	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q3TT30	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Mammalian Phenotype