Tmem221 (transmembrane protein 221) - Rat Genome Database

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Gene: Tmem221 (transmembrane protein 221) Mus musculus
Analyze
Symbol: Tmem221
Name: transmembrane protein 221
RGD ID: 1622659
MGI Page MGI
Description: Predicted to be located in membrane. Orthologous to human TMEM221 (transmembrane protein 221).
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,006,947 - 72,011,659 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,006,882 - 72,011,515 (-)EnsemblGRCm39 Ensembl
GRCm38871,554,303 - 71,559,015 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,554,238 - 71,558,871 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,078,202 - 74,082,770 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36874,483,220 - 74,487,965 (-)NCBIMGSCv36mm8
Celera874,065,000 - 74,069,568 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:21267068  


Genomics

Comparative Map Data
Tmem221
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,006,947 - 72,011,659 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,006,882 - 72,011,515 (-)EnsemblGRCm39 Ensembl
GRCm38871,554,303 - 71,559,015 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,554,238 - 71,558,871 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,078,202 - 74,082,770 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36874,483,220 - 74,487,965 (-)NCBIMGSCv36mm8
Celera874,065,000 - 74,069,568 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
TMEM221
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,435,509 - 17,448,668 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1917,435,509 - 17,448,668 (-)EnsemblGRCh38hg38GRCh38
GRCh371917,546,318 - 17,559,477 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,408,267 - 17,420,493 (-)NCBINCBI36Build 36hg18NCBI36
Celera1917,448,072 - 17,461,124 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,112,238 - 17,125,017 (-)NCBIHuRef
CHM1_11917,545,819 - 17,558,888 (-)NCBICHM1_1
T2T-CHM13v2.01917,570,277 - 17,583,426 (-)NCBIT2T-CHM13v2.0
Tmem221
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,296,036 - 18,305,077 (-)NCBIGRCr8
mRatBN7.21618,253,622 - 18,271,094 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,262,052 - 18,266,967 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01619,984,368 - 19,992,507 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,984,301 - 19,988,004 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,843,726 - 19,850,930 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,737,596 - 18,741,584 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1618,467,034 - 18,475,546 (-)NCBICelera
Cytogenetic Map16p14NCBI
Tmem221
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955524830,555 - 839,089 (+)NCBIChiLan1.0ChiLan1.0
TMEM221
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,304,279 - 22,323,633 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,301,561 - 21,330,169 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01916,922,770 - 16,936,459 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11917,895,562 - 17,909,597 (-)NCBIpanpan1.1PanPan1.1panPan2
TMEM221
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,353,366 - 45,361,175 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2045,267,185 - 45,275,015 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,840,535 - 45,848,323 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,840,149 - 45,847,512 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12045,076,930 - 45,084,679 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,486,723 - 45,494,548 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,762,751 - 45,770,574 (+)NCBIUU_Cfam_GSD_1.0
Tmem221
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,914,176 - 203,918,250 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365963,452,433 - 3,467,389 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM221
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,256,487 - 60,263,915 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,256,477 - 60,264,026 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,719,285 - 59,726,739 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM221
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,930,946 - 15,938,414 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl615,931,893 - 15,938,065 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660743,495,366 - 3,508,225 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem221
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624908555,619 - 561,932 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624908555,619 - 562,318 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem221
158 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:332
Count of miRNA genes:252
Interacting mature miRNAs:284
Transcripts:ENSMUST00000052072
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84819016882190288Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86872247983326976Mouse
11039503Ccc4_mcolitis susceptibility in the Collaborative Cross 4 (mouse)86517423778002730Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7158942790929226Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000052072   ⟹   ENSMUSP00000058317
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl872,006,882 - 72,011,515 (-)Ensembl
GRCm38.p6 Ensembl871,554,238 - 71,558,871 (-)Ensembl
RefSeq Acc Id: NM_001100462   ⟹   NP_001093932
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,006,947 - 72,011,515 (-)NCBI
GRCm38871,554,303 - 71,558,871 (-)NCBI
MGSCv37874,078,202 - 74,082,770 (-)RGD
Celera874,065,000 - 74,069,568 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509705   ⟹   XP_006509768
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,007,800 - 72,011,659 (-)NCBI
GRCm38871,555,156 - 71,559,015 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001093932 (Get FASTA)   NCBI Sequence Viewer  
  XP_006509768 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH33932 (Get FASTA)   NCBI Sequence Viewer  
  AAI47817 (Get FASTA)   NCBI Sequence Viewer  
  AAI47832 (Get FASTA)   NCBI Sequence Viewer  
  EDL28935 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000058317
  ENSMUSP00000058317.7
GenBank Protein Q8K071 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001093932   ⟸   NM_001100462
- UniProtKB: B2RWI9 (UniProtKB/Swiss-Prot),   Q8K071 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509768   ⟸   XM_006509705
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000058317   ⟸   ENSMUST00000052072

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K071-F1-model_v2 AlphaFold Q8K071 1-230 view protein structure

Promoters
RGD ID:8667409
Promoter ID:EPDNEW_M11736
Type:multiple initiation site
Name:Tmem221_1
Description:Mus musculus transmembrane protein 221 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38871,558,917 - 71,558,977EPDNEW
RGD ID:6842835
Promoter ID:MM_KWN:54795
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Lung
Transcripts:UC009MDU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,082,639 - 74,083,139 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3525074 AgrOrtholog
Ensembl Genes ENSMUSG00000043664 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000052072 ENTREZGENE
  ENSMUST00000052072.8 UniProtKB/Swiss-Prot
InterPro Jiraiya UniProtKB/Swiss-Prot
  TM221 UniProtKB/Swiss-Prot
KEGG Report mmu:434325 UniProtKB/Swiss-Prot
MGD MGI:3525074 ENTREZGENE
NCBI Gene 434325 ENTREZGENE
PANTHER TRANSMEMBRANE PROTEIN 221 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 221 UniProtKB/Swiss-Prot
Pfam Jiraiya UniProtKB/Swiss-Prot
PhenoGen Tmem221 PhenoGen
UniProt B2RWI9 ENTREZGENE
  Q8K071 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RWI9 UniProtKB/Swiss-Prot