Advanced Search (OLGA)

Gene: Ren2 (renin 2 tandem duplication of Ren1) Mus musculus

Analyze

No known orthologs.

Symbol:

Ren2

Name:

renin 2 tandem duplication of Ren1

RGD ID:

1622375

MGI Page

MGI

Description:

Enables endopeptidase activity. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within positive regulation of blood pressure. Located in extracellular space. Is expressed in several structures, including adrenal medulla; embryo mesenchyme; medulla oblongata alar plate mantle layer; metanephros; and submandibular gland. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

angiotensinogenase; R; Ren; Ren-2; Ren-B; renin-2; Rn; Rn-2; Rnr; submandibular gland renin

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	REN (renin)	HGNC	Panther
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Ren (renin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	REN (renin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ren (renin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PEP4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	asp-1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	CG10104	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	asp-3	Alliance	DIOPT (PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	asp-12	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	asp-15	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	asp-16	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	asp-18	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	asp-19	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	asp-5	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	ren	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Is Marker For:

Strains: F344-Tg(Cyp1a1-Ren2)10Jmul

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

NCBI Annotation Information:

Genome Annotation Status: not in current annotation release

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Celera	1	177,256,233 - 177,265,990 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Albuminuria (EXP)

Cardiomegaly (EXP)

focal segmental glomerulosclerosis (EXP)

hypertension (EXP)

hypertrophic cardiomyopathy (EXP)

Inflammation (EXP)

interstitial nephritis (EXP)

Left Ventricular Hypertrophy (EXP)

malignant hypertension (EXP)

Weight Loss (EXP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

14,15-EET (EXP)

8-epi-prostaglandin F2alpha (EXP)

bisphenol A (EXP)

cobalt dichloride (EXP)

dinitrogen oxide (EXP)

folic acid (EXP)

sodium arsenite (EXP)

tamoxifen (EXP)

trandolapril (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiotensin maturation (IBA,ISO)

gene expression (IMP)

kidney development (ISO)

positive regulation of blood pressure (IDA)

proteolysis (IEA,ISO)

regulation of blood pressure (ISO)

regulation of MAPK cascade (ISO)

response to cAMP (ISO)

response to cGMP (ISO)

response to xenobiotic stimulus (ISO)

Cellular Component

apical part of cell (ISO)

extracellular space (IBA,IDA,ISO)

Molecular Function

aspartic-type endopeptidase activity (IBA,IEA,ISO)

endopeptidase activity (IDA,ISO)

insulin-like growth factor receptor binding (ISO)

peptidase activity (ISO)

signaling receptor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

renin-angiotensin cascade pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

no abnormal phenotype detected (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15253	PMID:281712	PMID:1350294	PMID:1358796	PMID:1608447	PMID:1672292	PMID:1673105	PMID:1683707	PMID:1685136	PMID:1970330	PMID:1981051	PMID:2172970
PMID:2307472	PMID:2480233	PMID:2571577	PMID:2574151	PMID:2574991	PMID:2691339	PMID:2833727	PMID:2882954	PMID:2894402	PMID:2895697	PMID:2971731	PMID:2993224
PMID:3384439	PMID:3416634	PMID:3898081	PMID:4042679	PMID:6089205	PMID:6095203	PMID:6171818	PMID:6283373	PMID:6327268	PMID:6327270	PMID:6357783	PMID:6378791
PMID:6389258	PMID:6392850	PMID:6751556	PMID:6812055	PMID:6934364	PMID:7028030	PMID:7031061	PMID:7165695	PMID:7692390	PMID:8188220	PMID:8203556	PMID:8482578
PMID:8952516	PMID:8952610	PMID:9622149	PMID:9693135	PMID:10729219	PMID:11145610	PMID:11161799	PMID:11395546	PMID:11457727	PMID:11751275	PMID:12397037	PMID:12477932
PMID:12512695	PMID:15489334	PMID:15795515	PMID:16446393	PMID:16522658	PMID:17083061	PMID:17386351	PMID:17425782	PMID:17630347	PMID:17641813	PMID:17898695	PMID:18424632
PMID:18456730	PMID:18483625	PMID:18486983	PMID:18826488	PMID:19252086	PMID:19293336	PMID:19307186	PMID:19403863	PMID:19531557	PMID:19710239	PMID:19749160	PMID:20007350
PMID:20462965	PMID:20666571	PMID:20884641	PMID:21078594	PMID:21267068	PMID:21389089	PMID:21565284	PMID:21873635	PMID:22328091	PMID:22526299	PMID:25194129	PMID:25194138
PMID:25224811	PMID:25407269	PMID:26180185	PMID:27754863	PMID:28527294	PMID:29358217	PMID:32199017	PMID:32507043	PMID:35103284	PMID:36602864

Genomics

Related Rat Strains

The following Strains have been annotated to Ren2

F344-Tg(Cyp1a1-Ren2)10Jmul

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031193	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC034108	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF237860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC011157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC011473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BG867251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BG869802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J00621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	K02597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M22747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M34191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

NM_031193 ⟹ NP_112470

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
Celera	1	177,256,233 - 177,265,990 (+)	ENTREZGENE

Sequence:

show sequence

GCCAGAAAACAGGCTGCCTTTCATGGTCCCACAGGCCCTGGGGTAATAAATCAGAGCAGAGCCT
GTGATACATGGTGTGTATAAAAGAAGGCTCAGGGGGTCTGGGCTACACAGCTCTTAGAAAGCCT
TGGCTGAACCAGATGGACAGGAGGAGGATGCCTCTCTGGGCACTCTTGTTGCTCTGGAGTCCTT
GCACCTTCAGTCTCCCAACGGGCACCACCTTTGAACGAATCCCACTCAAGAAAATGCCCTCTGT
CCGGGAAATCCTGGAGGAGCGGGGAGTGGACATGACCAGGCTCAGTGCTGAATGGGACGTATTC
ACAAAGAGGTCTTCCTTGACTGATCTTATCTCCCCCGTGGTCCTCACCAACTACCTGAATAGCC
AGTACTATGGCGAGATCGGCATTGGTACCCCACCCCAGACCTTCAAAGTCATCTTTGACACGGG
CTCCGCCAACCTCTGGGTGCCCTCCACCAAGTGCAGCCGCCTCTACCTTGCTTGTGGGATTCAC
AGCCTCTATGAGTCCTCTGACTCCTCCAGCTACATGGAGAATGGAGACGACTTCACCATCCACT
ACGGATCAGGGAGAGTCAAAGGTTTCCTCAGCCAGGACTCGGTGACTGTGGGTGGAATCACTGT
GACACAGACCTTTGGAGAGGTCACCGAGCTGCCCCTGATCCCTTTCATGCTGGCCCAGTTTGAC
GGGGTTCTAGGCATGGGCTTTCCCGCTCAGGCCGTCGGCGGGGTCACCCCTGTCTTTGACCACA
TTCTCTCCCAGGGGGTGCTGAAGGAGAAAGTGTTCTCTGTCTACTACAACAGGGGTCCCCACCT
GCTGGGGGGCGAGGTGGTGCTAGGAGGCAGCGACCCGGAGCATTACCAAGGCGATTTTCACTAT
GTGAGCCTCAGCAAGACTGATTCCTGGCAGATCACAATGAAGGGGGTGTCTGTGGGGTCTTCCA
CCCTACTGTGTGAAGAAGGCTGTGAGGTAGTGGTGGACACTGGTTCATCCTTTATCTCGGCTCC
TACGAGCTCCCTGAAGTTGATCATGCAAGCCCTGGGAGCCAAGGAGAAGAGACTACATGAATAT
GTTGTGAGCTGTAGCCAGGTGCCCACCCTCCCCGACATCTCCTTCAACCTGGGAGGCAGGGCCT
ACACACTCAGCAGTACGGACTACGTGCTACAGTATCCCAACAGGAGAGACAAGCTGTGCACAGT
GGCTCTCCATGCCATGGACATCCCACCACCCACTGGGCCTGTCTGGGTCCTGGGTGCCACCTTC
ATCCGCAAGTTCTATACAGAGTTTGATCGGCATAACAATCGCATTGGATTCGCCTTGGCCCGCT
AAGGCCCTCTGCCACCCAGTAACCCTAGGCCAAGCCAAGCTGGCACTCCTGGGGGCCATTTTGT
CTGGCTTTGTCCCCAACATAGGGACACTGGACACAGAGACCCTAACGAGTGTTTGCCCCTTCAC
CTGCACTCACCCTTCCCTGCTTTAAGGAAAAACCGAATAAAGATTTCATGTTTAAAGCCAAAAA
AAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_112470	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA40046	(Get FASTA)	NCBI Sequence Viewer
	AAA40047	(Get FASTA)	NCBI Sequence Viewer
	AAA40048	(Get FASTA)	NCBI Sequence Viewer
	AAA40050	(Get FASTA)	NCBI Sequence Viewer
	AAH11157	(Get FASTA)	NCBI Sequence Viewer
	AAH11473	(Get FASTA)	NCBI Sequence Viewer
	ABM47580	(Get FASTA)	NCBI Sequence Viewer
	ABM47581	(Get FASTA)	NCBI Sequence Viewer
	ABM47582	(Get FASTA)	NCBI Sequence Viewer
	ABM47583	(Get FASTA)	NCBI Sequence Viewer
	P00796	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_112470 ⟸ NM_031193

- UniProtKB:

Q62155 (UniProtKB/Swiss-Prot), P97955 (UniProtKB/Swiss-Prot), P70229 (UniProtKB/Swiss-Prot), P00796 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MVCIKEGSGGLGYTALRKPWLNQMDRRRMPLWALLLLWSPCTFSLPTGTTFERIPLKKMPSVRE
ILEERGVDMTRLSAEWDVFTKRSSLTDLISPVVLTNYLNSQYYGEIGIGTPPQTFKVIFDTGSA
NLWVPSTKCSRLYLACGIHSLYESSDSSSYMENGDDFTIHYGSGRVKGFLSQDSVTVGGITVTQ
TFGEVTELPLIPFMLAQFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKEKVFSVYYNRGPHLLG
GEVVLGGSDPEHYQGDFHYVSLSKTDSWQITMKGVSVGSSTLLCEEGCEVVVDTGSSFISAPTS
SLKLIMQALGAKEKRLHEYVVSCSQVPTLPDISFNLGGRAYTLSSTDYVLQYPNRRDKLCTVAL
HAMDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR

hide sequence

Protein Domains

Peptidase A1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure	Video
AF-P00796-F1-model_v2	AlphaFold	P00796	1-401	view protein structure
Renin2	pdb 2x0b	P00796	64-401	view protein structure	view video

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:97899	AgrOrtholog
Gene3D-CATH	2.40.70.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Aspartic_peptidase_A1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aspartic_peptidase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aspartic_peptidase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PEPTIDASE_A1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_aspartic_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Renin-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:19702	UniProtKB/Swiss-Prot
MGD	MGI:97899	ENTREZGENE
NCBI Gene	19702	ENTREZGENE
PANTHER	PTHR47966	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RENIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	A1_Propeptide	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Asp	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ren2	PhenoGen
PRINTS	PEPSIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ASP_PROTEASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PEPTIDASE_A1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF50630	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	P00796	ENTREZGENE
	P70229	ENTREZGENE
	P97955	ENTREZGENE
	Q62155	ENTREZGENE
	Q91X66_MOUSE	UniProtKB/TrEMBL
	RENI2_MOUSE	UniProtKB/Swiss-Prot
UniProt Secondary	P70229	UniProtKB/Swiss-Prot
	P97955	UniProtKB/Swiss-Prot
	Q62155	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Mammalian Phenotype

Send us a Message

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Mammalian Phenotype