Pbx2 (pre B cell leukemia homeobox 2)

Advanced Search (OLGA)

Gene: Pbx2 (pre B cell leukemia homeobox 2) Mus musculus

Analyze

Symbol:

Pbx2

Name:

pre B cell leukemia homeobox 2

RGD ID:

1621601

MGI Page

MGI

Description:

Enables chromatin binding activity. Acts upstream of or within embryonic limb morphogenesis; positive regulation of transcription by RNA polymerase II; and proximal/distal pattern formation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; eye; and genitourinary system. Orthologous to human PBX2 (PBX homeobox 2).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AU043397; G17; homeobox protein PBX2; pre B-cell leukemia transcription factor 2; pre-B-cell leukemia transcription factor 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PBX2 (PBX homeobox 2)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Pbx2 (PBX homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pbx2 (PBX homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PBX2 (PBX homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PBX2 (PBX homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pbx2 (PBX homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PBX2 (PBX homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PBX2 (PBX homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pbx2 (PBX homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Pbx2 (PBX homeobox 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PBX2 (PBX homeobox 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pbx2 (pre-B-cell leukemia homeobox 2)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB\|ZFIN)
Drosophila melanogaster (fruit fly):	exd	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ceh-20	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ceh-40	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	pbx2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	34,811,233 - 34,816,374 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	34,810,240 - 34,816,374 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	34,592,259 - 34,597,400 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	34,591,266 - 34,597,400 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	34,729,416 - 34,734,286 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	34,200,527 - 34,205,397 (+)	NCBI		MGSCv36	mm8
Celera	17	37,687,631 - 37,692,501 (+)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	18.17	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

proteasome-associated autoinflammatory syndrome 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrotoluene (ISO)

2-butoxyethanol (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

acrylamide (EXP)

all-trans-retinoic acid (EXP,ISO)

amitrole (ISO)

arsane (ISO)

arsenic atom (ISO)

belinostat (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-chloroethyl) sulfide (EXP)

bisphenol A (ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calciol (EXP)

carmustine (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

cocaine (EXP)

coumarin (ISO)

cyclosporin A (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethanol (EXP)

flavonoids (ISO)

folic acid (EXP)

gentamycin (ISO)

hydralazine (ISO)

lipopolysaccharide (EXP)

methimazole (ISO)

methotrexate (EXP,ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

niclosamide (ISO)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (EXP)

potassium chromate (ISO)

propiconazole (EXP)

SB 431542 (ISO)

silver atom (EXP)

silver(0) (EXP)

sulfadimethoxine (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (ISO)

thioacetamide (ISO)

titanium dioxide (EXP)

triphenyl phosphate (ISO)

triptonide (EXP)

tunicamycin (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ morphogenesis (IBA)

brain development (IBA)

embryonic limb morphogenesis (IGI)

embryonic organ development (IBA)

eye development (IBA)

neuron development (IBA)

positive regulation of transcription by RNA polymerase II (IDA,ISO)

proximal/distal pattern formation (IGI)

Cellular Component

nucleus (IDA,ISO)

transcription regulator complex (IDA)

Molecular Function

chromatin binding (IDA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA,ISO)

DNA-binding transcription factor binding (IEA,ISO)

protein binding (IPI)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal lateral nasal prominence morphology (IAGP)

abnormal maxillary prominence morphology (IAGP)

abnormal maxillary shelf morphology (IAGP)

abnormal medial nasal prominence morphology (IAGP)

abnormal nasal capsule morphology (IAGP)

abnormal spleen morphology (IAGP)

absent premaxilla (IAGP)

bilateral cleft upper lip (IAGP)

cleft palate (IAGP)

cleft upper lip (IAGP)

decreased apoptosis (IAGP)

edema (IAGP)

micrognathia (IAGP)

neonatal lethality, complete penetrance (IAGP)

no abnormal phenotype detected (IAGP)

postnatal lethality, complete penetrance (IAGP)

small snout (IAGP)

spleen hypoplasia (IAGP)

tongue hypoplasia (IAGP)

unilateral cleft upper lip (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:1682799	PMID:10082572	PMID:10349636	PMID:10381567	PMID:10679934	PMID:10725249	PMID:10842069	PMID:10871872	PMID:11042159	PMID:11076861	PMID:11217851	PMID:11335119
PMID:11468159	PMID:12183364	PMID:12397630	PMID:12466851	PMID:12477932	PMID:14656967	PMID:15087118	PMID:15141091	PMID:15169896	PMID:15226823	PMID:15489334	PMID:15618518
PMID:15944191	PMID:16141072	PMID:16141073	PMID:16438966	PMID:16515781	PMID:16672333	PMID:16847320	PMID:17049510	PMID:17178831	PMID:17609113	PMID:17623278	PMID:17942707
PMID:18287559	PMID:18676817	PMID:18691704	PMID:18723445	PMID:19369396	PMID:20059953	PMID:20211142	PMID:20412781	PMID:20573694	PMID:20627960	PMID:20932939	PMID:21455939
PMID:21497760	PMID:21873635	PMID:21982646	PMID:22438573	PMID:22560297	PMID:22748019	PMID:22987645	PMID:22988430	PMID:23650387	PMID:23756022	PMID:24146773	PMID:24952961
PMID:26671461	PMID:26904955	PMID:27226325	PMID:27287812	PMID:27568519	PMID:29031500	PMID:29251627	PMID:29437830	PMID:29797482	PMID:30071041	PMID:31221640	PMID:31550482
PMID:31625560	PMID:32098917	PMID:32156753	PMID:32857951	PMID:34446717	PMID:37414772	PMID:38230761

Genomics

Comparative Map Data

Pbx2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	34,811,233 - 34,816,374 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	34,810,240 - 34,816,374 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	34,592,259 - 34,597,400 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	34,591,266 - 34,597,400 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	34,729,416 - 34,734,286 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	34,200,527 - 34,205,397 (+)	NCBI		MGSCv36	mm8
Celera	17	37,687,631 - 37,692,501 (+)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	18.17	NCBI

PBX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	32,184,733 - 32,190,202 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	32,184,733 - 32,190,202 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	32,152,510 - 32,157,979 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	32,260,488 - 32,265,941 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	32,260,495 - 32,265,941	NCBI
Celera	6	33,719,557 - 33,725,007 (-)	NCBI		Celera
Cytogenetic Map	6	p21.32	NCBI
HuRef	6	31,906,708 - 31,912,158 (-)	NCBI		HuRef
CHM1_1	6	32,154,994 - 32,160,447 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	32,037,924 - 32,043,391 (-)	NCBI		T2T-CHM13v2.0

Pbx2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	4,156,107 - 4,161,503 (-)	NCBI		GRCr8
mRatBN7.2	20	4,151,500 - 4,156,425 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	4,151,500 - 4,156,425 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	4,858,099 - 4,863,027 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	4,219,851 - 4,224,779 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	4,750,751 - 4,755,674 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	4,357,805 - 4,362,730 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	4,357,733 - 4,362,682 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	6,437,161 - 6,442,086 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	4,253,962 - 4,259,185 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	4,254,236 - 4,259,412 (-)	NCBI
Celera	20	3,873,856 - 3,878,704 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

Pbx2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	646,906 - 654,008 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	648,935 - 654,008 (-)	NCBI	ChiLan1.0	ChiLan1.0

PBX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	46,647,812 - 46,653,296 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	42,609,292 - 42,614,773 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	31,832,131 - 31,837,585 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	32,708,252 - 32,717,181 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	32,711,166 - 32,717,453 (-)	Ensembl	panpan1.1		panPan2

PBX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	1,577,639 - 1,582,609 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	1,578,707 - 1,584,688 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	1,711,340 - 1,716,366 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	1,715,867 - 1,720,898 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	1,715,861 - 1,720,883 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	1,578,901 - 1,583,922 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	1,644,490 - 1,649,520 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	1,710,814 - 1,715,841 (-)	NCBI		UU_Cfam_GSD_1.0

Pbx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	36,143,042 - 36,148,303 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936727	1,412,632 - 1,419,438 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936727	1,413,063 - 1,418,304 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PBX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	24,221,565 - 24,226,940 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	24,221,565 - 24,226,940 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	28,042,407 - 28,047,793 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PBX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	39,841,798 - 39,847,244 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	39,842,064 - 39,845,618 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	32,084,507 - 32,089,966 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pbx2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624754	24,132,886 - 24,137,699 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1762
Count of miRNA genes:	636
Interacting mature miRNAs:	772
Transcripts:	ENSMUST00000038149, ENSMUST00000173229, ENSMUST00000173328, ENSMUST00000174532, ENSMUST00000183827
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10045977	Tir9_m	trypanosome infection response 9 (mouse)			Not determined		17	27878119	43885114	Mouse
26884379	Skwq5_m	skull length QTL 5, 5 week (mouse)					17	33118974	54107028	Mouse
1300890	Bhr3_m	bronchial hyperresponsiveness 3 (mouse)			Not determined		17	3974890	48866091	Mouse
11075105	Modc1_m	modifier of Odc1 (mouse)					17	27715792	45622654	Mouse
1300995	Fembrs4_m	femur breaking strength 4 (mouse)			Not determined		17	15061652	49061760	Mouse
15039348	Nmrs37_m	NAFLD-associated magnetic resonance shift 37 (mouse)					17	27815209	61815209	Mouse
4141357	Mrdq1_m	modifier of retinal degeneration QTL 1 (mouse)			Not determined			30987903	48039703	Mouse
1302152	Skull25_m	skull morphology 25 (mouse)			Not determined		17	16819721	50819843	Mouse
1302028	Asbb3_m	autoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)			Not determined		17	10878119	44878219	Mouse
15039354	Nmrs36_m	NAFLD-associated magnetic resonance shift 36 (mouse)					17	19145025	53145025	Mouse
1300787	Cd8mts5_m	CD8 memory T cell subset 5 (mouse)			Not determined		17	8584914	42585149	Mouse
4141215	Mnic1_m	macronutrient intake, carbohydrate 1 (mouse)			Not determined			4854752	45670266	Mouse
1300914	Pcir4_m	periosteal circumference 4 (mouse)			Not determined		17	15061652	49061760	Mouse
13452396	Leusq3_m	leucocytosis susceptibility QTL 3 (mouse)					17	17462208	51462345	Mouse
13524847	Asrq8a_m	acoustic startle response 8a (mouse)					17	12646961	46646961	Mouse
13452399	Leusq6_m	leucocytosis susceptibility QTL 6 (mouse)					17	17462208	51462345	Mouse
1300535	Char3_m	P. chabaudi malaria resistance QTL 3 (mouse)			Not determined		17	17462208	51462345	Mouse
4140955	Plgr1_m	plague resistance locus 1 (mouse)			Not determined			31033500	65033630	Mouse
1302070	Tbbmd7_m	total body bone mineral density 7 (mouse)			Not determined		17	15061652	49061760	Mouse
10412214	Sxbq3_m	SGC/Knj cross B6 QTL 3 (mouse)			Not determined		17	17462208	51462345	Mouse
10412083	Sm2_m	susceptibility to Schistosoma mansoni infection 2 (mouse)			Not determined		17	17029943	51030078	Mouse
10412204	Bbaa29_m	B.burgdorferi-associated arthritis 29 (mouse)			Not determined		17	26051185	60051352	Mouse
4141067	Hbnr2_m	Heligmosomoides bakeri nematode resistance 2 (mouse)			Not determined			11885971	45886119	Mouse
10043949	Pbft7_m	percent body fat 7 (mouse)			Not determined		17	6893936	40893936	Mouse
12904946	Tammq8_m	tibialis anterior muscle mass QTL 8 (mouse)					17	12451787	46451787	Mouse
10412198	Sst5_m	susceptibility to tuberculosis 5 (mouse)			Not determined		17	25076583	55712970	Mouse
4142342	Lfnq4_m	lung function QTL 4 (mouse)			Not determined			11206484	39364059	Mouse
10412196	Bbaa28_m	B.burgdorferi-associated arthritis 28 (mouse)			Not determined		17	25584914	43976235	Mouse
1301935	Skull24_m	skull morphology 24 (mouse)			Not determined		17	8584914	42585149	Mouse
1302189	Dps3_m	delta power in slow-wave sleep 3 (mouse)			Not determined		17	33819721	36250180	Mouse
1301331	Lbw1_m	lupus NZB x NZW 1 (mouse)			Not determined		17	18418357	52420983	Mouse
1301840	Ssial4_m	susceptibility to sialadenitiss 4 (mouse)			Not determined		17	18175412	52178214	Mouse
1300692	Blmpf1_m	bleomycin-induced pulmonary fibrosis 1 (mouse)			Not determined		17	32061652	37644775	Mouse
1301338	Lmr1_m	leishmaniasis resistance 1 (mouse)			Not determined		17	10081340	86996400	Mouse
1357789	Kdnw3_m	kidney weight 3 (mouse)			Not determined		17	4854752	47885665	Mouse
1300703	Uvbi2_m	UVB induced immunosuppression 2 (mouse)			Not determined		17	28622406	62622654	Mouse
1301056	Pas2_m	pulmonary adenoma susceptibility 2 (mouse)			Not determined		17	18422141	52424327	Mouse
1301454	Eae5_m	susceptibility to experimental allergic encephalomyelitis 5 (mouse)			Not determined		17	24612750	58612864	Mouse
14747010	Mancz14_m	mandible centroid size 14 (mouse)					17	11998184	45998184	Mouse
1302005	Loco2_m	locomotor activity 2 (mouse)			Not determined		17	26884972	60885114	Mouse
4141272	Tfv1_m	total food volume 1 (mouse)			Not determined			4854752	65637357	Mouse
1300602	Eye2_m	eye weight 2 (mouse)			Not determined		17	26505337	41105037	Mouse
25394538	Skmw84_m	skeletal muscle weight 84, TA (mouse)					17	32660426	35520036	Mouse
10412276	Leci2_m	leukocyte endothelial cell interactions 2 (mouse)			Not determined		17	3348175	37348299	Mouse
1301759	Sles1_m	systemic lupus erythmatosus suppressor 1 (mouse)			Not determined		17	34219890	35175937	Mouse
1302140	Wta4_m	weight adult 4 (mouse)			Not determined		17	16819721	50819843	Mouse
1558758	Kcal2_m	kilocalorie 2 (mouse)			Not determined		17	26401012	52911704	Mouse
1300706	Alan1_m	alloantigen response 1 (mouse)			Not determined		17	4854752	46469702	Mouse
1558886	Lgth9_m	body length 9 (mouse)			Not determined		17	15061652	49061760	Mouse
4142150	Stheal11_m	soft tissue heal 11 (mouse)			Not determined		17	12286211	83361768	Mouse
11081168	Tir7_m	trypanosome infection response 7 (mouse)					17	14123372	48123496	Mouse
1300589	Myaa2_m	modifier of Yaa 2 (mouse)			Not determined		17	30132555	64132666	Mouse

Markers in Region

RH126902

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	17	34,597,152 - 34,597,392	UniSTS	GRCm38
MGSCv37	17	34,734,097 - 34,734,337	UniSTS	GRCm37
Celera	17	37,692,312 - 37,692,552	UniSTS
Cytogenetic Map	17	B1	UniSTS
Whitehead/MRC_RH	17	463.85	UniSTS

AA960287

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	17	34,591,409 - 34,591,643	UniSTS	GRCm38
MGSCv37	17	34,728,354 - 34,728,588	UniSTS	GRCm37
Celera	17	37,686,569 - 37,686,803	UniSTS
Cytogenetic Map	17	B1	UniSTS
Whitehead/MRC_RH	17	469.74	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF020198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF030001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK134357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK141763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK159623	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK165859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC010287	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087615	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT009767	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT010391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU407310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU463834	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000038149 ⟹ ENSMUSP00000040464

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	17	34,811,237 - 34,816,374 (+)	Ensembl
GRCm38.p6 Ensembl	17	34,592,263 - 34,597,400 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000173229

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	17	34,814,434 - 34,815,201 (+)	Ensembl
GRCm38.p6 Ensembl	17	34,595,460 - 34,596,227 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000173328 ⟹ ENSMUSP00000133766

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	17	34,810,240 - 34,815,581 (+)	Ensembl
GRCm38.p6 Ensembl	17	34,591,266 - 34,596,607 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000174532 ⟹ ENSMUSP00000133744

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	17	34,812,369 - 34,813,357 (+)	Ensembl
GRCm38.p6 Ensembl	17	34,593,395 - 34,594,383 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000183827 ⟹ ENSMUSP00000139079

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	17	34,811,708 - 34,815,390 (+)	Ensembl
GRCm38.p6 Ensembl	17	34,592,734 - 34,596,416 (+)	Ensembl

RefSeq Acc Id:

NM_017463 ⟹ NP_059491

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	17	34,811,233 - 34,816,374 (+)	NCBI
GRCm38	17	34,592,259 - 34,597,400 (+)	NCBI
MGSCv37	17	34,729,416 - 34,734,286 (+)	RGD
Celera	17	37,687,631 - 37,692,501 (+)	RGD
cM Map	17		ENTREZGENE

Sequence:

show sequence

CTTCTCCCTCCTCCCTCCTCTCGCACACACACCCCCGCTTGGGCCTCCTCTCTCTCTCTCTCTC
TCTCCGGCTCCATTTTCTCCGCCGCCGGGGGCCGGGGTCTCCTGTGGGGGTGCCCAGGCGGCAC
CCCGGGTCTCCCCTTCAGTGCCGGGGTGAACCCCCGAGGGGAGCCGGGAGGCGGGTTGCCGGGC
GGGGTTGGGGCGGAGGGAGCAGCGGCCCCAGCGAGTTTGGGGGGGAAGTCACCCGGCGGGGGGA
GGGGCGAGCAGGGAGGGGGCCTCAGGCCCCCCCCCAGCTATGGACGAGCGGCTGCTGGGGCCGC
CTCCTCCGGGCGGGGGCCGTGGGGGTCTGGGGCTGGTAGGTGCGGAGCCCGGGGGCCCTGGCGA
GCCTCCCGGTGGCGGAGACCCCGGTGGGGGAAGTGGGGGGGTCCCGGGAGGCCGAGGGAAGCAA
GACATCGGGGACATTCTGCAACAGATAATGACCATCACGGACCAGAGCCTGGACGAGGCCCAGG
CCAAGAAACATGCCCTAAACTGTCACCGAATGAAACCTGCCCTGTTTAGTGTCCTGTGTGAAAT
CAAGGAGAAAACTGGCCTTAGCATTCGGAGCTCCCAAGAGGAGGAGCCCGTGGACCCACAGCTG
ATGCGCCTGGACAACATGCTTCTGGCAGAAGGTGTGGCTGGACCCGAGAAAGGGGGCGGCTCCG
CAGCAGCTGCTGCAGCTGCCGCAGCCTCCGGTGGTGGCGTATCCCCGGACAACTCCATCGAACA
CTCAGACTATCGCAGCAAGCTTGCCCAGATCCGCCACATCTACCACTCAGAGCTGGAGAAGTAT
GAGCAGGCATGCAATGAGTTCACAACTCACGTCATGAACCTGCTGAGGGAGCAGAGCCGCACTC
GCCCGGTCGCCCCCAAGGAGATGGAGCGCATGGTTAGCATCATCCATCGAAAGTTCAGCGCCAT
TCAGATGCAGCTGAAGCAAAGCACCTGTGAGGCCGTCATGATCCTGCGTTCTCGCTTCCTGGAT
GCCAGACGGAAACGCCGGAACTTCAGCAAACAGGCCACTGAGGTCCTGAATGAGTATTTCTACT
CCCACCTGAGCAACCCTTACCCTAGTGAGGAGGCCAAAGAGGAGCTTGCCAAGAAGTGTGGCAT
CACCGTCTCTCAGGTTTCCAACTGGTTCGGTAACAAGCGAATTCGCTACAAGAAGAATATTGGG
AAGTTCCAAGAGGAGGCGAACATCTATGCTGTGAAGACAGCCGTGTCAGTTGCCCAGGGGGGCC
ACAGCCGCACCAGCTCTCCAACGCCCCCTTCCTCTGCAGGCTCTGGCGGCTCTTTCAATCTCTC
AGGATCCGGAGACATGTTTCTGGGGATGCCCGGGCTCAATGGCGATTCCTACCCTGCTTCCCAG
GTGGAATCACTCCGACACTCGATGGGGCCGGGGAGCTACGGGGATAACATTGGGGGAGGTCAGA
TATACAGTCCTCGAGAAATTCGGGCCAATGGTGGCTGGCAGGAGGCTGTGACCCCGTCCTCGGT
GACATCCCCGACAGAGGGACCAGGAAGTGTTCACTCTGACACCTCCAACTGACCTTGCCCCTCA
AGGTCGCGGGGCTAGGGGCTTCCACCAGGCAACTCTTAAGGACTCTGGGCATCTAGAGGACAAA
CCCCACAGAAGCACAAAACAGAGGGCGATTGGGGTTGTGCCCTCCCCGACCAGACGCTTGGTGC
TGGGGTGCTGACAACATGGCAGGGAGAGTGGGGTGTCCCCATTTCTTCTTTCTTTTTTTCGTCT
CACCTCTCACCAAAACCAGATACCTATTTCTCAGATGTCTCTCTTAAATCTACAACCTAACACC
AGTTGTGTTTGTCTTGGACTCCTCCTACTTCTGTTCCCCACCCCACTTATATACTCTGGAATCT
GGAGATGTCAGCCCTGCCCGACCCAGAGATGCCAAAAATGGGGACTCTTGGACAGAGGCCCTGG
GCCAACACCCCCTCCCCCATGCACCCCCACCTCCTGCCCCTCCAGACGGCTTTATTACCTCATA
CGCAGCTCATCTTAAACCAATAGAACCGCTCGGTGGACAAGAGTGTCTGACTCGGATATCTACC
TCGGAGGGAGTTTCTGCTACTTTAGAAAACTGTTGACTAGGCTTTGGAGTTGGACTTTTTGTTT
TGTTTGTTTGTTTTTTAAGAAAAGAAACCCTGAATCTGTATTTCTTTTTAATTGTTTCTGTTGG
TAGTGGTGATCCTTAAGTTTTAATATAGTTTGAAGAAGTAGGGTTTTGGGTGTGTGTGGGGTGT
GTGTGTGTGTCTTAAATAAACATGCTGATTTATTTTTGTTTACCCACTTGAGAAGTAAGAGCCA
AAGGGGCCTAGTAAGAGACAAGACAGATCTGGTGGTGGCTACTTGACCCAGCCCCCCAGTGGGG
AATCGGATTTTGTAGGACACCAGGTCCTCAGCCTGGACACGTGGGTTTCTTAGCCTGCGCAGGC
AGATCTCTGCTGTATTTCCTATGGAGCATGAAGCCCTGTAGCCTCCTGCCTCCCCCACCTCCCC
AGTAACCTTTGGGCAAGACTAGACTGAACTCAGTGATTTTGAAAAAGTCAAAAGGCTTTTGTTT
TGTTTTTTAAACTATTTGCAGAGTGGAAAAGATTGATCGGGGAGGGGAGTTCTTGCCAAATACG
CTAAATATGGGCTGGGTGCTTCTATATGTGTCTCCCCCAGTTTCCCAGAAGTACATGTTTCTGT
TCAGTTCTTAATCTCATGCCAAAATCAAGGGGGTGGGGAGAAGAGGGCGGTCACAGAAAGCCAG
GTATGAGGGAAGGCTAAAAAAGTCTCAGCCCTGAACCCTTCTATCTGACCCCCTCAGACATCCT
CAGGATCTTCAAGACTGTCACCATGGGGAACCCCTCCCATCAAAGGCCCAGGCTGGACTGAGGG
AGTGAAGAGGGTGGTGGGAGGCAGGGGCCAGGGGCAGTTTCTCTCCTCACTTGTAAACATAGAT
TCACAGAAAAAAAAAAAAAAGAAAGAAGTGGCAGTTTTAAATAAAGATATTTCTTTTTCCCCTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_059491	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB71193	(Get FASTA)	NCBI Sequence Viewer
	AAB82006	(Get FASTA)	NCBI Sequence Viewer
	AAH10287	(Get FASTA)	NCBI Sequence Viewer
	AAH62147	(Get FASTA)	NCBI Sequence Viewer
	AAH87615	(Get FASTA)	NCBI Sequence Viewer
	BAE22112	(Get FASTA)	NCBI Sequence Viewer
	BAE24825	(Get FASTA)	NCBI Sequence Viewer
	BAE35238	(Get FASTA)	NCBI Sequence Viewer
	BAE38419	(Get FASTA)	NCBI Sequence Viewer
	CAJ18598	(Get FASTA)	NCBI Sequence Viewer
	EDL26801	(Get FASTA)	NCBI Sequence Viewer
	EDL26802	(Get FASTA)	NCBI Sequence Viewer
	EDL26803	(Get FASTA)	NCBI Sequence Viewer
	EDL26804	(Get FASTA)	NCBI Sequence Viewer
	EDL26805	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000040464
	ENSMUSP00000040464.7
	ENSMUSP00000133744.2
	ENSMUSP00000133766.2
	ENSMUSP00000139079.2
GenBank Protein	O35984	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_059491 ⟸ NM_017463

- UniProtKB:

O35984 (UniProtKB/Swiss-Prot), Q4FJL3 (UniProtKB/TrEMBL), Q3UYU9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDERLLGPPPPGGGRGGLGLVGAEPGGPGEPPGGGDPGGGSGGVPGGRGKQDIGDILQQIMTIT
DQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRSSQEEEPVDPQLMRLDNMLLAEGVA
GPEKGGGSAAAAAAAAASGGGVSPDNSIEHSDYRSKLAQIRHIYHSELEKYEQACNEFTTHVMN
LLREQSRTRPVAPKEMERMVSIIHRKFSAIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQAT
EVLNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAVKT
AVSVAQGGHSRTSSPTPPSSAGSGGSFNLSGSGDMFLGMPGLNGDSYPASQVESLRHSMGPGSY
GDNIGGGQIYSPREIRANGGWQEAVTPSSVTSPTEGPGSVHSDTSN

hide sequence

Ensembl Acc Id:

ENSMUSP00000139079 ⟸ ENSMUST00000183827

Ensembl Acc Id:

ENSMUSP00000133744 ⟸ ENSMUST00000174532

Ensembl Acc Id:

ENSMUSP00000133766 ⟸ ENSMUST00000173328

Ensembl Acc Id:

ENSMUSP00000040464 ⟸ ENSMUST00000038149

Protein Domains

Homeobox PBC

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35984-F1-model_v2	AlphaFold	O35984	1-430	view protein structure

Promoters

RGD ID:

13675710

Promoter ID:

EPDNEW_M22004

Type:

multiple initiation site

Name:

Pbx2_1

Description:

Mus musculus pre B cell leukemia homeobox 2 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	17	34,592,538 - 34,592,598	EPDNEW

RGD ID:

6828438

Promoter ID:

MM_KWN:23207

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

ENSMUST00000038149

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	17	34,728,341 - 34,729,097 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1341793	AgrOrtholog
Ensembl Genes	ENSMUSG00000034673	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000038149	ENTREZGENE
	ENSMUST00000038149.13	UniProtKB/Swiss-Prot
	ENSMUST00000173328.8	UniProtKB/TrEMBL
	ENSMUST00000174532.2	UniProtKB/TrEMBL
	ENSMUST00000183827.8	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_KN_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PBX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TALE_homeobox	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:18515	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:1341793	ENTREZGENE
NCBI Gene	18515	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN TRANSCRIPTION FACTORS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Homeobox_KN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PBC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pbx2	PhenoGen
PROSITE	HOMEOBOX_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PBC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	HOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	G3UXL9_MOUSE	UniProtKB/TrEMBL
	O35984	ENTREZGENE, UniProtKB/Swiss-Prot
	Q3TMM2_MOUSE	UniProtKB/TrEMBL
	Q3TWM8_MOUSE	UniProtKB/TrEMBL
	Q3UR63_MOUSE	UniProtKB/TrEMBL
	Q3UYU9	ENTREZGENE, UniProtKB/TrEMBL
	Q4FJL3	ENTREZGENE, UniProtKB/TrEMBL
	Q5PPM1_MOUSE	UniProtKB/TrEMBL
	V9GXB8_MOUSE	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-02-07	Pbx2	pre B cell leukemia homeobox 2	Pbx2	pre B-cell leukemia transcription factor 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar

Mammalian Phenotype