Tslp (thymic stromal lymphopoietin) - Rat Genome Database

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Gene: Tslp (thymic stromal lymphopoietin) Mus musculus
Analyze
Symbol: Tslp
Name: thymic stromal lymphopoietin
RGD ID: 1621562
MGI Page MGI
Description: Enables cytokine activity. Acts upstream of or within signal transduction. Is active in extracellular space. Is expressed in ductus deferens; epididymis; ileum; and testis. Used to study atopic dermatitis; autoimmune hemolytic anemia; cryoglobulinemia; and membranoproliferative glomerulonephritis. Orthologous to human TSLP (thymic stromal lymphopoietin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: thymic stroma-derived lymphopoietin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,948,436 - 32,952,852 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,948,436 - 32,952,850 (+)EnsemblGRCm39 Ensembl
GRCm381832,815,383 - 32,819,799 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,815,383 - 32,819,797 (+)EnsemblGRCm38mm10GRCm38
MGSCv371832,975,037 - 32,979,453 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361832,958,393 - 32,962,802 (+)NCBIMGSCv36mm8
Celera1833,286,509 - 33,290,920 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->3)-beta-D-glucan  (ISO)
1,2-dichloroethane  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amorolfine  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
benomyl  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butenafine  (ISO)
Calcimycin  (ISO)
calcipotriol  (EXP)
calcitriol  (EXP,ISO)
ceric oxide  (ISO)
CGP 52608  (ISO)
cisplatin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP)
Didecyldimethylammonium  (EXP)
diethyl malate  (EXP)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ferric oxide  (EXP)
fluorescein 5-isothiocyanate  (EXP)
formaldehyde  (ISO)
furan  (ISO)
glyphosate  (EXP)
GW 4064  (EXP)
helenalin  (ISO)
hydroquinone  (ISO)
itraconazole  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
lipopolysaccharide  (EXP,ISO)
Liranaftate  (EXP,ISO)
Luliconazole  (ISO)
Maxacalcitol  (EXP)
melatonin  (EXP)
methoxychlor  (EXP)
N-acetyl-L-cysteine  (ISO)
naringin  (ISO)
nickel dichloride  (EXP,ISO)
ozone  (EXP)
paracetamol  (ISO)
parthenolide  (ISO)
perfluorobutyric acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phloxine O  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
poly(I:C)  (ISO)
progesterone  (ISO)
pyrrolidine dithiocarbamate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
terbinafine  (ISO)
tetrachloromethane  (EXP)
toluene 2,4-diisocyanate  (EXP,ISO)
triclosan  (EXP,ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TSLP Protects Corneas From Pseudomonas aeruginosa Infection by Regulating Dendritic Cells and IL-23-IL-17 Pathway. Cui X, etal., Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):4228-4237. doi: 10.1167/iovs.18-24672.
2. Interactions of thymic stromal lymphopoietin with TLR2 and TLR4 regulate anti-fungal innate immunity in Aspergillus fumigatus-induced corneal infection. Dai C, etal., Exp Eye Res. 2019 May;182:19-29. doi: 10.1016/j.exer.2019.02.020. Epub 2019 Mar 8.
3. Adjuvant selection for vaccination against murine schistosomiasis. El Ridi R and Tallima H, Scand J Immunol. 2012 Dec;76(6):552-8. doi: 10.1111/j.1365-3083.2012.02768.x.
4. Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis. García-García ML, etal., Medicine (Baltimore). 2017 May;96(18):e6787. doi: 10.1097/MD.0000000000006787.
5. Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection. Giacomin PR, etal., J Immunol. 2012 Nov 1;189(9):4371-8. doi: 10.4049/jimmunol.1200691. Epub 2012 Sep 28.
6. The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice. Han M, etal., J Immunol. 2017 Aug 15;199(4):1308-1318. doi: 10.4049/jimmunol.1700216. Epub 2017 Jul 12.
7. Alteration of cytokine production during visceral larva migrans by Toxascaris leonina in mice. Kang SA, etal., Korean J Parasitol. 2013 Oct;51(5):583-8. doi: 10.3347/kjp.2013.51.5.583. Epub 2013 Oct 31.
8. Thymic stromal lymphopoietin mediates the host response and increases mortality during sepsis. Kuethe JW, etal., J Surg Res. 2014 Sep;191(1):19-24. doi: 10.1016/j.jss.2014.05.024. Epub 2014 May 20.
9. Phloxine O, a Cosmetic Colorant, Suppresses the Expression of Thymic Stromal Lymphopoietin and Acute Dermatitis Symptoms in Mice. Lee HE, etal., Biomol Ther (Seoul). 2018 Sep 1;26(5):481-486. doi: 10.4062/biomolther.2017.130.
10. Sex-associated TSLP-induced immune alterations following early-life RSV infection leads to enhanced allergic disease. Malinczak CA, etal., Mucosal Immunol. 2019 Jul;12(4):969-979. doi: 10.1038/s41385-019-0171-3. Epub 2019 May 11.
11. Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33. Mehta AK, etal., J Allergy Clin Immunol. 2016 Jan;137(1):278-88.e6. doi: 10.1016/j.jaci.2015.05.007. Epub 2015 Jun 19.
12. Itching in a trichophytin contact dermatitis mouse model and the antipruritic effect of antifungal agents. Nakamura T, etal., Clin Exp Dermatol. 2019 Jun;44(4):381-389. doi: 10.1111/ced.13719. Epub 2018 Sep 6.
13. Thymic Stromal Lymphopoietin Is Critical for Regulation of Proinflammatory Cytokine Response and Resistance to Experimental Trypanosoma congolense Infection. Onyilagha C, etal., Front Immunol. 2017 Jul 14;8:803. doi: 10.3389/fimmu.2017.00803. eCollection 2017.
14. Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis. Piliponsky AM, etal., Am J Respir Cell Mol Biol. 2016 Aug;55(2):264-74. doi: 10.1165/rcmb.2015-0380OC.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. A potential link between TSLP/TSLPR/STAT5 and TLR2/MyD88/NFκB-p65 in human corneal epithelial cells for Aspergillus fumigatus tolerance. Ren X, etal., Mol Immunol. 2016 Mar;71:98-106. doi: 10.1016/j.molimm.2015.12.014. Epub 2016 Feb 11.
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Thymic stromal lymphopoietin in hepatitis C virus-related cryoglobulinemic vasculitis: gene expression level and protein distribution. Sansonno D, etal., Arthritis Res Ther. 2015 Mar 15;17:62. doi: 10.1186/s13075-015-0581-x.
20. Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine. Sato R, etal., Int Immunol. 2020 Jul 28;32(8):499-507. doi: 10.1093/intimm/dxaa012.
21. Oral interferon-alpha treatment of mice with cryoglobulinemic glomerulonephritis. Segerer S, etal., Am J Kidney Dis. 2002 Apr;39(4):876-88. doi: 10.1053/ajkd.2002.32011.
22. IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria. Shibui A, etal., Biochem Biophys Rep. 2015 Dec 14;5:191-195. doi: 10.1016/j.bbrep.2015.12.007. eCollection 2016 Mar.
23. Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin. Stier MT, etal., J Allergy Clin Immunol. 2016 Sep;138(3):814-824.e11. doi: 10.1016/j.jaci.2016.01.050. Epub 2016 Apr 9.
24. TSLP-activated dendritic cells induce T helper type 2 inflammation in Aspergillus fumigatus keratitis. Sun L, etal., Exp Eye Res. 2018 Jun;171:120-130. doi: 10.1016/j.exer.2018.03.014. Epub 2018 Mar 14.
25. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. Taylor BC, etal., J Exp Med. 2009 Mar 16;206(3):655-67. doi: 10.1084/jem.20081499. Epub 2009 Mar 9.
Additional References at PubMed
PMID:8566050   PMID:10349636   PMID:10974033   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11480573   PMID:11733384   PMID:12466851   PMID:12477932   PMID:14512322   PMID:15263024  
PMID:15263090   PMID:16141072   PMID:16141073   PMID:16172260   PMID:16579866   PMID:16785889   PMID:16880407   PMID:17213320   PMID:17237387   PMID:17640367   PMID:17652941   PMID:17702899  
PMID:17974483   PMID:18060034   PMID:18461563   PMID:18507503   PMID:18566323   PMID:18650845   PMID:18664628   PMID:18711124   PMID:18714000   PMID:18768889   PMID:18802348   PMID:18926564  
PMID:19017958   PMID:19155513   PMID:19188585   PMID:19403406   PMID:19414552   PMID:19414799   PMID:19427817   PMID:19557146   PMID:19658093   PMID:19666528   PMID:19995948   PMID:20030046  
PMID:20077120   PMID:20170316   PMID:20173025   PMID:20600023   PMID:20703245   PMID:20829437   PMID:20974963   PMID:21050044   PMID:21242516   PMID:21421477   PMID:21484783   PMID:21490155  
PMID:21690322   PMID:21820333   PMID:21820713   PMID:21841801   PMID:21873635   PMID:22057556   PMID:22236997   PMID:22270069   PMID:22274860   PMID:22281511   PMID:22340658   PMID:22345495  
PMID:22354320   PMID:22585305   PMID:22832486   PMID:22918211   PMID:22951731   PMID:23018454   PMID:23036746   PMID:23079658   PMID:23079659   PMID:23132931   PMID:23151848   PMID:23189186  
PMID:23213237   PMID:23275605   PMID:23300949   PMID:23333753   PMID:23335246   PMID:23363980   PMID:23437132   PMID:23472158   PMID:23515135   PMID:23698100   PMID:23835188   PMID:23872715  
PMID:24053327   PMID:24094650   PMID:24123684   PMID:24157859   PMID:24167583   PMID:24194600   PMID:24220317   PMID:24252242   PMID:24284909   PMID:24489089   PMID:24560412   PMID:24599138  
PMID:24632570   PMID:24670797   PMID:24723460   PMID:24751726   PMID:24860117   PMID:24961817   PMID:25015831   PMID:25057004   PMID:25172162   PMID:25365222   PMID:25441291   PMID:25544178  
PMID:25680454   PMID:25753260   PMID:26014813   PMID:26120956   PMID:26244295   PMID:26310839   PMID:26531761   PMID:26573878   PMID:26617780   PMID:26830114   PMID:26927668   PMID:26940862  
PMID:26975724   PMID:26993035   PMID:27271511   PMID:27626380   PMID:27742702   PMID:27749840   PMID:27924821   PMID:28017833   PMID:28092372   PMID:28095415   PMID:28115699   PMID:28214951  
PMID:28400057   PMID:28472780   PMID:28552763   PMID:28656964   PMID:28730605   PMID:28765890   PMID:28811323   PMID:28825702   PMID:29116372   PMID:29132961   PMID:29339496   PMID:29556001  
PMID:29596938   PMID:30011850   PMID:30143634   PMID:30575775   PMID:30924922   PMID:30991764   PMID:31227217   PMID:31425777   PMID:31480519   PMID:31564613   PMID:31610053   PMID:31682627  
PMID:31723054   PMID:31975538   PMID:32304753   PMID:32600615   PMID:33262394   PMID:33514510   PMID:33723298   PMID:33819747   PMID:34326208   PMID:34333403   PMID:34925342   PMID:35020848  
PMID:35240143   PMID:35351157   PMID:36050303   PMID:36107619  


Genomics

Comparative Map Data
Tslp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,948,436 - 32,952,852 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,948,436 - 32,952,850 (+)EnsemblGRCm39 Ensembl
GRCm381832,815,383 - 32,819,799 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,815,383 - 32,819,797 (+)EnsemblGRCm38mm10GRCm38
MGSCv371832,975,037 - 32,979,453 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361832,958,393 - 32,962,802 (+)NCBIMGSCv36mm8
Celera1833,286,509 - 33,290,920 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.12NCBI
TSLP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385111,070,062 - 111,078,026 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5111,070,062 - 111,078,026 (+)EnsemblGRCh38hg38GRCh38
GRCh375110,405,760 - 110,413,724 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365110,435,289 - 110,441,623 (+)NCBINCBI36Build 36hg18NCBI36
Celera5106,353,329 - 106,359,661 (+)NCBICelera
Cytogenetic Map5q22.1NCBI
HuRef5105,584,896 - 105,592,841 (+)NCBIHuRef
CHM1_15109,839,103 - 109,847,047 (+)NCBICHM1_1
T2T-CHM13v2.05111,580,695 - 111,588,660 (+)NCBIT2T-CHM13v2.0
Tslp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21824,447,409 - 24,454,244 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1824,449,844 - 24,453,548 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01825,613,601 - 25,618,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1825,613,831 - 25,617,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01825,326,396 - 25,333,230 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41825,268,082 - 25,274,214 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1824,198,059 - 24,202,524 (+)NCBICelera
Cytogenetic Map18p12NCBI
Tslp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554184,041,529 - 4,045,534 (-)NCBIChiLan1.0ChiLan1.0
TSLP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan15104,494,216 - 104,500,953 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05106,440,136 - 106,446,849 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15112,242,490 - 112,249,200 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5112,242,490 - 112,250,130 (+)Ensemblpanpan1.1panPan2
TSLP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.131,502,469 - 1,507,696 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl31,503,188 - 1,507,696 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha32,907,296 - 2,971,755 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.031,393,149 - 1,400,425 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.131,339,901 - 1,404,345 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.031,341,683 - 1,348,998 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.031,506,469 - 1,571,642 (-)NCBIUU_Cfam_GSD_1.0
Tslp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213156,110,394 - 156,115,633 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365315,495,872 - 5,500,462 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSLP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.12115,832,152 - 115,837,572 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22120,289,894 - 120,323,977 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TSLP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12314,419,820 - 14,423,331 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603464,056,775 - 64,060,255 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Tslp
124 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:172
Interacting mature miRNAs:175
Transcripts:ENSMUST00000025237
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207585Mwmlpt3_mMorris water maze latency to platform, training, 3 (mouse)18133547739Mouse
13207589Mwmlpa3_mMorris water maze latency to platform, all, 3 (mouse)18133547739Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
1301950Otx2m1_morthodenticle homolog 2 (Drosophila) modifier 1 (mouse)Not determined182156868236187740Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000025237   ⟹   ENSMUSP00000025237
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,948,436 - 32,952,845 (+)Ensembl
GRCm38.p6 Ensembl1832,815,383 - 32,819,792 (+)Ensembl
RefSeq Acc Id: ENSMUST00000234876
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,949,913 - 32,952,850 (+)Ensembl
GRCm38.p6 Ensembl1832,816,860 - 32,819,797 (+)Ensembl
RefSeq Acc Id: NM_021367   ⟹   NP_067342
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,948,436 - 32,952,852 (+)NCBI
GRCm381832,815,383 - 32,819,799 (+)ENTREZGENE
MGSCv371832,975,037 - 32,979,453 (+)RGD
Celera1833,286,509 - 33,290,920 (+)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_033206
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,949,913 - 32,952,852 (+)NCBI
GRCm381832,816,860 - 32,819,799 (+)NCBI
MGSCv371832,975,037 - 32,979,453 (+)RGD
Celera1833,286,509 - 33,290,920 (+)RGD
cM Map18 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_067342 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF81677 (Get FASTA)   NCBI Sequence Viewer  
  AAI30231 (Get FASTA)   NCBI Sequence Viewer  
  EDK97064 (Get FASTA)   NCBI Sequence Viewer  
  Q9JIE6 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_067342   ⟸   NM_021367
- Peptide Label: precursor
- UniProtKB: Q9JIE6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000025237   ⟸   ENSMUST00000025237

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JIE6-F1-model_v2 AlphaFold Q9JIE6 1-140 view protein structure

Promoters
RGD ID:6829598
Promoter ID:MM_KWN:24860
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung,   MEF_B4,   MEF_B6
Transcripts:NR_033206
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361832,976,219 - 32,976,719 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1855696 AgrOrtholog
Ensembl Genes ENSMUSG00000024379 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000025237 ENTREZGENE
  ENSMUSP00000025237.4 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025237 ENTREZGENE
  ENSMUST00000025237.5 UniProtKB/Swiss-Prot
  ENSMUST00000234876 ENTREZGENE
Gene3D-CATH 1.20.1250.90 UniProtKB/Swiss-Prot
InterPro TSLP UniProtKB/Swiss-Prot
  TSLP_sf UniProtKB/Swiss-Prot
KEGG Report mmu:53603 UniProtKB/Swiss-Prot
MGD MGI:1855696 ENTREZGENE
NCBI Gene 53603 ENTREZGENE
PANTHER PTHR38003 UniProtKB/Swiss-Prot
  THYMIC STROMAL LYMPHOPOIETIN UniProtKB/Swiss-Prot
Pfam TSLP UniProtKB/Swiss-Prot
PhenoGen Tslp PhenoGen
UniProt Q9JIE6 ENTREZGENE, UniProtKB/Swiss-Prot