Rflna (refilin A) - Rat Genome Database

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Gene: Rflna (refilin A) Mus musculus
Analyze
Symbol: Rflna
Name: refilin A
RGD ID: 1621493
MGI Page MGI
Description: Enables filamin binding activity. Acts upstream of or within several processes, including actin filament bundle organization; negative regulation of bone mineralization involved in bone maturation; and negative regulation of chondrocyte development. Located in actin filament bundle. Is expressed in several structures, including alimentary system; respiratory system; sensory organ; skeleton; and unsegmented mesenchyme. Orthologous to human RFLNA (refilin A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3110032G18Rik; cfm; cfm2; Fam10; Fam101a; family with sequence similarity 101, member A; filamin-interacting protein FAM101A; hypothetical protein LOC73121; refilin-A; refilinA; regulator of filamin protein A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395125,080,512 - 125,089,611 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5125,080,285 - 125,089,611 (+)EnsemblGRCm39 Ensembl
GRCm385125,003,448 - 125,012,547 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5125,003,221 - 125,012,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv375125,483,845 - 125,492,917 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365125,292,454 - 125,301,526 (+)NCBIMGSCv36mm8
Celera5122,021,370 - 122,030,413 (+)NCBICelera
Cytogenetic Map5G1.1NCBI
cM Map563.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:15661651   PMID:16141072   PMID:16141073   PMID:16169070   PMID:18554416  
PMID:20178780   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24436304   PMID:29555813   PMID:30021842  


Genomics

Comparative Map Data
Rflna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395125,080,512 - 125,089,611 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5125,080,285 - 125,089,611 (+)EnsemblGRCm39 Ensembl
GRCm385125,003,448 - 125,012,547 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5125,003,221 - 125,012,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv375125,483,845 - 125,492,917 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365125,292,454 - 125,301,526 (+)NCBIMGSCv36mm8
Celera5122,021,370 - 122,030,413 (+)NCBICelera
Cytogenetic Map5G1.1NCBI
cM Map563.95NCBI
RFLNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812123,973,215 - 124,316,024 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12123,973,241 - 124,316,024 (+)EnsemblGRCh38hg38GRCh38
GRCh3712124,457,762 - 124,800,570 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612123,339,663 - 123,366,521 (+)NCBINCBI36Build 36hg18NCBI36
Celera12124,374,399 - 124,401,227 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12121,419,911 - 121,763,336 (+)NCBIHuRef
CHM1_112124,278,627 - 124,622,098 (+)NCBICHM1_1
T2T-CHM13v2.012123,974,731 - 124,318,372 (+)NCBIT2T-CHM13v2.0
Rflna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,294,643 - 37,323,373 (-)NCBIGRCr8
mRatBN7.21231,633,360 - 31,642,313 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,633,361 - 31,642,317 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1232,806,382 - 32,815,296 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,417,705 - 33,426,620 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,469,557 - 32,478,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01237,038,732 - 37,047,628 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1237,038,733 - 37,047,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01238,914,965 - 38,923,860 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,730,785 - 32,739,680 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1233,324,655 - 33,333,550 (-)NCBICelera
Cytogenetic Map12q15NCBI
LOC102011120
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554825,033,914 - 5,042,790 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554825,034,075 - 5,044,162 (-)NCBIChiLan1.0ChiLan1.0
RFLNA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210132,050,056 - 132,396,155 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112132,046,434 - 132,392,533 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012121,737,946 - 121,903,635 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112126,027,350 - 126,191,071 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12126,164,592 - 126,191,071 (+)Ensemblpanpan1.1panPan2
LOC103239345
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111119,497,097 - 119,666,178 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11119,647,606 - 119,668,003 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037125,621,264 - 125,639,698 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rflna
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474723,766,856 - 23,774,397 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474723,766,756 - 23,775,238 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rflna
235 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:546
Count of miRNA genes:401
Interacting mature miRNAs:457
Transcripts:ENSMUST00000036109, ENSMUST00000145946
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
1357662Lprq4_mlipoprotein QTL 4 (mouse)Not determined5114021753129632606Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000036109   ⟹   ENSMUSP00000048230
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5125,080,285 - 125,089,611 (+)Ensembl
GRCm38.p6 Ensembl5125,003,221 - 125,012,547 (+)Ensembl
Ensembl Acc Id: ENSMUST00000145946
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5125,087,177 - 125,088,556 (+)Ensembl
GRCm38.p6 Ensembl5125,010,113 - 125,011,492 (+)Ensembl
Ensembl Acc Id: ENSMUST00000197746   ⟹   ENSMUSP00000142824
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5125,080,539 - 125,089,610 (+)Ensembl
GRCm38.p6 Ensembl5125,003,475 - 125,012,546 (+)Ensembl
RefSeq Acc Id: NM_028443   ⟹   NP_082719
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395125,080,512 - 125,089,611 (+)NCBI
GRCm385125,003,448 - 125,012,547 (+)NCBI
MGSCv375125,483,845 - 125,492,917 (+)RGD
Celera5122,021,370 - 122,030,413 (+)RGD
cM Map5 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_082719 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH53444 (Get FASTA)   NCBI Sequence Viewer  
  BAB29164 (Get FASTA)   NCBI Sequence Viewer  
  EDL19568 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000048230.4
  ENSMUSP00000142824
  ENSMUSP00000142824.2
GenBank Protein Q7TS73 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_082719   ⟸   NM_028443
- UniProtKB: Q9CXQ6 (UniProtKB/Swiss-Prot),   Q7TS73 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000142824   ⟸   ENSMUST00000197746
Ensembl Acc Id: ENSMUSP00000048230   ⟸   ENSMUST00000036109

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TS73-F1-model_v2 AlphaFold Q7TS73 1-204 view protein structure

Promoters
RGD ID:6888126
Promoter ID:EPDNEW_M7514
Type:multiple initiation site
Name:Rflna_1
Description:Mus musculus refilin A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385125,003,454 - 125,003,514EPDNEW
RGD ID:6837480
Promoter ID:MM_KWN:44126
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Lung
Transcripts:OTTMUST00000066378
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365125,483,821 - 125,484,321 (+)MPROMDB
RGD ID:6837482
Promoter ID:MM_KWN:44127
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000066379
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365125,489,746 - 125,490,942 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920371 AgrOrtholog
Ensembl Genes ENSMUSG00000037962 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000036109.8 UniProtKB/Swiss-Prot
  ENSMUST00000197746 ENTREZGENE
  ENSMUST00000197746.2 UniProtKB/Swiss-Prot
InterPro Refilin UniProtKB/Swiss-Prot
KEGG Report mmu:73121 UniProtKB/Swiss-Prot
MGD MGI:1920371 ENTREZGENE
NCBI Gene 73121 ENTREZGENE
PANTHER PTHR31848 UniProtKB/Swiss-Prot
  REFILIN-A UniProtKB/Swiss-Prot
Pfam FAM101 UniProtKB/Swiss-Prot
PhenoGen Rflna PhenoGen
UniProt Q7TS73 ENTREZGENE
  Q9CXQ6 ENTREZGENE
  RFLA_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9CXQ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-09-13 Rflna  refilin A  Fam101a  family with sequence similarity 101, member A  Symbol and/or name change 5135510 APPROVED