Nell1 (NEL-like 1) - Rat Genome Database

Name: Nell1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Nell1 (NEL-like 1) Mus musculus

Analyze

Symbol:

Nell1

Name:

NEL-like 1

RGD ID:

1621212

MGI Page

MGI

Description:

Predicted to enable heparin binding activity; identical protein binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including negative regulation of osteoblast proliferation; positive regulation of bone mineralization; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within cell differentiation. Predicted to be located in nuclear envelope and perinuclear region of cytoplasm. Predicted to be active in extracellular space. Is expressed in several structures, including basal columns; chondrocranium; tooth; tooth bud; and urinary system. Orthologous to human NELL1 (neural EGFL like 1).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

B230343H07Rik; l7; l7R6; NEL-like protein 1; protein kinase C-binding protein NELL1

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NELL1 (neural EGFL like 1)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Nell1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nell1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NELL1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NELL1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nell1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NELL1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NELL1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nell1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NELL2 (neural EGFL like 2)	HGNC	OrthoDB, OrthoMCL
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Nell1 (neural EGFL like 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NELL1 (neural EGFL like 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F19C6.3	Alliance	DIOPT (OrthoFinder\|PhylomeDB)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	49,625,098 - 50,513,037 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	49,624,612 - 50,516,356 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	49,975,350 - 50,863,289 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	49,974,864 - 50,866,608 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	57,230,720 - 58,118,659 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	39,598,885 - 40,491,802 (+)	NCBI		MGSCv36	mm8
MGSCv36	7	49,843,371 - 50,731,308 (+)	NCBI		MGSCv36	mm8
Celera	7	45,425,847 - 46,113,619 (+)	NCBI		Celera
Cytogenetic Map	7	B4	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

craniosynostosis (ISO)

esophagus adenocarcinoma (ISO)

genetic disease (ISO)

intellectual disability (ISO)

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (EXP)

4,4'-sulfonyldiphenol (EXP)

5-aza-2'-deoxycytidine (ISO)

7,12-dimethyltetraphene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (ISO)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

bathocuproine disulfonic acid (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

Butylbenzyl phthalate (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP)

copper(II) sulfate (ISO)

decabromodiphenyl ether (ISO)

dibutyl phthalate (ISO)

dichlorine (ISO)

diethyl phthalate (ISO)

diisobutyl phthalate (ISO)

diisononyl phthalate (ISO)

dorsomorphin (ISO)

ethanol (EXP)

flavonoids (ISO)

fonofos (ISO)

genistein (ISO)

hypochlorous acid (EXP)

ionomycin (ISO)

methylmercury chloride (ISO)

N,N-diethyl-m-toluamide (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (ISO)

paraquat (ISO)

parathion (ISO)

permethrin (ISO)

phorbol 13-acetate 12-myristate (ISO)

profenofos (ISO)

pyrrolidine dithiocarbamate (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

terbufos (ISO)

triclosan (ISO)

valproic acid (EXP,ISO)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

negative regulation of osteoblast proliferation (ISO)

negative regulation of protein catabolic process (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of bone mineralization (ISO)

positive regulation of ossification (IBA,ISO)

positive regulation of osteoblast differentiation (ISO)

regulation of gene expression (ISO)

regulation of osteoblast differentiation (IBA,ISO)

Cellular Component

cytoplasm (ISO)

extracellular region (IEA)

extracellular space (IBA,ISO)

nuclear envelope (ISO)

nucleus (IEA)

perinuclear region of cytoplasm (ISO)

Molecular Function

calcium ion binding (IEA)

heparin binding (IBA,ISO)

identical protein binding (ISO)

protein binding (ISO)

protein kinase C binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal axial skeleton morphology (IAGP)

abnormal bone mineralization (IAGP)

abnormal cervical vertebrae morphology (IAGP)

abnormal intervertebral disk development (IAGP)

abnormal intervertebral disk morphology (IAGP)

abnormal neurocranium morphology (IAGP)

abnormal reflex (IAGP)

abnormal spine curvature (IAGP)

abnormal vertebrae development (IAGP)

abnormal vitreous body morphology (IEA)

cataract (IEA)

decreased bone mineral density (IAGP)

decreased bone ossification (IAGP)

decreased mean corpuscular hemoglobin (IEA)

enlarged frontal bone (IAGP)

enlarged interparietal bone (IAGP)

enlarged nasal bone (IAGP)

enlarged parietal bone (IAGP)

megacephaly (IAGP)

perinatal lethality, complete penetrance (IAGP)

prenatal lethality, complete penetrance (IEA)

prenatal lethality, incomplete penetrance (IEA)

preweaning lethality, complete penetrance (IAGP)

respiratory failure (IAGP)

small kidney (IEA)

thin frontal bone (IAGP)

thin interparietal bone (IAGP)

thin parietal bone (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Craniosynostosis in transgenic mice overexpressing Nell-1.	Zhang X, etal., J Clin Invest 2002 Sep;110(6):861-70.

Additional References at PubMed

PMID:8889548	PMID:10349636	PMID:11042159	PMID:11076861	PMID:11217851	PMID:11792855	PMID:12466851	PMID:16141072	PMID:16141073	PMID:16537572	PMID:16652108	PMID:16936265
PMID:18287559	PMID:19864314	PMID:20939017	PMID:21611965	PMID:21723263	PMID:21873635	PMID:22157752	PMID:22337375	PMID:22728432	PMID:22807400	PMID:23264108	PMID:24563467
PMID:25376942	PMID:26082355	PMID:26586761	PMID:28302495	PMID:29137952	PMID:29905970	PMID:30352124	PMID:31351040	PMID:31582804	PMID:31634652	PMID:31675530	PMID:32325033

Genomics

Comparative Map Data

Nell1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	49,625,098 - 50,513,037 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	49,624,612 - 50,516,356 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	49,975,350 - 50,863,289 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	49,974,864 - 50,866,608 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	57,230,720 - 58,118,659 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	39,598,885 - 40,491,802 (+)	NCBI		MGSCv36	mm8
MGSCv36	7	49,843,371 - 50,731,308 (+)	NCBI		MGSCv36	mm8
Celera	7	45,425,847 - 46,113,619 (+)	NCBI		Celera
Cytogenetic Map	7	B4	NCBI

NELL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	20,669,551 - 21,575,686 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	11	20,669,551 - 21,575,686 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	20,691,097 - 21,597,232 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	20,647,712 - 21,553,577 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	20,647,711 - 21,553,576	NCBI
Celera	11	20,823,987 - 21,729,999 (+)	NCBI		Celera
Cytogenetic Map	11	p15.1	NCBI
HuRef	11	20,382,761 - 21,279,982 (+)	NCBI		HuRef
CHM1_1	11	20,691,076 - 21,597,225 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	20,790,315 - 21,696,309 (+)	NCBI		T2T-CHM13v2.0

Nell1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	99,709,305 - 100,573,872 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	99,709,793 - 100,573,860 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	105,063,381 - 105,953,646 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	113,535,301 - 114,425,557 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	106,857,549 - 107,748,146 (+)	NCBI	Rnor_WKY
Rnor_6.0	1	105,348,577 - 106,218,970 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	105,349,069 - 106,218,958 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	106,397,933 - 107,260,905 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	99,805,922 - 100,758,002 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	100,639,657 - 100,836,113 (+)	NCBI
Celera	1	93,902,928 - 94,754,650 (+)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

Nell1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955476	1,445,353 - 2,233,146 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955476	1,445,234 - 2,236,954 (+)	NCBI	ChiLan1.0	ChiLan1.0

NELL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	20,607,371 - 21,508,938 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	20,607,526 - 21,508,486 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	11	20,697,153 - 21,600,601 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

NELL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	42,654,925 - 43,468,806 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	42,656,339 - 43,468,806 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	42,126,909 - 42,948,580 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	43,772,115 - 44,588,353 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	43,772,165 - 44,596,808 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	42,773,602 - 43,589,728 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	42,949,431 - 43,761,387 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	43,331,499 - 44,154,079 (+)	NCBI		UU_Cfam_GSD_1.0

Nell1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	41,532,506 - 42,335,524 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936654	1,591,847 - 2,394,692 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936654	1,591,016 - 2,392,496 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NELL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	37,809,008 - 38,754,525 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	37,809,080 - 38,754,520 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	41,071,490 - 41,565,325 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NELL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	43,416,052 - 44,335,894 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	43,415,553 - 44,335,381 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	140,734,465 - 141,671,260 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nell1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624766	11,921,650 - 12,737,576 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624766	11,921,570 - 12,734,032 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1240
Count of miRNA genes:	636
Interacting mature miRNAs:	774
Transcripts:	ENSMUST00000081872, ENSMUST00000107603, ENSMUST00000145096, ENSMUST00000151721, ENSMUST00000154410
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300722	Sle3_m	systemic lupus erythmatosus susceptibility 3 (mouse)			Not determined		7	3511728	87142720	Mouse
38501068	Tip1_m	tuberculosis immunophenotype 1, spleen CFU (mouse)					7	3602999	72549748	Mouse
25314307	Mlh1fc2_m	MLH1 foci count 2 (mouse)					7	6502999	133501729	Mouse
12792978	Fbmd3_m	femoral bone mineral density 3, females only (mouse)					7	7050288	142367832	Mouse
10412199	Sst2_m	susceptibility to tuberculosis 2 (mouse)			Not determined		7	18728794	119485380	Mouse
1301158	Eae4_m	susceptibility to experimental allergic encephalomyelitis 4 (mouse)			Not determined		7	19147398	141919804	Mouse
1301622	Eae12_m	susceptibility to experimental allergic encephalomyelitis 12 (mouse)			Not determined		7	19280015	53280104	Mouse
1301052	Bhr6_m	bronchial hyperresponsiveness 6 (mouse)			Not determined		7	19842250	53842367	Mouse
12904742	Litsq2_m	litter size QTL 2 (mouse)					7	22673887	56674033	Mouse
1301709	Bdt4_m	bone density traits 4 (mouse)			Not determined		7	22888572	56888716	Mouse
11354952	Pdcc1_m	plasmacytoid dentritic cell compartment 1 (mouse)					7	23066531	57066531	Mouse
1301969	Lbw5_m	lupus NZB x NZW 5 (mouse)			Not determined		7	26847615	60851775	Mouse
12790989	Tgl6_m	triglyceride 6 (mouse)					7	27540549	61540549	Mouse
4141805	Sle19_m	systematic lupus erythematosus susceptibility 19 (mouse)			Not determined			30032485	81135653	Mouse
26884404	Huml1_m	humerus length 1, 5 week (mouse)					7	30199425	108999207	Mouse
1301175	Ap7q_m	alcohol preference 7 QTL (mouse)			Not determined		7	31714845	65715077	Mouse
1300996	Aorls2_m	aortic lesion size 2 (mouse)			Not determined		7	32394532	66394681	Mouse
4142003	W3q10_m	weight 3 weeks QTL 10 (mouse)			Not determined			33497727	58148965	Mouse
4142102	Tailq5_m	tail length QTL 5 (mouse)			Not determined			33497727	58148965	Mouse
4142218	W6q17_m	weight 6 weeks QTL 17 (mouse)			Not determined			33497727	58148965	Mouse
4141909	W10q18_m	weight 10 weeks QTL 18 (mouse)			Not determined			33497727	58148965	Mouse
1357883	Epfq5_m	epididymal fat pad weight QTL 5 (mouse)			Not determined		7	33497727	58148965	Mouse
1357634	Splq7_m	spleen weight QTL 7 (mouse)			Not determined		7	33497727	58148965	Mouse
39128210	Lwq19_m	liver weight QTL 19 (mouse)					7	33497727	58148965	Mouse
1357469	Kidq5_m	kidney weight QTL 5 (mouse)			Not determined		7	33497727	58148965	Mouse
1559000	Ossc1_m	osteosarcoma susceptibility 1 (mouse)			Not determined		7	34053025	68053223	Mouse
38501071	Stsl6_m	Salmonella typhimurium susceptibility locus 6 (mouse)					7	34199425	51149748	Mouse
10045622	Heal20_m	wound healing/regeneration 20 (mouse)			Not determined		7	34316887	68317043	Mouse
1357586	Mdmsc3_m	modifier of muscularity 3 (mouse)			Not determined		7	34447869	68448018	Mouse
1301514	Rigs1_m	radiation induced gastroschisis 1 (mouse)			Not determined		7	36280015	92394346	Mouse
1301082	Bbaa16_m	B.burgdorferi-associated arthritis 16 (mouse)			Not determined		7	36280015	116416877	Mouse
25314301	Vmm3_m	variable multisystem mineralization 3, lung (mouse)					7	37299425	72049748	Mouse
25314303	Vmm4_m	variable multisystem mineralization 4, kidney (mouse)					7	37299425	87049208	Mouse
1300878	Skts1_m	skin tumor susceptibility 1 (mouse)			Not determined		7	37891386	71891582	Mouse
10402488	Dipa2_m	drug induced psychomotor activation 2 (mouse)			Not determined		7	38421548	72421684	Mouse
1300791	Abbp3_m	A/J and C57BL/6 blood pressure 3 (mouse)			Not determined		7	39673887	103510010	Mouse
11252140	Fdr1_m	fat response to dietary restriction 1 (mouse)					7	41148820	75148965	Mouse
4141929	Chlq18_m	circulating hormone level QTL 18 (mouse)			Not determined		7	41148820	75148965	Mouse
10043926	Bw1n_m	body weight 1 in NSY (mouse)			Not determined		7	45161966	118693530	Mouse
12880417	V125Dq5_m	vitamin D active form serum level QTL 5 (mouse)					7	45249748	79249748	Mouse
25314304	Vmm1_m	variable multisystem mineralization 1, muzzle (mouse)					7	47149748	56549748	Mouse
25314302	Vmm2_m	variable multisystem mineralization 2, heart (mouse)					7	47149748	74149748	Mouse
12738423	Lfibq6_m	liver fibrosis QTL 6 (mouse)					7	47694378	66704862	Mouse
1302141	Fcsa6_m	femoral cross-sectional area 6 (mouse)			Not determined		7	48384461	82384607	Mouse
11532741	Tbrs5_m	tuberculosis resistance 5 (mouse)					7	49159227	83235415	Mouse
1357752	Tabw_m	tally ho asscoiated body weight (mouse)			Not determined		7	49193278	83193390	Mouse

Markers in Region

M-01545

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	7	50,349,044 - 50,349,196	UniSTS	GRCm38
MGSCv37	7	57,604,414 - 57,604,566	UniSTS	GRCm37
Celera	7	45,778,803 - 45,778,955	UniSTS
Cytogenetic Map	7	B4	UniSTS
Whitehead/MRC_RH	7	626.38	UniSTS

AV046776

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	7	50,600,401 - 50,600,490	UniSTS	GRCm38
MGSCv37	7	57,855,771 - 57,855,860	UniSTS	GRCm37
Celera	7	46,013,163 - 46,013,252	UniSTS
Cytogenetic Map	7	B4	UniSTS
Cytogenetic Map	7	B5	UniSTS
Whitehead/MRC_RH	7	630.01	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001037906	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC110036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC115080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC116694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC116734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC121109	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC128666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC128699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC161929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC163402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC171557	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AEKQ02145957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK032845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK046127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK079065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY622226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000081872 ⟹ ENSMUSP00000080550

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	49,624,612 - 50,516,356 (+)	Ensembl
GRCm38.p6 Ensembl	7	49,974,864 - 50,866,608 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000107603 ⟹ ENSMUSP00000103229

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	49,625,082 - 50,513,106 (+)	Ensembl
GRCm38.p6 Ensembl	7	49,975,334 - 50,863,358 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000145096

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	49,624,817 - 49,929,784 (+)	Ensembl
GRCm38.p6 Ensembl	7	49,975,069 - 50,280,036 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000151721 ⟹ ENSMUSP00000114706

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	49,624,612 - 50,210,637 (+)	Ensembl
GRCm38.p6 Ensembl	7	49,974,864 - 50,560,889 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000154410

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	49,748,058 - 49,878,609 (+)	Ensembl
GRCm38.p6 Ensembl	7	50,098,310 - 50,228,861 (+)	Ensembl

RefSeq Acc Id:

NM_001037906 ⟹ NP_001032995

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	49,625,098 - 50,513,037 (+)	NCBI
GRCm38	7	49,975,350 - 50,863,289 (+)	ENTREZGENE
MGSCv37	7	57,230,720 - 58,118,659 (+)	RGD
Celera	7	45,425,847 - 46,113,619 (+)	RGD
cM Map	7		ENTREZGENE

Sequence:

show sequence

GCGTTGGTGCGCCCTGCTTGGCGGGGGGCCTCCGGAGCGATGCCGATGGATGTGATTTTAGTTT
TGTGGTTCTGTGTGTGCACCGCCAGGACAGTGCTGGGCTTTGGGATGGACCCTGACCTTCAGAT
GGACATCATCACTGAACTTGACCTTGTGAACACCACCCTGGGCGTCACTCAGGTGGCTGGACTA
CACAATGCCAGTAAGGCATTTCTGTTTCAAGATGTACAGAGAGAGATCCACTCAGCCCCTCATG
TGAGTGAGAAGCTGATCCAGCTATTCCGGAATAAGAGTGAGTTTACCTTTTTGGCTACAGTGCA
GCAGAAGCCGTCCACCTCAGGGGTGATACTGTCGATCCGGGAGCTGGAACACAGCTATTTTGAA
CTGGAGAGCAGTGGCCCAAGAGAAGAGATACGCTATCATTACATCCATGGCGGCAAGCCCAGGA
CTGAGGCCCTTCCCTACCGCATGGCCGATGGACAGTGGCACAAGGTCGCGCTGTCTGTGAGCGC
CTCTCACCTCCTACTCCATGTCGACTGCAATAGGATTTATGAGCGTGTGATAGATCCTCCGGAG
ACCAACCTTCCTCCAGGAAGCAATCTATGGCTTGGGCAACGTAATCAAAAGCATGGCTTTTTCA
AAGGAATCATCCAAGATGGCAAGATCATCTTCATGCCGAACGGCTTCATCACACAGTGCCCCAA
CCTAAATCGCACTTGCCCAACATGCAGTGATTTCCTGAGCCTGGTTCAAGGAATAATGGATTTG
CAAGAGCTTTTGGCCAAGATGACTGCAAAACTGAATTATGCAGAGACGAGACTTGGTCAACTGG
AAAATTGCCACTGTGAGAAGACCTGCCAAGTGAGTGGGCTGCTCTACAGGGACCAAGACTCCTG
GGTAGATGGTGACAACTGCAGGAACTGCACATGCAAAAGTGGTGCTGTGGAGTGCCGAAGGATG
TCCTGTCCCCCACTCAACTGTTCCCCAGACTCACTTCCTGTGCATATTTCTGGCCAATGTTGTA
AAGTTTGCAGACCAAAATGTATCTATGGAGGAAAAGTTCTTGCTGAGGGCCAGCGGATTTTAAC
CAAGACCTGCCGGGAATGTCGAGGTGGAGTCTTGGTAAAAATCACAGAAGCTTGCCCTCCTTTG
AACTGCTCAGAGAAGGATCATATTCTTCCGGAGAACCAGTGCTGCAGGGTCTGCCGAGGTCATA
ACTTCTGTGCAGAAGCACCTAAGTGTGGAGAAAACTCGGAATGCAAAAATTGGAATACAAAAGC
GACTTGTGAGTGCAAGAATGGATACATCTCTGTCCAGGGCAACTCTGCATACTGTGAAGATATC
GATGAGTGTGCAGCAAAGATGCACTACTGTCATGCCAACACGGTGTGTGTCAACTTGCCGGGGT
TATATCGCTGTGACTGCATCCCAGGATACATCCGTGTGGATGACTTCTCTTGTACGGAGCATGA
TGATTGTGGCAGCGGACAACACAACTGTGACAAAAATGCCATCTGTACCAACACAGTCCAGGGA
CACAGCTGTACCTGCCAGCCAGGCTACGTGGGAAATGGTACTGTCTGCAAAGCATTCTGTGAAG
AGGGTTGCAGATACGGAGGTACCTGTGTGGCCCCTAACAAATGTGTCTGTCCTTCTGGATTCAC
AGGAAGCCACTGTGAGAAAGATATTGATGAATGTGCAGAGGGATTCGTTGAGTGCCACAACCAC
TCCCGCTGCGTTAACCTTCCAGGGTGGTACCACTGTGAGTGCAGAAGCGGTTTCCATGACGATG
GGACCTATTCACTGTCCGGGGAGTCCTGCATTGATATTGATGAATGTGCCTTAAGAACTCACAC
TTGTTGGAATGACTCTGCCTGCATCAACTTAGCAGGAGGATTTGACTGCCTGTGTCCCTCTGGG
CCCTCCTGCTCTGGTGACTGTCCCCACGAAGGGGGGCTGAAGCATAATGGGCAGGTGTGGATTC
TGAGAGAAGACAGGTGTTCAGTCTGTTCCTGTAAGGATGGGAAGATATTCTGCCGGCGGACAGC
TTGTGATTGCCAGAATCCAAATGTTGACCTTTTCTGCTGCCCAGAGTGTGACACCAGGGTCACT
AGCCAATGTTTAGATCAAAGCGGACAGAAGCTCTATCGAAGTGGAGACAACTGGACCCACAGCT
GCCAGCAGTGCCGATGTCTGGAAGGAGAGGCAGACTGCTGGCCTCTAGCTTGCCCTAGTTTGAG
CTGTGAATACACAGCCATCTTTGAAGGAGAGTGTTGTCCCCGCTGTGTCAGTGACCCCTGCCTG
GCTGATAATATTGCCTATGACATCAGAAAAACTTGCCTGGACAGCTCTGGTATTTCGAGGCTGA
GCGGCGCAGTGTGGACAATGGCTGGATCTCCCTGTACAACCTGTCAATGCAAGAATGGGAGAGT
CTGCTGCTCTGTGGATCTGGTGTGTCTTGAGAATAACTGAAGATTTTAAATGGACTCATCACAT
GAGAAAATGGACAAAATGACCATCCAACCTGAGGAAGAGGAGGGGCTGATTTCTTTTTCTTTTT
AACCACAGTCAATTACCAAAGTCTCCATCAGAGGAAGGCGTTTGGGTTGCCTTTACCACTTTGC
TCATCCTTGCTGACCTAGTCTAGATGCCTGCAGTACCGTGTATTTCGGTCGATGGTTGTTGAGT
CTCCGTGCTGTAAATCACATTTCCCTTGTCAGATCATTTACAGATACATTTAAAGGATTCCATG
ATAAATGTTAAAGTACCTTTTGTTTATTTTGTGTACCAACATAATAGAGACTTGGCACCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001032995	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAV41488	(Get FASTA)	NCBI Sequence Viewer
	Q2VWQ2	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001032995 ⟸ NM_001037906
- Peptide Label:	precursor
- UniProtKB:	Q2VWQ2 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MPMDVILVLWFCVCTARTVLGFGMDPDLQMDIITELDLVNTTLGVTQVAGLHNASKAFLFQDVQ REIHSAPHVSEKLIQLFRNKSEFTFLATVQQKPSTSGVILSIRELEHSYFELESSGPREEIRYH YIHGGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPETNLPPGSNLWLGQ RNQKHGFFKGIIQDGKIIFMPNGFITQCPNLNRTCPTCSDFLSLVQGIMDLQELLAKMTAKLNY AETRLGQLENCHCEKTCQVSGLLYRDQDSWVDGDNCRNCTCKSGAVECRRMSCPPLNCSPDSLP VHISGQCCKVCRPKCIYGGKVLAEGQRILTKTCRECRGGVLVKITEACPPLNCSEKDHILPENQ CCRVCRGHNFCAEAPKCGENSECKNWNTKATCECKNGYISVQGNSAYCEDIDECAAKMHYCHAN TVCVNLPGLYRCDCIPGYIRVDDFSCTEHDDCGSGQHNCDKNAICTNTVQGHSCTCQPGYVGNG TVCKAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECAEGFVECHNHSRCVNLPGWYHCE CRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGL KHNGQVWILREDRCSVCSCKDGKIFCRRTACDCQNPNVDLFCCPECDTRVTSQCLDQSGQKLYR SGDNWTHSCQQCRCLEGEADCWPLACPSLSCEYTAIFEGECCPRCVSDPCLADNIAYDIRKTCL DSSGISRLSGAVWTMAGSPCTTCQCKNGRVCCSVDLVCLENN hide sequence

RefSeq Acc Id:

ENSMUSP00000103229 ⟸ ENSMUST00000107603

RefSeq Acc Id:

ENSMUSP00000114706 ⟸ ENSMUST00000151721

RefSeq Acc Id:

ENSMUSP00000080550 ⟸ ENSMUST00000081872

Protein Domains

EGF-like Laminin G Laminin G-like VWFC

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q2VWQ2-F1-model_v2	AlphaFold	Q2VWQ2	1-810	view protein structure

Promoters

RGD ID:

8664215

Promoter ID:

EPDNEW_M10139

Type:

initiation region

Name:

Nell1_1

Description:

Mus musculus NEL-like 1 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	7	49,975,278 - 49,975,338	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2443902	AgrOrtholog
Ensembl Genes	ENSMUSG00000055409	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000080550	ENTREZGENE
	ENSMUSP00000080550.6	UniProtKB/Swiss-Prot
	ENSMUSP00000103229.2	UniProtKB/TrEMBL
	ENSMUSP00000114706.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000081872	ENTREZGENE
	ENSMUST00000081872.13	UniProtKB/Swiss-Prot
	ENSMUST00000107603.2	UniProtKB/TrEMBL
	ENSMUST00000151721.8	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.200	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	6.20.200.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Complement Module, domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Laminin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	ConA-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF-like_Ca-bd_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Growth_fac_rcpt_cys_sf	UniProtKB/Swiss-Prot
	Laminin_G	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWF_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:338352	UniProtKB/Swiss-Prot
MGD	MGI:2443902	ENTREZGENE
NCBI Gene	338352	ENTREZGENE
PANTHER	NEL HOMOLOG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN KINASE C-BINDING PROTEIN NELL1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	EGF_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_CA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Laminin_G_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Nell1	PhenoGen
PROSITE	ASX_HYDROXYL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_CA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LAM_G_DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWFC_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWFC_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	EGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_CA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LamG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSPN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWC_out	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FnI-like domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF49899	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF57184	UniProtKB/Swiss-Prot
UniProt	D3YV40_MOUSE	UniProtKB/TrEMBL
	D3YWD8_MOUSE	UniProtKB/TrEMBL
	NELL1_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-11-06	Nell1	NEL-like 1		NEL-like 1 (chicken)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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