Dnmt3a (DNA methyltransferase 3A) - Rat Genome Database

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Gene: Dnmt3a (DNA methyltransferase 3A) Mus musculus
Analyze
Symbol: Dnmt3a
Name: DNA methyltransferase 3A
RGD ID: 1620920
MGI Page MGI
Description: Enables DNA binding activity; S-adenosylmethionine-dependent methyltransferase activity; and lncRNA binding activity. Involved in autosome genomic imprinting; negative regulation of gene expression via chromosomal CpG island methylation; and transposable element silencing by piRNA-mediated DNA methylation. Acts upstream of or within several processes, including cellular response to bisphenol A; epigenetic regulation of gene expression; and oocyte development. Located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; limb mesenchyme; and sensory organ. Human ortholog(s) of this gene implicated in Tatton-Brown-Rahman syndrome; hematologic cancer (multiple); and stomach cancer. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU015806; cysteine methyltransferase DNMT3A; DNA (cytosine-5)-methyltransferase 3A; DNA methyltransferase MmuIIIA; DNA MTase MmuIIIA; m.MmuIIIA; MmuIIIA; W91664
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Dnmt3a-ps1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39123,851,559 - 3,964,442 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl123,856,007 - 3,964,443 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38123,801,559 - 3,914,443 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,806,007 - 3,914,443 (+)Ensemblmm10GRCm38
MGSCv37123,806,980 - 3,914,443 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36123,835,027 - 3,914,455 (+)NCBIMGSCv36mm8
Celera123,763,156 - 3,842,112 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute monocytic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
amyotrophic lateral sclerosis  (IEP)
autism spectrum disorder  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bone marrow disease  (IMP)
Brain Hypoxia-Ischemia  (ISO)
Breast Neoplasms  (ISO)
Carcinogenesis  (ISO)
chronic myeloid leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
congenital heart disease  (ISO)
Craniofacial Abnormalities  (ISO)
Crohn's disease  (ISO)
depressive disorder  (IDA,IEP)
diffuse large B-cell lymphoma  (ISO)
Dwarfism  (ISO)
endometriosis  (ISO)
endometriosis of uterus  (ISO)
Facies  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Growth Disorders  (ISO)
hepatocellular carcinoma  (ISO)
Heyn-Sproul-Jackson Syndrome  (ISO)
Immunoblastic Lymphadenopathy  (ISO)
intellectual disability  (ISO)
juvenile myelomonocytic leukemia  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
melanoma  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
Muscle Hypotonia  (ISO)
myelodysplastic syndrome  (ISO)
myeloid neoplasm  (ISO)
Neoplasm Recurrence, Local  (ISO)
Nervous System Malformations  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
peripheral T-cell lymphoma  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
prostate adenocarcinoma  (IEP)
prostatitis  (ISO)
sciatic neuropathy  (IEP)
Sezary's disease  (ISO)
stomach cancer  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
Tatton-Brown-Rahman syndrome  (IAGP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP,ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
amitrole  (ISO)
amphetamine  (ISO)
androgen antagonist  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aripiprazole  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asiatic acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (ISO)
buta-1,3-diene  (EXP)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (EXP)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
citalopram  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-penicillamine  (EXP)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP)
Diallyltetrasulfane  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP,ISO)
Difenacoum  (ISO)
disodium selenite  (EXP,ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enzacamene  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (ISO)
Flocoumafen  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (ISO)
gibberellin A3  (ISO)
glycitein  (ISO)
glycitin  (ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
hexane  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
isoprenaline  (EXP,ISO)
isorhapontigenin  (ISO)
ketoconazole  (ISO)
L-methionine  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
malathion  (ISO)
mancozeb  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (EXP)
Monobutylphthalate  (EXP)
morphine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methylformamide  (EXP)
N-nitrosodiethylamine  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
patulin  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP)
poly(I:C)  (ISO)
potassium dichromate  (ISO)
procyanidin B2  (ISO)
pterostilbene  (ISO)
pyrethrins  (ISO)
quartz  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-adenosyl-L-methioninate  (EXP,ISO)
S-adenosyl-L-methionine  (EXP,ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sinefungin  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
tangeretin  (EXP)
tartrazine  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (EXP)
troglitazone  (EXP)
tungsten  (EXP)
tyrphostin AG 1478  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)
vinyl carbamate  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autosome genomic imprinting  (IDA,IMP)
cellular response to amino acid stimulus  (IDA)
cellular response to bisphenol A  (IDA)
cellular response to ethanol  (IEA,ISO)
cellular response to hypoxia  (IEA,ISO)
chromatin organization  (IEA)
developmental process involved in reproduction  (IEA)
DNA methylation-dependent constitutive heterochromatin formation  (IEA,IGI,ISO)
epigenetic programming of gene expression  (IGI,IMP)
gamete generation  (IEA)
gene silencing by piRNA-directed DNA methylation  (IEA)
genomic imprinting  (IMP)
hepatocyte apoptotic process  (IEA,ISO)
heterochromatin formation  (IMP)
methylation  (IEA)
negative regulation of DNA-templated transcription  (IBA)
negative regulation of gene expression via chromosomal CpG island methylation  (IDA,IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neuron differentiation  (IEA,ISO)
oocyte development  (IMP)
positive regulation of cellular response to hypoxia  (IEA,ISO)
post-embryonic development  (IDA)
regulation of gene expression  (IEA)
regulatory ncRNA-mediated heterochromatin formation  (IEA,ISO)
response to cocaine  (IEA,ISO)
response to estradiol  (IEA,ISO)
response to ethanol  (IEA,ISO)
response to ionizing radiation  (IEA,ISO)
response to lead ion  (IEA,ISO)
response to nutrient levels  (IEA,ISO)
response to toxic substance  (IEA,ISO)
response to vitamin A  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
spermatogenesis  (IMP)
transposable element silencing by piRNA-mediated DNA methylation  (IPI)

Cellular Component
catalytic complex  (IEA,ISO)
chromosome  (IEA)
chromosome, centromeric region  (IDA,IEA)
cytoplasm  (IBA,IDA,IEA,ISO,ISS)
euchromatin  (IEA,ISO,ISS)
heterochromatin  (IDA,IEA)
nuclear matrix  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (IBA,IDA,IEA,ISO,ISS)
XY body  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal associative learning  (IAGP)
abnormal bone marrow adipose tissue morphology  (IAGP)
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal bone marrow hematopoietic cell morphology  (IAGP)
abnormal bone structure  (IEA)
abnormal brain morphology  (IAGP)
abnormal brain ventricle morphology  (IAGP)
abnormal brain white matter morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal DNA methylation  (IAGP)
abnormal DNA methylation during gametogenesis  (IAGP)
abnormal embryo size  (IEA)
abnormal fertility/fecundity  (IAGP)
abnormal gait  (IAGP)
abnormal imprinting  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal multipotent stem cell morphology  (IAGP)
abnormal neuromuscular synapse morphology  (IAGP)
abnormal pancreatic beta cell differentiation  (IAGP)
abnormal parturition  (IAGP)
abnormal pregnancy  (IAGP)
abnormal response to novel object  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal social/conspecific interaction behavior  (IAGP)
abnormal tibia morphology  (IAGP)
absent somites  (IAGP)
azoospermia  (IAGP)
convulsive seizures  (IEA)
decreased birth body size  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone stiffness  (IAGP)
decreased brain size  (IAGP)
decreased circulating cholesterol level  (IEA)
decreased circulating glucose level  (IEA)
decreased circulating HDL cholesterol level  (IEA)
decreased exploration in new environment  (IAGP)
decreased femur compact bone thickness  (IAGP)
decreased femur maximal load  (IAGP)
decreased femur yield load  (IAGP)
decreased food intake  (IAGP)
decreased grip strength  (IAGP)
decreased lean body mass  (IAGP)
decreased locomotor activity  (IAGP)
decreased motor neuron number  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased respiratory quotient  (IAGP)
decreased spermatid number  (IAGP)
decreased testis weight  (IAGP)
decreased vertical activity  (IAGP)
decreased vocalization  (IAGP)
dystocia  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enhanced contextual conditioning behavior  (IAGP)
enhanced cued conditioning behavior  (IAGP)
external male genitalia hypoplasia  (IAGP)
female infertility  (IAGP)
hypoactivity  (IAGP)
impaired coordination  (IAGP)
incomplete embryo turning  (IAGP)
increased acute myeloid leukemia incidence  (IAGP)
increased body fat mass  (IAGP)
increased body height  (IAGP)
increased body size  (IAGP)
increased body weight  (IAGP)
increased classified tumor incidence  (IAGP)
increased common myeloid progenitor cell number  (IAGP)
increased grip strength  (IEA)
increased hematopoietic stem cell number  (IAGP)
increased length of long bones  (IAGP)
increased leukemia incidence  (IAGP)
increased long bone epiphyseal plate size  (IAGP)
increased pancreatic alpha cell number  (IAGP)
increased stereotypic behavior  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased total body fat amount  (IAGP)
large mandible  (IAGP)
long femur  (IAGP)
long tibia  (IAGP)
male infertility  (IAGP)
obese  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
teratozoospermia  (IAGP)
thin cerebral cortex  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cavuoto P and Fenech MF, Cancer Treat Rev. 2012 Oct;38(6):726-36. doi: 10.1016/j.ctrv.2012.01.004. Epub 2012 Feb 17.
2. Vinclozolin exposure in utero induces postpubertal prostatitis and reduces sperm production via a reversible hormone-regulated mechanism. Cowin PA, etal., Endocrinology. 2010 Feb;151(2):783-92. doi: 10.1210/en.2009-0982. Epub 2010 Jan 7.
3. Cancer epigenetics: from mechanism to therapy. Dawson MA and Kouzarides T, Cell. 2012 Jul 6;150(1):12-27. doi: 10.1016/j.cell.2012.06.013.
4. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
5. DNMT3A R882 mutations in patients with cytogenetically normal acute myeloid leukemia and myelodysplastic syndrome. El Ghannam D, etal., Blood Cells Mol Dis. 2014 Jun-Aug;53(1-2):61-6. doi: 10.1016/j.bcmd.2014.01.004. Epub 2014 Feb 8.
6. A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma. Fan H, etal., BMC Med. 2010 Feb 3;8:12. doi: 10.1186/1741-7015-8-12.
7. Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart. Feng Y, etal., J Nutr Biochem. 2013 Jul;24(7):1373-80. doi: 10.1016/j.jnutbio.2012.11.005. Epub 2013 Jan 17.
8. [Expression and significance of DNA methyltransferase in sera of patients with lung cancer]. Feng YJ, etal., Zhonghua Yi Xue Za Zhi. 2013 Dec 24;93(48):3822-5.
9. The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL. Grossmann V, etal., Genes Chromosomes Cancer. 2013 Apr;52(4):410-22. doi: 10.1002/gcc.22039. Epub 2013 Jan 23.
10. Change in microRNAs associated with neuronal adaptive responses in the nucleus accumbens under neuropathic pain. Imai S, etal., J Neurosci. 2011 Oct 26;31(43):15294-9. doi: 10.1523/JNEUROSCI.0921-11.2011.
11. Phenotypic switching induced by damaged matrix is associated with DNA methyltransferase 3A (DNMT3A) activity and nuclear localization in smooth muscle cells (SMC). Jiang JX, etal., PLoS One. 2013 Aug 7;8(8):e69089. doi: 10.1371/journal.pone.0069089. eCollection 2013.
12. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. LaPlant Q, etal., Nat Neurosci. 2010 Sep;13(9):1137-43. doi: 10.1038/nn.2619. Epub 2010 Aug 22.
13. DNMT3A mutations and prognostic significance in childhood acute lymphoblastic leukemia. Li W, etal., Leuk Lymphoma. 2015 Apr;56(4):1066-71. doi: 10.3109/10428194.2014.947607. Epub 2014 Nov 10.
14. Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome. Lin J, etal., PLoS One. 2011;6(10):e26906. doi: 10.1371/journal.pone.0026906. Epub 2011 Oct 31.
15. Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a. Liu WB, etal., Toxicol Appl Pharmacol. 2011 Feb 15;251(1):70-8. doi: 10.1016/j.taap.2010.12.002. Epub 2010 Dec 14.
16. Aberrant immunoreactivity of deoxyribonucleic acid methyltransferases in adenomyosis. Liu X and Guo SW, Gynecol Obstet Invest. 2012;74(2):100-8. Epub 2012 May 4.
17. DNMT3A mutation analysis in adult patients with acute lymphoblastic leukemia. Liu YN, etal., J Huazhong Univ Sci Technolog Med Sci. 2015 Jun;35(3):337-42. doi: 10.1007/s11596-015-1434-1. Epub 2015 Jun 14.
18. Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. Majumder S, etal., J Biol Chem. 2002 May 3;277(18):16048-58. Epub 2002 Feb 13.
19. Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. Marcucci G, etal., J Clin Oncol. 2012 Mar 1;30(7):742-50. doi: 10.1200/JCO.2011.39.2092. Epub 2012 Jan 30.
20. Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. Mayle A, etal., Blood. 2015 Jan 22;125(4):629-38.
21. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Mizuno S, etal., Blood. 2001 Mar 1;97(5):1172-9.
22. DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Morey SR, etal., Cancer Res. 2006 Dec 15;66(24):11659-67.
23. MicroRNA miR-29c down-regulation leading to de-repression of its target DNA methyltransferase 3a promotes ischemic brain damage. Pandi G, etal., PLoS One. 2013;8(3):e58039. doi: 10.1371/journal.pone.0058039. Epub 2013 Mar 13.
24. DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. Park HJ, etal., Cancer Lett. 2006 Feb 28;233(2):271-8.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. Mouse MP Annotation Import Pipeline RGD automated import pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. DNMT3A Mutational Status Affects the Results of Dose-Escalated Induction Therapy in Acute Myelogenous Leukemia. Sehgal AR, etal., Clin Cancer Res. 2015 Apr 1;21(7):1614-20. doi: 10.1158/1078-0432.CCR-14-0327. Epub 2015 Jan 21.
30. Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura. Tao J, etal., J Clin Immunol. 2008 Sep;28(5):432-9. doi: 10.1007/s10875-008-9223-2. Epub 2008 Aug 6.
31. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Walter MJ, etal., Leukemia. 2011 Jul;25(7):1153-8. doi: 10.1038/leu.2011.44. Epub 2011 Mar 18.
32. Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS. Wong M, etal., Front Cell Neurosci. 2013 Dec 25;7:279. doi: 10.3389/fncel.2013.00279. eCollection 2013.
33. Chronic cerebrovascular hypoperfusion affects global DNA methylation and histone acetylation in rat brain. Wu X, etal., Neurosci Bull. 2013 Dec;29(6):685-92. doi: 10.1007/s12264-013-1345-8. Epub 2013 May 28.
34. Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis. Wu Y, etal., Fertil Steril. 2007 Jan;87(1):24-32. Epub 2006 Nov 1.
35. DNMT3A intragenic hypomethylation is associated with adverse prognosis in acute myeloid leukemia. Zhang YY, etal., Leuk Res. 2015 Oct;39(10):1041-7. doi: 10.1016/j.leukres.2015.06.015. Epub 2015 Jul 6.
Additional References at PubMed
PMID:8772199   PMID:8889548   PMID:9662389   PMID:10349636   PMID:10555141   PMID:10575238   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11350943  
PMID:11399089   PMID:11821381   PMID:11919202   PMID:11934864   PMID:12138111   PMID:12351185   PMID:12370304   PMID:12406579   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12616525  
PMID:12787669   PMID:12869530   PMID:12897133   PMID:12904583   PMID:14610273   PMID:14681479   PMID:14752048   PMID:14760703   PMID:14998934   PMID:14998998   PMID:15063176   PMID:15215868  
PMID:15310660   PMID:15317747   PMID:15456861   PMID:15456878   PMID:15489334   PMID:15522198   PMID:15533817   PMID:15567719   PMID:15616584   PMID:15634679   PMID:15671018   PMID:15672446  
PMID:15735669   PMID:15739230   PMID:15757890   PMID:15919778   PMID:16026162   PMID:16141072   PMID:16141073   PMID:16283622   PMID:16288735   PMID:16362968   PMID:16395332   PMID:16439359  
PMID:16472822   PMID:16501171   PMID:16565708   PMID:16584789   PMID:16602821   PMID:16631596   PMID:16682412   PMID:16725135   PMID:16824199   PMID:16840553   PMID:16973295   PMID:16999741  
PMID:17048991   PMID:17175537   PMID:17182866   PMID:17420264   PMID:17439403   PMID:17445268   PMID:17477386   PMID:17485486   PMID:17579209   PMID:17616512   PMID:17687327   PMID:17713477  
PMID:17938196   PMID:17982445   PMID:17989773   PMID:17994007   PMID:18157120   PMID:18191145   PMID:18241125   PMID:18365873   PMID:18381894   PMID:18452947   PMID:18536344   PMID:18536530  
PMID:18541703   PMID:18544626   PMID:18559477   PMID:18667590   PMID:18757295   PMID:18784354   PMID:18799693   PMID:18823905   PMID:18932249   PMID:18945701   PMID:18953337   PMID:19161295  
PMID:19228594   PMID:19386473   PMID:19509302   PMID:19625655   PMID:19632198   PMID:19680236   PMID:19727073   PMID:19798101   PMID:19921333   PMID:20011505   PMID:20059948   PMID:20059953  
PMID:20132320   PMID:20211142   PMID:20228804   PMID:20348135   PMID:20362542   PMID:20367604   PMID:20385583   PMID:20489138   PMID:20507910   PMID:20547484   PMID:20548288   PMID:20569692  
PMID:20573497   PMID:20577743   PMID:20651149   PMID:20889571   PMID:20966256   PMID:21047779   PMID:21057502   PMID:21057543   PMID:21092094   PMID:21118511   PMID:21172419   PMID:21174446  
PMID:21194568   PMID:21233130   PMID:21262766   PMID:21267068   PMID:21452232   PMID:21454628   PMID:21481189   PMID:21566127   PMID:21576263   PMID:21589869   PMID:21608077   PMID:21624812  
PMID:21677750   PMID:21695170   PMID:21706000   PMID:21731673   PMID:21873635   PMID:21905163   PMID:21980460   PMID:22011581   PMID:22056672   PMID:22086334   PMID:22090490   PMID:22134929  
PMID:22138693   PMID:22190484   PMID:22269950   PMID:22315408   PMID:22387999   PMID:22516971   PMID:22580371   PMID:22584578   PMID:22714992   PMID:22751036   PMID:22761581   PMID:22837034  
PMID:22898819   PMID:22913541   PMID:23284304   PMID:23293288   PMID:23393137   PMID:23399934   PMID:23444399   PMID:23611774   PMID:23637617   PMID:23641003   PMID:23665319   PMID:23772023  
PMID:23825703   PMID:23866265   PMID:23920106   PMID:24074865   PMID:24124161   PMID:24127215   PMID:24167195   PMID:24183668   PMID:24194600   PMID:24270360   PMID:24292811   PMID:24357321  
PMID:24362762   PMID:24457600   PMID:24497509   PMID:24530979   PMID:24599402   PMID:24645644   PMID:24698270   PMID:24837369   PMID:24895120   PMID:24937014   PMID:24941955   PMID:24952961  
PMID:25123312   PMID:25130491   PMID:25147181   PMID:25335909   PMID:25349213   PMID:25389311   PMID:25392496   PMID:25416276   PMID:25445743   PMID:25476147   PMID:25476906   PMID:25487288  
PMID:25569111   PMID:25634742   PMID:25639876   PMID:25686699   PMID:25706873   PMID:25713087   PMID:25762136   PMID:25766529   PMID:25772072   PMID:25801914   PMID:25821913   PMID:25822089  
PMID:26003733   PMID:26023099   PMID:26030024   PMID:26059604   PMID:26098432   PMID:26417043   PMID:26420038   PMID:26482727   PMID:26576615   PMID:26595813   PMID:26631740   PMID:26674863  
PMID:26710888   PMID:26751286   PMID:26791204   PMID:26808831   PMID:26812015   PMID:26843651   PMID:26876596   PMID:26952936   PMID:27010239   PMID:27016502   PMID:27122033   PMID:27134162  
PMID:27149841   PMID:27240213   PMID:27300438   PMID:27306334   PMID:27335278   PMID:27344947   PMID:27387481   PMID:27415617   PMID:27428748   PMID:27516062   PMID:27545441   PMID:27582468  
PMID:27626380   PMID:27636998   PMID:27677595   PMID:27681438   PMID:27690235   PMID:27824296   PMID:27826835   PMID:27841873   PMID:27841881   PMID:27865785   PMID:27895551   PMID:27906176  
PMID:27939986   PMID:27956497   PMID:27965390   PMID:28114345   PMID:28167789   PMID:28267064   PMID:28270689   PMID:28317850   PMID:28321121   PMID:28425913   PMID:28451635   PMID:28461508  
PMID:28614801   PMID:28648661   PMID:28712054   PMID:28849714   PMID:28872462   PMID:28976982   PMID:29027601   PMID:29056337   PMID:29074627   PMID:29091029   PMID:29146735   PMID:29162810  
PMID:29164502   PMID:29236683   PMID:29254152   PMID:29326230   PMID:29464054   PMID:29572461   PMID:29617651   PMID:29728415   PMID:29748607   PMID:29750576   PMID:29765016   PMID:29850805  
PMID:30001199   PMID:30058429   PMID:30102379   PMID:30186101   PMID:30258352   PMID:30321403   PMID:30366920   PMID:30385711   PMID:30487604   PMID:30518531   PMID:30530687   PMID:30638145  
PMID:30644360   PMID:30684388   PMID:30692594   PMID:30759395   PMID:30832495   PMID:30834655   PMID:30850438   PMID:30973865   PMID:30975723   PMID:31015495   PMID:31027045   PMID:31124216  
PMID:31361780   PMID:31435645   PMID:31467060   PMID:31530896   PMID:31558711   PMID:31634469   PMID:31665063   PMID:31703632   PMID:31784358   PMID:31784360   PMID:31792207   PMID:31823782  
PMID:31932841   PMID:32001657   PMID:32027825   PMID:32052888   PMID:32061563   PMID:32064321   PMID:32096741   PMID:32123907   PMID:32159514   PMID:32173286   PMID:32203468   PMID:32220332  
PMID:32222282   PMID:32325033   PMID:32353257   PMID:32445940   PMID:32514123   PMID:32514790   PMID:32561758   PMID:32579919   PMID:32581223   PMID:32589877   PMID:32674113   PMID:32756009  
PMID:32876528   PMID:32892421   PMID:32964508   PMID:33051852   PMID:33110091   PMID:33159179   PMID:33238114   PMID:33513138   PMID:33826889   PMID:33846253   PMID:33847380   PMID:33850140  
PMID:33986537   PMID:34048432   PMID:34067359   PMID:34092059   PMID:34315901   PMID:34533678   PMID:34685658   PMID:34686499   PMID:34698806   PMID:34716195   PMID:34824202   PMID:34879184  
PMID:34903841   PMID:34912016   PMID:34985827   PMID:34986190   PMID:35122024   PMID:35245608   PMID:35269409   PMID:35361955   PMID:35410378   PMID:35413095   PMID:35449309   PMID:35523401  
PMID:35534561   PMID:35574272   PMID:35604009   PMID:35608905   PMID:35635747   PMID:35639959   PMID:35714308   PMID:35765985   PMID:35858425   PMID:35927735   PMID:35943291   PMID:35946792  
PMID:36073548   PMID:36142137   PMID:36163261   PMID:36169447   PMID:36178098   PMID:36271073   PMID:36539615   PMID:36607262   PMID:36624173   PMID:36791985   PMID:36907530   PMID:36931244  
PMID:36976647   PMID:37024683   PMID:37045808   PMID:37127775   PMID:37163450   PMID:37217538   PMID:37272433   PMID:37282749   PMID:37527244   PMID:37610521   PMID:37615936   PMID:37660134  
PMID:37816598   PMID:37856473   PMID:37952155   PMID:37979214   PMID:38000729   PMID:38164795   PMID:38237590   PMID:38295174   PMID:38309617   PMID:38335290   PMID:38355793   PMID:38357791  
PMID:38414863   PMID:38493481   PMID:38499720   PMID:38512414   PMID:38522809   PMID:38523790   PMID:38627502   PMID:38643118   PMID:38699782   PMID:38795327   PMID:38834136   PMID:38838669  
PMID:39083377   PMID:39196062   PMID:39532065   PMID:39578572   PMID:39774947   PMID:39814015   PMID:40010350   PMID:40118070   PMID:40178977  


Genomics

Comparative Map Data
Dnmt3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39123,851,559 - 3,964,442 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl123,856,007 - 3,964,443 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38123,801,559 - 3,914,443 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,806,007 - 3,914,443 (+)Ensemblmm10GRCm38
MGSCv37123,806,980 - 3,914,443 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36123,835,027 - 3,914,455 (+)NCBIMGSCv36mm8
Celera123,763,156 - 3,842,112 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
DNMT3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38225,227,874 - 25,342,590 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl225,227,855 - 25,342,590 (-)Ensemblhg38GRCh38
GRCh37225,450,743 - 25,565,459 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36225,309,349 - 25,418,963 (-)NCBIBuild 36Build 36hg18NCBI36
Celera225,296,144 - 25,405,816 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef225,193,733 - 25,302,862 (-)NCBIHuRef
CHM1_1225,385,740 - 25,495,369 (-)NCBICHM1_1
T2T-CHM13v2.0225,263,222 - 25,377,928 (-)NCBIT2T-CHM13v2.0
Dnmt3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,507,316 - 32,621,678 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl632,512,070 - 32,614,970 (+)EnsemblGRCr8
mRatBN7.2626,791,517 - 26,902,161 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,822,609 - 26,896,687 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx627,114,932 - 27,188,991 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,430,833 - 27,504,894 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,909,402 - 26,983,738 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,205,375 - 28,346,052 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,235,695 - 28,340,577 (+)Ensemblrn6Rnor6.0
Rnor_5.0638,132,683 - 38,149,613 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0638,044,960 - 38,082,583 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4626,802,612 - 26,878,878 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera626,297,300 - 26,371,904 (+)NCBICelera
RGSC_v3.1626,805,564 - 26,881,831 (+)NCBI
Cytogenetic Map6q14NCBI
Dnmt3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554697,269,952 - 7,367,059 (-)Ensembl
ChiLan1.0NW_0049554697,264,431 - 7,367,059 (-)NCBIChiLan1.0ChiLan1.0
DNMT3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212101,173,664 - 101,289,206 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A101,177,630 - 101,288,083 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A25,229,593 - 25,344,733 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A25,331,095 - 25,441,785 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A25,331,095 - 25,412,605 (-)EnsemblpanPan2panpan1.1
DNMT3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11719,489,524 - 19,563,074 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1719,492,193 - 19,563,902 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1719,382,990 - 19,486,679 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01719,761,597 - 19,865,311 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1719,767,351 - 19,865,307 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11719,495,608 - 19,599,241 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01719,505,342 - 19,609,205 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01719,551,811 - 19,655,519 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dnmt3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629263,826,309 - 63,930,744 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364936,935,386 - 7,007,610 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364936,963,406 - 7,013,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNMT3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3113,528,926 - 113,603,087 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13113,501,972 - 113,609,148 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23120,579,692 - 120,663,698 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNMT3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11482,313,414 - 82,427,170 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1482,402,826 - 82,420,819 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604529,732,050 - 29,846,532 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnmt3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247387,485,842 - 7,581,056 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247387,481,084 - 7,581,332 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnmt3a
3180 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:8555
Count of miRNA genes:1029
Interacting mature miRNAs:1579
Transcripts:ENSMUST00000020991, ENSMUST00000085826, ENSMUST00000111186, ENSMUST00000172509, ENSMUST00000172689, ENSMUST00000172719, ENSMUST00000172749, ENSMUST00000172816, ENSMUST00000172879, ENSMUST00000172913, ENSMUST00000173197, ENSMUST00000173700, ENSMUST00000174102, ENSMUST00000174272, ENSMUST00000174483, ENSMUST00000174733, ENSMUST00000174774, ENSMUST00000174817
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884410Bzwq15_mbi-zygomatic width QTL 15, 16 week (mouse)12365000029749999Mouse
1301393Dyscalc3_mdystrophic cardiac calcinosis 3 (mouse)Not determined12122418579Mouse
12910983Pifs1_mpeptide-induced fatal syndrome 1 (mouse)12130433078Mouse
4141436Chldq7_mcholesterol and HDL QTL 7 (mouse)Not determined12127920733Mouse
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1234013434340302Mouse
1301143Skull17_mskull morphology 17 (mouse)Not determined12122418579Mouse
1301655Bmd12_mbone mineral density 12 (mouse)Not determined12124662697Mouse
1301207Circp1_mcircadian photosensitivity 1 (mouse)Not determined12133430339Mouse
11039525Tbbr2_mTrypanosoma brucei brucei response 2 (mouse)12122418579Mouse
4141296Femwf9_mfemur work to failure 9 (mouse)Not determined127920733Mouse
1301925Ath6_matherosclerosis 6 (mouse)Not determined12132758756Mouse
1357519Vtbt12_mvertebral trabecular bone trait 12 (mouse)Not determined12124662697Mouse
10402496Lmr22_mleishmaniasis resistance 22 (mouse)Not determined12122418579Mouse

Markers in Region
Dnmt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38123,899,943 - 3,900,012UniSTSGRCm38
MGSCv37123,899,943 - 3,900,012UniSTSGRCm37
Celera123,827,803 - 3,827,872UniSTS
Cytogenetic Map12A2-A3UniSTS
cM Map12 UniSTS
AU015806  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38123,908,667 - 3,908,795UniSTSGRCm38
MGSCv37123,908,667 - 3,908,795UniSTSGRCm37
Celera123,836,336 - 3,836,464UniSTS
Cytogenetic Map12A2-A3UniSTS
Whitehead/MRC_RH1225.08UniSTS
RH125299  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38123,908,793 - 3,908,913UniSTSGRCm38
MGSCv37123,908,793 - 3,908,913UniSTSGRCm37
Celera123,836,462 - 3,836,582UniSTS
Cytogenetic Map12A2-A3UniSTS
UniSTS:236800  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38123,912,482 - 3,912,681UniSTSGRCm38
MGSCv37123,912,482 - 3,912,681UniSTSGRCm37
Celera123,840,151 - 3,840,350UniSTS
Cytogenetic Map12A2-A3UniSTS
RH139204  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38123,908,152 - 3,908,365UniSTSGRCm38
MGSCv37123,908,152 - 3,908,365UniSTSGRCm37
Celera123,835,821 - 3,836,034UniSTS
Cytogenetic Map12A2-A3UniSTS
MARC_26721-26722:1034781098:3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38123,901,651 - 3,902,438UniSTSGRCm38
MGSCv37123,901,651 - 3,902,438UniSTSGRCm37
Celera123,829,320 - 3,830,107UniSTS
Cytogenetic Map12A2-A3UniSTS
RH130466  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38123,906,818 - 3,907,755UniSTSGRCm38
MGSCv37123,906,818 - 3,907,755UniSTSGRCm37
Celera123,834,487 - 3,835,424UniSTS
Cytogenetic Map12A2-A3UniSTS
Dnmt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12A2-A3UniSTS
Dnmt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12A2-A3UniSTS
Dnmt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38123,899,218 - 3,899,696UniSTSGRCm38
MGSCv37123,899,218 - 3,899,696UniSTSGRCm37
Celera123,827,078 - 3,827,556UniSTS
Cytogenetic Map12A2-A3UniSTS
Dnmt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12A2-A3UniSTS
Dnmt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12A2-A3UniSTS
cM Map12 UniSTS
AU015806  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38123,908,676 - 3,908,882UniSTSGRCm38
MGSCv37123,908,676 - 3,908,882UniSTSGRCm37
Celera123,836,345 - 3,836,551UniSTS
Cytogenetic Map12A2-A3UniSTS
Whitehead/MRC_RH1223.73UniSTS
Dnmt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12A2-A3UniSTS
Dnmt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12A2-A3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001421857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_153743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC159324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF068625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF480164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF503865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF503866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF503867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE855330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM963211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ042850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB058054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB590809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF580263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ104461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN526792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR974568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000020991   ⟹   ENSMUSP00000020991
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,857,030 - 3,964,443 (+)Ensembl
GRCm38.p6 Ensembl123,807,030 - 3,914,443 (+)Ensembl
Ensembl Acc Id: ENSMUST00000085826
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,856,498 - 3,917,484 (+)Ensembl
GRCm38.p6 Ensembl123,806,498 - 3,867,484 (+)Ensembl
Ensembl Acc Id: ENSMUST00000111186   ⟹   ENSMUSP00000106817
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,941,744 - 3,964,443 (+)Ensembl
GRCm38.p6 Ensembl123,891,744 - 3,914,443 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172509   ⟹   ENSMUSP00000133869
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,857,058 - 3,946,995 (+)Ensembl
GRCm38.p6 Ensembl123,807,058 - 3,896,995 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172689   ⟹   ENSMUSP00000133543
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,941,728 - 3,957,842 (+)Ensembl
GRCm38.p6 Ensembl123,891,728 - 3,907,842 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172719   ⟹   ENSMUSP00000133501
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,856,527 - 3,923,381 (+)Ensembl
GRCm38.p6 Ensembl123,806,527 - 3,873,381 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172749   ⟹   ENSMUSP00000134567
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,945,593 - 3,947,365 (+)Ensembl
GRCm38.p6 Ensembl123,895,593 - 3,897,365 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172816   ⟹   ENSMUSP00000134632
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,911,021 - 3,916,162 (+)Ensembl
GRCm38.p6 Ensembl123,861,021 - 3,866,162 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172879   ⟹   ENSMUSP00000134689
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,944,824 - 3,945,676 (+)Ensembl
GRCm38.p6 Ensembl123,894,824 - 3,895,676 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172913   ⟹   ENSMUSP00000134496
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,956,816 - 3,958,547 (+)Ensembl
GRCm38.p6 Ensembl123,906,816 - 3,908,547 (+)Ensembl
Ensembl Acc Id: ENSMUST00000173197   ⟹   ENSMUSP00000133567
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,916,191 - 3,926,062 (+)Ensembl
GRCm38.p6 Ensembl123,866,191 - 3,876,062 (+)Ensembl
Ensembl Acc Id: ENSMUST00000173700
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,856,007 - 3,888,814 (+)Ensembl
GRCm38.p6 Ensembl123,806,007 - 3,838,814 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174102   ⟹   ENSMUSP00000134480
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,935,449 - 3,946,121 (+)Ensembl
GRCm38.p6 Ensembl123,885,449 - 3,896,121 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174272
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,947,420 - 3,949,685 (+)Ensembl
GRCm38.p6 Ensembl123,897,420 - 3,899,685 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174483   ⟹   ENSMUSP00000133938
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,899,635 - 3,957,887 (+)Ensembl
GRCm38.p6 Ensembl123,849,635 - 3,907,887 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174733   ⟹   ENSMUSP00000134492
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,950,281 - 3,956,792 (+)Ensembl
GRCm38.p6 Ensembl123,900,281 - 3,906,792 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174774   ⟹   ENSMUSP00000134529
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,944,869 - 3,946,976 (+)Ensembl
GRCm38.p6 Ensembl123,894,869 - 3,896,976 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174817   ⟹   ENSMUSP00000134009
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl123,857,160 - 3,963,491 (+)Ensembl
GRCm38.p6 Ensembl123,807,160 - 3,913,491 (+)Ensembl
RefSeq Acc Id: NM_001271753   ⟹   NP_001258682
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39123,857,051 - 3,964,441 (+)NCBI
GRCm38123,807,160 - 3,914,443 (+)NCBI
Celera123,763,156 - 3,842,112 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001421857   ⟹   NP_001408786
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39123,856,548 - 3,964,441 (+)NCBI
RefSeq Acc Id: NM_007872   ⟹   NP_031898
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39123,857,051 - 3,964,441 (+)NCBI
GRCm38123,806,980 - 3,914,443 (+)NCBI
MGSCv37123,806,980 - 3,914,443 (+)RGD
Celera123,763,156 - 3,842,112 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_153743   ⟹   NP_714965
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39123,941,818 - 3,964,441 (+)NCBI
GRCm38123,891,744 - 3,914,443 (+)NCBI
MGSCv37123,806,980 - 3,914,443 (+)RGD
Celera123,763,156 - 3,842,112 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006514956   ⟹   XP_006515019
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39123,851,559 - 3,964,442 (+)NCBI
GRCm38123,801,559 - 3,914,442 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030246538   ⟹   XP_030102398
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39123,856,498 - 3,964,442 (+)NCBI
GRCm38123,806,498 - 3,914,442 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030246539   ⟹   XP_030102399
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39123,884,750 - 3,964,442 (+)NCBI
GRCm38123,834,695 - 3,914,442 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030246540   ⟹   XP_030102400
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39123,874,525 - 3,964,442 (+)NCBI
GRCm38123,824,521 - 3,914,442 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258682 (Get FASTA)   NCBI Sequence Viewer  
  NP_001408786 (Get FASTA)   NCBI Sequence Viewer  
  NP_031898 (Get FASTA)   NCBI Sequence Viewer  
  NP_714965 (Get FASTA)   NCBI Sequence Viewer  
  XP_006515019 (Get FASTA)   NCBI Sequence Viewer  
  XP_030102398 (Get FASTA)   NCBI Sequence Viewer  
  XP_030102399 (Get FASTA)   NCBI Sequence Viewer  
  XP_030102400 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC40177 (Get FASTA)   NCBI Sequence Viewer  
  AAN40038 (Get FASTA)   NCBI Sequence Viewer  
  BAB28644 (Get FASTA)   NCBI Sequence Viewer  
  BAC37013 (Get FASTA)   NCBI Sequence Viewer  
  BAC39637 (Get FASTA)   NCBI Sequence Viewer  
  BAC41110 (Get FASTA)   NCBI Sequence Viewer  
  BAE22854 (Get FASTA)   NCBI Sequence Viewer  
  BAE27806 (Get FASTA)   NCBI Sequence Viewer  
  BAE28033 (Get FASTA)   NCBI Sequence Viewer  
  BAE28043 (Get FASTA)   NCBI Sequence Viewer  
  BAE28067 (Get FASTA)   NCBI Sequence Viewer  
  BAE34200 (Get FASTA)   NCBI Sequence Viewer  
  BAE34626 (Get FASTA)   NCBI Sequence Viewer  
  EDL01387 (Get FASTA)   NCBI Sequence Viewer  
  EDL01388 (Get FASTA)   NCBI Sequence Viewer  
  EDL01389 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000020991
  ENSMUSP00000020991.9
  ENSMUSP00000133543
  ENSMUSP00000133543.2
  ENSMUSP00000134009
  ENSMUSP00000134009.2
GenBank Protein O88508 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_031898   ⟸   NM_007872
- Peptide Label: isoform 1
- UniProtKB: Q922J0 (UniProtKB/Swiss-Prot),   Q8CJ60 (UniProtKB/Swiss-Prot),   Q3UH24 (UniProtKB/Swiss-Prot),   Q3TZK8 (UniProtKB/Swiss-Prot),   Q9CSE1 (UniProtKB/Swiss-Prot),   O88508 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_714965   ⟸   NM_153743
- Peptide Label: isoform 2
- UniProtKB: O88508 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001258682   ⟸   NM_001271753
- Peptide Label: isoform 1
- UniProtKB: Q922J0 (UniProtKB/Swiss-Prot),   Q8CJ60 (UniProtKB/Swiss-Prot),   Q3UH24 (UniProtKB/Swiss-Prot),   Q3TZK8 (UniProtKB/Swiss-Prot),   Q9CSE1 (UniProtKB/Swiss-Prot),   O88508 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006515019   ⟸   XM_006514956
- Peptide Label: isoform X1
- UniProtKB: Q922J0 (UniProtKB/Swiss-Prot),   Q8CJ60 (UniProtKB/Swiss-Prot),   Q3UH24 (UniProtKB/Swiss-Prot),   Q3TZK8 (UniProtKB/Swiss-Prot),   Q9CSE1 (UniProtKB/Swiss-Prot),   O88508 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030102398   ⟸   XM_030246538
- Peptide Label: isoform X1
- UniProtKB: Q922J0 (UniProtKB/Swiss-Prot),   Q8CJ60 (UniProtKB/Swiss-Prot),   Q3UH24 (UniProtKB/Swiss-Prot),   Q3TZK8 (UniProtKB/Swiss-Prot),   O88508 (UniProtKB/Swiss-Prot),   Q9CSE1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_030102400   ⟸   XM_030246540
- Peptide Label: isoform X1
- UniProtKB: Q922J0 (UniProtKB/Swiss-Prot),   Q8CJ60 (UniProtKB/Swiss-Prot),   Q3UH24 (UniProtKB/Swiss-Prot),   Q3TZK8 (UniProtKB/Swiss-Prot),   O88508 (UniProtKB/Swiss-Prot),   Q9CSE1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_030102399   ⟸   XM_030246539
- Peptide Label: isoform X1
- UniProtKB: Q922J0 (UniProtKB/Swiss-Prot),   Q8CJ60 (UniProtKB/Swiss-Prot),   Q3UH24 (UniProtKB/Swiss-Prot),   Q3TZK8 (UniProtKB/Swiss-Prot),   O88508 (UniProtKB/Swiss-Prot),   Q9CSE1 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000106817   ⟸   ENSMUST00000111186
Ensembl Acc Id: ENSMUSP00000020991   ⟸   ENSMUST00000020991
Ensembl Acc Id: ENSMUSP00000134689   ⟸   ENSMUST00000172879
Ensembl Acc Id: ENSMUSP00000134632   ⟸   ENSMUST00000172816
Ensembl Acc Id: ENSMUSP00000134496   ⟸   ENSMUST00000172913
Ensembl Acc Id: ENSMUSP00000133869   ⟸   ENSMUST00000172509
Ensembl Acc Id: ENSMUSP00000133543   ⟸   ENSMUST00000172689
Ensembl Acc Id: ENSMUSP00000134567   ⟸   ENSMUST00000172749
Ensembl Acc Id: ENSMUSP00000133501   ⟸   ENSMUST00000172719
Ensembl Acc Id: ENSMUSP00000134492   ⟸   ENSMUST00000174733
Ensembl Acc Id: ENSMUSP00000134009   ⟸   ENSMUST00000174817
Ensembl Acc Id: ENSMUSP00000134529   ⟸   ENSMUST00000174774
Ensembl Acc Id: ENSMUSP00000134480   ⟸   ENSMUST00000174102
Ensembl Acc Id: ENSMUSP00000133938   ⟸   ENSMUST00000174483
Ensembl Acc Id: ENSMUSP00000133567   ⟸   ENSMUST00000173197
RefSeq Acc Id: NP_001408786   ⟸   NM_001421857
- Peptide Label: isoform 1
- UniProtKB: Q9CSE1 (UniProtKB/Swiss-Prot),   Q922J0 (UniProtKB/Swiss-Prot),   Q8CJ60 (UniProtKB/Swiss-Prot),   Q3UH24 (UniProtKB/Swiss-Prot),   Q3TZK8 (UniProtKB/Swiss-Prot),   O88508 (UniProtKB/Swiss-Prot)
Protein Domains
ADD   DNA (cytosine-5)-methyltransferase N-terminal   PWWP   SAM-dependent MTase C5-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88508-F1-model_v2 AlphaFold O88508 1-908 view protein structure

Promoters
RGD ID:8677818
Promoter ID:EPDNEW_M16940
Type:initiation region
Name:Dnmt3a_2
Description:Mus musculus DNA methyltransferase 3A , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16941  EPDNEW_M16942  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38123,806,564 - 3,806,624EPDNEW
RGD ID:8677820
Promoter ID:EPDNEW_M16941
Type:initiation region
Name:Dnmt3a_1
Description:Mus musculus DNA methyltransferase 3A , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16940  EPDNEW_M16942  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38123,807,051 - 3,807,111EPDNEW
RGD ID:6846962
Promoter ID:MM_ACW:9736
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver
Transcripts:DNMT3A.OSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36123,834,461 - 3,834,961 (+)MPROMDB
RGD ID:8677822
Promoter ID:EPDNEW_M16942
Type:initiation region
Name:Dnmt3a_3
Description:Mus musculus DNA methyltransferase 3A , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16940  EPDNEW_M16941  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38123,834,805 - 3,834,865EPDNEW
RGD ID:6822857
Promoter ID:MM_KWN:11066
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung
Transcripts:NM_153743,   UC007MXD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36123,891,221 - 3,891,877 (+)MPROMDB
RGD ID:6846960
Promoter ID:MM_ACW:9741
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Kidney
Transcripts:DNMT3A.HSEP07,   DNMT3A.NSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36123,894,639 - 3,895,139 (+)MPROMDB
RGD ID:6848609
Promoter ID:MM_TRO:1882
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney
Transcripts:MTR018151.12.20.10
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36123,897,301 - 3,897,801 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1261827 AgrOrtholog
Ensembl Genes ENSMUSG00000020661 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000020991 ENTREZGENE
  ENSMUST00000020991.15 UniProtKB/Swiss-Prot
  ENSMUST00000172689 ENTREZGENE
  ENSMUST00000172689.8 UniProtKB/Swiss-Prot
  ENSMUST00000174817 ENTREZGENE
  ENSMUST00000174817.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.30.140 UniProtKB/Swiss-Prot
  3.40.50.150 UniProtKB/Swiss-Prot
  PWWP, helical domain UniProtKB/Swiss-Prot
InterPro ADD UniProtKB/Swiss-Prot
  ADD_DNMT3A UniProtKB/Swiss-Prot
  C5_DNA_meth_AS UniProtKB/Swiss-Prot
  C5_MeTfrase UniProtKB/Swiss-Prot
  DNM3A_N UniProtKB/Swiss-Prot
  DNMT3_ADD UniProtKB/Swiss-Prot
  DNMT3_ADD_PHD UniProtKB/Swiss-Prot
  PWWP_dom UniProtKB/Swiss-Prot
  SAM-dependent_MTases UniProtKB/Swiss-Prot
KEGG Report mmu:13435 UniProtKB/Swiss-Prot
MGD MGI:1261827 ENTREZGENE
NCBI Gene 13435 ENTREZGENE
PANTHER DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED UniProtKB/Swiss-Prot
  PTHR23068:SF10 UniProtKB/Swiss-Prot
Pfam ADD_DNMT3 UniProtKB/Swiss-Prot
  ADDz_Dnmt3b UniProtKB/Swiss-Prot
  DNA_methylase UniProtKB/Swiss-Prot
  DNM3A_N UniProtKB/Swiss-Prot
  PWWP UniProtKB/Swiss-Prot
PhenoGen Dnmt3a PhenoGen
PROSITE ADD UniProtKB/Swiss-Prot
  C5_MTASE_1 UniProtKB/Swiss-Prot
  PWWP UniProtKB/Swiss-Prot
  SAM_MT_C5 UniProtKB/Swiss-Prot
SMART PWWP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot
  Tudor/PWWP/MBT UniProtKB/Swiss-Prot
UniProt DNM3A_MOUSE UniProtKB/Swiss-Prot
  G3UX07_MOUSE UniProtKB/TrEMBL
  G3UX63_MOUSE UniProtKB/TrEMBL
  G3UXY2_MOUSE UniProtKB/TrEMBL
  G3UY43_MOUSE UniProtKB/TrEMBL
  G3UZF8_MOUSE UniProtKB/TrEMBL
  G3UZG8_MOUSE UniProtKB/TrEMBL
  G3UZH2_MOUSE UniProtKB/TrEMBL
  G3UZK0_MOUSE UniProtKB/TrEMBL
  G3UZN5_MOUSE UniProtKB/TrEMBL
  G3UZU0_MOUSE UniProtKB/TrEMBL
  G3UZY8_MOUSE UniProtKB/TrEMBL
  O88508 ENTREZGENE
  Q3TYD7_MOUSE UniProtKB/TrEMBL
  Q3TZK8 ENTREZGENE
  Q3UH24 ENTREZGENE
  Q3UWR0_MOUSE UniProtKB/TrEMBL
  Q8CJ60 ENTREZGENE
  Q922J0 ENTREZGENE
  Q9CSE1 ENTREZGENE
UniProt Secondary Q3TZK8 UniProtKB/Swiss-Prot
  Q3UH24 UniProtKB/Swiss-Prot
  Q8CJ60 UniProtKB/Swiss-Prot
  Q922J0 UniProtKB/Swiss-Prot
  Q9CSE1 UniProtKB/Swiss-Prot