Adam26a (ADAM metallopeptidase domain 26A) - Rat Genome Database

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Gene: Adam26a (ADAM metallopeptidase domain 26A) Mus musculus
Analyze
Symbol: Adam26a
Name: ADAM metallopeptidase domain 26A
RGD ID: 1620125
MGI Page MGI
Description: Predicted to enable integrin binding activity and metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Located in external side of plasma membrane and sperm head plasma membrane. Is expressed in gut; male reproductive gland or organ; and olfactory lobe.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: a disintegrin and metallopeptidase domain 26a; a disintegrin and metallopeptidase domain 26A (testase 3); a disintegrin and metalloprotease domain 26; Adam; ADAM 26A; Adam26; disintegrin 4; disintegrin and metalloproteinase domain-containing protein 26A; Dtgn; Dtgn4; testase 3; testase-3
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39844,021,310 - 44,029,744 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl844,021,315 - 44,029,744 (-)EnsemblGRCm39 Ensembl
GRCm38843,568,273 - 43,576,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl843,568,278 - 43,576,707 (-)EnsemblGRCm38mm10GRCm38
MGSCv37844,653,627 - 44,662,061 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36845,067,090 - 45,075,483 (-)NCBIMGSCv36mm8
Celera846,254,925 - 46,263,359 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map824.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8146185   PMID:10349636   PMID:10395895   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:19129510   PMID:21267068   PMID:21873635  
PMID:24079728   PMID:24194600   PMID:26839965   PMID:27626380   PMID:32325033   PMID:38355793  


Genomics

Comparative Map Data
Adam26a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39844,021,310 - 44,029,744 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl844,021,315 - 44,029,744 (-)EnsemblGRCm39 Ensembl
GRCm38843,568,273 - 43,576,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl843,568,278 - 43,576,707 (-)EnsemblGRCm38mm10GRCm38
MGSCv37844,653,627 - 44,662,061 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36845,067,090 - 45,075,483 (-)NCBIMGSCv36mm8
Celera846,254,925 - 46,263,359 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map824.02NCBI
THSD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,802,069 - 12,804,389 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,802,031 - 12,813,581 (+)EnsemblGRCh38hg38GRCh38
GRCh371912,912,883 - 12,915,203 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map19p13.13NCBI
T2T-CHM13v2.01912,926,574 - 12,928,889 (+)NCBIT2T-CHM13v2.0
Thsd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21923,186,394 - 23,188,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,186,364 - 23,196,042 (+)EnsemblmRatBN7.2 Ensembl
Cytogenetic Map19q11NCBI
THSD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22017,730,785 - 17,735,994 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11916,731,366 - 16,736,584 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1913,107,406 - 13,109,635 (+)Ensemblpanpan1.1panPan2
THSD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2049,224,524 - 49,227,082 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,869,308 - 49,871,867 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12049,080,437 - 49,082,993 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,506,730 - 49,509,290 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,749,381 - 49,751,939 (-)NCBIUU_Cfam_GSD_1.0
Thsd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,453,734 - 208,456,935 (-)NCBIHiC_Itri_2
THSD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236660748,302,316 - 8,306,383 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Adam26a
1002 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:40
Interacting mature miRNAs:40
Transcripts:ENSMUST00000049577
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301139Lmr10_mleishmaniasis resistance 10 (mouse)Not determined83532109757797633Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
11049577Lmr10b_mleishmaniasis resistance 10b (mouse)83532109757797633Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3250657271740637Mouse
11049578Lmr10c_mleishmaniasis resistance 10c (mouse)83532109757797633Mouse
11041902Lmr10a_mleishmaniasis resistance 10a (mouse)83532109757797633Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3250657271740637Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
10043990Hbnr12_mHeligmosomoides bakeri nematode resistance 12 (mouse)Not determined83327701651290537Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3250657271740637Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
10043974Obq30_mobesity QTL 30 (mouse)Not determined82658332260583322Mouse
1301196Mnif1_mmacronutrient intake (mouse)Not determined83510993045305872Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
13524525Bodwtq7_mbody wweight QTL 7 (mouse)82824955647027681Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83429039768290537Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83250657271740637Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000049577   ⟹   ENSMUSP00000058256
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl844,021,315 - 44,029,744 (-)Ensembl
GRCm38.p6 Ensembl843,568,278 - 43,576,707 (-)Ensembl
RefSeq Acc Id: NM_010085   ⟹   NP_034215
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39844,021,310 - 44,029,744 (-)NCBI
GRCm38843,568,273 - 43,576,707 (-)ENTREZGENE
MGSCv37844,653,627 - 44,662,061 (-)RGD
Celera846,254,925 - 46,263,359 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_034215 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD48843 (Get FASTA)   NCBI Sequence Viewer  
  AGR55466 (Get FASTA)   NCBI Sequence Viewer  
  BAB29688 (Get FASTA)   NCBI Sequence Viewer  
  BAC26600 (Get FASTA)   NCBI Sequence Viewer  
  EDL35532 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000058256
  ENSMUSP00000058256.3
GenBank Protein Q9R158 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_034215   ⟸   NM_010085
- Peptide Label: preproprotein
- UniProtKB: G3X9D0 (UniProtKB/Swiss-Prot),   Q9R158 (UniProtKB/Swiss-Prot),   Q8BMR4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000058256   ⟸   ENSMUST00000049577
Protein Domains
Disintegrin   EGF-like   Peptidase M12B   Peptidase M12B propeptide

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R158-F1-model_v2 AlphaFold Q9R158 1-697 view protein structure

Promoters
RGD ID:8666977
Promoter ID:EPDNEW_M11519
Type:multiple initiation site
Name:Adam26a_1
Description:Mus musculus a disintegrin and metallopeptidase domain 26A ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38843,576,697 - 43,576,757EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105985 AgrOrtholog
Ensembl Genes ENSMUSG00000048516 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000049577 ENTREZGENE
  ENSMUST00000049577.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13525 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:105985 ENTREZGENE
NCBI Gene 13525 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPEPTIDASE DOMAIN 26B-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adam26a PhenoGen
PRINTS DISINTEGRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART ACR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AD26A_MOUSE UniProtKB/Swiss-Prot
  G3X9D0 ENTREZGENE
  Q8BMR4 ENTREZGENE, UniProtKB/TrEMBL
  Q9CUQ4_MOUSE UniProtKB/TrEMBL
  Q9R158 ENTREZGENE
UniProt Secondary G3X9D0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Adam26a  ADAM metallopeptidase domain 26A  Adam26a  a disintegrin and metallopeptidase domain 26A (testase 3)  Symbol and/or name change 5135510 APPROVED