Fdx2 (ferredoxin 2) - Rat Genome Database

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Gene: Fdx2 (ferredoxin 2) Mus musculus
Analyze
Symbol: Fdx2
Name: ferredoxin 2
RGD ID: 1620021
MGI Page MGI
Description: Predicted to enable electron transfer activity. Predicted to be involved in [2Fe-2S] cluster assembly and electron transport chain. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial myopathy. Orthologous to human FDX2 (ferredoxin 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adrenodoxin-like protein, mitochondrial; B230118G17Rik; Fdx1; Fdx1l; ferredoxin 1-like; ferredoxin-1-like protein; ferredoxin-2, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm51260   Gm6622  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,978,808 - 20,984,827 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,978,816 - 20,984,910 (-)EnsemblGRCm39 Ensembl
GRCm38921,067,512 - 21,073,531 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,067,520 - 21,073,614 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,871,964 - 20,877,958 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,817,920 - 20,823,946 (-)NCBIMGSCv36mm8
Celera918,336,235 - 18,342,228 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:18614015   PMID:18799693   PMID:21873635   PMID:27519411   PMID:29097656   PMID:32325033   PMID:38355793  


Genomics

Comparative Map Data
Fdx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,978,808 - 20,984,827 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,978,816 - 20,984,910 (-)EnsemblGRCm39 Ensembl
GRCm38921,067,512 - 21,073,531 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,067,520 - 21,073,614 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,871,964 - 20,877,958 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,817,920 - 20,823,946 (-)NCBIMGSCv36mm8
Celera918,336,235 - 18,342,228 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.7NCBI
FDX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,310,045 - 10,316,015 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,309,916 - 10,316,015 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,420,721 - 10,426,691 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,281,891 - 10,287,691 (-)NCBINCBI36Build 36hg18NCBI36
Celera1910,316,284 - 10,322,080 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,001,153 - 10,006,949 (-)NCBIHuRef
CHM1_11910,421,449 - 10,427,224 (-)NCBICHM1_1
T2T-CHM13v2.01910,436,158 - 10,442,125 (-)NCBIT2T-CHM13v2.0
Fdx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,881,091 - 27,886,230 (-)NCBIGRCr8
mRatBN7.2819,604,916 - 19,609,832 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,604,916 - 19,609,849 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,624,325 - 23,629,241 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,922,179 - 21,927,095 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,834,580 - 19,839,500 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,086,534 - 22,091,450 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,086,534 - 22,091,450 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,143,206 - 22,148,122 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,091,424 - 20,096,340 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera820,999,337 - 21,004,253 (-)NCBICelera
Cytogenetic Map8q13NCBI
Fdx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,590,493 - 1,594,760 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,590,493 - 1,594,760 (-)NCBIChiLan1.0ChiLan1.0
FDX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,227,211 - 15,232,999 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,225,844 - 14,231,631 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,860,316 - 9,866,442 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,520,072 - 10,532,163 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,526,287 - 10,532,152 (-)Ensemblpanpan1.1panPan2
FDX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,798,250 - 50,802,477 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,668,057 - 50,672,225 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,319,937 - 51,324,100 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,319,932 - 51,324,048 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,526,079 - 50,530,247 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,954,844 - 50,959,011 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,195,971 - 51,200,136 (+)NCBIUU_Cfam_GSD_1.0
LOC101962614
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,704,318 - 209,714,514 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659640,587 - 644,804 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_004936659645,191 - 650,246 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659640,243 - 650,350 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FDX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,359,446 - 9,364,702 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,359,719 - 9,364,689 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,673,535 - 10,679,013 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fdx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,468,757 - 2,473,600 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,468,761 - 2,473,657 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fdx2
148 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:129
Interacting mature miRNAs:130
Transcripts:ENSMUST00000010348
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
35673312Ari7_mantibody response to influenza 7, day 45, IgG3 (mouse)9780000122211296Mouse
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756237306370Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse

Markers in Region
UniSTS:236065  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,074,430 - 21,074,534UniSTSGRCm38
MGSCv37920,878,874 - 20,878,978UniSTSGRCm37
Celera918,343,144 - 18,343,248UniSTS
Cytogenetic Map9A3UniSTS
UniSTS:236068  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,067,535 - 21,067,746UniSTSGRCm38
MGSCv37920,871,979 - 20,872,190UniSTSGRCm37
Celera918,336,250 - 18,336,461UniSTS
Cytogenetic Map9A3UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000010348   ⟹   ENSMUSP00000010348
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,978,816 - 20,984,840 (-)Ensembl
GRCm38.p6 Ensembl921,067,520 - 21,073,544 (-)Ensembl
Ensembl Acc Id: ENSMUST00000215338
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,979,068 - 20,979,802 (-)Ensembl
GRCm38.p6 Ensembl921,067,772 - 21,068,506 (-)Ensembl
Ensembl Acc Id: ENSMUST00000215631
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,978,991 - 20,984,802 (-)Ensembl
GRCm38.p6 Ensembl921,067,695 - 21,073,506 (-)Ensembl
Ensembl Acc Id: ENSMUST00000216484
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,979,125 - 20,984,818 (-)Ensembl
GRCm38.p6 Ensembl921,067,829 - 21,073,522 (-)Ensembl
Ensembl Acc Id: ENSMUST00000217150
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,978,817 - 20,984,910 (-)Ensembl
GRCm38.p6 Ensembl921,067,521 - 21,073,614 (-)Ensembl
RefSeq Acc Id: NM_001039824   ⟹   NP_001034913
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39920,978,808 - 20,984,827 (-)NCBI
GRCm38921,067,512 - 21,073,531 (-)NCBI
MGSCv37920,871,964 - 20,877,958 (-)RGD
Celera918,336,235 - 18,342,228 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_157201
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39920,978,808 - 20,984,827 (-)NCBI
GRCm38921,067,512 - 21,073,531 (-)NCBI
Sequence:
RefSeq Acc Id: NR_157202
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39920,978,808 - 20,984,827 (-)NCBI
GRCm38921,067,512 - 21,073,531 (-)NCBI
Sequence:
RefSeq Acc Id: NR_157203
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39920,978,808 - 20,984,827 (-)NCBI
GRCm38921,067,512 - 21,073,531 (-)NCBI
Sequence:
RefSeq Acc Id: NR_157204
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39920,978,808 - 20,984,827 (-)NCBI
GRCm38921,067,512 - 21,073,531 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001034913 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61189 (Get FASTA)   NCBI Sequence Viewer  
  BAB25650 (Get FASTA)   NCBI Sequence Viewer  
  BAB26771 (Get FASTA)   NCBI Sequence Viewer  
  BAB32267 (Get FASTA)   NCBI Sequence Viewer  
  EDL25154 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000010348
  ENSMUSP00000010348.6
GenBank Protein Q9CPW2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001034913   ⟸   NM_001039824
- Peptide Label: precursor
- UniProtKB: Q6P8M0 (UniProtKB/Swiss-Prot),   Q9CV00 (UniProtKB/Swiss-Prot),   Q9CPW2 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000010348   ⟸   ENSMUST00000010348
Protein Domains
2Fe-2S ferredoxin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CPW2-F1-model_v2 AlphaFold Q9CPW2 1-174 view protein structure

Promoters
RGD ID:6845376
Promoter ID:MM_KWN:56545
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000115494,   UC009OKB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36920,877,681 - 20,878,917 (-)MPROMDB
RGD ID:8668918
Promoter ID:EPDNEW_M12490
Type:multiple initiation site
Name:Fdx1l_1
Description:Mus musculus ferredoxin 1-like , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38921,073,527 - 21,073,587EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915415 AgrOrtholog
Ensembl Genes ENSMUSG00000079677 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000010348 ENTREZGENE
  ENSMUST00000010348.7 UniProtKB/Swiss-Prot
  ENSMUST00000217150 ENTREZGENE
Gene3D-CATH 3.10.20.30 UniProtKB/Swiss-Prot
InterPro 2Fe-2S_ferredoxin-like_sf UniProtKB/Swiss-Prot
  2Fe-2S_ferredoxin-type UniProtKB/Swiss-Prot
  Adrenodoxin UniProtKB/Swiss-Prot
  Adrenodoxin_Fe-S_BS UniProtKB/Swiss-Prot
  Beta-grasp_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:68165 UniProtKB/Swiss-Prot
MGD MGI:1915415 ENTREZGENE
NCBI Gene 68165 ENTREZGENE
PANTHER FERREDOXIN-2, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR23426 UniProtKB/Swiss-Prot
Pfam Fer2 UniProtKB/Swiss-Prot
PhenoGen Fdx2 PhenoGen
PRINTS ADRENODOXIN UniProtKB/Swiss-Prot
PROSITE 2FE2S_FER_2 UniProtKB/Swiss-Prot
  ADX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54292 UniProtKB/Swiss-Prot
UniProt FDX2_MOUSE UniProtKB/Swiss-Prot
  Q6P8M0 ENTREZGENE
  Q9CPW2 ENTREZGENE
  Q9CV00 ENTREZGENE
UniProt Secondary Q6P8M0 UniProtKB/Swiss-Prot
  Q9CV00 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-23 Fdx2  ferredoxin 2  Fdx1l  ferredoxin 1-like  Symbol and/or name change 5135510 APPROVED