Anks4b (ankyrin repeat and sterile alpha motif domain containing 4B) - Rat Genome Database

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Gene: Anks4b (ankyrin repeat and sterile alpha motif domain containing 4B) Mus musculus
Analyze
Symbol: Anks4b
Name: ankyrin repeat and sterile alpha motif domain containing 4B
RGD ID: 1619981
MGI Page MGI
Description: Acts upstream of or within response to endoplasmic reticulum stress. Located in several cellular components, including brush border; endoplasmic reticulum membrane; and microvillus. Is expressed in alimentary system; cochlea epithelium; genitourinary system; liver; and lung epithelium. Orthologous to human ANKS4B (ankyrin repeat and sterile alpha motif domain containing 4B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2010013E14Rik; AI956809; ankyrin repeat and SAM domain-containing protein 4B; H; harmonin-interacting ankyrin repeat-containing protein; harmonin-interacting ankyrin-repeat containing; Harp; MGC144693; MGC144694
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397119,773,081 - 119,782,939 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7119,773,081 - 119,784,809 (+)EnsemblGRCm39 Ensembl
GRCm387120,173,858 - 120,183,716 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7120,173,858 - 120,185,586 (+)EnsemblGRCm38mm10GRCm38
MGSCv377127,317,372 - 127,327,230 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367119,965,025 - 119,974,863 (+)NCBIMGSCv36mm8
Celera7120,083,279 - 120,093,146 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map764.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15461667   PMID:16141072   PMID:16141073   PMID:19525957   PMID:21267068   PMID:21677750  
PMID:22589549   PMID:26812018   PMID:30973865   PMID:38355793  


Genomics

Comparative Map Data
Anks4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397119,773,081 - 119,782,939 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7119,773,081 - 119,784,809 (+)EnsemblGRCm39 Ensembl
GRCm387120,173,858 - 120,183,716 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7120,173,858 - 120,185,586 (+)EnsemblGRCm38mm10GRCm38
MGSCv377127,317,372 - 127,327,230 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367119,965,025 - 119,974,863 (+)NCBIMGSCv36mm8
Celera7120,083,279 - 120,093,146 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map764.45NCBI
ANKS4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381621,233,699 - 21,253,850 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1621,233,699 - 21,253,850 (+)EnsemblGRCh38hg38GRCh38
GRCh371621,245,020 - 21,265,171 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361621,152,517 - 21,171,251 (+)NCBINCBI36Build 36hg18NCBI36
Celera1620,559,328 - 20,578,058 (+)NCBICelera
Cytogenetic Map16p12.2NCBI
HuRef1619,780,267 - 19,798,999 (+)NCBIHuRef
CHM1_11621,332,353 - 21,351,089 (+)NCBICHM1_1
T2T-CHM13v2.01621,168,996 - 21,189,143 (+)NCBIT2T-CHM13v2.0
Anks4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81183,934,528 - 183,989,127 (+)NCBIGRCr8
mRatBN7.21174,534,195 - 174,557,798 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1174,547,473 - 174,557,797 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1182,872,512 - 182,882,615 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01190,058,556 - 190,068,657 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,784,909 - 182,795,235 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,940,305 - 189,942,113 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,940,291 - 189,942,112 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01196,869,693 - 196,871,501 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1172,297,007 - 172,306,740 (+)NCBICelera
Cytogenetic Map1q36NCBI
Anks4b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955493428,895 - 440,379 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955493429,339 - 439,456 (+)NCBIChiLan1.0ChiLan1.0
ANKS4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21822,406,254 - 22,421,664 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11626,926,784 - 26,942,201 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01617,154,209 - 17,170,120 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11621,267,573 - 21,283,015 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1621,267,573 - 21,283,015 (+)Ensemblpanpan1.1panPan2
ANKS4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1624,209,125 - 24,230,355 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl624,209,125 - 24,267,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha625,646,863 - 25,683,978 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0624,360,462 - 24,397,584 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl624,358,101 - 24,419,328 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1624,163,860 - 24,200,973 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0624,057,504 - 24,094,624 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0624,442,579 - 24,480,050 (-)NCBIUU_Cfam_GSD_1.0
Anks4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344118,325,830 - 118,339,050 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365016,423,719 - 6,435,835 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365016,423,719 - 6,436,639 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANKS4B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl324,828,224 - 24,852,764 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1324,836,446 - 24,852,816 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2325,642,959 - 25,654,471 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANKS4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1519,347,736 - 19,380,959 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl519,358,962 - 19,380,332 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606810,500,124 - 10,521,156 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anks4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247827,289,623 - 7,315,717 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247827,287,514 - 7,316,577 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:151
Count of miRNA genes:137
Interacting mature miRNAs:144
Transcripts:ENSMUST00000033201
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7115699235128501724Mouse
1301647Elpt_melevated leptin (mouse)Not determined786500186120500329Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787043932121044066Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7117750722127967336Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
1558745Tsiq1_mT-cell secretion of IL-4 QTL 1 (mouse)Not determined7119485219125141349Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787043932121044066Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787043932121044066Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse

Markers in Region
AI956809  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387120,183,514 - 120,183,607UniSTSGRCm38
MGSCv377127,327,028 - 127,327,121UniSTSGRCm37
Celera7120,092,944 - 120,093,037UniSTS
Cytogenetic Map7F2UniSTS
cM Map757.5UniSTS
Whitehead/MRC_RH71207.15UniSTS
Anks4b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F2UniSTS
cM Map764.45UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000033201   ⟹   ENSMUSP00000033201
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7119,773,081 - 119,784,809 (+)Ensembl
GRCm38.p6 Ensembl7120,173,858 - 120,185,586 (+)Ensembl
RefSeq Acc Id: NM_028085   ⟹   NP_082361
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397119,773,081 - 119,782,939 (+)NCBI
GRCm387120,173,858 - 120,183,716 (+)ENTREZGENE
MGSCv377127,317,372 - 127,327,230 (+)RGD
Celera7120,083,279 - 120,093,146 (+)RGD
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_082361 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI15785 (Get FASTA)   NCBI Sequence Viewer  
  AAI18014 (Get FASTA)   NCBI Sequence Viewer  
  AAM81375 (Get FASTA)   NCBI Sequence Viewer  
  BAB25545 (Get FASTA)   NCBI Sequence Viewer  
  EDL17204 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000033201
  ENSMUSP00000033201.6
GenBank Protein Q8K3X6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_082361   ⟸   NM_028085
- UniProtKB: Q148R3 (UniProtKB/Swiss-Prot),   Q9D8A5 (UniProtKB/Swiss-Prot),   Q8K3X6 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000033201   ⟸   ENSMUST00000033201
Protein Domains
SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K3X6-F1-model_v2 AlphaFold Q8K3X6 1-423 view protein structure

Promoters
RGD ID:8665407
Promoter ID:EPDNEW_M10735
Type:initiation region
Name:Anks4b_1
Description:Mus musculus ankyrin repeat and sterile alpha motif domain containing4B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387120,173,880 - 120,173,940EPDNEW
RGD ID:6840600
Promoter ID:MM_KWN:52508
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000041641
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367127,317,161 - 127,317,661 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919324 AgrOrtholog
Ensembl Genes ENSMUSG00000030909 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033201 ENTREZGENE
  ENSMUST00000033201.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot
  1.25.40.20 UniProtKB/Swiss-Prot
InterPro ANKS4B_SAM UniProtKB/Swiss-Prot
  Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  SAM/pointed_sf UniProtKB/Swiss-Prot
KEGG Report mmu:72074 UniProtKB/Swiss-Prot
MGD MGI:1919324 ENTREZGENE
NCBI Gene 72074 ENTREZGENE
PANTHER ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED UniProtKB/Swiss-Prot
  ANKYRIN REPEAT AND SAM DOMAIN-CONTAINING PROTEIN 4B UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  SAM_1 UniProtKB/Swiss-Prot
PhenoGen Anks4b PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
SMART ANK UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot
  SSF48403 UniProtKB/Swiss-Prot
UniProt ANS4B_MOUSE UniProtKB/Swiss-Prot
  Q148R3 ENTREZGENE
  Q8K3X6 ENTREZGENE
  Q9D8A5 ENTREZGENE
UniProt Secondary Q148R3 UniProtKB/Swiss-Prot
  Q9D8A5 UniProtKB/Swiss-Prot