Eid2 (EP300 interacting inhibitor of differentiation 2) - Rat Genome Database

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Gene: Eid2 (EP300 interacting inhibitor of differentiation 2) Mus musculus
Analyze
Symbol: Eid2
Name: EP300 interacting inhibitor of differentiation 2
RGD ID: 1619657
MGI Page MGI
Description: Predicted to enable SMAD binding activity and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and transforming growth factor beta receptor complex assembly. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in several structures, including heart; liver; lung; metanephros; and pancreas. Orthologous to human EID2 (EP300 interacting inhibitor of differentiation 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cr; CREBBP/EP300 inhibitor 2; CREBBP/EP300 inhibitory protein 2; Cri2; E1A like inhibitor of differentiation 2; EID-; EID-1-like inhibitor of differentiation 2; EID-2; EP300-interacting inhibitor of differentiation 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,967,306 - 27,968,593 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,967,306 - 27,968,697 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38728,267,881 - 28,269,168 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,267,881 - 28,269,272 (+)Ensemblmm10GRCm38
MGSCv37729,052,900 - 29,054,187 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36727,976,641 - 27,977,928 (+)NCBIMGSCv36mm8
Celera722,829,501 - 22,830,788 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.67NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IBA,IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14585496   PMID:14610273   PMID:15970276   PMID:21267068   PMID:21873635   PMID:30550785   PMID:38355793  


Genomics

Comparative Map Data
Eid2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,967,306 - 27,968,593 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,967,306 - 27,968,697 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38728,267,881 - 28,269,168 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,267,881 - 28,269,272 (+)Ensemblmm10GRCm38
MGSCv37729,052,900 - 29,054,187 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36727,976,641 - 27,977,928 (+)NCBIMGSCv36mm8
Celera722,829,501 - 22,830,788 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.67NCBI
EID2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,538,707 - 39,540,161 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,538,707 - 39,540,161 (-)Ensemblhg38GRCh38
GRCh371940,029,347 - 40,030,801 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,721,286 - 44,722,678 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341944,721,288 - 44,722,664NCBI
Celera1936,831,159 - 36,832,551 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,475,800 - 36,477,192 (-)NCBIHuRef
CHM1_11940,030,067 - 40,031,459 (-)NCBICHM1_1
T2T-CHM13v2.01942,342,965 - 42,344,419 (-)NCBIT2T-CHM13v2.0
Eid2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,665,837 - 92,667,162 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl192,665,481 - 92,675,307 (+)EnsemblGRCr8
mRatBN7.2183,538,274 - 83,539,599 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx188,950,031 - 88,951,356 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,408,374 - 97,409,699 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,705,890 - 90,707,215 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,515,610 - 85,517,516 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,516,653 - 85,517,360 (-)Ensemblrn6Rnor6.0
Rnor_5.0186,727,248 - 86,728,627 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,349,864 - 83,351,093 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera177,937,290 - 77,939,197 (+)NCBICelera
Cytogenetic Map1q21NCBI
Eid2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546830,076 - 31,387 (+)Ensembl
ChiLan1.0NW_00495546829,927 - 32,947 (+)NCBIChiLan1.0ChiLan1.0
EID2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,834,023 - 45,835,477 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,704,605 - 47,706,071 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,636,855 - 36,638,308 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,184,477 - 45,185,988 (-)NCBIPanPan1.1PanPan1.1panPan2
LOC612523
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,712,193 - 113,713,420 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,115,982 - 113,117,182 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01114,312,730 - 114,313,924 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,312,799 - 114,313,350 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,871,796 - 113,872,990 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,505,019 - 113,506,226 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,499,292 - 114,500,486 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Eid2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,936,110 - 13,938,675 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,365,861 - 2,366,586 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,364,179 - 2,366,739 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100520248
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,184,566 - 48,185,203 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1648,182,580 - 48,185,328 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,968,287 - 43,971,043 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EID2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,144,294 - 34,145,712 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,144,860 - 34,145,570 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607312,167,612 - 12,169,134 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eid2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,857,055 - 12,857,894 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479412,855,406 - 12,858,032 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Eid2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12167,746,111 - 167,747,475 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Eid2
33 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:121
Interacting mature miRNAs:123
Transcripts:ENSMUST00000059596
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
7394747asp3_maudiogenic seizure prone 3 (mouse)Not determined72730579836842367Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse

Markers in Region
UniSTS:493185  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38728,267,918 - 28,268,905UniSTSGRCm38
MGSCv37729,052,937 - 29,053,924UniSTSGRCm37
Celera722,829,538 - 22,830,525UniSTS
Cytogenetic Map7A3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000059596   ⟹   ENSMUSP00000062345
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,967,306 - 27,968,697 (+)Ensembl
GRCm38.p6 Ensembl728,267,881 - 28,269,272 (+)Ensembl
RefSeq Acc Id: NM_198425   ⟹   NP_940817
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39727,967,306 - 27,968,593 (+)NCBI
GRCm38728,267,881 - 28,269,168 (+)ENTREZGENE
MGSCv37729,052,900 - 29,054,187 (+)RGD
Celera722,829,501 - 22,830,788 (+)RGD
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_940817 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH94513 (Get FASTA)   NCBI Sequence Viewer  
  AAP12560 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000062345
  ENSMUSP00000062345.7
GenBank Protein Q6X7S9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_940817   ⟸   NM_198425
- UniProtKB: Q6X7S9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000062345   ⟸   ENSMUST00000059596

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6X7S9-F1-model_v2 AlphaFold Q6X7S9 1-236 view protein structure

Promoters
RGD ID:6892434
Promoter ID:EPDNEW_M9668
Type:initiation region
Name:Eid2_1
Description:Mus musculus EP300 interacting inhibitor of differentiation 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38728,267,856 - 28,267,916EPDNEW
RGD ID:6840996
Promoter ID:MM_KWN:49622
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_2Hour,   Brain,   ES_Cell,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_198425
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,052,841 - 29,053,727 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2681174 AgrOrtholog
Ensembl Genes ENSMUSG00000046058 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000059596 ENTREZGENE
  ENSMUST00000059596.8 UniProtKB/Swiss-Prot
InterPro EID UniProtKB/Swiss-Prot
KEGG Report mmu:386655 UniProtKB/Swiss-Prot
MGD MGI:2681174 ENTREZGENE
NCBI Gene 386655 ENTREZGENE
PANTHER PTHR15556 UniProtKB/Swiss-Prot
  PTHR15556:SF3 UniProtKB/Swiss-Prot
PhenoGen Eid2 PhenoGen
UniProt EID2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE