Suz12 (SUZ12 polycomb repressive complex 2 subunit) - Rat Genome Database

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Gene: Suz12 (SUZ12 polycomb repressive complex 2 subunit) Mus musculus
Analyze
Symbol: Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
RGD ID: 1619223
MGI Page MGI
Description: Enables DNA binding activity; lncRNA binding activity; and promoter-specific chromatin binding activity. Involved in facultative heterochromatin formation. Acts upstream of or within several processes, including negative regulation of macromolecule biosynthetic process; oligodendrocyte differentiation; and positive regulation of cell population proliferation. Located in nucleus and sex chromatin. Part of nucleus; protein-DNA complex; and ribonucleoprotein complex. Is expressed in several structures, including bone; branchial arch; central nervous system; limb bud; and sensory organ. Human ortholog(s) of this gene implicated in renal Wilms' tumor. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 2610028O16Rik; AI195385; AU016842; AW536442; D11Ertd530; D11Ertd530e; KIAA0160; mKIAA0160; polycomb protein Suz12; RP23-253E9.4; suppressor of zeste 12 homolog; suppressor of zeste 12 homolog (Drosophila); suppressor of zeste 12 protein homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm14752  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391179,883,932 - 79,924,949 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1179,883,932 - 79,924,949 (+)EnsemblGRCm39 Ensembl
GRCm381179,993,106 - 80,034,123 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1179,993,106 - 80,034,123 (+)EnsemblGRCm38mm10GRCm38
MGSCv371179,806,608 - 79,847,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361179,809,301 - 79,850,318 (+)NCBIMGSCv36mm8
Celera1189,626,764 - 89,670,208 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1147.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal amnion morphology  (IAGP)
abnormal amniotic cavity morphology  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal chorion morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal ectoplacental cavity morphology  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal extraembryonic coelom morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal megakaryocyte differentiation  (IAGP)
abnormal melanocyte morphology  (IAGP)
abnormal posture  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal stratification in cerebral cortex  (IAGP)
abnormal thrombopoiesis  (IAGP)
cervical vertebral transformation  (IAGP)
decreased cell proliferation  (IAGP)
decreased corpus callosum size  (IAGP)
decreased embryo size  (IAGP)
diastematomyelia  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged tectum  (IAGP)
hindlimb paralysis  (IAGP)
hydrocephaly  (IAGP)
increased embryonic tissue cell apoptosis  (IAGP)
increased glioma incidence  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased histiocytic sarcoma incidence  (IAGP)
increased inferior colliculus size  (IAGP)
increased intestinal adenoma incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased lymphocyte cell number  (IAGP)
increased lymphoma incidence  (IAGP)
increased neurofibroma incidence  (IAGP)
increased neurofibrosarcoma incidence  (IAGP)
increased rib number  (IAGP)
increased Schwannoma incidence  (IAGP)
increased superior colliculus size  (IAGP)
increased tumor incidence  (IAGP)
lumbar vertebral transformation  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
spina bifida  (IAGP)
thoracic vertebral transformation  (IAGP)
thrombocytopenia  (IAGP)
thrombocytosis  (IAGP)
vertebral transformation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Herz HM, etal., Trends Biochem Sci. 2013 Dec;38(12):621-39. doi: 10.1016/j.tibs.2013.09.004. Epub 2013 Oct 20.
2. Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes. Metsuyanim S, etal., Stem Cells. 2008 Jul;26(7):1808-17. doi: 10.1634/stemcells.2007-0322. Epub 2008 May 8.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.
7. Polycomb group proteins are essential for spinal cord development. Wang C, etal., Front Biosci (Landmark Ed). 2010 Jun 1;15:1018-22.
Additional References at PubMed
PMID:10349636   PMID:10512203   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12693553  
PMID:12696059   PMID:12904583   PMID:14610273   PMID:15226823   PMID:15385962   PMID:15489334   PMID:15525528   PMID:15782199   PMID:15840001   PMID:16138909   PMID:16141072   PMID:16141073  
PMID:16359901   PMID:16625203   PMID:16687444   PMID:17339329   PMID:17406994   PMID:17875646   PMID:17970752   PMID:18311137   PMID:18416604   PMID:18483221   PMID:18519590   PMID:18799693  
PMID:19026994   PMID:19535498   PMID:19575012   PMID:19796622   PMID:19933700   PMID:20064375   PMID:20064376   PMID:20075857   PMID:20123894   PMID:20144788   PMID:20150217   PMID:20569692  
PMID:20571128   PMID:20857416   PMID:20956546   PMID:21059868   PMID:21267068   PMID:21460039   PMID:21498568   PMID:21677750   PMID:21811233   PMID:21873635   PMID:22139358   PMID:22158708  
PMID:22279536   PMID:22438827   PMID:22469984   PMID:22505317   PMID:22770845   PMID:22843710   PMID:22911650   PMID:22922362   PMID:23104054   PMID:23160351   PMID:23180766   PMID:23273982  
PMID:23333148   PMID:23352431   PMID:23624931   PMID:23624935   PMID:23671187   PMID:23727134   PMID:23932971   PMID:23982173   PMID:23987249   PMID:24040135   PMID:24074865   PMID:24124161  
PMID:24183668   PMID:24268575   PMID:24457600   PMID:24469834   PMID:24711647   PMID:24999238   PMID:25119042   PMID:25119045   PMID:25228648   PMID:25418731   PMID:25547114   PMID:25601759  
PMID:25680957   PMID:26036803   PMID:26423156   PMID:26523946   PMID:26584622   PMID:26658965   PMID:26959361   PMID:26994968   PMID:27150236   PMID:27892467   PMID:28041882   PMID:28223321  
PMID:28254491   PMID:28512107   PMID:29033324   PMID:29137925   PMID:29342143   PMID:29453456   PMID:29483650   PMID:29606589   PMID:29727681   PMID:30080881   PMID:31077711   PMID:31281901  
PMID:31451685   PMID:31492675   PMID:32325033   PMID:33903225   PMID:34533976   PMID:35006254   PMID:35084365   PMID:35675765   PMID:35796552   PMID:36544159   PMID:36635505   PMID:36994588  
PMID:37158107   PMID:37553330   PMID:38180241   PMID:38346162  


Genomics

Comparative Map Data
Suz12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391179,883,932 - 79,924,949 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1179,883,932 - 79,924,949 (+)EnsemblGRCm39 Ensembl
GRCm381179,993,106 - 80,034,123 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1179,993,106 - 80,034,123 (+)EnsemblGRCm38mm10GRCm38
MGSCv371179,806,608 - 79,847,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361179,809,301 - 79,850,318 (+)NCBIMGSCv36mm8
Celera1189,626,764 - 89,670,208 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1147.36NCBI
SUZ12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381731,937,007 - 32,001,038 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1731,937,007 - 32,001,045 (+)EnsemblGRCh38hg38GRCh38
GRCh371730,264,026 - 30,328,057 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361727,288,185 - 27,352,162 (+)NCBINCBI36Build 36hg18NCBI36
Build 341727,288,184 - 27,352,162NCBI
Celera1727,183,671 - 27,247,908 (+)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1726,474,180 - 26,538,191 (+)NCBIHuRef
CHM1_11730,326,518 - 30,390,534 (+)NCBICHM1_1
T2T-CHM13v2.01732,882,881 - 32,946,915 (+)NCBIT2T-CHM13v2.0
Suz12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81065,464,948 - 65,510,846 (+)NCBIGRCr8
mRatBN7.21064,967,035 - 65,012,916 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1064,966,967 - 65,012,738 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01067,325,101 - 67,371,588 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1067,325,347 - 67,369,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01066,983,892 - 67,031,108 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1063,933,379 - 63,979,240 (+)NCBICelera
Cytogenetic Map10q25NCBI
Suz12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554816,867,175 - 6,917,548 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554816,867,175 - 6,917,548 (+)NCBIChiLan1.0ChiLan1.0
LOC103785028
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21932,420,755 - 32,536,735 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11734,351,660 - 34,415,575 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01724,790,921 - 24,853,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11725,559,017 - 25,586,616 (-)NCBIpanpan1.1PanPan1.1panPan2
SUZ12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1940,992,797 - 41,038,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl940,994,825 - 41,038,645 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha940,152,869 - 40,198,325 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0941,811,525 - 41,857,240 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl941,811,933 - 41,857,217 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1940,596,240 - 40,641,695 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0940,890,422 - 40,935,894 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0940,966,346 - 41,011,837 (-)NCBIUU_Cfam_GSD_1.0
Suz12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560240,044,040 - 40,093,576 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365382,921,719 - 2,971,552 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365382,921,987 - 2,971,521 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SUZ12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1242,983,601 - 43,032,654 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11242,983,597 - 43,032,671 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21244,772,363 - 44,821,466 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SUZ12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11625,413,928 - 25,474,311 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1625,413,954 - 25,476,479 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660754,597,733 - 4,660,749 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Suz12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248754,425,418 - 4,477,909 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248754,425,486 - 4,477,338 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Suz12
1395 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1396
Count of miRNA genes:511
Interacting mature miRNAs:602
Transcripts:ENSMUST00000017692, ENSMUST00000126091, ENSMUST00000132312, ENSMUST00000144188, ENSMUST00000148140, ENSMUST00000163272
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4141365Ltxs3_mlethal factor toxin susceptibility 3 (mouse)Not determined117757387380746358Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117220979684731462Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
12903994Opfaq3_mopen field activity QTL 3 (mouse)117373754182069425Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse

Markers in Region
RH135952  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,029,219 - 80,030,078UniSTSGRCm38
MGSCv371179,842,721 - 79,843,580UniSTSGRCm37
Celera1189,665,304 - 89,666,163UniSTS
Cytogenetic Map11B5UniSTS
cM Map1147.2UniSTS
AW536442  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,033,571 - 80,033,652UniSTSGRCm38
MGSCv371179,847,073 - 79,847,154UniSTSGRCm37
Celera1189,669,656 - 89,669,737UniSTS
Cytogenetic Map11B5UniSTS
cM Map1147.2UniSTS
Whitehead/MRC_RH111021.83UniSTS
Suz12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B5UniSTS
cM Map1147.2UniSTS
AU016842  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,033,132 - 80,033,218UniSTSGRCm38
MGSCv371179,846,634 - 79,846,720UniSTSGRCm37
Celera1189,669,217 - 89,669,303UniSTS
Cytogenetic Map11B5UniSTS
cM Map1147.2UniSTS
Whitehead/MRC_RH111018.14UniSTS
UniSTS:236662  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,023,434 - 80,023,643UniSTSGRCm38
MGSCv371179,836,936 - 79,837,145UniSTSGRCm37
Celera1189,659,519 - 89,659,728UniSTS
Cytogenetic Map11B5UniSTS
cM Map1147.2UniSTS
UniSTS:236667  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381375,648,473 - 75,648,676UniSTSGRCm38
GRCm381180,033,631 - 80,033,831UniSTSGRCm38
MGSCv371179,847,133 - 79,847,333UniSTSGRCm37
MGSCv371375,785,921 - 75,786,124UniSTSGRCm37
Celera1377,968,097 - 77,968,300UniSTS
Celera1189,669,716 - 89,669,916UniSTS
Cytogenetic Map11B5UniSTS
cM Map1147.2UniSTS
AU022339  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,033,405 - 80,033,626UniSTSGRCm38
MGSCv371179,846,907 - 79,847,128UniSTSGRCm37
Celera1189,669,490 - 89,669,711UniSTS
Cytogenetic Map11B5UniSTS
cM Map1147.2UniSTS
cM Map1145.0UniSTS
Whitehead/MRC_RH111014.79UniSTS
A007E42  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,033,806 - 80,033,959UniSTSGRCm38
MGSCv371179,847,308 - 79,847,461UniSTSGRCm37
Celera1189,669,891 - 89,670,044UniSTS
Cytogenetic Map11B5UniSTS
cM Map1147.2UniSTS
D11Bhm110  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381179,998,463 - 79,998,612UniSTSGRCm38
MGSCv371179,811,965 - 79,812,114UniSTSGRCm37
Celera1189,634,548 - 89,634,697UniSTS
Cytogenetic Map11B5UniSTS
cM Map1146.18UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001163018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_199196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK076010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC084591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  W13031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000017692   ⟹   ENSMUSP00000017692
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1179,883,932 - 79,924,949 (+)Ensembl
GRCm38.p6 Ensembl1179,993,106 - 80,034,123 (+)Ensembl
Ensembl Acc Id: ENSMUST00000126091   ⟹   ENSMUSP00000129070
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1179,886,617 - 79,904,413 (+)Ensembl
GRCm38.p6 Ensembl1179,995,791 - 80,013,587 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132312
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1179,886,412 - 79,890,390 (+)Ensembl
GRCm38.p6 Ensembl1179,995,586 - 79,999,564 (+)Ensembl
Ensembl Acc Id: ENSMUST00000144188   ⟹   ENSMUSP00000128945
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1179,916,021 - 79,922,827 (+)Ensembl
GRCm38.p6 Ensembl1180,025,195 - 80,032,001 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148140
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1179,886,443 - 79,904,483 (+)Ensembl
GRCm38.p6 Ensembl1179,995,617 - 80,013,657 (+)Ensembl
Ensembl Acc Id: ENSMUST00000163272   ⟹   ENSMUSP00000126932
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1179,883,932 - 79,924,948 (+)Ensembl
GRCm38.p6 Ensembl1179,993,106 - 80,034,122 (+)Ensembl
RefSeq Acc Id: NM_001163018   ⟹   NP_001156490
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391179,883,932 - 79,924,949 (+)NCBI
GRCm381179,993,106 - 80,034,123 (+)ENTREZGENE
MGSCv371179,806,608 - 79,847,625 (+)RGD
Celera1189,626,764 - 89,670,208 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_199196   ⟹   NP_954666
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391179,883,932 - 79,924,949 (+)NCBI
GRCm381179,993,106 - 80,034,123 (+)ENTREZGENE
MGSCv371179,806,608 - 79,847,625 (+)RGD
Celera1189,626,764 - 89,670,208 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_954666   ⟸   NM_199196
- Peptide Label: isoform 1
- UniProtKB: Q80Y10 (UniProtKB/Swiss-Prot),   B1AQE5 (UniProtKB/Swiss-Prot),   Q99L07 (UniProtKB/Swiss-Prot),   Q80U70 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001156490   ⟸   NM_001163018
- Peptide Label: isoform 2
- UniProtKB: E9PW15 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000128945   ⟸   ENSMUST00000144188
Ensembl Acc Id: ENSMUSP00000126932   ⟸   ENSMUST00000163272
Ensembl Acc Id: ENSMUSP00000129070   ⟸   ENSMUST00000126091
Ensembl Acc Id: ENSMUSP00000017692   ⟸   ENSMUST00000017692
Protein Domains
Polycomb protein VEFS-Box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80U70-F1-model_v2 AlphaFold Q80U70 1-741 view protein structure

Promoters
RGD ID:6822266
Promoter ID:MM_KWN:8785
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK133080_GM10386,   NM_001163018,   OTTMUST00000000571
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361179,806,211 - 79,807,452 (+)MPROMDB
RGD ID:8675778
Promoter ID:EPDNEW_M15920
Type:initiation region
Name:Suz12_1
Description:Mus musculus SUZ12 polycomb repressive complex 2 subunit , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15921  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381179,993,087 - 79,993,147EPDNEW
RGD ID:8675780
Promoter ID:EPDNEW_M15921
Type:initiation region
Name:Suz12_2
Description:Mus musculus SUZ12 polycomb repressive complex 2 subunit , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15920  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381179,993,217 - 79,993,277EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1261758 AgrOrtholog
Ensembl Genes ENSMUSG00000017548 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000017692 ENTREZGENE
  ENSMUST00000017692.15 UniProtKB/Swiss-Prot
  ENSMUST00000126091.2 UniProtKB/TrEMBL
  ENSMUST00000144188.2 UniProtKB/TrEMBL
  ENSMUST00000163272 ENTREZGENE
  ENSMUST00000163272.2 UniProtKB/TrEMBL
InterPro Polycomb_protein_VEFS-Box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:52615 UniProtKB/Swiss-Prot
MGD MGI:1261758 ENTREZGENE
NCBI Gene 52615 ENTREZGENE
PANTHER POLYCOMB GROUP PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLYCOMB PROTEIN SUZ12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam VEFS-Box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Suz12 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
UniProt B1AQE5 ENTREZGENE
  E9PW15 ENTREZGENE, UniProtKB/TrEMBL
  F6Z494_MOUSE UniProtKB/TrEMBL
  F7B7H9_MOUSE UniProtKB/TrEMBL
  Q3URR6_MOUSE UniProtKB/TrEMBL
  Q3UX45_MOUSE UniProtKB/TrEMBL
  Q5XG68_MOUSE UniProtKB/TrEMBL
  Q80U70 ENTREZGENE
  Q80Y10 ENTREZGENE
  Q99L07 ENTREZGENE
  SUZ12_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary B1AQE5 UniProtKB/Swiss-Prot
  Q80Y10 UniProtKB/Swiss-Prot
  Q99L07 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Suz12  SUZ12 polycomb repressive complex 2 subunit  Suz12  suppressor of zeste 12 homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED