Dchs2 (dachsous cadherin related 2) - Rat Genome Database

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Gene: Dchs2 (dachsous cadherin related 2) Mus musculus
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Symbol: Dchs2
Name: dachsous cadherin related 2
RGD ID: 1618980
MGI Page MGI
Description: Predicted to enable calcium ion binding activity. Acts upstream of or within condensed mesenchymal cell proliferation and nephron development. Predicted to be active in cell-cell junction. Is expressed in brain; pharyngo-tympanic tube; and spinal cord. Orthologous to human DCHS2 (dachsous cadherin-related 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dachsous 2; dachsous 2 (Drosophila); EG627094; Gm417; Gm6731; predicted gene 6731; protocadherin alpha 5; protocadherin-23
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39383,032,589 - 83,270,336 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl383,035,255 - 83,264,516 (+)EnsemblGRCm39 Ensembl
GRCm38383,126,944 - 83,363,029 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,127,948 - 83,357,209 (+)EnsemblGRCm38mm10GRCm38
MGSCv37383,040,453 - 83,160,389 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,322,458 - 83,442,394 (+)NCBIMGSCv36mm8
Celera383,359,655 - 83,362,168 (+)NCBICelera
Cytogenetic Map3E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16059920   PMID:17967808   PMID:21267068   PMID:21303848   PMID:21873635   PMID:26116661   PMID:35420656  


Genomics

Comparative Map Data
Dchs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39383,032,589 - 83,270,336 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl383,035,255 - 83,264,516 (+)EnsemblGRCm39 Ensembl
GRCm38383,126,944 - 83,363,029 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,127,948 - 83,357,209 (+)EnsemblGRCm38mm10GRCm38
MGSCv37383,040,453 - 83,160,389 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,322,458 - 83,442,394 (+)NCBIMGSCv36mm8
Celera383,359,655 - 83,362,168 (+)NCBICelera
Cytogenetic Map3E3NCBI
DCHS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384154,231,742 - 154,491,799 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4154,231,742 - 154,491,799 (-)EnsemblGRCh38hg38GRCh38
GRCh374155,152,894 - 155,412,951 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364155,375,138 - 155,531,899 (-)NCBINCBI36Build 36hg18NCBI36
Celera4152,487,107 - 152,744,394 (-)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4150,896,142 - 151,153,669 (-)NCBIHuRef
CHM1_14155,133,499 - 155,390,873 (-)NCBICHM1_1
T2T-CHM13v2.04157,563,483 - 157,823,579 (-)NCBIT2T-CHM13v2.0
Dchs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82170,775,818 - 170,983,844 (+)NCBIGRCr8
mRatBN7.22168,478,298 - 168,685,802 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2168,478,826 - 168,682,732 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02182,112,787 - 182,319,003 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02201,527,880 - 201,733,437 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42174,852,149 - 175,056,529 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2162,497,522 - 162,704,249 (+)NCBICelera
Cytogenetic Map2q34NCBI
Dchs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,482,256 - 8,705,890 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,485,532 - 8,707,033 (-)NCBIChiLan1.0ChiLan1.0
DCHS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23152,131,900 - 152,403,873 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14152,488,207 - 152,759,391 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04146,597,168 - 146,858,314 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14158,414,929 - 158,676,163 (-)NCBIpanpan1.1PanPan1.1panPan2
DCHS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11551,910,985 - 52,038,538 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1551,915,989 - 52,138,739 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1552,257,488 - 52,483,107 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01552,598,926 - 52,825,401 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1552,602,627 - 52,825,857 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11551,854,124 - 52,080,442 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01551,959,217 - 52,185,021 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01552,272,809 - 52,499,451 (-)NCBIUU_Cfam_GSD_1.0
Dchs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,313,853 - 38,561,542 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936576988,868 - 1,119,150 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936576987,927 - 1,169,210 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCHS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl874,664,598 - 74,934,835 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1874,664,505 - 74,936,954 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2879,273,291 - 79,415,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DCHS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17100,770,541 - 101,036,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603780,425,267 - 80,692,234 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dchs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248585,466,947 - 5,717,482 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248585,464,552 - 5,717,086 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dchs2
8841 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35262550986625745Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35292318386923183Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34949500583495118Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35262550986625745Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34949500583495118Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35262550986625745Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4935758183357581Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse

Markers in Region
Dchs2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3E3UniSTS
cM Map3 UniSTS
D3Mit97  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38383,277,524 - 83,277,639UniSTSGRCm38
MGSCv37383,081,446 - 83,081,561UniSTSGRCm37
Celera383,282,310 - 83,282,411UniSTS
Cytogenetic Map3E3UniSTS
cM Map339.7UniSTS
Whitehead Genetic329.5UniSTS
Whitehead/MRC_RH3807.86UniSTS
Whitehead_YAC3 UniSTS
D3Mit212  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38383,317,410 - 83,317,530UniSTSGRCm38
MGSCv37383,121,332 - 83,121,452UniSTSGRCm37
Celera392,527,846 - 92,527,968UniSTS
Cytogenetic Map3E3UniSTS
cM Map339.7UniSTS
Whitehead Genetic329.5UniSTS
Whitehead_YAC3 UniSTS
Dchs2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3E3UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000191829   ⟹   ENSMUSP00000141425
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl383,035,255 - 83,264,516 (+)Ensembl
GRCm38.p6 Ensembl383,127,948 - 83,357,209 (+)Ensembl
RefSeq Acc Id: NM_001357165   ⟹   NP_001344094
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39383,034,834 - 83,264,516 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162801   ⟹   XP_036018694
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39383,032,589 - 83,270,336 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001344094 (Get FASTA)   NCBI Sequence Viewer  
  XP_036018694 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000141425
  ENSMUSP00000141425.2
Ensembl Acc Id: ENSMUSP00000141425   ⟸   ENSMUST00000191829
RefSeq Acc Id: XP_036018694   ⟸   XM_036162801
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001344094   ⟸   NM_001357165
- UniProtKB: A0A0A6YW72 (UniProtKB/TrEMBL)
Protein Domains
Cadherin


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685263 AgrOrtholog
Ensembl Genes ENSMUSG00000102692 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000191829 ENTREZGENE
  ENSMUST00000191829.2 UniProtKB/TrEMBL
Gene3D-CATH Cadherins UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin-like UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
MGD MGI:2685263 ENTREZGENE
NCBI Gene Dchs2 ENTREZGENE
PANTHER CADHERIN-RELATED TUMOR SUPPRESSOR UniProtKB/TrEMBL
  FAT ATYPICAL CADHERIN-RELATED UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
PhenoGen Dchs2 PhenoGen
PRINTS CADHERIN UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
SMART SM00112 UniProtKB/TrEMBL
Superfamily-SCOP SSF49313 UniProtKB/TrEMBL
UniProt A0A0A6YW72 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Dchs2  dachsous cadherin related 2  Dchs2  dachsous 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED
2024-08-21 Dchs2  dachsous 2 (Drosophila)  Dchs2  dachsous cadherin related 2  Symbol and/or name change 5135510 APPROVED
2017-11-21 Dchs2  dachsous cadherin related 2  Gm6731  predicted gene 6731  Data merged from RGD:1620282 737654 PROVISIONAL
2017-10-31 Dchs2  dachsous cadherin related 2    dachsous 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED