H2ac12 (H2A clustered histone 12) - Rat Genome Database

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Gene: H2ac12 (H2A clustered histone 12) Mus musculus
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Symbol: H2ac12
Name: H2A clustered histone 12
RGD ID: 1618817
MGI Page MGI
Description: Predicted to enable nucleosomal DNA binding activity. Predicted to be involved in heterochromatin formation. Predicted to be located in chromosome. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human H2AC12 (H2A clustered histone 12).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Hist1h; Hist1h2ah; histone 1, H2ah; histone cluster 1, H2ah; histone H2A type 1-H; RP23-9O16.9
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391322,219,292 - 22,219,813 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1322,219,334 - 22,219,738 (-)EnsemblGRCm39 Ensembl
GRCm381322,035,122 - 22,035,643 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1322,035,164 - 22,035,568 (-)EnsemblGRCm38mm10GRCm38
MGSCv371322,127,035 - 22,127,421 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361322,042,631 - 22,043,017 (-)NCBIMGSCv36mm8
Celera1322,307,610 - 22,307,996 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map138.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
nucleosome  (IBA)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12408966   PMID:12477932   PMID:15509584   PMID:15525528   PMID:16699504   PMID:21873635   PMID:26206133   PMID:28671696   PMID:30595499   PMID:30713523   PMID:32325033   PMID:36114006  
PMID:36293380  


Genomics

Comparative Map Data
H2ac12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391322,219,292 - 22,219,813 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1322,219,334 - 22,219,738 (-)EnsemblGRCm39 Ensembl
GRCm381322,035,122 - 22,035,643 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1322,035,164 - 22,035,568 (-)EnsemblGRCm38mm10GRCm38
MGSCv371322,127,035 - 22,127,421 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361322,042,631 - 22,043,017 (-)NCBIMGSCv36mm8
Celera1322,307,610 - 22,307,996 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map138.14NCBI
H2AC12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38627,147,106 - 27,147,562 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl627,147,106 - 27,147,562 (+)EnsemblGRCh38hg38GRCh38
GRCh37627,114,885 - 27,115,341 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36627,222,887 - 27,223,373 (+)NCBINCBI36Build 36hg18NCBI36
Build 34627,222,886 - 27,223,325NCBI
Celera628,720,909 - 28,721,395 (+)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef626,922,924 - 26,923,404 (+)NCBIHuRef
CHM1_1627,117,174 - 27,117,654 (+)NCBICHM1_1
T2T-CHM13v2.0627,015,922 - 27,016,378 (+)NCBIT2T-CHM13v2.0
H2ac12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81747,182,193 - 47,182,658 (+)NCBIGRCr8
mRatBN7.21742,486,415 - 42,486,880 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1742,486,415 - 42,486,941 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01744,527,990 - 44,528,557 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1744,528,125 - 44,528,511 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01758,940,554 - 58,942,457 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41750,119,480 - 50,119,866 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1753,974,759 - 53,975,326 (-)NCBICelera
Cytogenetic Map17p11NCBI
LOC100982497
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2541,779,821 - 41,795,629 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1637,781,292 - 37,797,102 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0626,980,174 - 26,981,215 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1627,642,074 - 27,642,553 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl627,642,115 - 27,642,501 (+)Ensemblpanpan1.1panPan2
H2AC14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13525,004,598 - 25,006,416 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3525,005,826 - 25,006,212 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3524,860,836 - 24,861,888 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03525,194,135 - 25,195,254 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3525,194,790 - 25,195,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13524,969,479 - 24,970,516 (-)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.03526,486,474 - 26,487,591 (-)NCBIUU_Cfam_GSD_1.0
H2AC17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl721,632,862 - 21,936,037 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1721,632,867 - 21,633,939 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2723,188,135 - 23,188,608 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103221968
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11745,362,328 - 45,362,820 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604426,842,068 - 26,842,554 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in H2ac12
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:162
Count of miRNA genes:158
Interacting mature miRNAs:162
Transcripts:ENSMUST00000091742
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse
1301661Tshp13_mtooth shape 13 (mouse)Not determined13123454672Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301890Adip7_madiposity 7 (mouse)Not determined13123454672Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1301984Pbd2_mpeak bone density 2 (mouse)Not determined131718950838947406Mouse
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
1301227Skull19_mskull morphology 19 (mouse)Not determined13123454672Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000091742   ⟹   ENSMUSP00000089336
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1322,219,334 - 22,219,738 (-)Ensembl
GRCm38.p6 Ensembl1322,035,164 - 22,035,568 (-)Ensembl
RefSeq Acc Id: NM_175659   ⟹   NP_783590
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391322,219,292 - 22,219,813 (-)NCBI
GRCm381322,035,122 - 22,035,643 (-)NCBI
MGSCv371322,127,035 - 22,127,421 (-)RGD
Celera1322,307,566 - 22,308,087 (-)NCBI
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_783590   ⟸   NM_175659
- UniProtKB: Q8CGP6 (UniProtKB/Swiss-Prot),   A3KPD0 (UniProtKB/TrEMBL),   A0AUV1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000089336   ⟸   ENSMUST00000091742
Protein Domains
Histone H2A C-terminal   Histone H2A/H2B/H3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CGP6-F1-model_v2 AlphaFold Q8CGP6 1-128 view protein structure

Promoters
RGD ID:8679754
Promoter ID:EPDNEW_M17908
Type:initiation region
Name:Hist1h2ah_1
Description:Mus musculus histone cluster 1, H2ah , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381322,035,596 - 22,035,656EPDNEW
RGD ID:6824029
Promoter ID:MM_KWN:13422
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000076487,   ENSMUST00000110456,   NM_175659,   NM_175665
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361322,126,041 - 22,128,497 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2448295 AgrOrtholog
Ensembl Genes ENSMUSG00000069302 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000091742 ENTREZGENE
  ENSMUST00000091742.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Histone-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A/H2B/H3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:319168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2448295 ENTREZGENE
NCBI Gene 319168 ENTREZGENE
PANTHER HISTONE H2A TYPE 1-D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Histone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen H2ac12 PhenoGen
PRINTS HISTONEH2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HISTONE_H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0AUV1 ENTREZGENE, UniProtKB/TrEMBL
  A3KPD0 ENTREZGENE, UniProtKB/TrEMBL
  H2A1H_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-13 H2ac12  H2A clustered histone 12  Hist1h2ah  histone cluster 1, H2ah  Symbol and/or name change 5135510 APPROVED