Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | increases expression | ISO | RGD:2932 | 6480464 | Nicotine results in increased expression of ITPKB mRNA | CTD | PMID:11478936 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ITPKB mRNA | CTD | PMID:33956508 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:2932 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ITPKB mRNA | CTD | PMID:33387578 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of ITPKB mRNA | CTD | PMID:20188158 | 4,4'-sulfonyldiphenol | increases methylation | EXP | | 6480464 | bis(4-hydroxyphenyl)sulfone results in increased methylation of ITPKB exon | CTD | PMID:33297965 | 8-Br-cAMP | increases expression | ISO | RGD:1345915 | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ITPKB mRNA | CTD | PMID:22079614 | acetamide | increases expression | ISO | RGD:2932 | 6480464 | acetamide results in increased expression of ITPKB mRNA | CTD | PMID:31881176 | acrolein | multiple interactions | ISO | RGD:1345915 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of ITPKB mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of ITPKB mRNA | CTD | PMID:32699268 | acrylamide | decreases expression | ISO | RGD:2932 | 6480464 | Acrylamide results in decreased expression of ITPKB mRNA | CTD | PMID:28959563 | aflatoxin B1 | decreases methylation | ISO | RGD:1345915 | 6480464 | Aflatoxin B1 results in decreased methylation of ITPKB intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | increases methylation | ISO | RGD:1345915 | 6480464 | aflatoxin B2 results in increased methylation of ITPKB intron | CTD | PMID:30157460 | alpha-pinene | multiple interactions | ISO | RGD:1345915 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of ITPKB mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of ITPKB mRNA | CTD | PMID:32699268 | ammonium chloride | affects expression | ISO | RGD:2932 | 6480464 | Ammonium Chloride affects the expression of ITPKB mRNA | CTD | PMID:16483693 | antirheumatic drug | increases expression | ISO | RGD:1345915 | 6480464 | Antirheumatic Agents results in increased expression of ITPKB mRNA | CTD | PMID:24449571 | avobenzone | increases expression | ISO | RGD:1345915 | 6480464 | avobenzone results in increased expression of ITPKB mRNA | CTD | PMID:31016361 | benzo[a]pyrene | decreases methylation | ISO | RGD:1345915 | 6480464 | Benzo(a)pyrene results in decreased methylation of ITPKB exon, Benzo(a)pyrene results in decreased methylation of ITPKB promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | RGD:1345915 | 6480464 | Benzo(a)pyrene results in increased methylation of ITPKB 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzo(a)pyrene results in increased methylation of ITPKB exon, Benzo(a)pyrene results in increased methylation of ITPKB intron | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | ISO | RGD:1345915 | 6480464 | benzo(e)pyrene results in increased methylation of ITPKB exon | CTD | PMID:30157460 | beta-naphthoflavone | multiple interactions | ISO | RGD:2932 | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ITPKB mRNA, [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ITPKB mRNA | CTD | PMID:18164116 | bisphenol A | multiple interactions | ISO | RGD:2932 | 6480464 | [bisphenol A co-treated with Testosterone] results in decreased expression of ITPKB mRNA | CTD | PMID:26496021 | bisphenol A | decreases methylation | ISO | RGD:1345915 | 6480464 | bisphenol A results in decreased methylation of ITPKB gene | CTD | PMID:31601247 | bisphenol A | increases expression | ISO | RGD:2932 | 6480464 | bisphenol A results in increased expression of ITPKB mRNA | CTD | PMID:29097150 more ... | bisphenol A | increases expression | ISO | RGD:1345915 | 6480464 | bisphenol A results in increased expression of ITPKB mRNA | CTD | PMID:27685785 | bisphenol A | decreases expression | ISO | RGD:2932 | 6480464 | bisphenol A results in decreased expression of ITPKB mRNA | CTD | PMID:25181051 | Brodifacoum | decreases expression | ISO | RGD:2932 | 6480464 | bromfenacoum results in decreased expression of ITPKB protein | CTD | PMID:28903499 | cefaloridine | increases expression | ISO | RGD:2932 | 6480464 | Cephaloridine results in increased expression of ITPKB mRNA | CTD | PMID:18500788 | chlordecone | increases expression | EXP | | 6480464 | Chlordecone results in increased expression of ITPKB mRNA | CTD | PMID:33711761 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ITPKB gene | CTD | PMID:20938992 | cocaine | increases expression | ISO | RGD:2932 | 6480464 | Cocaine results in increased expression of ITPKB mRNA | CTD | PMID:16076954 | copper atom | increases expression | ISO | RGD:2932 | 6480464 | Copper deficiency results in increased expression of ITPKB mRNA | CTD | PMID:26033743 | copper(0) | increases expression | ISO | RGD:2932 | 6480464 | Copper deficiency results in increased expression of ITPKB mRNA | CTD | PMID:26033743 | dorsomorphin | multiple interactions | ISO | RGD:1345915 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | RGD:1345915 | 6480464 | Doxorubicin results in decreased expression of ITPKB mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | ISO | RGD:2932 | 6480464 | Endosulfan results in decreased expression of ITPKB mRNA | CTD | PMID:31464424 | ethanol | affects expression | EXP | | 6480464 | Ethanol affects the expression of ITPKB mRNA | CTD | PMID:30319688 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of ITPKB mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ITPKB gene | CTD | PMID:20938992 | gentamycin | decreases expression | ISO | RGD:2932 | 6480464 | Gentamicins results in decreased expression of ITPKB mRNA | CTD | PMID:33387578 | isoprenaline | decreases expression | EXP | | 6480464 | Isoproterenol results in decreased expression of ITPKB mRNA | CTD | PMID:20003209 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ITPKB gene | CTD | PMID:20938992 | lead(0) | affects expression | ISO | RGD:1345915 | 6480464 | Lead affects the expression of ITPKB mRNA | CTD | PMID:28903495 | lead(2+) | affects expression | ISO | RGD:1345915 | 6480464 | Lead affects the expression of ITPKB mRNA | CTD | PMID:28903495 | lipopolysaccharide | multiple interactions | ISO | RGD:1345915 | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | lipopolysaccharide | decreases expression | ISO | RGD:1345915 | 6480464 | Lipopolysaccharides results in decreased expression of ITPKB mRNA | CTD | PMID:35811015 | methapyrilene | increases methylation | ISO | RGD:1345915 | 6480464 | Methapyrilene results in increased methylation of ITPKB exon | CTD | PMID:30157460 | methylmercury chloride | increases expression | ISO | RGD:1345915 | 6480464 | methylmercuric chloride results in increased expression of ITPKB mRNA | CTD | PMID:28001369 | N-ethyl-N-nitrosourea | increases mutagenesis | EXP | | 6480464 | Ethylnitrosourea results in increased mutagenesis of ITPKB gene | CTD | PMID:16724327 | N-nitrosodiethylamine | decreases expression | EXP | | 6480464 | Diethylnitrosamine results in decreased expression of ITPKB mRNA | CTD | PMID:17942915 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of ITPKB mRNA] | CTD | PMID:17942915 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:2932 | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ITPKB mRNA, [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ITPKB mRNA | CTD | PMID:18164116 | nicotine | increases expression | ISO | RGD:2932 | 6480464 | Nicotine results in increased expression of ITPKB mRNA | CTD | PMID:11478936 | nitrofen | decreases expression | ISO | RGD:2932 | 6480464 | nitrofen results in decreased expression of ITPKB mRNA | CTD | PMID:26720608 | ochratoxin A | increases expression | ISO | RGD:1345915 | 6480464 | ochratoxin A results in increased expression of ITPKB mRNA | CTD | PMID:30559759 | ozone | multiple interactions | ISO | RGD:1345915 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of ITPKB mRNA more ... | CTD | PMID:32699268 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of ITPKB mRNA | CTD | PMID:34911549 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of ITPKB mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | RGD:2932 | 6480464 | Acetaminophen results in decreased expression of ITPKB mRNA | CTD | PMID:33387578 | paracetamol | increases expression | ISO | RGD:1345915 | 6480464 | Acetaminophen results in increased expression of ITPKB mRNA | CTD | PMID:26690555 | phenylmercury acetate | increases expression | ISO | RGD:1345915 | 6480464 | Phenylmercuric Acetate results in increased expression of ITPKB mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | RGD:1345915 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPKB mRNA | CTD | PMID:27188386 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | RGD:1345915 | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | RGD:1345915 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | RGD:1345915 | 6480464 | Silicon Dioxide results in increased expression of ITPKB mRNA | CTD | PMID:25351596 | sodium arsenate | increases expression | EXP | | 6480464 | sodium arsenate results in increased expression of ITPKB mRNA | CTD | PMID:21795629 | sunitinib | decreases expression | ISO | RGD:1345915 | 6480464 | Sunitinib results in decreased expression of ITPKB mRNA | CTD | PMID:31533062 | testosterone | multiple interactions | ISO | RGD:2932 | 6480464 | [bisphenol A co-treated with Testosterone] results in decreased expression of ITPKB mRNA | CTD | PMID:26496021 | tetrachloromethane | decreases expression | ISO | RGD:2932 | 6480464 | Carbon Tetrachloride results in decreased expression of ITPKB mRNA | CTD | PMID:31150632 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of ITPKB mRNA | CTD | PMID:29264374 | trichostatin A | multiple interactions | ISO | RGD:1345915 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPKB mRNA | CTD | PMID:27188386 | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of ITPKB mRNA | CTD | PMID:30912803 | valproic acid | decreases expression | ISO | RGD:1345915 | 6480464 | Valproic Acid results in decreased expression of ITPKB mRNA | CTD | PMID:23179753, PMID:28001369 | valproic acid | affects expression | ISO | RGD:1345915 | 6480464 | Valproic Acid affects the expression of ITPKB mRNA | CTD | PMID:25979313 | vincristine | decreases expression | ISO | RGD:1345915 | 6480464 | Vincristine results in decreased expression of ITPKB mRNA | CTD | PMID:23649840 | vitamin E | increases expression | ISO | RGD:1345915 | 6480464 | Vitamin E results in increased expression of ITPKB mRNA | CTD | PMID:19244175 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Analyze GeneStrainQTL List |
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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Molecular Pathway Annotations Click to see Annotation Detail View
Imported Annotations - KEGG (archival)
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Biological Process
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Cellular Component
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Molecular Function
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Phenotype Annotations
Click to see Annotation Detail View
Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 2. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 3. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:8889548 | PMID:9027500 | PMID:9226383 | PMID:10349636 | PMID:10725249 | PMID:11042159 | PMID:11076861 | PMID:11092979 | PMID:11217851 | PMID:11919667 | PMID:12466851 | PMID:12477932 |
| PMID:14517551 | PMID:14610273 | PMID:14681479 | PMID:15064401 | PMID:15381088 | PMID:15782199 | PMID:16141072 | PMID:16141073 | PMID:16262249 | PMID:17355905 | PMID:17412921 | PMID:17417640 |
| PMID:17709751 | PMID:17825589 | PMID:18339802 | PMID:19342645 | PMID:20452702 | PMID:21267068 | PMID:21677750 | PMID:21873635 | PMID:22981169 | PMID:23175687 | PMID:25788703 | PMID:26121493 |
| PMID:26880557 | PMID:31697815 | PMID:33443159 | PMID:33785611 |
Genomics
Comparative Map Data
| Itpkb (Mus musculus - house mouse) |
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| ITPKB (Homo sapiens - human) |
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| Itpkb (Rattus norvegicus - Norway rat) |
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| Itpkb (Chinchilla lanigera - long-tailed chinchilla) |
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| ITPKB (Pan paniscus - bonobo/pygmy chimpanzee) |
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| ITPKB (Canis lupus familiaris - dog) |
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| Itpkb (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| ITPKB (Sus scrofa - pig) |
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| ITPKB (Chlorocebus sabaeus - green monkey) |
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| Itpkb (Heterocephalus glaber - naked mole-rat) |
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miRNA Target Status
Predicted Target Of
| The detailed report is available here: |  | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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QTLs in Region (GRCm39)
| The following QTLs overlap with this region. | | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Markers in Region
| RH94655 |
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| D1Mit426 |
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| UniSTS:234290 |
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| RH140655 |
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| Itpkb |
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| Itpkb |
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