Aarsd1 (alanyl-tRNA synthetase domain containing 1) - Rat Genome Database

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Gene: Aarsd1 (alanyl-tRNA synthetase domain containing 1) Mus musculus
Analyze
Symbol: Aarsd1
Name: alanyl-tRNA synthetase domain containing 1
RGD ID: 1618340
MGI Page MGI
Description: Enables Ser-tRNA(Ala) hydrolase activity. Acts upstream of or within regulation of translational fidelity. Predicted to be located in cytoplasm. Is expressed in submandibular gland primordium. Orthologous to several human genes including AARSD1 (alanyl-tRNA synthetase domain containing 1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1110069E20Rik; 2310044P18Rik; AA589600; alanyl-tRNA deacylase alaX; alanyl-tRNA editing protein Aarsd1; alanyl-tRNA synthetase domain-containing protein 1; AlaX; AlaXp-II
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,297,489 - 101,308,422 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,297,665 - 101,308,441 (-)EnsemblGRCm39 Ensembl
GRCm3811101,406,663 - 101,417,508 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,406,839 - 101,417,615 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,268,153 - 101,278,747 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,222,929 - 101,233,523 (-)NCBIMGSCv36mm8
Celera11113,094,285 - 113,104,855 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15102471   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:18172502   PMID:18799693   PMID:19906978   PMID:21267068   PMID:21285375   PMID:21873635   PMID:26884463   PMID:32325033  


Genomics

Comparative Map Data
Aarsd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,297,489 - 101,308,422 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,297,665 - 101,308,441 (-)EnsemblGRCm39 Ensembl
GRCm3811101,406,663 - 101,417,508 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,406,839 - 101,417,615 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,268,153 - 101,278,747 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,222,929 - 101,233,523 (-)NCBIMGSCv36mm8
Celera11113,094,285 - 113,104,855 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.95NCBI
AARSD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,950,526 - 42,964,454 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,950,526 - 42,964,498 (-)EnsemblGRCh38hg38GRCh38
GRCh371741,102,543 - 41,116,471 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,356,069 - 38,385,546 (-)NCBINCBI36Build 36hg18NCBI36
Celera1737,758,676 - 37,788,796 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1736,868,387 - 36,882,289 (-)NCBIHuRef
CHM1_11741,338,174 - 41,352,160 (-)NCBICHM1_1
T2T-CHM13v2.01743,807,669 - 43,821,595 (-)NCBIT2T-CHM13v2.0
Aarsd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,840,874 - 86,854,077 (-)NCBIGRCr8
mRatBN7.21086,340,625 - 86,353,732 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,340,626 - 86,353,729 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,377,995 - 91,391,213 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,852,888 - 90,865,992 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,246,194 - 86,259,298 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,317,974 - 89,331,078 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,317,975 - 89,331,078 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,115,998 - 89,136,327 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,002,331 - 90,015,435 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1085,058,109 - 85,071,213 (-)NCBICelera
Cytogenetic Map10q31NCBI
AARSD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,024,338 - 22,040,513 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11723,913,605 - 23,929,784 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,358,207 - 14,372,668 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,586,286 - 14,600,413 (+)NCBIpanpan1.1PanPan1.1panPan2
LOC480510
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,091,116 - 20,102,125 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,552,733 - 19,563,743 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,809,562 - 20,820,578 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1919,594,654 - 19,605,668 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,861,356 - 19,872,205 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,963,452 - 19,974,463 (+)NCBIUU_Cfam_GSD_1.0
LOC101974638
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,410,489 - 19,422,843 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493649017,652,296 - 17,664,589 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AARSD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,918,248 - 19,926,825 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,918,235 - 19,926,828 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Aarsd1
377 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:627
Count of miRNA genes:433
Interacting mature miRNAs:495
Transcripts:ENSMUST00000070395, ENSMUST00000125472, ENSMUST00000133240, ENSMUST00000140123
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
13513919Heal56_mwound healing/ regeneration 56 (mouse)11101156468101540293Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse

Markers in Region
RH125015  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,411,304 - 101,411,384UniSTSGRCm38
MGSCv3711101,272,618 - 101,272,698UniSTSGRCm37
Celera11113,098,726 - 113,098,806UniSTS
Cytogenetic Map11DUniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000070395   ⟹   ENSMUSP00000067912
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,297,665 - 101,308,441 (-)Ensembl
GRCm38.p6 Ensembl11101,406,839 - 101,417,615 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125472
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,307,574 - 101,308,232 (-)Ensembl
GRCm38.p6 Ensembl11101,416,748 - 101,417,406 (-)Ensembl
Ensembl Acc Id: ENSMUST00000133240
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,301,634 - 101,308,210 (-)Ensembl
GRCm38.p6 Ensembl11101,410,808 - 101,417,384 (-)Ensembl
Ensembl Acc Id: ENSMUST00000140123
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,302,235 - 101,308,208 (-)Ensembl
GRCm38.p6 Ensembl11101,411,409 - 101,417,382 (-)Ensembl
Ensembl Acc Id: ENSMUST00000189049
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,304,589 - 101,305,405 (-)Ensembl
GRCm38.p6 Ensembl11101,413,763 - 101,414,579 (-)Ensembl
RefSeq Acc Id: NM_144829   ⟹   NP_659078
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,297,665 - 101,308,259 (-)NCBI
GRCm3811101,406,839 - 101,417,433 (-)NCBI
MGSCv3711101,268,153 - 101,278,747 (-)RGD
Celera11113,094,285 - 113,104,855 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006534121   ⟹   XP_006534184
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,297,489 - 101,308,422 (-)NCBI
GRCm3811101,406,663 - 101,417,508 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156964   ⟹   XP_036012857
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,297,489 - 101,308,225 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156965   ⟹   XP_036012858
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,297,489 - 101,308,225 (-)NCBI
Sequence:
RefSeq Acc Id: NP_659078   ⟸   NM_144829
- UniProtKB: Q8BVJ6 (UniProtKB/Swiss-Prot),   Q3UWH8 (UniProtKB/Swiss-Prot),   Q99JS9 (UniProtKB/Swiss-Prot),   Q3THG9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006534184   ⟸   XM_006534121
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSMUSP00000067912   ⟸   ENSMUST00000070395
RefSeq Acc Id: XP_036012857   ⟸   XM_036156964
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036012858   ⟸   XM_036156965
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3THG9-F1-model_v2 AlphaFold Q3THG9 1-412 view protein structure

Promoters
RGD ID:6820223
Promoter ID:MM_KWN:9890
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK136332_AARSD1,   OTTMUST00000005671,   OTTMUST00000005821,   OTTMUST00000005822
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611101,278,506 - 101,279,006 (-)MPROMDB
RGD ID:6820248
Promoter ID:MM_KWN:9891
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   MEF_B4,   MEF_B6
Transcripts:AK007198_1700113I22RIK,   ENSMUST00000080965,   ENSMUST00000107257,   OTTMUST00000005663,   OTTMUST00000005666,   OTTMUST00000005667,   OTTMUST00000005668,   OTTMUST00000005669,   OTTMUST00000005670,   OTTMUST00000014223
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611101,285,711 - 101,286,537 (-)MPROMDB
RGD ID:8676796
Promoter ID:EPDNEW_M16428
Type:initiation region
Name:Aarsd1_1
Description:Mus musculus alanyl-tRNA synthetase domain containing 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811101,417,401 - 101,417,461EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916934 AgrOrtholog
Ensembl Genes ENSMUSG00000075528 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000070395 ENTREZGENE
  ENSMUST00000070395.9 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.30.130 UniProtKB/Swiss-Prot
  Threonyl-trna Synthetase, Chain A, domain 2 UniProtKB/Swiss-Prot
InterPro Ala-tRNA-synth_IIc_core UniProtKB/Swiss-Prot
  Alanyl-tRNA_Editing_Enzymes UniProtKB/Swiss-Prot
  Thr/Ala-tRNA-synth_IIc_edit UniProtKB/Swiss-Prot
  Transl_B-barrel_sf UniProtKB/Swiss-Prot
  tRNA_SAD UniProtKB/Swiss-Prot
KEGG Report mmu:69684 UniProtKB/Swiss-Prot
MGD MGI:1916934 ENTREZGENE
NCBI Gene 69684 ENTREZGENE
PANTHER ALANYL-TRNA EDITING PROTEIN UniProtKB/Swiss-Prot
  ALANYL-TRNA EDITING PROTEIN AARSD1 UniProtKB/Swiss-Prot
Pfam tRNA_SAD UniProtKB/Swiss-Prot
PhenoGen Aarsd1 PhenoGen
PROSITE AA_TRNA_LIGASE_II_ALA UniProtKB/Swiss-Prot
SMART tRNA_SAD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50447 UniProtKB/Swiss-Prot
  SSF55186 UniProtKB/Swiss-Prot
UniProt AASD1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UWH8 ENTREZGENE
  Q8BVJ6 ENTREZGENE
  Q99JS9 ENTREZGENE
UniProt Secondary Q3UWH8 UniProtKB/Swiss-Prot
  Q8BVJ6 UniProtKB/Swiss-Prot
  Q99JS9 UniProtKB/Swiss-Prot