Kat6b (K(lysine) acetyltransferase 6B) - Rat Genome Database

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Gene: Kat6b (K(lysine) acetyltransferase 6B) Mus musculus
Analyze
Symbol: Kat6b
Name: K(lysine) acetyltransferase 6B
RGD ID: 1617572
MGI Page MGI
Description: Enables histone acetyltransferase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including central nervous system; early conceptus; facial prominence; genitourinary system; and limb mesenchyme. Used to study Noonan syndrome. Human ortholog(s) of this gene implicated in Ohdo syndrome, SBBYS variant; bipolar disorder; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI507552; B130044K16Rik; histone acetyltransferase KAT6B; histone acetyltransferase MYST4; histone acetyltransferase querkopf; mKIAA0383; Mo; monocytic leukemia; Morf; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; Myst; MYST histone acetyltransferase monocytic leukemia 4; MYST-4; Myst4; qkf; querk; querkopf
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Kat6b-ps1   Kat6b-ps2  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391421,549,284 - 21,722,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1421,531,502 - 21,722,546 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381421,499,216 - 21,672,478 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1421,481,434 - 21,672,478 (+)Ensemblmm10GRCm38
MGSCv371422,319,076 - 22,491,355 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361420,288,420 - 20,460,685 (+)NCBIMGSCv36mm8
Celera1417,881,664 - 18,055,053 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.73NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chloroacetaldehyde  (ISO)
choline  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
D-glucose  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
glucose  (EXP)
ifosfamide  (ISO)
L-methionine  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methoxychlor  (ISO)
N,N-diethyl-m-toluamide  (ISO)
nickel atom  (ISO)
nicotine  (EXP)
ozone  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP)
PhIP  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pyrimidifen  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
MOZ/MORF histone acetyltransferase complex  (IBA,ISO,ISS)
nucleosome  (IEA)
nucleus  (IBA,IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Whole-exome-sequencing identifies mutations in histone acetyltransferase gene KAT6B in individuals with the Say-Barber-Biesecker variant of Ohdo syndrome. Clayton-Smith J, etal., Am J Hum Genet. 2011 Nov 11;89(5):675-81. doi: 10.1016/j.ajhg.2011.10.008.
2. Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice. Kraft M, etal., J Clin Invest. 2011 Sep;121(9):3479-91. doi: 10.1172/JCI43428. Epub 2011 Aug 1.
3. Identification of novel loci for bipolar I disorder in a multi-stage genome-wide association study. Kuo PH, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:58-64. doi: 10.1016/j.pnpbp.2014.01.003. Epub 2014 Jan 18.
4. Can unknown predisposition in familial breast cancer be family-specific? Lynch H, etal., Breast J. 2013 Sep-Oct;19(5):520-8. doi: 10.1111/tbj.12145. Epub 2013 Jun 26.
5. Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF. Moore SD, etal., Cancer Res. 2004 Aug 15;64(16):5570-7.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. De novo mutations of the gene encoding the histone acetyltransferase KAT6B cause Genitopatellar syndrome. Simpson MA, etal., Am J Hum Genet. 2012 Feb 10;90(2):290-4. doi: 10.1016/j.ajhg.2011.11.024. Epub 2012 Jan 19.
Additional References at PubMed
PMID:10349636   PMID:10512203   PMID:10821753   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11782361   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12904583  
PMID:14610273   PMID:14621295   PMID:14766340   PMID:15618518   PMID:15741177   PMID:15747579   PMID:15840001   PMID:16141072   PMID:16141073   PMID:16387653   PMID:16602821   PMID:17079664  
PMID:17460191   PMID:17967808   PMID:17980166   PMID:18022353   PMID:18287559   PMID:18799693   PMID:20059953   PMID:20412781   PMID:20439489   PMID:21267068   PMID:21731673   PMID:21873635  
PMID:22174793   PMID:22331353   PMID:22951486   PMID:22988430   PMID:25773539   PMID:29268844   PMID:30186101   PMID:30790630   PMID:31077711   PMID:32014431   PMID:32325033   PMID:34321999  
PMID:37058271   PMID:38518784   PMID:38557491   PMID:39537341   PMID:39832706   PMID:40000651   PMID:40083716  


Genomics

Comparative Map Data
Kat6b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391421,549,284 - 21,722,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1421,531,502 - 21,722,546 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381421,499,216 - 21,672,478 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1421,481,434 - 21,672,478 (+)Ensemblmm10GRCm38
MGSCv371422,319,076 - 22,491,355 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361420,288,420 - 20,460,685 (+)NCBIMGSCv36mm8
Celera1417,881,664 - 18,055,053 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.73NCBI
KAT6B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381074,824,936 - 75,032,624 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1074,824,912 - 75,032,631 (+)Ensemblhg38GRCh38
GRCh371076,585,013 - 76,792,382 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361076,256,385 - 76,462,645 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341076,268,463 - 76,460,810NCBI
Celera1069,874,402 - 70,080,888 (+)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1070,584,503 - 70,790,954 (+)NCBIHuRef
CHM1_11076,868,040 - 77,074,125 (+)NCBICHM1_1
T2T-CHM13v2.01075,698,186 - 75,906,154 (+)NCBIT2T-CHM13v2.0
Kat6b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,688,535 - 2,861,443 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl152,688,811 - 2,844,343 (-)EnsemblGRCr8
mRatBN7.2152,638,885 - 2,811,977 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,639,200 - 2,812,316 (-)EnsemblmRatBN7.2
Rnor_6.0152,811,933 - 2,966,833 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,813,537 - 2,966,576 (-)Ensemblrn6Rnor6.0
Rnor_5.0152,792,817 - 2,960,466 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera151,779,554 - 1,945,321 (+)NCBICelera
Cytogenetic Map15p16NCBI
KAT6B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2886,982,465 - 87,189,469 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11086,987,799 - 87,194,794 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01071,354,585 - 71,561,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11074,020,143 - 74,225,546 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1074,035,496 - 74,223,975 (+)EnsemblpanPan2panpan1.1
KAT6B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1425,131,580 - 25,303,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl425,131,844 - 25,301,825 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha425,253,256 - 25,438,393 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0425,399,632 - 25,585,839 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl425,400,521 - 25,584,563 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1425,295,642 - 25,481,027 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0425,495,394 - 25,681,653 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0425,850,710 - 26,037,089 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kat6b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721355,816,974 - 56,005,037 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365214,309,694 - 4,496,904 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365214,309,699 - 4,497,755 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KAT6B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1477,404,136 - 77,597,673 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11477,390,790 - 77,597,674 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21483,529,553 - 83,722,784 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KAT6B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1956,340,579 - 56,525,809 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl956,340,026 - 56,536,512 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604816,828,363 - 17,063,158 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kat6b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247548,204,943 - 8,392,724 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247548,204,266 - 8,391,328 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kat6b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11291,279,734 - 91,448,935 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kat6b
5406 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2000
Count of miRNA genes:634
Interacting mature miRNAs:784
Transcripts:ENSMUST00000069648, ENSMUST00000096222, ENSMUST00000112458, ENSMUST00000182405, ENSMUST00000182553, ENSMUST00000182732, ENSMUST00000182855, ENSMUST00000182859, ENSMUST00000182964, ENSMUST00000182996, ENSMUST00000183055, ENSMUST00000183201, ENSMUST00000183228
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
11532711Sluc40_msusceptibility to lung cancer 40 (mouse)14127379943Mouse
4141265Appd2_mAPP associated premature death 2 (mouse)Not determined14594555230114862Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
4141550Dbm3_mdiabetes modifier 3 (mouse)Not determined514347339143596Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse
1301991Wta3_mweight adult 3 (mouse)Not determined14388747337887650Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
1300779Dyscalc4_mdystrophic cardiac calcinosis 4 (mouse)Not determined141221287146213007Mouse
10412071Ssen3_msuseptibility to Sendai virus 3 (mouse)Not determined14126987934Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)141376927347237457Mouse

Markers in Region
RH136273  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381421,603,253 - 21,603,448UniSTSGRCm38
MGSCv371422,422,475 - 22,422,670UniSTSGRCm37
Celera1417,986,254 - 17,986,449UniSTS
Cytogenetic Map14A3UniSTS
AI507552  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381421,671,952 - 21,672,031UniSTSGRCm38
MGSCv371422,491,174 - 22,491,253UniSTSGRCm37
Celera1418,054,872 - 18,054,951UniSTS
Cytogenetic Map14A3UniSTS
Whitehead/MRC_RH14139.68UniSTS
D10Mit157  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371422,384,379 - 22,384,621UniSTSGRCm37
MGSCv37831,354,929 - 31,355,067UniSTSGRCm37
Celera1417,947,231 - 17,947,465UniSTS
cM Map14 UniSTS
cM Map1040.0UniSTS
cM Map8 UniSTS
Whitehead Genetic1033.9UniSTS
D14Ertd725e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381421,603,115 - 21,603,346UniSTSGRCm38
MGSCv371422,422,337 - 22,422,568UniSTSGRCm37
Celera1417,986,116 - 17,986,347UniSTS
Cytogenetic Map14A3UniSTS
cM Map145.0UniSTS
UniSTS:225283  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381421,636,541 - 21,636,696UniSTSGRCm38
MGSCv371422,455,763 - 22,455,918UniSTSGRCm37
Celera1418,019,643 - 18,019,798UniSTS
Cytogenetic Map14A3UniSTS
MYST4_3804  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381421,670,198 - 21,670,949UniSTSGRCm38
MGSCv371422,489,420 - 22,490,171UniSTSGRCm37
Celera1418,053,118 - 18,053,869UniSTS
Cytogenetic Map14A3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001205241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001408695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001408696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006519263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006519264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006519265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006519269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030247887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030247888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC148978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF222800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC116664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP753863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000069648   ⟹   ENSMUSP00000066693
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1421,549,853 - 21,722,546 (+)Ensembl
GRCm38.p6 Ensembl1421,499,785 - 21,672,478 (+)Ensembl
Ensembl Acc Id: ENSMUST00000096222
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1421,550,921 - 21,671,469 (+)Ensembl
GRCm38.p6 Ensembl1421,500,853 - 21,621,401 (+)Ensembl
Ensembl Acc Id: ENSMUST00000112458   ⟹   ENSMUSP00000108077
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1421,566,819 - 21,721,274 (+)Ensembl
GRCm38.p6 Ensembl1421,516,751 - 21,671,206 (+)Ensembl
Ensembl Acc Id: ENSMUST00000182405   ⟹   ENSMUSP00000138377
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1421,549,853 - 21,722,201 (+)Ensembl
GRCm38.p6 Ensembl1421,499,785 - 21,672,133 (+)Ensembl
Ensembl Acc Id: ENSMUST00000182732
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1421,672,610 - 21,684,657 (+)Ensembl
GRCm38.p6 Ensembl1421,622,542 - 21,634,589 (+)Ensembl
Ensembl Acc Id: ENSMUST00000182855   ⟹   ENSMUSP00000138511
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1421,549,838 - 21,722,139 (+)Ensembl
GRCm38.p6 Ensembl1421,499,770 - 21,672,071 (+)Ensembl
Ensembl Acc Id: ENSMUST00000182859
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1421,549,922 - 21,568,711 (+)Ensembl
GRCm38.p6 Ensembl1421,499,854 - 21,518,643 (+)Ensembl
Ensembl Acc Id: ENSMUST00000182964   ⟹   ENSMUSP00000138421
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1421,550,921 - 21,722,546 (+)Ensembl
GRCm38.p6 Ensembl1421,500,853 - 21,672,478 (+)Ensembl
Ensembl Acc Id: ENSMUST00000182996   ⟹   ENSMUSP00000138746
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1421,531,502 - 21,567,179 (+)Ensembl
GRCm38.p6 Ensembl1421,481,434 - 21,517,111 (+)Ensembl
Ensembl Acc Id: ENSMUST00000183055
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1421,550,957 - 21,670,673 (+)Ensembl
GRCm38.p6 Ensembl1421,500,889 - 21,620,605 (+)Ensembl
Ensembl Acc Id: ENSMUST00000183201
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1421,531,527 - 21,672,045 (+)Ensembl
GRCm38.p6 Ensembl1421,481,459 - 21,621,977 (+)Ensembl
Ensembl Acc Id: ENSMUST00000183228
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1421,550,953 - 21,570,372 (+)Ensembl
GRCm38.p6 Ensembl1421,500,885 - 21,520,304 (+)Ensembl
Ensembl Acc Id: ENSMUST00000226589
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1421,675,820 - 21,676,794 (+)Ensembl
GRCm38.p6 Ensembl1421,625,752 - 21,626,726 (+)Ensembl
Ensembl Acc Id: ENSMUST00000238837   ⟹   ENSMUSP00000159058
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1421,566,943 - 21,720,941 (+)Ensembl
GRCm38.p6 Ensembl1421,516,875 - 21,670,873 (+)Ensembl
RefSeq Acc Id: NM_001205241   ⟹   NP_001192170
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,549,833 - 21,722,545 (+)NCBI
GRCm381421,499,770 - 21,672,478 (+)NCBI
Celera1417,854,199 - 18,055,398 (+)ENTREZGENE
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001408695   ⟹   NP_001395624
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,550,957 - 21,722,545 (+)NCBI
RefSeq Acc Id: NM_001408696   ⟹   NP_001395625
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,550,957 - 21,722,545 (+)NCBI
RefSeq Acc Id: NM_017479   ⟹   NP_059507
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,549,922 - 21,722,545 (+)NCBI
GRCm381421,499,785 - 21,672,478 (+)NCBI
MGSCv371422,319,076 - 22,491,355 (+)RGD
Celera1417,854,199 - 18,055,398 (+)ENTREZGENE
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006519263   ⟹   XP_006519326
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,550,529 - 21,722,546 (+)NCBI
GRCm381421,500,454 - 21,672,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006519264   ⟹   XP_006519327
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,549,794 - 21,722,318 (+)NCBI
GRCm381421,499,727 - 21,672,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006519265   ⟹   XP_006519328
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,549,284 - 21,722,318 (+)NCBI
GRCm381421,499,216 - 21,672,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006519269   ⟹   XP_006519332
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,580,526 - 21,722,318 (+)NCBI
GRCm381421,557,574 - 21,672,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017316082   ⟹   XP_017171571
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,550,528 - 21,722,546 (+)NCBI
GRCm381421,500,454 - 21,672,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017316084   ⟹   XP_017171573
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,550,536 - 21,722,318 (+)NCBI
GRCm381421,500,461 - 21,672,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030247887   ⟹   XP_030103747
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,550,026 - 21,722,318 (+)NCBI
GRCm381421,499,990 - 21,672,477 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030247888   ⟹   XP_030103748
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,676,787 - 21,722,546 (+)NCBI
GRCm381421,622,123 - 21,672,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036158756   ⟹   XP_036014649
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,549,813 - 21,722,318 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036158757   ⟹   XP_036014650
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,550,531 - 21,722,318 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036158758   ⟹   XP_036014651
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,549,284 - 21,722,318 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036158759   ⟹   XP_036014652
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391421,549,899 - 21,722,318 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001192170 (Get FASTA)   NCBI Sequence Viewer  
  NP_001395624 (Get FASTA)   NCBI Sequence Viewer  
  NP_001395625 (Get FASTA)   NCBI Sequence Viewer  
  NP_059507 (Get FASTA)   NCBI Sequence Viewer  
  XP_006519326 (Get FASTA)   NCBI Sequence Viewer  
  XP_006519327 (Get FASTA)   NCBI Sequence Viewer  
  XP_006519328 (Get FASTA)   NCBI Sequence Viewer  
  XP_006519332 (Get FASTA)   NCBI Sequence Viewer  
  XP_017171571 (Get FASTA)   NCBI Sequence Viewer  
  XP_017171573 (Get FASTA)   NCBI Sequence Viewer  
  XP_030103747 (Get FASTA)   NCBI Sequence Viewer  
  XP_030103748 (Get FASTA)   NCBI Sequence Viewer  
  XP_036014649 (Get FASTA)   NCBI Sequence Viewer  
  XP_036014650 (Get FASTA)   NCBI Sequence Viewer  
  XP_036014651 (Get FASTA)   NCBI Sequence Viewer  
  XP_036014652 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF26744 (Get FASTA)   NCBI Sequence Viewer  
  AAH95974 (Get FASTA)   NCBI Sequence Viewer  
  AAI16665 (Get FASTA)   NCBI Sequence Viewer  
  BAC32253 (Get FASTA)   NCBI Sequence Viewer  
  BAC33305 (Get FASTA)   NCBI Sequence Viewer  
  BAC34930 (Get FASTA)   NCBI Sequence Viewer  
  BAC38771 (Get FASTA)   NCBI Sequence Viewer  
  BAC97939 (Get FASTA)   NCBI Sequence Viewer  
  BAE22542 (Get FASTA)   NCBI Sequence Viewer  
  BAE27963 (Get FASTA)   NCBI Sequence Viewer  
  EDL01470 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000066693.8
  ENSMUSP00000138377
  ENSMUSP00000138377.2
  ENSMUSP00000138421
  ENSMUSP00000138421.2
  ENSMUSP00000138511
  ENSMUSP00000138511.2
  ENSMUSP00000159058
GenBank Protein Q8BRB7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_059507   ⟸   NM_017479
- Peptide Label: isoform 1
- UniProtKB: Q3UH94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001192170   ⟸   NM_001205241
- Peptide Label: isoform 1
- UniProtKB: Q3UH94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006519328   ⟸   XM_006519265
- Peptide Label: isoform X1
- UniProtKB: A0A5F8MQ39 (UniProtKB/TrEMBL),   Q3UH94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006519327   ⟸   XM_006519264
- Peptide Label: isoform X1
- UniProtKB: A0A5F8MQ39 (UniProtKB/TrEMBL),   Q3UH94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006519326   ⟸   XM_006519263
- Peptide Label: isoform X1
- UniProtKB: A0A5F8MQ39 (UniProtKB/TrEMBL),   Q3UH94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006519332   ⟸   XM_006519269
- Peptide Label: isoform X5
- UniProtKB: Q3UH94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017171571   ⟸   XM_017316082
- Peptide Label: isoform X2
- UniProtKB: Q3UH94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017171573   ⟸   XM_017316084
- Peptide Label: isoform X7
- UniProtKB: Q3UH94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030103747   ⟸   XM_030247887
- Peptide Label: isoform X1
- UniProtKB: A0A5F8MQ39 (UniProtKB/TrEMBL),   Q3UH94 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030103748   ⟸   XM_030247888
- Peptide Label: isoform X8
Ensembl Acc Id: ENSMUSP00000138511   ⟸   ENSMUST00000182855
Ensembl Acc Id: ENSMUSP00000138421   ⟸   ENSMUST00000182964
Ensembl Acc Id: ENSMUSP00000138746   ⟸   ENSMUST00000182996
Ensembl Acc Id: ENSMUSP00000108077   ⟸   ENSMUST00000112458
Ensembl Acc Id: ENSMUSP00000159058   ⟸   ENSMUST00000238837
Ensembl Acc Id: ENSMUSP00000066693   ⟸   ENSMUST00000069648
Ensembl Acc Id: ENSMUSP00000138377   ⟸   ENSMUST00000182405
RefSeq Acc Id: XP_036014651   ⟸   XM_036158758
- Peptide Label: isoform X6
- UniProtKB: Q3UH94 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036014649   ⟸   XM_036158756
- Peptide Label: isoform X1
- UniProtKB: A0A5F8MQ39 (UniProtKB/TrEMBL),   Q3UH94 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036014652   ⟸   XM_036158759
- Peptide Label: isoform X7
- UniProtKB: Q3UH94 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036014650   ⟸   XM_036158757
- Peptide Label: isoform X3
- UniProtKB: Q3UH94 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001395625   ⟸   NM_001408696
- Peptide Label: isoform 2
- UniProtKB: Q8C441 (UniProtKB/Swiss-Prot),   Q8BRB7 (UniProtKB/Swiss-Prot),   Q8BG35 (UniProtKB/Swiss-Prot),   Q7TNW5 (UniProtKB/Swiss-Prot),   E9QK86 (UniProtKB/Swiss-Prot),   Q9JKX5 (UniProtKB/Swiss-Prot),   Q3UH94 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001395624   ⟸   NM_001408695
- Peptide Label: isoform 1
- UniProtKB: Q3UH94 (UniProtKB/TrEMBL)
Protein Domains
H15   MYST-type HAT   PHD-type   SAMD1-like winged helix (WH)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BRB7-F1-model_v2 AlphaFold Q8BRB7 1-1872 view protein structure

Promoters
RGD ID:8681640
Promoter ID:EPDNEW_M18850
Type:initiation region
Name:Kat6b_2
Description:Mus musculus K acetyltransferase 6B , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18851  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381421,499,762 - 21,499,822EPDNEW
RGD ID:8681642
Promoter ID:EPDNEW_M18851
Type:multiple initiation site
Name:Kat6b_1
Description:Mus musculus K acetyltransferase 6B , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18850  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381421,500,889 - 21,500,949EPDNEW
RGD ID:6825199
Promoter ID:MM_KWN:15829
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   ES_Cell
Transcripts:ENSMUST00000069648,   NM_017479,   UC007SLF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361422,318,279 - 22,318,779 (+)MPROMDB
RGD ID:6825198
Promoter ID:MM_KWN:15830
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000096222,   UC007SLI.1,   UC007SLJ.1,   UC007SLK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361422,319,186 - 22,320,507 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1858746 AgrOrtholog
Ensembl Genes ENSMUSG00000021767 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000069648.14 UniProtKB/Swiss-Prot
  ENSMUST00000182405 ENTREZGENE
  ENSMUST00000182405.9 UniProtKB/Swiss-Prot
  ENSMUST00000182855 ENTREZGENE
  ENSMUST00000182855.8 UniProtKB/Swiss-Prot
  ENSMUST00000182964 ENTREZGENE
  ENSMUST00000182964.3 UniProtKB/Swiss-Prot
  ENSMUST00000238837 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot
  3.40.630.30 UniProtKB/Swiss-Prot
  N-acetyl transferase-like UniProtKB/Swiss-Prot
InterPro Acyl_CoA_acyltransferase UniProtKB/Swiss-Prot
  HAT_MYST-type UniProtKB/Swiss-Prot
  Histone_H1/H5_H15 UniProtKB/Swiss-Prot
  MYST_HAT UniProtKB/Swiss-Prot
  SAMD1-like_WH UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
  Zf-MYST UniProtKB/Swiss-Prot
  Znf_FYVE_PHD UniProtKB/Swiss-Prot
  Znf_PHD UniProtKB/Swiss-Prot
  Znf_PHD-finger UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
KEGG Report mmu:54169 UniProtKB/Swiss-Prot
MGD MGI:1858746 ENTREZGENE
NCBI Gene 54169 ENTREZGENE
PANTHER HISTONE ACETYLTRANSFERASE UniProtKB/Swiss-Prot
  HISTONE ACETYLTRANSFERASE KAT6B UniProtKB/Swiss-Prot
Pfam Linker_histone UniProtKB/Swiss-Prot
  MOZ_SAS UniProtKB/Swiss-Prot
  PHD UniProtKB/Swiss-Prot
  SAMD1_WH UniProtKB/Swiss-Prot
  zf-MYST UniProtKB/Swiss-Prot
PhenoGen Kat6b PhenoGen
PROSITE H15 UniProtKB/Swiss-Prot
  MYST_HAT UniProtKB/Swiss-Prot
  SAMD1_WH UniProtKB/Swiss-Prot
  ZF_PHD_1 UniProtKB/Swiss-Prot
  ZF_PHD_2 UniProtKB/Swiss-Prot
SMART H15 UniProtKB/Swiss-Prot
  PHD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
  SSF55729 UniProtKB/Swiss-Prot
  SSF57903 UniProtKB/Swiss-Prot
UniProt A0A5F8MQ39 ENTREZGENE, UniProtKB/TrEMBL
  E9QK86 ENTREZGENE
  KAT6B_MOUSE UniProtKB/Swiss-Prot
  Q14AW2_MOUSE UniProtKB/TrEMBL
  Q3UH94 ENTREZGENE, UniProtKB/TrEMBL
  Q3UXM1_MOUSE UniProtKB/TrEMBL
  Q501M5_MOUSE UniProtKB/TrEMBL
  Q6ZQC7_MOUSE UniProtKB/TrEMBL
  Q7TNW5 ENTREZGENE
  Q8BG35 ENTREZGENE
  Q8BRB7 ENTREZGENE
  Q8C441 ENTREZGENE
  Q9JKX5 ENTREZGENE
  S4R2Q8_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QK86 UniProtKB/Swiss-Prot
  Q7TNW5 UniProtKB/Swiss-Prot
  Q8BG35 UniProtKB/Swiss-Prot
  Q8C441 UniProtKB/Swiss-Prot
  Q9JKX5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-25 Kat6b  K(lysine) acetyltransferase 6B  Myst4  MYST histone acetyltransferase monocytic leukemia 4  Symbol and/or name change 5135510 APPROVED