Tardbp (TAR DNA binding protein) - Rat Genome Database

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Gene: Tardbp (TAR DNA binding protein) Mus musculus
Analyze
Symbol: Tardbp
Name: TAR DNA binding protein
RGD ID: 1617357
MGI Page MGI
Description: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and pre-mRNA intronic binding activity. Involved in positive regulation of protein import into nucleus; regulation of circadian rhythm; and regulation of protein stability. Acts upstream of or within RNA splicing. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and heart. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions; amyotrophic lateral sclerosis type 10; and frontotemporal dementia. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1190002A23Rik; C85084; TAR DNA-binding protein 43; TDP-4; TDP-43; Tdp4; Tdp43
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm13886  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,696,839 - 148,711,672 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,696,839 - 148,711,476 (-)EnsemblGRCm39 Ensembl
GRCm384148,612,382 - 148,627,084 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,612,382 - 148,627,019 (-)EnsemblGRCm38mm10GRCm38
MGSCv374147,986,491 - 148,001,105 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,454,416 - 147,470,796 (-)NCBIMGSCv36mm8
Celera4150,873,662 - 150,888,313 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.77NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3',5'-cyclic UMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
aconitine  (ISO)
acrolein  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bufalin  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
chloroprene  (EXP)
chloroquine  (EXP,ISO)
chromium(6+)  (EXP)
chrysene  (EXP)
cisplatin  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucitol  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diallyl trisulfide  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
digoxin  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxycycline  (ISO)
emetine  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxomicin  (ISO)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
geraniol  (ISO)
glafenine  (ISO)
hexachlorophene  (ISO)
hydrogen cyanide  (EXP)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
irinotecan  (EXP)
ivermectin  (ISO)
L-serine  (ISO)
lanatoside C  (ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
mercury atom  (EXP)
mercury dichloride  (ISO)
mercury(0)  (EXP)
methimazole  (ISO)
methylmercury chloride  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
nimesulide  (ISO)
nitrates  (EXP)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
PF-670462  (ISO)
phenobarbital  (EXP)
phenol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium cyanide  (EXP)
progesterone  (ISO)
Proscillaridin  (ISO)
pyocyanine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
succimer  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
tin atom  (ISO)
tin(0)  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autophagosome formation  (IAGP)
abnormal axon morphology  (IAGP)
abnormal brain interneuron morphology  (IAGP)
abnormal brown fat cell morphology  (IAGP)
abnormal calcium ion homeostasis  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal chromosomal synapsis  (IAGP)
abnormal chromosome morphology  (IAGP)
abnormal chromosome number  (IAGP)
abnormal cognition  (IAGP)
abnormal double-strand DNA break repair  (IAGP)
abnormal eating behavior  (IAGP)
abnormal endoplasmic reticulum morphology  (IAGP)
abnormal food intake  (IAGP)
abnormal frontal lobe morphology  (IAGP)
abnormal GABAergic neuron morphology  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal lipid oxidation  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal motor neuron innervation pattern  (IAGP)
abnormal motor neuron morphology  (IAGP)
abnormal muscle tone  (IAGP)
abnormal neuromuscular synapse morphology  (IAGP)
abnormal object recognition memory  (IAGP)
abnormal primary motor cortex morphology  (IAGP)
abnormal respiratory quotient  (IAGP)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal sperm flagellum morphology  (IAGP)
abnormal sperm head morphology  (IAGP)
abnormal spinal cord ventral horn morphology  (IAGP)
abnormal startle reflex  (IEA)
abnormal survival  (IAGP)
abnormal white adipose tissue morphology  (IAGP)
abnormal white fat cell morphology  (IAGP)
absent inner cell mass proliferation  (IAGP)
absent sperm head  (IAGP)
arrest of male meiosis  (IAGP)
arrest of spermatogenesis  (IAGP)
astrocytosis  (IAGP)
axon degeneration  (IAGP)
cognitive inflexibility  (IAGP)
decreased blood urea nitrogen level  (IEA)
decreased body weight  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IEA)
decreased extensor digitorum longus weight  (IAGP)
decreased grip strength  (IAGP)
decreased male germ cell number  (IAGP)
decreased mean platelet volume  (IEA)
decreased mesenteric fat pad weight  (IAGP)
decreased motor neuron number  (IAGP)
decreased stereotypic behavior  (IAGP)
decreased testis weight  (IAGP)
decreased total body fat amount  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality prior to organogenesis  (IEA)
embryonic lethality prior to organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
hindlimb paralysis  (IAGP)
impaired coordination  (IAGP)
impaired muscle relaxation  (IAGP)
impaired spatial learning  (IAGP)
increased anxiety-related response  (IAGP)
increased body weight  (IAGP)
increased male germ cell apoptosis  (IAGP)
increased microglial cell activation  (IAGP)
increased vertical activity  (IAGP)
kyphosis  (IAGP)
limb grasping  (IAGP)
microgliosis  (IAGP)
motor neuron degeneration  (IAGP)
muscle weakness  (IAGP)
muscular atrophy  (IAGP)
neuronal cytoplasmic inclusions  (IAGP)
oligozoospermia  (IAGP)
polyphagia  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IAGP)
reduced male fertility  (IAGP)
seminiferous tubule degeneration  (IAGP)
short stride length  (IAGP)
skeletal muscle atrophy  (IAGP)
slow postnatal weight gain  (IAGP)
small seminiferous tubules  (IAGP)
small testis  (IAGP)
spasticity  (IAGP)
teratozoospermia  (IAGP)
tremors  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Abeta oligomers accumulation. Caccamo A, etal., Mol Neurodegener. 2010 Nov 11;5:51.
2. Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Dayton RD, etal., Exp Neurol. 2011 Dec 9.
3. TAR-DNA binding protein 43 in Pick disease. Freeman SH, etal., J Neuropathol Exp Neurol. 2008 Jan;67(1):62-7.
4. TDP-43 A315T mutation in familial motor neuron disease. Gitcho MA, etal., Ann Neurol. 2008 Apr;63(4):535-8.
5. beta-Amyloid triggers ALS-associated TDP-43 pathology in AD models. Herman AM, etal., Brain Res. 2011 Apr 22;1386:191-9. Epub 2011 Mar 2.
6. Acute and chronically increased immunoreactivity to phosphorylation-independent but not pathological TDP-43 after a single traumatic brain injury in humans. Johnson VE, etal., Acta Neuropathol. 2011 Dec;122(6):715-26. Epub 2011 Nov 19.
7. TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. Kabashi E, etal., Nat Genet. 2008 May;40(5):572-4. Epub 2008 Mar 30.
8. Caspase-cleaved transactivation response DNA-binding protein 43 in Parkinson's disease and dementia with Lewy bodies. Kokoulina P and Rohn TT, Neurodegener Dis. 2010;7(4):243-50. Epub 2010 May 5.
9. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. McKee AC, etal., J Neuropathol Exp Neurol. 2010 Sep;69(9):918-29.
10. Amyotrophic lateral sclerosis multiprotein biomarkers in peripheral blood mononuclear cells. Nardo G, etal., PLoS One. 2011;6(10):e25545. Epub 2011 Oct 5.
11. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Neumann M, etal., Science. 2006 Oct 6;314(5796):130-3.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Clinical heterogeneity in Italian patients with amyotrophic lateral sclerosis. Piaceri I, etal., Clin Genet. 2011 Jun 8. doi: 10.1111/j.1399-0004.2011.01726.x.
14. Broadening the phenotype of TARDBP mutations: the TARDBP Ala382Thr mutation and Parkinson's disease in Sardinia. Quadri M, etal., Neurogenetics. 2011 Aug;12(3):203-9. Epub 2011 Jun 11.
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Sreedharan J, etal., Science. 2008 Mar 21;319(5870):1668-72. Epub 2008 Feb 28.
19. Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments. Swarup V, etal., Brain. 2011 Sep;134(Pt 9):2610-26. Epub 2011 Jul 13.
20. Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease. Tremblay C, etal., J Neuropathol Exp Neurol. 2011 Sep;70(9):788-98.
21. Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U. Tsai KJ, etal., J Exp Med. 2010 Aug 2;207(8):1661-73. Epub 2010 Jul 26.
22. Effect of topographical distribution of alpha-synuclein pathology on TDP-43 accumulation in Lewy body disease. Yokota O, etal., Acta Neuropathol. 2010 Dec;120(6):789-801. Epub 2010 Jul 29.
23. Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy. Yokota O, etal., Acta Neuropathol. 2010 Jul;120(1):55-66. Epub 2010 May 30.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12361981   PMID:12466851   PMID:12477932  
PMID:12520002   PMID:12904583   PMID:14610273   PMID:14667816   PMID:15489334   PMID:15782199   PMID:15840001   PMID:16033648   PMID:16139793   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:16919269   PMID:17932037   PMID:17967808   PMID:17981595   PMID:18238900   PMID:18287559   PMID:18305110   PMID:18703504   PMID:18799693   PMID:18836447   PMID:18957104   PMID:18957508  
PMID:18973680   PMID:19046946   PMID:19535326   PMID:19619516   PMID:19782731   PMID:19910924   PMID:20014337   PMID:20040602   PMID:20059953   PMID:20139417   PMID:20188146   PMID:20198480  
PMID:20211142   PMID:20616880   PMID:20660762   PMID:20731760   PMID:20736350   PMID:20933032   PMID:21151134   PMID:21194568   PMID:21206091   PMID:21252238   PMID:21339291   PMID:21358643  
PMID:21677750   PMID:21873635   PMID:22052911   PMID:22084410   PMID:22193716   PMID:22323604   PMID:22427648   PMID:22459357   PMID:22526419   PMID:22539017   PMID:22570411   PMID:22608070  
PMID:22641816   PMID:22718532   PMID:22718760   PMID:22733568   PMID:22760527   PMID:22794259   PMID:22855830   PMID:22916266   PMID:22932872   PMID:23001869   PMID:23022214   PMID:23023293  
PMID:23055941   PMID:23063673   PMID:23134510   PMID:23172908   PMID:23175812   PMID:23236149   PMID:23258539   PMID:23382207   PMID:23449777   PMID:23575225   PMID:23665500   PMID:23747512  
PMID:23798570   PMID:23827948   PMID:23922830   PMID:23954172   PMID:23954745   PMID:23967244   PMID:24120466   PMID:24154542   PMID:24194600   PMID:24312274   PMID:24381309   PMID:24457600  
PMID:24465814   PMID:24466128   PMID:24515116   PMID:24595038   PMID:24616503   PMID:24740308   PMID:24917042   PMID:24938805   PMID:24986919   PMID:25155018   PMID:25213598   PMID:25256353  
PMID:25392493   PMID:25457553   PMID:25557830   PMID:25678563   PMID:25811799   PMID:26037142   PMID:26044557   PMID:26064939   PMID:26078717   PMID:26089325   PMID:26130692   PMID:26136049  
PMID:26222336   PMID:26334913   PMID:26336360   PMID:26496610   PMID:26518462   PMID:26521126   PMID:26525917   PMID:26614389   PMID:26672899   PMID:26936937   PMID:26994698   PMID:27103069  
PMID:27113764   PMID:27123980   PMID:27193329   PMID:27348499   PMID:27352031   PMID:27378374   PMID:27418600   PMID:27466204   PMID:27496536   PMID:27785573   PMID:27897242   PMID:28007900  
PMID:28129109   PMID:28378742   PMID:28416393   PMID:28487370   PMID:28497562   PMID:28510254   PMID:28560609   PMID:28585542   PMID:28600885   PMID:28663553   PMID:28669544   PMID:28724966  
PMID:28832631   PMID:28941811   PMID:29109149   PMID:29118263   PMID:29125873   PMID:29142232   PMID:29295857   PMID:29556029   PMID:29577934   PMID:29618024   PMID:29715546   PMID:29764981  
PMID:29765078   PMID:29802307   PMID:29859100   PMID:30130494   PMID:30146158   PMID:30196744   PMID:30273599   PMID:30354839   PMID:30373824   PMID:30377984   PMID:30404641   PMID:30410094  
PMID:30450515   PMID:30464263   PMID:30595499   PMID:30625319   PMID:30692134   PMID:30853299   PMID:30922385   PMID:31047794   PMID:31062657   PMID:31138677   PMID:31162944   PMID:31242080  
PMID:31345270   PMID:31355778   PMID:31611772   PMID:31678156   PMID:31728929   PMID:31754024   PMID:31953403   PMID:31959210   PMID:31964415   PMID:32157143   PMID:32187538   PMID:32212857  
PMID:32307524   PMID:32325033   PMID:32371051   PMID:32410044   PMID:32558887   PMID:32686835   PMID:32709255   PMID:32866962   PMID:32907630   PMID:32907941   PMID:32979923   PMID:33031745  
PMID:33054766   PMID:33127758   PMID:33149110   PMID:33154447   PMID:33230138   PMID:33391478   PMID:33398173   PMID:33613100   PMID:33689679   PMID:33908654   PMID:33945510   PMID:33971027  
PMID:34075102   PMID:34112844   PMID:34130995   PMID:34133714   PMID:34347016   PMID:34385591   PMID:34427634   PMID:34599968   PMID:34630013   PMID:34687812   PMID:34697451   PMID:34824257  
PMID:34830093   PMID:34916658   PMID:34988393   PMID:35243489   PMID:35262486   PMID:35277554   PMID:35311646   PMID:35568882   PMID:35713704   PMID:35767949   PMID:35778392   PMID:35778567  
PMID:35850054   PMID:35986894   PMID:35994036   PMID:36056157   PMID:36293380   PMID:36417507   PMID:36443249   PMID:36536457   PMID:36584679   PMID:36675095   PMID:36921783   PMID:36951214  
PMID:37011806   PMID:37118836   PMID:37158107   PMID:37315918   PMID:37460529   PMID:37474791   PMID:37555859   PMID:37608352   PMID:37819053   PMID:38124145   PMID:38157451   PMID:38287033  
PMID:38300714   PMID:38343132   PMID:38355793   PMID:38366598   PMID:38367882   PMID:38374041   PMID:38585660   PMID:38615036   PMID:38853250   PMID:39305312   PMID:39603486  


Genomics

Comparative Map Data
Tardbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,696,839 - 148,711,672 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,696,839 - 148,711,476 (-)EnsemblGRCm39 Ensembl
GRCm384148,612,382 - 148,627,084 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,612,382 - 148,627,019 (-)EnsemblGRCm38mm10GRCm38
MGSCv374147,986,491 - 148,001,105 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,454,416 - 147,470,796 (-)NCBIMGSCv36mm8
Celera4150,873,662 - 150,888,313 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.77NCBI
TARDBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,012,654 - 11,030,528 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,012,344 - 11,030,528 (+)EnsemblGRCh38hg38GRCh38
GRCh37111,072,711 - 11,085,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36110,995,266 - 11,008,136 (+)NCBINCBI36Build 36hg18NCBI36
Build 34111,006,944 - 11,019,814NCBI
Celera110,184,976 - 10,197,861 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef110,224,341 - 10,237,229 (+)NCBIHuRef
CHM1_1111,060,321 - 11,073,209 (+)NCBICHM1_1
T2T-CHM13v2.0110,553,914 - 10,571,805 (+)NCBIT2T-CHM13v2.0
Tardbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,330,452 - 164,348,435 (-)NCBIGRCr8
mRatBN7.25159,050,518 - 159,062,218 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5159,051,799 - 159,062,055 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,768,493 - 161,778,784 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05163,590,953 - 163,601,242 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05163,547,298 - 163,557,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,432,089 - 165,442,232 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,432,095 - 165,442,048 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05169,088,684 - 169,099,216 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,698,665 - 165,709,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,708,851 - 165,719,708 (-)NCBI
Celera5157,327,910 - 157,337,955 (-)NCBICelera
Cytogenetic Map5q36NCBI
Tardbp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,656,121 - 2,674,807 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,656,121 - 2,674,808 (-)NCBIChiLan1.0ChiLan1.0
TARDBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21217,200,843 - 217,212,563 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,840,309 - 215,858,530 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019,775,084 - 9,786,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1110,996,006 - 11,008,732 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl110,996,006 - 11,008,732 (+)Ensemblpanpan1.1panPan2
TARDBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,987,752 - 84,998,136 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,989,952 - 84,998,593 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,515,040 - 81,527,435 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,647,107 - 85,659,313 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,649,924 - 85,659,763 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,395,167 - 82,407,547 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,396,611 - 83,408,986 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,459,460 - 84,471,855 (-)NCBIUU_Cfam_GSD_1.0
Tardbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,266,198 - 34,278,928 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647490,813 - 103,713 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TARDBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,213,860 - 71,227,704 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,213,584 - 71,227,707 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,135,826 - 65,147,430 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TARDBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120120,753,764 - 120,765,259 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605424,661,891 - 24,675,297 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tardbp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,759,497 - 1,789,813 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,759,496 - 1,789,806 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tardbp
582 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:6343
Count of miRNA genes:789
Interacting mature miRNAs:1015
Transcripts:ENSMUST00000045180, ENSMUST00000084125, ENSMUST00000095719, ENSMUST00000105699, ENSMUST00000105700, ENSMUST00000105702, ENSMUST00000140897, ENSMUST00000147391, ENSMUST00000165113, ENSMUST00000172073
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
12738431Lfibq20_mliver fibrosis QTL 20 (mouse)4144699835148907426Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137674005150676858Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse

Markers in Region
C85084  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,615,527 - 148,615,611UniSTSGRCm38
MGSCv374147,989,636 - 147,989,720UniSTSGRCm37
Celera4150,876,809 - 150,876,893UniSTS
Cytogenetic Map4E1UniSTS
Cytogenetic Map4E2UniSTS
Whitehead/MRC_RH41916.82UniSTS
Tardbp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv374147,991,423 - 147,991,962UniSTSGRCm37
MGSCv374147,992,440 - 147,993,328UniSTSGRCm37
Celera4150,878,596 - 150,879,135UniSTS
Celera4150,879,613 - 150,880,505UniSTS
Cytogenetic Map4E2UniSTS
cM Map4 UniSTS
HSC11D022  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,616,885 - 148,617,167UniSTSGRCm38
GRCm38373,000,941 - 73,001,223UniSTSGRCm38
MGSCv374147,990,994 - 147,991,276UniSTSGRCm37
MGSCv37372,804,863 - 72,805,145UniSTSGRCm37
Celera4150,878,167 - 150,878,449UniSTS
Celera373,120,790 - 73,121,070UniSTS
Cytogenetic Map4E2UniSTS
Tardbp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4E2UniSTS
Tardbp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,618,331 - 148,619,219UniSTSGRCm38
MGSCv374147,992,440 - 147,993,328UniSTSGRCm37
Celera4150,879,613 - 150,880,505UniSTS
Cytogenetic Map4E2UniSTS
Tardbp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,617,314 - 148,617,853UniSTSGRCm38
MGSCv374147,991,423 - 147,991,962UniSTSGRCm37
Celera4150,878,596 - 150,879,135UniSTS
Cytogenetic Map4E2UniSTS
cM Map4 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001003899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001008545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001008546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001305425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_027864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_131120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_149751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_390742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA146195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL606969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV376362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY319513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY319514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY319515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY319516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB614725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB616478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE335004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE853411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE949621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF658781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG089151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG918909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG921962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI686052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA316311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD353594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD540288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD548243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF725038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF741580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK780683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU207385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU207387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX202635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ428775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ428776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ428777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU250735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB886955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB887015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC944364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC944424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000045180   ⟹   ENSMUSP00000038113
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,700,376 - 148,711,222 (-)Ensembl
GRCm38.p6 Ensembl4148,615,919 - 148,626,765 (-)Ensembl
Ensembl Acc Id: ENSMUST00000084125   ⟹   ENSMUSP00000081142
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,696,839 - 148,711,476 (-)Ensembl
GRCm38.p6 Ensembl4148,612,382 - 148,627,019 (-)Ensembl
Ensembl Acc Id: ENSMUST00000095719   ⟹   ENSMUSP00000093386
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,702,011 - 148,709,819 (-)Ensembl
GRCm38.p6 Ensembl4148,617,554 - 148,625,362 (-)Ensembl
Ensembl Acc Id: ENSMUST00000105699   ⟹   ENSMUSP00000101324
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,701,183 - 148,711,215 (-)Ensembl
GRCm38.p6 Ensembl4148,616,726 - 148,626,758 (-)Ensembl
Ensembl Acc Id: ENSMUST00000105700   ⟹   ENSMUSP00000101325
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,702,011 - 148,709,819 (-)Ensembl
GRCm38.p6 Ensembl4148,617,554 - 148,625,362 (-)Ensembl
Ensembl Acc Id: ENSMUST00000105702   ⟹   ENSMUSP00000101327
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,696,839 - 148,711,453 (-)Ensembl
GRCm38.p6 Ensembl4148,612,382 - 148,626,996 (-)Ensembl
Ensembl Acc Id: ENSMUST00000140897   ⟹   ENSMUSP00000135135
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,701,178 - 148,705,147 (-)Ensembl
GRCm38.p6 Ensembl4148,616,721 - 148,620,690 (-)Ensembl
Ensembl Acc Id: ENSMUST00000147391   ⟹   ENSMUSP00000140333
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,701,093 - 148,702,824 (-)Ensembl
GRCm38.p6 Ensembl4148,616,636 - 148,618,367 (-)Ensembl
Ensembl Acc Id: ENSMUST00000165113   ⟹   ENSMUSP00000129342
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,696,839 - 148,711,453 (-)Ensembl
GRCm38.p6 Ensembl4148,612,382 - 148,626,996 (-)Ensembl
Ensembl Acc Id: ENSMUST00000172073   ⟹   ENSMUSP00000130963
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,696,839 - 148,711,453 (-)Ensembl
GRCm38.p6 Ensembl4148,612,382 - 148,626,996 (-)Ensembl
Ensembl Acc Id: ENSMUST00000185673   ⟹   ENSMUSP00000141010
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,705,145 - 148,710,780 (-)Ensembl
GRCm38.p6 Ensembl4148,620,688 - 148,626,323 (-)Ensembl
Ensembl Acc Id: ENSMUST00000185824   ⟹   ENSMUSP00000140110
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,702,065 - 148,706,554 (-)Ensembl
GRCm38.p6 Ensembl4148,617,608 - 148,622,097 (-)Ensembl
Ensembl Acc Id: ENSMUST00000186317
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,700,216 - 148,702,309 (-)Ensembl
GRCm38.p6 Ensembl4148,615,759 - 148,617,852 (-)Ensembl
Ensembl Acc Id: ENSMUST00000186711   ⟹   ENSMUSP00000140057
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,701,503 - 148,703,137 (-)Ensembl
GRCm38.p6 Ensembl4148,617,046 - 148,618,680 (-)Ensembl
Ensembl Acc Id: ENSMUST00000186729   ⟹   ENSMUSP00000139547
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,696,942 - 148,703,733 (-)Ensembl
GRCm38.p6 Ensembl4148,612,485 - 148,619,276 (-)Ensembl
Ensembl Acc Id: ENSMUST00000186947   ⟹   ENSMUSP00000140529
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,703,062 - 148,711,211 (-)Ensembl
GRCm38.p6 Ensembl4148,618,605 - 148,626,754 (-)Ensembl
Ensembl Acc Id: ENSMUST00000187937
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,700,067 - 148,701,437 (-)Ensembl
GRCm38.p6 Ensembl4148,615,610 - 148,616,980 (-)Ensembl
Ensembl Acc Id: ENSMUST00000187939   ⟹   ENSMUSP00000140928
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,701,320 - 148,705,069 (-)Ensembl
GRCm38.p6 Ensembl4148,616,863 - 148,620,612 (-)Ensembl
Ensembl Acc Id: ENSMUST00000188134   ⟹   ENSMUSP00000139476
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,696,844 - 148,711,219 (-)Ensembl
GRCm38.p6 Ensembl4148,612,387 - 148,626,762 (-)Ensembl
Ensembl Acc Id: ENSMUST00000188380
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,696,845 - 148,700,595 (-)Ensembl
GRCm38.p6 Ensembl4148,612,388 - 148,616,138 (-)Ensembl
Ensembl Acc Id: ENSMUST00000188488   ⟹   ENSMUSP00000140989
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,696,845 - 148,703,228 (-)Ensembl
GRCm38.p6 Ensembl4148,612,388 - 148,618,771 (-)Ensembl
Ensembl Acc Id: ENSMUST00000189041
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,699,923 - 148,702,532 (-)Ensembl
GRCm38.p6 Ensembl4148,615,466 - 148,618,075 (-)Ensembl
Ensembl Acc Id: ENSMUST00000189048   ⟹   ENSMUSP00000140364
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,701,908 - 148,709,819 (-)Ensembl
GRCm38.p6 Ensembl4148,617,451 - 148,625,362 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190287   ⟹   ENSMUSP00000140859
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,701,183 - 148,703,807 (-)Ensembl
GRCm38.p6 Ensembl4148,616,726 - 148,619,350 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190478
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,709,542 - 148,711,215 (-)Ensembl
GRCm38.p6 Ensembl4148,625,085 - 148,626,758 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190552   ⟹   ENSMUSP00000141052
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,701,173 - 148,706,447 (-)Ensembl
GRCm38.p6 Ensembl4148,616,716 - 148,621,990 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190630   ⟹   ENSMUSP00000140385
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,701,765 - 148,703,743 (-)Ensembl
GRCm38.p6 Ensembl4148,617,308 - 148,619,286 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190696   ⟹   ENSMUSP00000139637
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,702,492 - 148,711,227 (-)Ensembl
GRCm38.p6 Ensembl4148,618,035 - 148,626,770 (-)Ensembl
Ensembl Acc Id: ENSMUST00000191378   ⟹   ENSMUSP00000140718
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,701,182 - 148,705,142 (-)Ensembl
GRCm38.p6 Ensembl4148,616,725 - 148,620,685 (-)Ensembl
Ensembl Acc Id: ENSMUST00000191450   ⟹   ENSMUSP00000140832
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,701,182 - 148,711,215 (-)Ensembl
GRCm38.p6 Ensembl4148,616,725 - 148,626,758 (-)Ensembl
RefSeq Acc Id: NM_001003898   ⟹   NP_001003898
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,696,839 - 148,711,453 (-)NCBI
GRCm384148,612,382 - 148,626,996 (-)ENTREZGENE
MGSCv374147,986,491 - 148,001,105 (-)RGD
Celera4150,873,662 - 150,888,313 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001003899   ⟹   NP_001003899
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,696,839 - 148,711,453 (-)NCBI
GRCm384148,612,382 - 148,626,996 (-)ENTREZGENE
MGSCv374147,986,491 - 148,001,105 (-)RGD
Celera4150,873,662 - 150,888,313 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001008545   ⟹   NP_001008545
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,696,839 - 148,711,453 (-)NCBI
GRCm384148,612,382 - 148,626,996 (-)ENTREZGENE
MGSCv374147,986,491 - 148,001,105 (-)RGD
Celera4150,873,662 - 150,888,313 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001008546   ⟹   NP_001008546
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,696,839 - 148,711,453 (-)NCBI
GRCm384148,612,382 - 148,626,996 (-)ENTREZGENE
MGSCv374147,986,491 - 148,001,105 (-)RGD
Celera4150,873,662 - 150,888,313 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001305425   ⟹   NP_001292354
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,696,839 - 148,711,453 (-)NCBI
GRCm384148,612,382 - 148,626,996 (-)NCBI
Sequence:
RefSeq Acc Id: NM_145556   ⟹   NP_663531
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,696,839 - 148,711,453 (-)NCBI
GRCm384148,612,382 - 148,626,996 (-)ENTREZGENE
MGSCv374147,986,491 - 148,001,105 (-)RGD
Celera4150,873,662 - 150,888,313 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_027864
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,696,839 - 148,711,453 (-)NCBI
GRCm384148,612,382 - 148,626,996 (-)ENTREZGENE
MGSCv374147,986,491 - 148,001,105 (-)RGD
Celera4150,873,662 - 150,888,313 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_131120
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,696,839 - 148,711,453 (-)NCBI
GRCm384148,612,382 - 148,626,996 (-)NCBI
Sequence:
RefSeq Acc Id: NR_149751
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,696,839 - 148,711,453 (-)NCBI
GRCm384148,612,382 - 148,626,996 (-)NCBI
Sequence:
RefSeq Acc Id: XR_390742
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,699,925 - 148,711,672 (-)NCBI
GRCm384148,615,468 - 148,627,084 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003898 (Get FASTA)   NCBI Sequence Viewer  
  NP_001003899 (Get FASTA)   NCBI Sequence Viewer  
  NP_001008545 (Get FASTA)   NCBI Sequence Viewer  
  NP_001008546 (Get FASTA)   NCBI Sequence Viewer  
  NP_001292354 (Get FASTA)   NCBI Sequence Viewer  
  NP_663531 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH12873 (Get FASTA)   NCBI Sequence Viewer  
  AAH25544 (Get FASTA)   NCBI Sequence Viewer  
  AAH27105 (Get FASTA)   NCBI Sequence Viewer  
  AAH27772 (Get FASTA)   NCBI Sequence Viewer  
  AAH29728 (Get FASTA)   NCBI Sequence Viewer  
  AAH31126 (Get FASTA)   NCBI Sequence Viewer  
  AAH33475 (Get FASTA)   NCBI Sequence Viewer  
  AAP92688 (Get FASTA)   NCBI Sequence Viewer  
  AAP92689 (Get FASTA)   NCBI Sequence Viewer  
  AAP92690 (Get FASTA)   NCBI Sequence Viewer  
  AAP92691 (Get FASTA)   NCBI Sequence Viewer  
  ACV52542 (Get FASTA)   NCBI Sequence Viewer  
  ACV52543 (Get FASTA)   NCBI Sequence Viewer  
  ACV52544 (Get FASTA)   NCBI Sequence Viewer  
  ADA71972 (Get FASTA)   NCBI Sequence Viewer  
  BAC27753 (Get FASTA)   NCBI Sequence Viewer  
  BAC32395 (Get FASTA)   NCBI Sequence Viewer  
  BAC38861 (Get FASTA)   NCBI Sequence Viewer  
  BAE21557 (Get FASTA)   NCBI Sequence Viewer  
  BAE26823 (Get FASTA)   NCBI Sequence Viewer  
  BAE32189 (Get FASTA)   NCBI Sequence Viewer  
  CBF67634 (Get FASTA)   NCBI Sequence Viewer  
  CBF67664 (Get FASTA)   NCBI Sequence Viewer  
  CBU92508 (Get FASTA)   NCBI Sequence Viewer  
  CBU92538 (Get FASTA)   NCBI Sequence Viewer  
  EDL14830 (Get FASTA)   NCBI Sequence Viewer  
  EDL14831 (Get FASTA)   NCBI Sequence Viewer  
  EDL14835 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000081142
  ENSMUSP00000081142.4
  ENSMUSP00000101324
  ENSMUSP00000101327
  ENSMUSP00000129342
  ENSMUSP00000130963
GenBank Protein Q921F2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_663531   ⟸   NM_145556
- Peptide Label: isoform 1
- UniProtKB: Q3U591 (UniProtKB/Swiss-Prot),   Q3V0E7 (UniProtKB/Swiss-Prot),   Q921F2 (UniProtKB/Swiss-Prot),   Q544R5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001008545   ⟸   NM_001008545
- Peptide Label: isoform 2
- UniProtKB: Q6VYI4 (UniProtKB/TrEMBL),   D2KPZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001008546   ⟸   NM_001008546
- Peptide Label: isoform 4
- UniProtKB: Q6VYI5 (UniProtKB/TrEMBL),   Q8BUM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001003898   ⟸   NM_001003898
- Peptide Label: isoform 5
- UniProtKB: Q8BLD4 (UniProtKB/TrEMBL),   C9DT14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001003899   ⟸   NM_001003899
- Peptide Label: isoform 3
- UniProtKB: Q8R0B4 (UniProtKB/TrEMBL),   C9DT14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001292354   ⟸   NM_001305425
- Peptide Label: isoform 6
- UniProtKB: Q921F2 (UniProtKB/Swiss-Prot),   Q544R5 (UniProtKB/TrEMBL),   Q8BLD4 (UniProtKB/TrEMBL),   Q8R0B4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000101325   ⟸   ENSMUST00000105700
Ensembl Acc Id: ENSMUSP00000101327   ⟸   ENSMUST00000105702
Ensembl Acc Id: ENSMUSP00000101324   ⟸   ENSMUST00000105699
Ensembl Acc Id: ENSMUSP00000038113   ⟸   ENSMUST00000045180
Ensembl Acc Id: ENSMUSP00000081142   ⟸   ENSMUST00000084125
Ensembl Acc Id: ENSMUSP00000139547   ⟸   ENSMUST00000186729
Ensembl Acc Id: ENSMUSP00000140057   ⟸   ENSMUST00000186711
Ensembl Acc Id: ENSMUSP00000130963   ⟸   ENSMUST00000172073
Ensembl Acc Id: ENSMUSP00000140529   ⟸   ENSMUST00000186947
Ensembl Acc Id: ENSMUSP00000140333   ⟸   ENSMUST00000147391
Ensembl Acc Id: ENSMUSP00000140718   ⟸   ENSMUST00000191378
Ensembl Acc Id: ENSMUSP00000140832   ⟸   ENSMUST00000191450
Ensembl Acc Id: ENSMUSP00000141010   ⟸   ENSMUST00000185673
Ensembl Acc Id: ENSMUSP00000140110   ⟸   ENSMUST00000185824
Ensembl Acc Id: ENSMUSP00000129342   ⟸   ENSMUST00000165113
Ensembl Acc Id: ENSMUSP00000139637   ⟸   ENSMUST00000190696
Ensembl Acc Id: ENSMUSP00000140385   ⟸   ENSMUST00000190630
Ensembl Acc Id: ENSMUSP00000140859   ⟸   ENSMUST00000190287
Ensembl Acc Id: ENSMUSP00000141052   ⟸   ENSMUST00000190552
Ensembl Acc Id: ENSMUSP00000135135   ⟸   ENSMUST00000140897
Ensembl Acc Id: ENSMUSP00000140989   ⟸   ENSMUST00000188488
Ensembl Acc Id: ENSMUSP00000093386   ⟸   ENSMUST00000095719
Ensembl Acc Id: ENSMUSP00000139476   ⟸   ENSMUST00000188134
Ensembl Acc Id: ENSMUSP00000140928   ⟸   ENSMUST00000187939
Ensembl Acc Id: ENSMUSP00000140364   ⟸   ENSMUST00000189048
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q921F2-F1-model_v2 AlphaFold Q921F2 1-414 view protein structure

Promoters
RGD ID:6836482
Promoter ID:MM_KWN:40830
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   Liver,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000025676
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,993,169 - 147,993,669 (-)MPROMDB
RGD ID:6836479
Promoter ID:MM_KWN:40831
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   ES_Cell,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000095719,   ENSMUST00000105700,   UC008VVB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,999,126 - 148,000,327 (-)MPROMDB
RGD ID:6836485
Promoter ID:MM_KWN:40832
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001003898,   NM_001003899,   NM_001008545,   NM_001008546,   NR_027864,   OTTMUST00000025673,   UC008VVH.1,   UC008VVI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364148,000,721 - 148,001,397 (-)MPROMDB
RGD ID:6885532
Promoter ID:EPDNEW_M6217
Type:initiation region
Name:Tardbp_1
Description:Mus musculus TAR DNA binding protein , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384148,626,765 - 148,626,825EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2387629 AgrOrtholog
Ensembl Genes ENSMUSG00000041459 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000084125 ENTREZGENE
  ENSMUST00000084125.10 UniProtKB/Swiss-Prot
  ENSMUST00000105699 ENTREZGENE
  ENSMUST00000105702 ENTREZGENE
  ENSMUST00000165113 ENTREZGENE
  ENSMUST00000172073 ENTREZGENE
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
  TDP-43_C UniProtKB/Swiss-Prot
  TDP43_N UniProtKB/Swiss-Prot
KEGG Report mmu:230908 UniProtKB/Swiss-Prot
MGD MGI:2387629 ENTREZGENE
NCBI Gene 230908 ENTREZGENE
PANTHER RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN UniProtKB/Swiss-Prot
  TAR DNA-BINDING PROTEIN 43 UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
  TDP-43_C UniProtKB/Swiss-Prot
  TDP43_N UniProtKB/Swiss-Prot
PhenoGen Tardbp PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A087WNY6_MOUSE UniProtKB/TrEMBL
  A0A087WP57_MOUSE UniProtKB/TrEMBL
  A0A087WQ63_MOUSE UniProtKB/TrEMBL
  A0A087WQA5_MOUSE UniProtKB/TrEMBL
  A0A087WQT4_MOUSE UniProtKB/TrEMBL
  A0A087WQX8_MOUSE UniProtKB/TrEMBL
  A0A087WR97_MOUSE UniProtKB/TrEMBL
  A0A087WRP4_MOUSE UniProtKB/TrEMBL
  A0A087WRZ5_MOUSE UniProtKB/TrEMBL
  A0A087WS17_MOUSE UniProtKB/TrEMBL
  A0A087WS74_MOUSE UniProtKB/TrEMBL
  A0A087WSC6_MOUSE UniProtKB/TrEMBL
  A0A087WSE4_MOUSE UniProtKB/TrEMBL
  A0A087WSH7_MOUSE UniProtKB/TrEMBL
  C9DT14 ENTREZGENE, UniProtKB/TrEMBL
  D2KPZ5 ENTREZGENE, UniProtKB/TrEMBL
  H3BJV1_MOUSE UniProtKB/TrEMBL
  Q05C33_MOUSE UniProtKB/TrEMBL
  Q3U591 ENTREZGENE
  Q3V0E7 ENTREZGENE
  Q544R5 ENTREZGENE, UniProtKB/TrEMBL
  Q6VYI4 ENTREZGENE, UniProtKB/TrEMBL
  Q6VYI5 ENTREZGENE, UniProtKB/TrEMBL
  Q8BLD4 ENTREZGENE, UniProtKB/TrEMBL
  Q8BUM1 ENTREZGENE, UniProtKB/TrEMBL
  Q8R0B4 ENTREZGENE, UniProtKB/TrEMBL
  Q921F2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3U591 UniProtKB/Swiss-Prot
  Q3V0E7 UniProtKB/Swiss-Prot