Cdhr2 (cadherin-related family member 2) - Rat Genome Database

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Gene: Cdhr2 (cadherin-related family member 2) Mus musculus
Analyze
Symbol: Cdhr2
Name: cadherin-related family member 2
RGD ID: 1617254
MGI Page MGI
Description: Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by cadherin; intermicrovillar adhesion; and negative regulation of cell growth involved in contact inhibition. Predicted to be located in apical plasma membrane; brush border membrane; and microvillus membrane. Predicted to be active in plasma membrane. Orthologous to human CDHR2 (cadherin related family member 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm624; PC-LKC; Pcdh2; Pcdh24; protocadherin 24; protocadherin LKC
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,849,276 - 54,884,475 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1354,849,274 - 54,884,475 (+)EnsemblGRCm39 Ensembl
GRCm381354,701,463 - 54,736,662 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,701,461 - 54,736,662 (+)EnsemblGRCm38mm10GRCm38
MGSCv371354,802,824 - 54,838,023 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361354,711,085 - 54,746,277 (+)NCBIMGSCv36mm8
Celera1355,767,386 - 55,802,298 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1329.03NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:30403560   PMID:37832537  
PMID:39292922  


Genomics

Comparative Map Data
Cdhr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,849,276 - 54,884,475 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1354,849,274 - 54,884,475 (+)EnsemblGRCm39 Ensembl
GRCm381354,701,463 - 54,736,662 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,701,461 - 54,736,662 (+)EnsemblGRCm38mm10GRCm38
MGSCv371354,802,824 - 54,838,023 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361354,711,085 - 54,746,277 (+)NCBIMGSCv36mm8
Celera1355,767,386 - 55,802,298 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1329.03NCBI
CDHR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385176,542,511 - 176,595,974 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5176,542,511 - 176,595,974 (+)EnsemblGRCh38hg38GRCh38
GRCh375175,969,512 - 176,022,975 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365175,908,971 - 175,955,375 (+)NCBINCBI36Build 36hg18NCBI36
Celera5172,478,089 - 172,531,637 (-)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5170,893,401 - 170,947,042 (+)NCBIHuRef
CHM1_15175,402,210 - 175,455,196 (+)NCBICHM1_1
T2T-CHM13v2.05177,087,074 - 177,142,566 (+)NCBIT2T-CHM13v2.0
Cdhr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,881,979 - 9,917,698 (-)NCBIGRCr8
mRatBN7.2179,876,853 - 9,913,356 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,876,860 - 9,912,575 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01710,415,044 - 10,450,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1710,415,123 - 10,439,691 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01712,540,996 - 12,576,334 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,937,987 - 15,962,796 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera179,951,957 - 9,976,839 (-)NCBICelera
Cytogenetic Map17p14NCBI
Cdhr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540828,832,325 - 28,875,534 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540828,832,362 - 28,871,345 (+)NCBIChiLan1.0ChiLan1.0
CDHR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24171,630,262 - 171,676,130 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15169,769,801 - 169,815,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05171,846,538 - 171,893,797 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15178,916,707 - 178,963,944 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5178,916,707 - 178,964,893 (+)Ensemblpanpan1.1panPan2
CDHR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1436,740,964 - 36,777,118 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl436,740,966 - 36,777,803 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha436,707,763 - 36,743,827 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0437,107,067 - 37,143,175 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl437,107,075 - 37,143,174 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,932,892 - 36,968,996 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0437,120,701 - 37,156,839 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0437,628,842 - 37,664,949 (-)NCBIUU_Cfam_GSD_1.0
Cdhr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213121,785,575 - 121,831,018 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936597831,855 - 857,013 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936597831,895 - 855,925 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDHR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl281,318,407 - 81,361,606 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1281,319,179 - 81,361,598 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2282,920,844 - 82,963,238 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDHR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12378,571,170 - 78,602,699 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2378,571,792 - 78,602,552 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660759,688,711 - 9,736,431 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdhr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473313,535,809 - 13,576,940 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473313,537,363 - 13,582,390 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdhr2
1208 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:169
Interacting mature miRNAs:173
Transcripts:ENSMUST00000037145
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
25671382Hrsq4_mhost response to SARS QTL 4, vascular cuffing (mouse)135288165154992738Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135031841184318559Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134785347673148119Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000037145   ⟹   ENSMUSP00000043596
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1354,849,274 - 54,884,475 (+)Ensembl
GRCm38.p6 Ensembl1354,701,461 - 54,736,662 (+)Ensembl
RefSeq Acc Id: NM_001033364   ⟹   NP_001028536
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391354,849,276 - 54,884,475 (+)NCBI
GRCm381354,701,463 - 54,736,662 (+)ENTREZGENE
MGSCv371354,802,824 - 54,838,023 (+)RGD
Celera1355,767,386 - 55,802,298 (+)RGD
cM Map13 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001028536 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH34067 (Get FASTA)   NCBI Sequence Viewer  
  AAI41302 (Get FASTA)   NCBI Sequence Viewer  
  AAI45625 (Get FASTA)   NCBI Sequence Viewer  
  BAE25870 (Get FASTA)   NCBI Sequence Viewer  
  E9Q7P9 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000043596
  ENSMUSP00000043596.8
RefSeq Acc Id: NP_001028536   ⟸   NM_001033364
- Peptide Label: precursor
- UniProtKB: B9EJ32 (UniProtKB/Swiss-Prot),   B7ZP46 (UniProtKB/Swiss-Prot),   Q3UN77 (UniProtKB/Swiss-Prot),   E9Q7P9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000043596   ⟸   ENSMUST00000037145
Protein Domains
Cadherin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9Q7P9-F1-model_v2 AlphaFold E9Q7P9 1-1308 view protein structure

Promoters
RGD ID:8680402
Promoter ID:EPDNEW_M18232
Type:multiple initiation site
Name:Cdhr2_1
Description:Mus musculus cadherin-related family member 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381354,701,472 - 54,701,532EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2687323 AgrOrtholog
Ensembl Genes ENSMUSG00000034918 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000037145 ENTREZGENE
  ENSMUST00000037145.8 UniProtKB/Swiss-Prot
Gene3D-CATH Cadherins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/Swiss-Prot
  Cadherin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protocadherin/Cadherin-CA UniProtKB/TrEMBL
KEGG Report mmu:268663 UniProtKB/Swiss-Prot
MGD MGI:2687323 ENTREZGENE
NCBI Gene 268663 ENTREZGENE
PANTHER CADHERIN-23 UniProtKB/Swiss-Prot
  CADHERIN-87A UniProtKB/Swiss-Prot
  CADHERIN-87A UniProtKB/TrEMBL
  CADHERIN-RELATED FAMILY MEMBER 2 UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdhr2 PhenoGen
PRINTS CADHERIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49313 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B7ZP46 ENTREZGENE
  B9EJ32 ENTREZGENE
  CDHR2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UN77 ENTREZGENE
  Q8K066_MOUSE UniProtKB/TrEMBL
UniProt Secondary B7ZP46 UniProtKB/Swiss-Prot
  B9EJ32 UniProtKB/Swiss-Prot
  Q3UN77 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Cdhr2  cadherin-related family member 2  Pcdh24  protocadherin 24  Symbol and/or name change 5135510 APPROVED