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Gene: Terc (telomerase RNA component) Mus musculus
Analyze
Symbol:
Terc
Name:
telomerase RNA component
RGD ID:
1616824
MGI Page
MGI
Description:
Enables telomerase activity. Acts upstream of or within several processes, including DNA metabolic process; determination of adult lifespan; and hemopoiesis. Is expressed in embryo. Used to study Duchenne muscular dystrophy; Werner syndrome; and osteoporosis.
Type:
ncrna (Ensembl: lncRNA)
RefSeq Status:
REVIEWED
Previously known as:
mT; mTE; mTER; mTR
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Latest Assembly:
GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 3 96,321,753 - 96,322,149 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 3 96,321,753 - 96,322,149 (-) Ensembl GRCm39 Ensembl GRCm38 3 96,414,437 - 96,414,833 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 3 96,414,437 - 96,414,859 (-) Ensembl GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 3 96,414,437 - 96,414,833 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 3 96,218,360 - 96,218,756 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 3 96,499,842 - 96,500,238 (-) NCBI MGSCv36 mm8 Celera 3 97,832,081 - 97,832,477 (-) NCBI Celera Cytogenetic Map 3 F2.1 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Disease Annotations - ClinVar
Imported Disease Annotations - CTD
Imported Disease Annotations - MGI
Imported Disease Annotations - OMIM
Only show annotations with direct experimental evidence (0 objects hidden)
1,2-dimethylhydrazine decreases expression EXP 6480464 1, 2-Dimethylhydrazine results in decreased expression of TERC mRNA CTD PMID:22206623 2,2',4,4',5,5'-hexachlorobiphenyl decreases expression ISO RGD:1353130 6480464 2 more ... CTD PMID:26330309 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:1353130 6480464 2 more ... CTD PMID:26330309 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO RGD:1353130 6480464 3 more ... CTD PMID:26330309 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO RGD:1353130 6480464 3 more ... CTD PMID:26330309 3-chloropropane-1,2-diol decreases expression ISO RGD:727802 6480464 alpha-Chlorohydrin results in decreased expression of TERC mRNA CTD PMID:28522335 4-hydroperoxycyclophosphamide decreases expression EXP 6480464 perfosfamide results in decreased expression of TERC mRNA CTD PMID:24571982 6-propyl-2-thiouracil increases expression ISO RGD:727802 6480464 Propylthiouracil results in increased expression of TERC mRNA CTD PMID:25825206 aflatoxin B1 increases expression ISO RGD:727802 6480464 Aflatoxin B1 results in increased expression of TERC mRNA CTD PMID:25378103 aflatoxin M1 decreases expression ISO RGD:1353130 6480464 Aflatoxin M1 results in decreased expression of TERC mRNA CTD PMID:30928695 all-trans-retinoic acid multiple interactions ISO RGD:1353130 6480464 2 more ... CTD PMID:26330309 arsane increases methylation ISO RGD:1353130 6480464 Arsenic results in increased methylation of TERC gene CTD PMID:24525453 arsenic atom increases methylation ISO RGD:1353130 6480464 Arsenic results in increased methylation of TERC gene CTD PMID:24525453 arsenous acid increases expression ISO RGD:1353130 6480464 Arsenic Trioxide results in increased expression of TERC mRNA CTD PMID:11714746 benzo[a]pyrene decreases methylation ISO RGD:1353130 6480464 Benzo(a)pyrene results in decreased methylation of TERC promoter CTD PMID:27901495 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of TERC mRNA CTD PMID:28085963 bisphenol A affects expression ISO RGD:727802 6480464 bisphenol A affects the expression of TERC mRNA CTD PMID:25181051 butan-1-ol multiple interactions ISO RGD:1353130 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of TERC mRNA CTD PMID:29432896 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of TERC mRNA CTD PMID:24571982 cisplatin increases expression ISO RGD:1353130 6480464 Cisplatin results in increased expression of TERC mRNA CTD PMID:27594783 diarsenic trioxide increases expression ISO RGD:1353130 6480464 Arsenic Trioxide results in increased expression of TERC mRNA CTD PMID:11714746 dimethyl sulfoxide multiple interactions ISO RGD:1353130 6480464 2 more ... CTD PMID:26330309 dioxygen increases expression ISO RGD:1353130 6480464 Oxygen deficiency results in increased expression of TERC mRNA CTD PMID:24236059 folic acid increases expression EXP 6480464 Folic Acid results in increased expression of TERC mRNA CTD PMID:25629700 furan increases methylation ISO RGD:727802 6480464 furan results in increased methylation of TERC gene CTD PMID:22079235 N-methyl-N-nitrosourea affects response to substance EXP 6480464 TERC protein affects the susceptibility to Methylnitrosourea CTD PMID:14612493 nickel sulfate decreases expression ISO RGD:1353130 6480464 nickel sulfate results in decreased expression of TERC mRNA CTD PMID:22714537 potassium dichromate increases expression EXP 6480464 Potassium Dichromate results in increased expression of TERC mRNA CTD PMID:23608068 sodium arsenite decreases expression ISO RGD:1353130 6480464 sodium arsenite results in decreased expression of TERC mRNA CTD PMID:30460075 T-2 toxin decreases expression ISO RGD:727802 6480464 T-2 Toxin results in decreased expression of TERC mRNA CTD PMID:26141394 urethane multiple interactions EXP 6480464 Urethane results in increased activity of [TERC protein binds to TEP1 protein binds to TERT protein] CTD PMID:11323394 valproic acid increases expression ISO RGD:727802 6480464 Valproic Acid results in increased expression of TERC mRNA CTD PMID:35594946 vinclozolin decreases expression ISO RGD:727802 6480464 vinclozolin results in decreased expression of TERC mRNA CTD PMID:23034163
Biological Process
Only show annotations with direct experimental evidence (0 objects hidden)
cellular response to hypoxia involved_in ISO RGD:1353130 9068941 PMID:11313459 BHF-UCL PMID:11313459 determination of adult lifespan acts_upstream_of_or_within IGI MGI:109635 2290270 MGI:3050262 , PMID:15235603 MGI MGI:3050262 , PMID:15235603 DNA biosynthetic process involved_in ISO RGD:1353130 9068941 PMID:19701182 BHF-UCL PMID:19701182 hematopoietic stem cell differentiation acts_upstream_of_or_within IMP MGI:1857930 2290270 MGI:3715429 , PMID:17554309 MGI MGI:3715429 , PMID:17554309 hematopoietic stem cell proliferation acts_upstream_of_or_within IMP MGI:1857930 2290270 MGI:3715429 , PMID:17554309 MGI MGI:3715429 , PMID:17554309 negative regulation of cell differentiation ISO RGD:727802 9068941 RGD PMID:16424384 , REF_RGD_ID:2291976 negative regulation of cellular senescence involved_in ISO RGD:1353130 9068941 PMID:11313459 BHF-UCL PMID:11313459 positive regulation of telomere maintenance via telomerase acts_upstream_of_or_within IMP MGI:1857930 2290270 MGI:3774867 , PMID:17982445 MGI MGI:3774867 , PMID:17982445 post-embryonic development acts_upstream_of_or_within IMP MGI:1857930 2290270 MGI:3715429 , PMID:17554309 MGI MGI:3715429 , PMID:17554309 regulation of cell population proliferation acts_upstream_of_or_within IGI MGI:88039 2290270 MGI:2135372 , PMID:11381263 MGI MGI:2135372 , PMID:11381263 RNA-templated DNA biosynthetic process acts_upstream_of_or_within IMP MGI:1857930 2290270 MGI:3774867 , PMID:17982445 GOC MGI:3774867 , PMID:17982445 telomere maintenance acts_upstream_of_or_within IMP MGI:1857930 2290270 MGI:3700621 , PMID:17145779 MGI MGI:3700621 , PMID:17145779 telomere maintenance acts_upstream_of_or_within IGI MGI:109635 2290270 MGI:3050262 , PMID:15235603 MGI MGI:3050262 , PMID:15235603 telomere maintenance acts_upstream_of_or_within IGI MGI:109635 , MGI:1328362 2290270 MGI:3055614 , PMID:15367665 MGI MGI:3055614 , PMID:15367665 telomere maintenance via telomerase acts_upstream_of IMP MGI:1857930 2290270 MGI:3774867 , PMID:17982445 MGI MGI:3774867 , PMID:17982445 telomere maintenance via telomerase involved_in ISO RGD:1353130 9068941 PMID:17940095 more ... BHF-UCL PMID:17940095 more ...
1,2-dimethylhydrazine (EXP) 2,2',4,4',5,5'-hexachlorobiphenyl (ISO) 3,3',4,4',5-pentachlorobiphenyl (ISO) 3-chloropropane-1,2-diol (ISO) 4-hydroperoxycyclophosphamide (EXP) 6-propyl-2-thiouracil (ISO) aflatoxin B1 (ISO) aflatoxin M1 (ISO) all-trans-retinoic acid (ISO) arsane (ISO) arsenic atom (ISO)
References
References - curated
#
Reference Title
Reference Citation
1.
Expression of telomerase subunits in gastric cancer.
Chen F, etal., J Huazhong Univ Sci Technolog Med Sci. 2005;25(6):741-3. doi: 10.1007/BF02896189.
2.
Telomerase RNA as a detection marker in the serum of breast cancer patients.
Chen XQ, etal., Clin Cancer Res. 2000 Oct;6(10):3823-6.
3.
High telomerase RNA expression level is an adverse prognostic factor for favorable-histology Wilms' tumor.
Dome JS, etal., J Clin Oncol. 2005 Dec 20;23(36):9138-45. Epub 2005 Sep 19.
4.
Gene amplifications associated with the development of hormone-resistant prostate cancer.
Edwards J, etal., Clin Cancer Res. 2003 Nov 1;9(14):5271-81.
5.
Detection of telomerase in urine by 3 methods: evaluation of diagnostic accuracy for bladder cancer.
Eissa S, etal., J Urol. 2007 Sep;178(3 Pt 1):1068-72. Epub 2007 Jul 20.
6.
Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer.
Heselmeyer-Haddad K, etal., Am J Pathol. 2005 Apr;166(4):1229-38.
7.
Genomic integration of oncogenic HPV and gain of the human telomerase gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer.
Hopman AH, etal., J Pathol. 2006 Dec;210(4):412-9.
8.
The effect on melanoma risk of genes previously associated with telomere length.
Iles MM, etal., J Natl Cancer Inst. 2014 Sep 17;106(10). pii: dju267. doi: 10.1093/jnci/dju267. Print 2014 Oct.
9.
Telomere length, telomerase activity and telomerase RNA expression during mouse mammary tumor progression.
Kiyozuka Y, etal., Int J Mol Med. 1998 Oct;2(4):437-44.
10.
Detection of human telomerase RNA in the tumour-surrounding mucosa of bladder carcinomas as a marker for premalignant transformation.
Leuenroth S, etal., BJU Int. 2005 Sep;96(4):553-7.
11.
Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer.
Montanaro L, etal., J Pathol. 2006 Sep;210(1):10-8.
12.
Expression of telomerase mRNA component (hTR) in transitional cell carcinoma of the upper urinary tract.
Nakanishi K, etal., Cancer. 1999 Nov 15;86(10):2109-16.
13.
Detection of telomerase RNA in the plasma of patients with breast cancer, malignant melanoma or thyroid cancer.
Novakovic S, etal., Oncol Rep. 2004 Jan;11(1):245-52.
14.
OMIM Disease Annotation Pipeline
OMIM Disease Annotation Pipeline
15.
In situ nucleic acid detection of human telomerase in intrahepatic cholangiocarcinoma and its preneoplastic lesion.
Ozaki S, etal., Hepatology. 1999 Oct;30(4):914-9. doi: 10.1002/hep.510300419.
16.
Telomerase as a prognostic marker in breast cancer: high-throughput tissue microarray analysis of hTERT and hTR.
Poremba C, etal., J Pathol. 2002 Oct;198(2):181-9.
17.
Mouse MP Annotation Import Pipeline
RGD automated import pipeline
18.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
20.
Expression of the human telomerase reverse transcriptase is not related to telomerase activity in normal and malignant renal tissue.
Rohde V, etal., Clin Cancer Res. 2000 Dec;6(12):4803-9.
21.
Telomerase in relation to expression of p53, c-Myc and estrogen receptor in ovarian tumours.
Wisman GB, etal., Int J Oncol. 2003 Nov;23(5):1451-9.
Additional References at PubMed
Genomics
Comparative Map Data
Terc (Mus musculus - house mouse)
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 3 96,321,753 - 96,322,149 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 3 96,321,753 - 96,322,149 (-) Ensembl GRCm39 Ensembl GRCm38 3 96,414,437 - 96,414,833 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 3 96,414,437 - 96,414,859 (-) Ensembl GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 3 96,414,437 - 96,414,833 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 3 96,218,360 - 96,218,756 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 3 96,499,842 - 96,500,238 (-) NCBI MGSCv36 mm8 Celera 3 97,832,081 - 97,832,477 (-) NCBI Celera Cytogenetic Map 3 F2.1 NCBI
TERC (Homo sapiens - human)
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 3 169,764,610 - 169,765,060 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p13 Ensembl 3 169,764,520 - 169,765,060 (-) Ensembl GRCh38 hg38 GRCh38 GRCh38.p13 Ensembl 3 169,764,610 - 169,765,047 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 3 169,482,398 - 169,482,848 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 3 170,965,092 - 170,965,542 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Celera 3 167,881,540 - 167,881,990 (-) NCBI Celera Cytogenetic Map 3 q26.2 NCBI HuRef 3 166,852,038 - 166,852,488 (-) NCBI HuRef CHM1_1 3 169,445,476 - 169,445,926 (-) NCBI CHM1_1 T2T-CHM13v2.0 3 172,548,562 - 172,549,012 (-) NCBI T2T-CHM13v2.0
Terc (Rattus norvegicus - Norway rat)
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 2 112,815,654 - 112,816,041 (+) NCBI mRatBN7.2 mRatBN7.2 UTH_Rnor_SHR_Utx 2 119,466,989 - 119,467,376 (+) NCBI Rnor_SHR UTH_Rnor_SHRSP_BbbUtx_1.0 2 117,579,552 - 117,579,939 (+) NCBI Rnor_SHRSP UTH_Rnor_WKY_Bbb_1.0 2 112,290,386 - 112,290,773 (+) NCBI Rnor_WKY Rnor_6.0 2 116,432,723 - 116,433,110 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 2 116,432,691 - 116,433,110 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 2 136,126,300 - 136,126,687 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 2 117,234,446 - 117,234,833 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 2 117,179,407 - 117,179,795 (+) NCBI Celera 2 107,993,694 - 107,994,082 (+) NCBI Celera Cytogenetic Map 2 q24 NCBI
QTLs in Region (GRCm39)
26884436 Zlq3_m zygomatic length QTL 3, 10 week (mouse) 3 3265060 142405761 Mouse 4142399 Aec1_m autoimmune exocrinopathy 1 (mouse) Not determined 7586174 102690034 Mouse 26884427 Cvht4_m cranial vault height 4, 10 week (mouse) 3 16054164 109707316 Mouse 13207570 Tcq12_m total cholesterol QTL 12 (mouse) 3 16504164 130163649 Mouse 26884422 Cvht7_m cranial vault height 7, 16 week (mouse) 3 28954149 118893649 Mouse 1302056 Orgwq4_m organ weight QTL 4 (mouse) Not determined 3 30067588 147304689 Mouse 1301705 Sles3_m systemic lupus erythmatosus suppressor 3 (mouse) Not determined 3 37174862 143353183 Mouse 13208566 Bmiq5_m body mass index QTL 5 (mouse) 3 40954435 115793649 Mouse 26884380 Skwq1_m skull length QTL 1, 5 week (mouse) 3 43954435 101607316 Mouse 26884378 Skwq6_m skull length QTL 6, 10 week (mouse) 3 51907421 102307316 Mouse 26884382 Bzwq1_m bi-zygomatic width QTL 1, 5 week (mouse) 3 52207421 137205761 Mouse 11039519 Ltpr3_m Leishmania tropica response 3 (mouse) 3 56704102 100464137 Mouse 1301971 Cia5_m collagen induced arthritis QTL 5 (mouse) Not determined 3 66046658 100046795 Mouse 25314313 Syncl1_m synaptonemal complex length 1 (mouse) 3 67907333 128393649 Mouse 11251721 Ewc3_m ethanol withdrawal and consumption 3 (mouse) 3 69568554 103568554 Mouse 1301791 Char4_m P. chabaudi malaria resistance QTL 4 (mouse) Not determined 3 69625509 100655290 Mouse 1301422 Sle11_m systematic lupus erythematosus susceptibility 11 (mouse) Not determined 3 70208904 104209042 Mouse 11049572 Lmr11c_m leishmaniasis resistance 11c (mouse) 3 72139967 106140094 Mouse 1300982 Lmr11_m leishmaniasis resistance 11 (mouse) Not determined 3 72139967 106140094 Mouse 1300595 Tmevd2_m Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse) Not determined 3 75463302 109463549 Mouse 1301392 Eae3_m susceptibility to experimental allergic encephalomyelitis 3 (mouse) Not determined 3 79548730 113548837 Mouse 1301947 Pcfm3_m periosteal circumference and femur length 3 (mouse) Not determined 3 81084652 115084797 Mouse 1301904 Iba2_m induction of brown adipocytes 2 (mouse) Not determined 3 82147043 116147184 Mouse 11041900 Lmr11a_m leishmaniasis resistance 11a (mouse) 3 83463991 117464137 Mouse 11039510 Ltpr3d_m Leishmania tropica response 3d (mouse) 3 83463991 117464137 Mouse 11039511 Ltpr3c_m Leishmania tropica response 3c (mouse) 3 83463991 117464137 Mouse 11039507 Ltpr3g_m Leishmania tropica response 3g (mouse) 3 83463991 117464137 Mouse 11039508 Ltpr3f_m Leishmania tropica response 3f (mouse) 3 83463991 117464137 Mouse 11039509 Ltpr3e_m Leishmania tropica response 3e (mouse) 3 83463991 117464137 Mouse 11039512 Ltpr3b_m Leishmania tropica response 3b (mouse) 3 83463991 117464137 Mouse 1301272 Cfsw1_m cystic fibrosis survival to weaning 1 (mouse) Not determined 3 83882912 117883044 Mouse 4142099 Cq3_m cholesterol QTL 3 (mouse) Not determined 3 84888918 118889067 Mouse 14746984 Manh54_m mandible shape 54 (mouse) 3 85289152 119289152 Mouse 1357583 Sle18_m systematic lupus erythematosus susceptibility 18 (mouse) Not determined 3 87208904 125316236 Mouse 12738440 Twq3_m testis weight QTL 3 (mouse) 3 87228015 121228015 Mouse 4142178 Ctrq2_m C. trachomatis resistance QTL 2 (mouse) Not determined 3 89139967 137453008 Mouse 10766455 Sle22_m systematic lupus erythematosus susceptibility 22 (mouse) 3 90376936 124377072 Mouse 14747001 Mancz4_m mandible centroid size 4 (mouse) 3 90378017 124378017 Mouse 1301398 Rapop3_m radiation-induced apoptosis 3 (mouse) Not determined 3 90511217 100464137 Mouse 1302052 Etohcta4_m ethanol conditioned taste aversion 4 (mouse) Not determined 3 91000105 125008748 Mouse 1301349 Pgia26_m proteoglycan induced arthritis 26 (mouse) Not determined 3 92251533 126251650 Mouse