Lgr4 (leucine-rich repeat-containing G protein-coupled receptor 4) - Rat Genome Database

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Gene: Lgr4 (leucine-rich repeat-containing G protein-coupled receptor 4) Mus musculus
Analyze
Symbol: Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
RGD ID: 1616653
MGI Page MGI
Description: Enables transmembrane signaling receptor activity. Involved in several processes, including metanephric nephron development; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; intestinal stem cell homeostasis; and male genitalia development. Located in plasma membrane. Is expressed in several structures, including alimentary system; eye; integumental system; metanephros; and telencephalon. Used to study glaucoma. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9130225G07; A330106J01Rik; A930009A08Rik; G protein-coupled receptor 48; G protein-coupled receptor GPR48; G-protein coupled receptor 48; Gpr; Gpr48; leucine-rich repeat-containing G-protein coupled receptor 4; RIKEN cDNA A330106J01 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392109,747,919 - 109,844,602 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2109,747,992 - 109,844,602 (+)EnsemblGRCm39 Ensembl
GRCm382109,917,647 - 110,014,257 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2109,917,647 - 110,014,257 (+)EnsemblGRCm38mm10GRCm38
MGSCv372109,757,804 - 109,854,414 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362109,709,007 - 109,815,096 (+)NCBIMGSCv36mm8
Celera2111,078,651 - 111,175,891 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methoxyethanol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
choline  (EXP)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
gentamycin  (ISO)
hydralazine  (ISO)
hydroquinone  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methoxyacetic acid  (EXP)
methyl methanesulfonate  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
trovafloxacin  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior eye segment morphology  (IAGP)
abnormal canal of Schlemm morphology  (IAGP)
abnormal caput epididymis morphology  (IAGP)
abnormal cornea epithelium morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal cornea stroma morphology  (IAGP)
abnormal efferent ductules of testis morphology  (IAGP)
abnormal epidermal stem cell proliferation  (IAGP)
abnormal epididymal fat pad morphology  (IAGP)
abnormal epididymis epithelium morphology  (IAGP)
abnormal epididymis morphology  (IAGP)
abnormal glomerular capsule space morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal intestine development  (IAGP)
abnormal intestine physiology  (IAGP)
abnormal iridocorneal angle  (IAGP)
abnormal keratinocyte physiology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lens morphology  (IAGP)
abnormal metanephric mesenchyme morphology  (IAGP)
abnormal metanephric ureteric bud development  (IAGP)
abnormal nephron morphology  (IAGP)
abnormal reproductive system morphology  (IAGP)
abnormal reproductive system physiology  (IAGP)
abnormal rete testis morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal skin development  (IAGP)
abnormal small intestinal crypt cell proliferation  (IAGP)
abnormal sperm number  (IAGP)
abnormal testis morphology  (IAGP)
abnormal testis physiology  (IAGP)
anterior iris synechia  (IAGP)
asthenozoospermia  (IAGP)
cataract  (IAGP)
ciliary body hypoplasia  (IAGP)
cornea deposits  (IAGP)
cornea epithelium hypoplasia  (IAGP)
cornea opacity  (IAGP)
cornea vascularization  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased cornea epithelium thickness  (IAGP)
decreased cornea stroma thickness  (IAGP)
decreased cornea thickness  (IAGP)
decreased epididymal cell proliferation  (IAGP)
decreased epididymis weight  (IAGP)
decreased fetal weight  (IAGP)
decreased hair follicle number  (IAGP)
decreased kidney cell proliferation  (IAGP)
decreased kidney weight  (IAGP)
decreased liver weight  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased small intestinal villus size  (IAGP)
decreased survivor rate  (IAGP)
dilated renal tubule  (IAGP)
dilated rete testis  (IAGP)
disorganized retina inner nuclear layer  (IAGP)
disorganized retina outer nuclear layer  (IAGP)
disorganized secondary lens fibers  (IAGP)
embryonic growth retardation  (IAGP)
enlarged testis  (IAGP)
enlarged uterus  (IAGP)
epididymal cyst  (IAGP)
epididymis hypoplasia  (IAGP)
eyelids open at birth  (IAGP)
hypoplastic trabecular meshwork  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
increased circulating creatinine level  (IAGP)
increased incidence of corneal inflammation  (IAGP)
increased kidney apoptosis  (IAGP)
increased testis weight  (IAGP)
infertility  (IAGP)
iris hypoplasia  (IAGP)
iris stroma hypoplasia  (IAGP)
kidney cyst  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
male infertility  (IAGP)
microphthalmia  (IAGP)
mydriasis  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
polycystic kidney  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
reduced female fertility  (IAGP)
renal hypoplasia  (IAGP)
rete testis obstruction  (IAGP)
retina ganglion cell degeneration  (IAGP)
small caput epididymis  (IAGP)
small lens  (IAGP)
small metanephros  (IAGP)
thin epidermis  (IAGP)
thin retina inner nuclear layer  (IAGP)
thin retina outer nuclear layer  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Secreted and transmembrane wnt inhibitors and activators. Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11242070   PMID:11401528   PMID:11544199   PMID:11812828   PMID:12466851   PMID:12477932  
PMID:12520002   PMID:12679517   PMID:12904583   PMID:14610273   PMID:14691545   PMID:15192078   PMID:15782199   PMID:15840001   PMID:16028069   PMID:16141072   PMID:16141073   PMID:16406039  
PMID:16602821   PMID:16785743   PMID:16822657   PMID:17079737   PMID:17850793   PMID:17967808   PMID:18287559   PMID:18331719   PMID:18424556   PMID:18487371   PMID:18651655   PMID:18799693  
PMID:18955481   PMID:19301269   PMID:19301403   PMID:19474196   PMID:19605502   PMID:20023170   PMID:20223988   PMID:20638054   PMID:20732323   PMID:21267068   PMID:21508962   PMID:21523854  
PMID:21693646   PMID:21727895   PMID:21873635   PMID:22135314   PMID:22738954   PMID:23393138   PMID:23444378   PMID:23533175   PMID:23589304   PMID:23712846   PMID:23897697   PMID:23975934  
PMID:24139799   PMID:24212090   PMID:24344199   PMID:24353284   PMID:24519938   PMID:24595031   PMID:24616052   PMID:24680895   PMID:24877628   PMID:25063812   PMID:25158167   PMID:25188337  
PMID:25811370   PMID:25910078   PMID:26102032   PMID:26273529   PMID:26332449   PMID:26333992   PMID:26581094   PMID:26776520   PMID:27064449   PMID:27088858   PMID:27140682   PMID:27178473  
PMID:27559308   PMID:27693558   PMID:27861872   PMID:28130056   PMID:28272338   PMID:28400434   PMID:28634819   PMID:28768769   PMID:28813421   PMID:28842478   PMID:28986711   PMID:29269400  
PMID:29555474   PMID:29572179   PMID:29688375   PMID:29769720   PMID:29859889   PMID:29967265   PMID:30146491   PMID:30406697   PMID:30536377   PMID:31376385   PMID:31772170   PMID:32035093  
PMID:32324134   PMID:32375050   PMID:32457899   PMID:32468660   PMID:32493844   PMID:32600176   PMID:32926477   PMID:33950533   PMID:36410420   PMID:36538378   PMID:36547788   PMID:37165865  
PMID:37437654   PMID:37651925   PMID:38440827   PMID:38677673   PMID:38782937   PMID:39033139  


Genomics

Comparative Map Data
Lgr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392109,747,919 - 109,844,602 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2109,747,992 - 109,844,602 (+)EnsemblGRCm39 Ensembl
GRCm382109,917,647 - 110,014,257 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2109,917,647 - 110,014,257 (+)EnsemblGRCm38mm10GRCm38
MGSCv372109,757,804 - 109,854,414 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362109,709,007 - 109,815,096 (+)NCBIMGSCv36mm8
Celera2111,078,651 - 111,175,891 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.65NCBI
LGR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381127,365,961 - 27,472,790 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1127,365,961 - 27,472,790 (-)EnsemblGRCh38hg38GRCh38
GRCh371127,387,508 - 27,494,337 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361127,344,084 - 27,450,910 (-)NCBINCBI36Build 36hg18NCBI36
Celera1127,532,862 - 27,640,072 (-)NCBICelera
Cytogenetic Map11p14.1NCBI
HuRef1127,084,852 - 27,193,084 (-)NCBIHuRef
CHM1_11127,386,916 - 27,493,708 (-)NCBICHM1_1
T2T-CHM13v2.01127,506,453 - 27,613,276 (-)NCBIT2T-CHM13v2.0
Lgr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83116,901,968 - 117,004,584 (+)NCBIGRCr8
mRatBN7.2396,447,385 - 96,550,006 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl396,447,858 - 96,548,899 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3100,007,532 - 100,109,518 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03108,606,494 - 108,708,483 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03106,370,036 - 106,472,231 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03101,051,960 - 101,152,119 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3101,051,955 - 101,152,119 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03107,652,233 - 107,752,743 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4395,370,049 - 95,471,040 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1395,266,473 - 95,367,468 (+)NCBI
Celera395,472,374 - 95,573,289 (+)NCBICelera
Cytogenetic Map3q34NCBI
Lgr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554766,610,103 - 6,629,264 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554766,611,102 - 6,629,294 (-)NCBIChiLan1.0ChiLan1.0
LGR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2929,576,585 - 29,683,037 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11129,577,034 - 29,683,557 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01127,330,279 - 27,437,201 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,232,801 - 27,291,571 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,229,963 - 27,291,571 (-)Ensemblpanpan1.1panPan2
LGR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12147,952,019 - 47,995,530 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2147,952,890 - 47,996,288 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2147,448,894 - 47,548,000 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02149,092,130 - 49,194,350 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2149,093,704 - 49,165,497 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12148,077,244 - 48,176,850 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02148,247,673 - 48,347,510 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02148,839,453 - 48,939,290 (-)NCBIUU_Cfam_GSD_1.0
Lgr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494736,597,365 - 36,690,743 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365405,752,197 - 5,845,159 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365405,752,319 - 5,846,074 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl232,871,871 - 32,979,148 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1232,871,837 - 32,979,150 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2235,582,601 - 35,614,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LGR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1137,632,748 - 37,741,100 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl137,632,710 - 37,741,330 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038134,942,734 - 135,051,210 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476617,112,909 - 17,147,785 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476617,110,809 - 17,147,585 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lgr4
2718 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1090
Count of miRNA genes:381
Interacting mature miRNAs:459
Transcripts:ENSMUST00000046548, ENSMUST00000111037, ENSMUST00000142869, ENSMUST00000152584
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
1301909Smdq2_msegregation of mitochondrial DNA QTL 2 (mouse)Not determined292778465126778607Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288015003122015170Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297210364131210364Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88143423122143570Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
4141448Mpaps1_mmicrophthalmia anophthalmia susceptibility 1 (mouse)Not determined97028557112115196Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297210364131210364Mouse
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286095716120095823Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286095716120095823Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297123370131123532Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297123370131123532Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106233580140233729Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287440643121440778Mouse
11041906Lmr28a_mleishmaniasis resistance 28a (mouse)2103095716129213005Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284008488118008593Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286095716120095823Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276421483110421651Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined280895334114895334Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286095716120095823Mouse
1301098Cd8mts3_mCD8 memory T cell subset 3 (mouse)Not determined291089974125090104Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107255676141255676Mouse

Markers in Region
D2Jcs2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382109,929,176 - 109,929,387UniSTSGRCm38
MGSCv372109,769,333 - 109,769,544UniSTSGRCm37
Celera2111,089,988 - 111,090,332UniSTS
Cytogenetic Map2E3UniSTS
cM Map251.7UniSTS
01.MMHAP6FLA1.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382109,999,971 - 110,000,125UniSTSGRCm38
MGSCv372109,840,128 - 109,840,282UniSTSGRCm37
Celera2111,161,609 - 111,161,763UniSTS
Cytogenetic Map2E3UniSTS
Whitehead/MRC_RH21432.09UniSTS
Whitehead_YAC2 UniSTS
D2Mit480  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382109,948,120 - 109,948,262UniSTSGRCm38
MGSCv372109,788,277 - 109,788,419UniSTSGRCm37
Celera2111,109,245 - 111,109,377UniSTS
Cytogenetic Map2E3UniSTS
cM Map251.4UniSTS
Whitehead Genetic251.4UniSTS
Whitehead/MRC_RH21432.09UniSTS
Whitehead_YAC2 UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_172671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK020738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL845423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY255619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC056637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE861913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE987673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU520309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX294391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA527305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF164628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ093786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN456468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN667965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000046548   ⟹   ENSMUSP00000047325
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2109,747,992 - 109,844,602 (+)Ensembl
GRCm38.p6 Ensembl2109,917,647 - 110,014,257 (+)Ensembl
Ensembl Acc Id: ENSMUST00000111037   ⟹   ENSMUSP00000106666
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2109,747,992 - 109,844,602 (+)Ensembl
GRCm38.p6 Ensembl2109,917,647 - 110,014,257 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142869
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2109,830,873 - 109,831,805 (+)Ensembl
GRCm38.p6 Ensembl2110,000,528 - 110,001,460 (+)Ensembl
Ensembl Acc Id: ENSMUST00000152584
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2109,805,887 - 109,827,997 (+)Ensembl
GRCm38.p6 Ensembl2109,975,542 - 109,997,652 (+)Ensembl
RefSeq Acc Id: NM_172671   ⟹   NP_766259
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392109,747,992 - 109,844,602 (+)NCBI
GRCm382109,917,647 - 110,014,257 (+)ENTREZGENE
MGSCv372109,757,804 - 109,854,414 (+)RGD
Celera2111,078,651 - 111,175,891 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036157249   ⟹   XP_036013142
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392109,747,919 - 109,844,602 (+)NCBI
Sequence:
RefSeq Acc Id: NP_766259   ⟸   NM_172671
- Peptide Label: precursor
- UniProtKB: Q8BXS9 (UniProtKB/Swiss-Prot),   Q80T31 (UniProtKB/Swiss-Prot),   Q6PHA3 (UniProtKB/Swiss-Prot),   A2ARI4 (UniProtKB/Swiss-Prot),   A2ARI3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000106666   ⟸   ENSMUST00000111037
Ensembl Acc Id: ENSMUSP00000047325   ⟸   ENSMUST00000046548
RefSeq Acc Id: XP_036013142   ⟸   XM_036157249
- Peptide Label: isoform X1
Protein Domains
G-protein coupled receptors family 1 profile   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A2ARI4-F1-model_v2 AlphaFold A2ARI4 1-951 view protein structure

Promoters
RGD ID:6831692
Promoter ID:MM_KWN:30956
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_172671,   OTTMUST00000035908
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362109,757,561 - 109,758,061 (+)MPROMDB
RGD ID:6831690
Promoter ID:MM_KWN:30958
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000035909
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362109,814,811 - 109,815,847 (+)MPROMDB
RGD ID:6878182
Promoter ID:EPDNEW_M2542
Type:initiation region
Name:Lgr4_1
Description:Mus musculus leucine-rich repeat-containing G protein-coupledreceptor 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382109,917,647 - 109,917,707EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1891468 AgrOrtholog
Ensembl Genes ENSMUSG00000050199 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000046548 ENTREZGENE
  ENSMUST00000046548.14 UniProtKB/Swiss-Prot
  ENSMUST00000111037.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gphrmn_rcpt_fam UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
KEGG Report mmu:107515 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1891468 ENTREZGENE
NCBI Gene Lgr4 ENTREZGENE
PANTHER GLYCOPROTEIN HORMONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR INSULIN LIKE RECEPTOR 1 UniProtKB/Swiss-Prot
  LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 4 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
PhenoGen Lgr4 PhenoGen
PRINTS GLYCHORMONER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR UniProtKB/Swiss-Prot
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/Swiss-Prot
  LRR_SD22 UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L domain-like UniProtKB/Swiss-Prot
UniProt A2ARI3 ENTREZGENE
  A2ARI4 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6PHA3 ENTREZGENE
  Q80T31 ENTREZGENE
  Q8BXS9 ENTREZGENE
  Q8BZR7_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2ARI3 UniProtKB/Swiss-Prot
  Q6PHA3 UniProtKB/Swiss-Prot
  Q80T31 UniProtKB/Swiss-Prot
  Q8BXS9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Lgr4  leucine-rich repeat-containing G protein-coupled receptor 4  Gpr48  G protein-coupled receptor 48  Symbol and/or name change 5135510 APPROVED
2024-08-21 Gpr48  G protein-coupled receptor 48  Lgr4  leucine-rich repeat-containing G protein-coupled receptor 4  Symbol and/or name change 5135510 APPROVED
2016-04-05 Lgr4  leucine-rich repeat-containing G protein-coupled receptor 4  A330106J01Rik  RIKEN cDNA A330106J01 gene  Data merged from RGD:1607325 737654 PROVISIONAL