Angptl7 (angiopoietin-like 7) - Rat Genome Database

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Gene: Angptl7 (angiopoietin-like 7) Mus musculus
Analyze
Symbol: Angptl7
Name: angiopoietin-like 7
RGD ID: 1616240
MGI Page MGI
Description: Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of vasculature development involved in avascular cornea development in camera-type eye and regulation of extracellular matrix organization. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in brain. Orthologous to human ANGPTL7 (angiopoietin like 7).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: angiopoietin-like protein 7; angiopoietin-related protein 7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,579,737 - 148,584,919 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,579,640 - 148,584,917 (-)EnsemblGRCm39 Ensembl
GRCm384148,495,181 - 148,500,462 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,495,183 - 148,500,460 (-)EnsemblGRCm38mm10GRCm38
MGSCv374147,869,389 - 147,874,571 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,339,080 - 147,344,262 (-)NCBIMGSCv36mm8
Celera4150,756,629 - 150,761,851 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:20562862   PMID:21677750   PMID:21873635  
PMID:22350948   PMID:24952961   PMID:25652910   PMID:26973239   PMID:27689697   PMID:31835268   PMID:32786125   PMID:36192519   PMID:37319434   PMID:38497513  


Genomics

Comparative Map Data
Angptl7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,579,737 - 148,584,919 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,579,640 - 148,584,917 (-)EnsemblGRCm39 Ensembl
GRCm384148,495,181 - 148,500,462 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,495,183 - 148,500,460 (-)EnsemblGRCm38mm10GRCm38
MGSCv374147,869,389 - 147,874,571 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,339,080 - 147,344,262 (-)NCBIMGSCv36mm8
Celera4150,756,629 - 150,761,851 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.76NCBI
ANGPTL7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,189,355 - 11,195,981 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,189,355 - 11,195,981 (+)EnsemblGRCh38hg38GRCh38
GRCh37111,249,412 - 11,256,038 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,171,985 - 11,178,625 (+)NCBINCBI36Build 36hg18NCBI36
Build 34111,183,663 - 11,190,303NCBI
Celera110,361,738 - 10,368,376 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef110,400,659 - 10,407,349 (+)NCBIHuRef
CHM1_1111,237,291 - 11,243,982 (+)NCBICHM1_1
T2T-CHM13v2.0110,730,945 - 10,737,571 (+)NCBIT2T-CHM13v2.0
Angptl7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,215,223 - 164,220,408 (-)NCBIGRCr8
mRatBN7.25158,932,096 - 158,937,281 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,932,794 - 158,937,324 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05165,311,794 - 165,318,361 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,312,130 - 165,316,652 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,968,399 - 168,974,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5157,209,230 - 157,215,797 (-)NCBICelera
Cytogenetic Map5q36NCBI
Angptl7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,539,781 - 2,545,630 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,539,781 - 2,545,630 (-)NCBIChiLan1.0ChiLan1.0
ANGPTL7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21217,024,131 - 217,039,357 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,671,259 - 215,678,351 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019,955,033 - 9,961,886 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,176,355 - 11,183,048 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,176,355 - 11,183,048 (+)Ensemblpanpan1.1panPan2
ANGPTL7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,876,881 - 84,883,582 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,877,682 - 84,883,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,406,973 - 81,413,699 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,538,985 - 85,545,711 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,538,989 - 85,545,456 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,287,098 - 82,293,820 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,288,839 - 83,295,563 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,351,373 - 84,358,097 (-)NCBIUU_Cfam_GSD_1.0
Angptl7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,399,896 - 34,405,900 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474224,576 - 230,711 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474224,836 - 230,682 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANGPTL7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,350,033 - 71,356,662 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,350,872 - 71,356,299 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,255,362 - 65,260,791 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANGPTL7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120120,589,968 - 120,598,751 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20120,589,812 - 120,597,017 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605424,498,681 - 24,505,848 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Angptl7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,619,790 - 1,626,474 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,620,741 - 1,626,704 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Angptl7
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:397
Count of miRNA genes:288
Interacting mature miRNAs:329
Transcripts:ENSMUST00000030840
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
12738431Lfibq20_mliver fibrosis QTL 20 (mouse)4144699835148907426Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137674005150676858Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001039554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK031675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL713995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU210865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000030840   ⟹   ENSMUSP00000030840
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,579,640 - 148,584,917 (-)Ensembl
GRCm38.p6 Ensembl4148,495,183 - 148,500,460 (-)Ensembl
RefSeq Acc Id: NM_001039554   ⟹   NP_001034643
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,579,737 - 148,584,919 (-)NCBI
GRCm384148,495,280 - 148,500,462 (-)NCBI
MGSCv374147,869,389 - 147,874,571 (-)RGD
Celera4150,756,629 - 150,761,851 (-)RGD
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001034643 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH23373 (Get FASTA)   NCBI Sequence Viewer  
  BAC27507 (Get FASTA)   NCBI Sequence Viewer  
  EDL14821 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000030840
  ENSMUSP00000030840.4
GenBank Protein Q8R1Q3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001034643   ⟸   NM_001039554
- Peptide Label: precursor
- UniProtKB: Q8R1Q3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000030840   ⟸   ENSMUST00000030840
Protein Domains
Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R1Q3-F1-model_v2 AlphaFold Q8R1Q3 1-337 view protein structure

Promoters
RGD ID:6834873
Promoter ID:MM_KWN:40819
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Kidney
Transcripts:ENSMUST00000030840
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,874,156 - 147,874,872 (-)MPROMDB
RGD ID:6885524
Promoter ID:EPDNEW_M6213
Type:single initiation site
Name:Angptl7_1
Description:Mus musculus angiopoietin-like 7 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384148,500,460 - 148,500,520EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3605801 AgrOrtholog
Ensembl Genes ENSMUSG00000028989 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030840 ENTREZGENE
  ENSMUST00000030840.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.215.10 UniProtKB/Swiss-Prot
InterPro Fibrinogen-like_C UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_dom UniProtKB/Swiss-Prot
  Fibrinogen_C-term_domain UniProtKB/Swiss-Prot
KEGG Report mmu:654812 UniProtKB/Swiss-Prot
MGD MGI:3605801 ENTREZGENE
NCBI Gene 654812 ENTREZGENE
PANTHER ANGIOPOIETIN-RELATED PROTEIN 7 UniProtKB/Swiss-Prot
  FIBRINOGEN/TENASCIN/ANGIOPOEITIN UniProtKB/Swiss-Prot
Pfam Fibrinogen_C UniProtKB/Swiss-Prot
PhenoGen Angptl7 PhenoGen
PROSITE FIBRINOGEN_C_2 UniProtKB/Swiss-Prot
SMART FBG UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56496 UniProtKB/Swiss-Prot
UniProt ANGL7_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE