Mfsd12 (major facilitator superfamily domain containing 12) - Rat Genome Database

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Gene: Mfsd12 (major facilitator superfamily domain containing 12) Mus musculus
Analyze
Symbol: Mfsd12
Name: major facilitator superfamily domain containing 12
RGD ID: 1615836
MGI Page MGI
Description: Predicted to enable cysteine transmembrane transporter activity. Involved in negative regulation of melanin biosynthetic process and pigment metabolic process involved in pigmentation. Acts upstream of or within hair follicle development and pigmentation. Predicted to be located in late endosome; lysosome; and melanosome. Predicted to be active in plasma membrane. Is expressed in thymus primordium. Orthologous to human MFSD12 (major facilitator superfamily domain containing 12).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C19orf28; F630110N24Rik; g; gr; hypothetical protein LOC73822; major facilitator superfamily domain-containing protein 12; MGC148235; uncharacterized MFS-type transporter C19orf28 homolog; Wdt1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,193,325 - 81,202,059 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,193,325 - 81,202,059 (+)EnsemblGRCm39 Ensembl
GRCm381081,357,491 - 81,366,225 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,357,491 - 81,366,225 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,820,315 - 80,826,780 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,820,236 - 80,828,967 (+)NCBIMGSCv36mm8
Celera1082,378,603 - 82,385,068 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:678292   PMID:1183807   PMID:1655629   PMID:2778559   PMID:4448900   PMID:5098070   PMID:6971254   PMID:7333462   PMID:7665168   PMID:7851892   PMID:8889548   PMID:9615234  
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11500834   PMID:12466851   PMID:12477932   PMID:12668055   PMID:12904583   PMID:14556008   PMID:14610273  
PMID:15073168   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16788073   PMID:20664521   PMID:21267068   PMID:21873635   PMID:23226316   PMID:29025994  
PMID:33208952   PMID:37874775  


Genomics

Comparative Map Data
Mfsd12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,193,325 - 81,202,059 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,193,325 - 81,202,059 (+)EnsemblGRCm39 Ensembl
GRCm381081,357,491 - 81,366,225 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,357,491 - 81,366,225 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,820,315 - 80,826,780 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,820,236 - 80,828,967 (+)NCBIMGSCv36mm8
Celera1082,378,603 - 82,385,068 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
MFSD12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,538,275 - 3,557,586 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl193,538,261 - 3,574,290 (-)EnsemblGRCh38hg38GRCh38
GRCh37193,544,197 - 3,557,584 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,489,263 - 3,508,571 (-)NCBINCBI36Build 36hg18NCBI36
Build 34193,495,197 - 3,508,561NCBI
Celera193,475,073 - 3,494,380 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,303,815 - 3,323,043 (-)NCBIHuRef
CHM1_1193,537,933 - 3,557,234 (-)NCBICHM1_1
T2T-CHM13v2.0193,516,446 - 3,535,742 (-)NCBIT2T-CHM13v2.0
Mfsd12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,998,050 - 9,004,724 (-)NCBIGRCr8
mRatBN7.278,345,171 - 8,354,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,347,314 - 8,353,988 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,232,889 - 11,239,559 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,108,376 - 13,115,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,976,036 - 10,982,709 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,214,832 - 11,223,713 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,216,975 - 11,223,649 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,383,866 - 11,390,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,831,853 - 9,838,324 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,829,711 - 9,837,769 (-)NCBI
Celera76,536,377 - 6,543,051 (-)NCBICelera
Cytogenetic Map7q11NCBI
Mfsd12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,506,154 - 5,516,142 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,505,528 - 5,516,330 (-)NCBIChiLan1.0ChiLan1.0
MFSD12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2207,936,086 - 7,954,989 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,173,528 - 7,186,956 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,570,068 - 2,583,505 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,519,886 - 3,548,934 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,520,399 - 3,532,767 (-)Ensemblpanpan1.1panPan2
MFSD12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,855,102 - 55,863,606 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,858,687 - 55,862,181 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,579,634 - 55,588,060 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,514,447 - 56,522,856 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,514,215 - 56,524,326 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,570,115 - 55,578,534 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,053,492 - 56,061,939 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,252,252 - 56,260,682 (+)NCBIUU_Cfam_GSD_1.0
Mfsd12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,815,659 - 215,823,018 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,011,506 - 2,019,125 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,011,838 - 2,019,119 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFSD12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,107,529 - 75,120,705 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,098,531 - 75,120,795 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,765,114 - 75,775,975 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MFSD12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,307,855 - 3,322,966 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,304,960 - 3,322,896 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660815,171,004 - 5,184,456 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfsd12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,259,618 - 6,268,272 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248286,255,889 - 6,268,697 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mfsd12
228 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1144
Count of miRNA genes:570
Interacting mature miRNAs:710
Transcripts:ENSMUST00000044844, ENSMUST00000132368
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse

Markers in Region
AI854616  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381081,363,816 - 81,363,961UniSTSGRCm38
MGSCv371080,826,561 - 80,826,706UniSTSGRCm37
Celera1082,384,849 - 82,384,994UniSTS
Cytogenetic Map10C1UniSTS
Whitehead/MRC_RH10918.1UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_028657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC155937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI852143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC118620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC119790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000044844   ⟹   ENSMUSP00000036116
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,193,325 - 81,202,059 (+)Ensembl
GRCm38.p6 Ensembl1081,357,491 - 81,366,225 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132368   ⟹   ENSMUSP00000120259
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,193,386 - 81,197,066 (+)Ensembl
GRCm38.p6 Ensembl1081,357,552 - 81,361,232 (+)Ensembl
RefSeq Acc Id: NM_028657   ⟹   NP_082933
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,193,325 - 81,202,059 (+)NCBI
GRCm381081,357,491 - 81,366,225 (+)NCBI
MGSCv371080,820,315 - 80,826,780 (+)RGD
Celera1082,378,603 - 82,385,068 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006514219   ⟹   XP_006514282
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,193,334 - 81,202,059 (+)NCBI
GRCm381081,357,500 - 81,366,225 (+)NCBI
Sequence:
RefSeq Acc Id: NP_082933   ⟸   NM_028657
- UniProtKB: Q3U376 (UniProtKB/Swiss-Prot),   Q3U481 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006514282   ⟸   XM_006514219
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000120259   ⟸   ENSMUST00000132368
Ensembl Acc Id: ENSMUSP00000036116   ⟸   ENSMUST00000044844

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3U481-F1-model_v2 AlphaFold Q3U481 1-476 view protein structure

Promoters
RGD ID:8672796
Promoter ID:EPDNEW_M14429
Type:initiation region
Name:Mfsd12_1
Description:Mus musculus major facilitator superfamily domain containing12 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381081,357,569 - 81,357,629EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3604804 AgrOrtholog
Ensembl Genes ENSMUSG00000034854 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000044844 ENTREZGENE
  ENSMUST00000044844.9 UniProtKB/Swiss-Prot
  ENSMUST00000132368.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:73822 UniProtKB/Swiss-Prot
MGD MGI:3604804 ENTREZGENE
NCBI Gene 73822 ENTREZGENE
PANTHER MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11328 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MFS_2 UniProtKB/Swiss-Prot
PhenoGen Mfsd12 PhenoGen
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D6RJ45_MOUSE UniProtKB/TrEMBL
  MFS12_MOUSE UniProtKB/Swiss-Prot
  Q3U376 ENTREZGENE
  Q3U481 ENTREZGENE
UniProt Secondary Q3U376 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-03-20 Mfsd12  major facilitator superfamily domain containing 12  F630110N24Rik  RIKEN cDNA F630110N24 gene  Symbol and/or name change 5135510 APPROVED