(+)-schisandrin B multiple interactions ISO RGD:2311 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CD59 mRNA] CTD PMID:31150632 (-)-alpha-phellandrene decreases expression ISO RGD:736600 6480464 alpha phellandrene results in decreased expression of CD59A mRNA CTD PMID:25075043 (S)-colchicine increases mutagenesis ISO RGD:736600 6480464 Colchicine results in increased mutagenesis of CD59 protein CTD PMID:17045307 (S)-nicotine increases expression ISO RGD:736600 6480464 Nicotine results in increased expression of CD59 mRNA CTD PMID:18247414 1,3-Propane sultone decreases lipidation ISO RGD:2311 6480464 1, 3-propane sultone results in decreased lipidation of CD59 protein CTD PMID:27931811 17alpha-ethynylestradiol increases expression ISO RGD:2311 6480464 Ethinyl Estradiol results in increased expression of CD59 mRNA CTD PMID:17557909 17beta-estradiol multiple interactions ISO RGD:736600 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of CD59 mRNA CTD PMID:30165855 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:736600 6480464 2 more ... CTD PMID:19095052 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CD59B mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:2311 6480464 Tetrachlorodibenzodioxin affects the expression of CD59 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:736600 6480464 Tetrachlorodibenzodioxin affects the expression of CD59 mRNA CTD PMID:22574217 2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expression ISO RGD:736600 6480464 2 more ... CTD PMID:26705709 2-amino-14,16-dimethyloctadecan-3-ol decreases expression ISO RGD:736600 6480464 2-amino-14, 16-dimethyloctadecan-3-ol results in decreased expression of CD59 protein CTD PMID:32044396 2-hydroxypropanoic acid decreases expression ISO RGD:736600 6480464 Lactic Acid results in decreased expression of CD59 mRNA CTD PMID:30851411 2-naphthylamine increases expression ISO RGD:736600 6480464 2-Naphthylamine results in increased expression of CD59 mRNA CTD PMID:18247414 3,4-methylenedioxymethamphetamine increases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of CD59B mRNA CTD PMID:26251327 3,4-methylenedioxymethamphetamine increases methylation EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased methylation of CD59B promoter CTD PMID:26251327 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:736600 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CD59 mRNA CTD PMID:28628672 3-methylcholanthrene increases mutagenesis ISO RGD:736600 6480464 Methylcholanthrene results in increased mutagenesis of CD59 protein CTD PMID:17045307 4,4'-sulfonyldiphenol multiple interactions ISO RGD:736600 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CD59 mRNA CTD PMID:28628672 4-nitroquinoline N-oxide multiple interactions ISO RGD:2311 6480464 [4-Nitroquinoline-1-oxide results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein, [4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein CTD PMID:19965957 , PMID:20202993 6-propyl-2-thiouracil decreases expression ISO RGD:2311 6480464 Propylthiouracil results in decreased expression of CD59 mRNA CTD PMID:24780913 7,12-dimethyltetraphene multiple interactions ISO RGD:2311 6480464 [9 more ... CTD PMID:19965957 , PMID:20202993 aflatoxin B1 affects expression ISO RGD:736600 6480464 Aflatoxin B1 affects the expression of CD59 protein CTD PMID:20106945 all-trans-retinoic acid increases expression ISO RGD:736600 6480464 Tretinoin results in increased expression of CD59 mRNA CTD PMID:33167477 alpha-phellandrene decreases expression ISO RGD:736600 6480464 alpha phellandrene results in decreased expression of CD59A mRNA CTD PMID:25075043 ammonium chloride affects expression ISO RGD:2311 6480464 Ammonium Chloride affects the expression of CD59 mRNA CTD PMID:16483693 aristolochic acid A decreases expression ISO RGD:736600 6480464 aristolochic acid I results in decreased expression of CD59 mRNA CTD PMID:33212167 aristolochic acids decreases lipidation ISO RGD:2311 6480464 Aristolochic Acids results in decreased lipidation of CD59 protein CTD PMID:27931811 arsane affects methylation ISO RGD:736600 6480464 Arsenic affects the methylation of CD59 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:736600 6480464 Arsenic affects the methylation of CD59 gene CTD PMID:25304211 benzene increases expression ISO RGD:736600 6480464 Benzene results in increased expression of CD59 mRNA CTD PMID:16188091 benzo[a]pyrene increases expression ISO RGD:736600 6480464 Benzo(a)pyrene results in increased expression of CD59 mRNA CTD PMID:18247414 benzo[a]pyrene affects methylation ISO RGD:736600 6480464 Benzo(a)pyrene affects the methylation of CD59 3' UTR, Benzo(a)pyrene affects the methylation of CD59 5' UTR CTD PMID:27901495 , PMID:30157460 benzo[a]pyrene increases methylation ISO RGD:736600 6480464 Benzo(a)pyrene results in increased methylation of CD59 promoter CTD PMID:27901495 benzo[a]pyrene decreases lipidation ISO RGD:2311 6480464 Benzo(a)pyrene results in decreased lipidation of CD59 protein CTD PMID:27931811 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CD59B mRNA CTD PMID:22228805 benzo[a]pyrene multiple interactions ISO RGD:2311 6480464 [Benzo(a)pyrene results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein, [Benzo(a)pyrene results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein CTD PMID:19965957 , PMID:20202993 benzo[a]pyrene increases mutagenesis ISO RGD:736600 6480464 Benzo(a)pyrene results in increased mutagenesis of CD59 protein CTD PMID:17045307 benzo[a]pyrene diol epoxide I increases expression ISO RGD:736600 6480464 7 more ... CTD PMID:19150397 bisphenol A multiple interactions ISO RGD:2311 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of CD59 mRNA CTD PMID:26496021 bisphenol A decreases expression ISO RGD:2311 6480464 bisphenol A results in decreased expression of CD59 mRNA CTD PMID:34947998 bisphenol A decreases expression ISO RGD:736600 6480464 bisphenol A results in decreased expression of CD59 mRNA CTD PMID:29275510 bisphenol A increases expression ISO RGD:2311 6480464 bisphenol A results in increased expression of CD59 mRNA CTD PMID:25181051 more ... Bisphenol B increases expression ISO RGD:736600 6480464 bisphenol B results in increased expression of CD59 protein CTD PMID:34186270 bisphenol F increases expression ISO RGD:736600 6480464 bisphenol F results in increased expression of CD59 protein CTD PMID:34186270 butanal decreases expression ISO RGD:736600 6480464 butyraldehyde results in decreased expression of CD59 mRNA CTD PMID:26079696 cadmium atom multiple interactions ISO RGD:736600 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CD59 mRNA CTD PMID:35301059 cadmium dichloride multiple interactions ISO RGD:736600 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CD59 mRNA CTD PMID:35301059 caffeine increases expression ISO RGD:736600 6480464 Caffeine results in increased expression of CD59 protein CTD PMID:31195006 calcitriol increases expression ISO RGD:736600 6480464 Calcitriol results in increased expression of CD59 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:736600 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of CD59 mRNA CTD PMID:21592394 cannabidiol decreases expression ISO RGD:736600 6480464 Cannabidiol results in decreased expression of CD59 mRNA CTD PMID:27932991 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of CD59B mRNA CTD PMID:25620056 CGP 52608 multiple interactions ISO RGD:736600 6480464 CGP 52608 promotes the reaction [RORA protein binds to CD59 gene] CTD PMID:28238834 chlorambucil decreases lipidation ISO RGD:2311 6480464 Chlorambucil results in decreased lipidation of CD59 protein CTD PMID:27931811 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CD59B mRNA CTD PMID:20938992 cisplatin multiple interactions ISO RGD:736600 6480464 [Cisplatin co-treated with Etoposide] results in decreased expression of CD59 protein, [Cisplatin co-treated with jinfukang] results in decreased expression of CD59 mRNA CTD PMID:21826740 , PMID:27392435 cisplatin decreases expression ISO RGD:736600 6480464 Cisplatin results in decreased expression of CD59 protein CTD PMID:24798381 cisplatin decreases lipidation ISO RGD:2311 6480464 Cisplatin results in decreased lipidation of CD59 protein CTD PMID:27931811 cobalt dichloride increases expression ISO RGD:2311 6480464 cobaltous chloride results in increased expression of CD59 mRNA CTD PMID:24386269 copper(II) sulfate increases expression ISO RGD:736600 6480464 Copper Sulfate results in increased expression of CD59 mRNA CTD PMID:19549813 corticosterone increases expression ISO RGD:2311 6480464 Corticosterone results in increased expression of CD59 mRNA CTD PMID:15755911 coumestrol multiple interactions ISO RGD:736600 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CD59 mRNA CTD PMID:19167446 crocidolite asbestos increases mutagenesis ISO RGD:736600 6480464 Asbestos, Crocidolite results in increased mutagenesis of CD59 gene CTD PMID:12361925 , PMID:15033018 crocidolite asbestos multiple interactions ISO RGD:736600 6480464 CAT protein inhibits the reaction [Asbestos more ... CTD PMID:12361925 , PMID:15033018 cyclosporin A decreases expression ISO RGD:736600 6480464 Cyclosporine results in decreased expression of CD59 mRNA CTD PMID:20106945 more ... dexamethasone multiple interactions ISO RGD:736600 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CD59 mRNA CTD PMID:28628672 dibutyl phthalate increases expression ISO RGD:2311 6480464 Dibutyl Phthalate results in increased expression of CD59 mRNA CTD PMID:21266533 dicrotophos decreases expression ISO RGD:736600 6480464 dicrotophos results in decreased expression of CD59 mRNA CTD PMID:28302478 dimethyl sulfoxide multiple interactions ISO RGD:736600 6480464 Dimethyl Sulfoxide inhibits the reaction [Asbestos more ... CTD PMID:12361925 , PMID:15033018 diuron decreases expression ISO RGD:2311 6480464 Diuron results in decreased expression of CD59 mRNA CTD PMID:21551480 dorsomorphin multiple interactions ISO RGD:736600 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD59 mRNA CTD PMID:27188386 doxorubicin increases response to substance EXP 6480464 CD59 gene mutant form results in increased susceptibility to Doxorubicin CTD PMID:16951374 doxorubicin decreases expression ISO RGD:736600 6480464 Doxorubicin results in decreased expression of CD59 mRNA CTD PMID:29803840 doxorubicin affects expression ISO RGD:736600 6480464 Doxorubicin affects the expression of CD59 protein CTD PMID:29385562 endosulfan decreases expression ISO RGD:2311 6480464 Endosulfan results in decreased expression of CD59 mRNA CTD PMID:29391264 Enterolactone multiple interactions ISO RGD:736600 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CD59 mRNA CTD PMID:19167446 ethidium increases mutagenesis ISO RGD:736600 6480464 Ethidium results in increased mutagenesis of CD59 protein CTD PMID:17045307 ethyl methanesulfonate increases mutagenesis ISO RGD:736600 6480464 Ethyl Methanesulfonate results in increased mutagenesis of CD59 protein CTD PMID:17045307 ethyl methanesulfonate decreases lipidation ISO RGD:2311 6480464 Ethyl Methanesulfonate results in decreased lipidation of CD59 protein CTD PMID:27931811 etoposide multiple interactions ISO RGD:736600 6480464 [Cisplatin co-treated with Etoposide] results in decreased expression of CD59 protein CTD PMID:21826740 fenthion increases expression EXP 6480464 Fenthion results in increased expression of CD59B mRNA CTD PMID:34813904 fipronil increases expression ISO RGD:2311 6480464 fipronil results in increased expression of CD59 mRNA CTD PMID:23962444 flavonoids increases expression ISO RGD:2311 6480464 Flavonoids results in increased expression of CD59 mRNA CTD PMID:18035473 flutamide increases expression ISO RGD:2311 6480464 Flutamide results in increased expression of CD59 mRNA CTD PMID:24136188 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CD59B mRNA CTD PMID:20938992 gallic acid decreases expression ISO RGD:736600 6480464 Gallic Acid results in decreased expression of CD59 mRNA CTD PMID:34408198 glafenine decreases expression ISO RGD:2311 6480464 Glafenine results in decreased expression of CD59 mRNA CTD PMID:24136188 glyphosate decreases expression ISO RGD:2311 6480464 glyphosate results in decreased expression of CD59 mRNA CTD PMID:26302742 hexachlorobenzene increases expression ISO RGD:2311 6480464 Hexachlorobenzene results in increased expression of CD59 mRNA CTD PMID:15159207 hydrogen peroxide increases mutagenesis ISO RGD:736600 6480464 Hydrogen Peroxide results in increased mutagenesis of CD59 gene, Hydrogen Peroxide results in increased mutagenesis of CD59 protein CTD PMID:12361925 , PMID:17045307 hydrogen peroxide multiple interactions ISO RGD:736600 6480464 CAT protein inhibits the reaction [Hydrogen Peroxide results in increased mutagenesis of CD59 gene], Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased mutagenesis of CD59 gene] CTD PMID:12361925 indometacin multiple interactions ISO RGD:736600 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CD59 mRNA CTD PMID:28628672 ivermectin decreases expression ISO RGD:736600 6480464 Ivermectin results in decreased expression of CD59 protein CTD PMID:32959892 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CD59B mRNA CTD PMID:20938992 lead diacetate increases mutagenesis ISO RGD:736600 6480464 lead acetate results in increased mutagenesis of CD59 protein CTD PMID:17045307 lead(0) affects expression ISO RGD:736600 6480464 Lead affects the expression of CD59 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:736600 6480464 Lead affects the expression of CD59 mRNA CTD PMID:28903495 melphalan decreases lipidation ISO RGD:2311 6480464 Melphalan results in decreased lipidation of CD59 protein CTD PMID:27931811 methidathion decreases expression EXP 6480464 methidathion results in decreased expression of CD59B mRNA CTD PMID:34813904 methyl methanesulfonate decreases expression ISO RGD:736600 6480464 Methyl Methanesulfonate results in decreased expression of CD59 mRNA CTD PMID:23649840 mitomycin C increases mutagenesis ISO RGD:736600 6480464 Mitomycin results in increased mutagenesis of CD59 protein CTD PMID:17045307 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:736600 6480464 Ethylnitrosourea results in increased mutagenesis of CD59 protein CTD PMID:17045307 N-ethyl-N-nitrosourea decreases lipidation ISO RGD:2311 6480464 Ethylnitrosourea results in decreased lipidation of CD59 protein CTD PMID:27931811 N-ethyl-N-nitrosourea multiple interactions ISO RGD:2311 6480464 [Ethylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein, [Ethylnitrosourea results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein CTD PMID:19965957 , PMID:20202993 N-methyl-N'-nitro-N-nitrosoguanidine increases mutagenesis ISO RGD:736600 6480464 Methylnitronitrosoguanidine results in increased mutagenesis of CD59 protein CTD PMID:17045307 N-methyl-N-nitrosourea multiple interactions ISO RGD:2311 6480464 [Methylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein, [Methylnitrosourea results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein CTD PMID:19965957 , PMID:20202993 N-methyl-N-nitrosourea decreases lipidation ISO RGD:2311 6480464 Methylnitrosourea results in decreased lipidation of CD59 protein CTD PMID:27931811 nicotine increases expression ISO RGD:736600 6480464 Nicotine results in increased expression of CD59 mRNA CTD PMID:18247414 nimesulide decreases expression ISO RGD:2311 6480464 nimesulide results in decreased expression of CD59 mRNA CTD PMID:24136188 paracetamol increases expression ISO RGD:736600 6480464 Acetaminophen results in increased expression of CD59 mRNA CTD PMID:22230336 perfluorooctanoic acid decreases expression ISO RGD:2311 6480464 perfluorooctanoic acid results in decreased expression of CD59 mRNA CTD PMID:19162173 phenylmercury acetate increases expression ISO RGD:736600 6480464 Phenylmercuric Acetate results in increased expression of CD59 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:736600 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD59 mRNA CTD PMID:27188386 quercetin increases expression ISO RGD:736600 6480464 Quercetin results in increased expression of CD59 mRNA CTD PMID:21632981 rac-lactic acid decreases expression ISO RGD:736600 6480464 Lactic Acid results in decreased expression of CD59 mRNA CTD PMID:30851411 rotenone decreases expression ISO RGD:736600 6480464 Rotenone results in decreased expression of CD59 mRNA CTD PMID:29955902 S-butyl-DL-homocysteine (S,R)-sulfoximine increases mutagenesis ISO RGD:736600 6480464 Buthionine Sulfoximine results in increased mutagenesis of CD59 gene CTD PMID:15033018 SB 431542 multiple interactions ISO RGD:736600 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD59 mRNA CTD PMID:27188386 SB 431542 increases expression ISO RGD:736600 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of CD59 protein CTD PMID:25670856 serpentine asbestos increases mutagenesis ISO RGD:736600 6480464 Asbestos, Serpentine results in increased mutagenesis of CD59 protein CTD PMID:17045307 sodium arsenite decreases expression ISO RGD:736600 6480464 sodium arsenite results in decreased expression of CD59 mRNA CTD PMID:25879800 sodium arsenite increases mutagenesis ISO RGD:736600 6480464 sodium arsenite results in increased mutagenesis of CD59 protein CTD PMID:17045307 sulfasalazine decreases expression ISO RGD:2311 6480464 Sulfasalazine results in decreased expression of CD59 mRNA, Sulfasalazine results in decreased expression of CD59 protein CTD PMID:15625186 , PMID:17166698 temozolomide decreases expression ISO RGD:736600 6480464 Temozolomide results in decreased expression of CD59 mRNA CTD PMID:31758290 temozolomide decreases lipidation ISO RGD:2311 6480464 temozolomide results in decreased lipidation of CD59 protein CTD PMID:27931811 testosterone multiple interactions ISO RGD:736600 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of CD59 mRNA CTD PMID:21592394 testosterone decreases expression EXP 6480464 Testosterone deficiency results in decreased expression of CD59B mRNA CTD PMID:33848595 testosterone multiple interactions ISO RGD:2311 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of CD59 mRNA CTD PMID:26496021 testosterone increases expression ISO RGD:736600 6480464 Testosterone results in increased expression of CD59 mRNA CTD PMID:21592394 tetrachloromethane decreases expression ISO RGD:2311 6480464 Carbon Tetrachloride results in decreased expression of CD59 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions ISO RGD:2311 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CD59 mRNA] CTD PMID:31150632 thioacetamide decreases expression ISO RGD:2311 6480464 Thioacetamide results in decreased expression of CD59 mRNA CTD PMID:34492290 Thiotepa decreases lipidation ISO RGD:2311 6480464 Thiotepa results in decreased lipidation of CD59 protein CTD PMID:27931811 trichloroethene multiple interactions EXP 6480464 CD59 protein inhibits the reaction [Trichloroethylene results in decreased expression of CUBN mRNA] more ... CTD PMID:31618666 Triptolide increases expression ISO RGD:2311 6480464 triptolide results in increased expression of CD59 protein CTD PMID:32519852 triptonide increases expression EXP 6480464 triptonide results in increased expression of CD59B mRNA CTD PMID:33045310 urethane decreases lipidation ISO RGD:2311 6480464 Urethane results in decreased lipidation of CD59 protein CTD PMID:27931811 valproic acid decreases expression ISO RGD:736600 6480464 Valproic Acid results in decreased expression of CD59 mRNA CTD PMID:29154799 valproic acid increases expression ISO RGD:2311 6480464 Valproic Acid results in increased expression of CD59 mRNA CTD PMID:23665938 valproic acid increases expression ISO RGD:736600 6480464 Valproic Acid results in increased expression of CD59 mRNA CTD PMID:23179753 , PMID:27188386 zoledronic acid increases expression ISO RGD:736600 6480464 zoledronic acid results in increased expression of CD59 mRNA CTD PMID:24714768