Hsd3b6 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6) - Rat Genome Database

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Gene: Hsd3b6 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6) Mus musculus
Analyze
No known orthologs.
Symbol: Hsd3b6
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
RGD ID: 1615185
MGI Page MGI
Description: Predicted to enable 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity and steroid delta-isomerase activity. Predicted to be involved in C21-steroid hormone biosynthetic process; androgen biosynthetic process; and negative regulation of iron ion transport. Predicted to be located in several cellular components, including intercellular bridge; mitochondrial envelope; and nucleolus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; brain; cardiovascular system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type VI; 3-beta-HSD VI; 3beta-HSD VI; D19210; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 pseudogene; hydroxysteroid dehydrogenase-6, delta<5>-3-beta
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39398,712,820 - 98,721,759 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl398,712,820 - 98,721,759 (-)EnsemblGRCm39 Ensembl
GRCm38398,805,504 - 98,814,443 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,805,504 - 98,814,443 (-)EnsemblGRCm38mm10GRCm38
MGSCv37398,609,427 - 98,618,366 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36398,934,566 - 98,943,498 (-)NCBIMGSCv36mm8
Celera3100,140,076 - 100,149,017 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.88NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Opposite effects of prolactin and corticosterone on the expression and activity of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in rat skin. Couet J, etal., J Invest Dermatol. 1994 Jul;103(1):60-4.
2. Endogenous ouabain: upregulation of steroidogenic genes in hypertensive hypothalamus but not adrenal. Murrell JR, etal., Circulation. 2005 Aug 30;112(9):1301-8. Epub 2005 Aug 22.
3. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure. Rosmond R, etal., Biochem Biophys Res Commun. 2002 Apr 26;293(1):629-32.
Additional References at PubMed
PMID:8924213   PMID:9075693   PMID:9492048   PMID:10103023   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11773066   PMID:12466851   PMID:12477932   PMID:14665668  
PMID:14681479   PMID:16141072   PMID:16141073   PMID:17062636   PMID:18583422   PMID:20023637   PMID:21267068   PMID:21286865   PMID:21873635   PMID:23874215   PMID:24075909   PMID:25668066  
PMID:25713029   PMID:25933105   PMID:26108225   PMID:26269506   PMID:27121848   PMID:27732090   PMID:28935707   PMID:30518625   PMID:30793514   PMID:33913480   PMID:34321999   PMID:35317954  
PMID:37117756   PMID:38521877  


Genomics

Variants

.
Variants in Hsd3b6
255 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:364
Count of miRNA genes:160
Interacting mature miRNAs:165
Transcripts:ENSMUST00000029463, ENSMUST00000170847
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1301277nctm1_mNakano cataract modifier 1 (mouse)Not determined397698638100373060Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse


Sequence


Ensembl Acc Id: ENSMUST00000029463   ⟹   ENSMUSP00000029463
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl398,712,820 - 98,721,759 (-)Ensembl
GRCm38.p6 Ensembl398,805,504 - 98,814,443 (-)Ensembl
Ensembl Acc Id: ENSMUST00000170847   ⟹   ENSMUSP00000129911
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl398,712,821 - 98,718,424 (-)Ensembl
GRCm38.p6 Ensembl398,805,505 - 98,811,108 (-)Ensembl
Ensembl Acc Id: ENSMUST00000196706
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl398,713,793 - 98,721,738 (-)Ensembl
GRCm38.p6 Ensembl398,806,477 - 98,814,422 (-)Ensembl
RefSeq Acc Id: NM_013821   ⟹   NP_038849
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39398,712,820 - 98,721,759 (-)NCBI
GRCm38398,805,504 - 98,814,443 (-)ENTREZGENE
MGSCv37398,609,427 - 98,618,366 (-)RGD
Celera3100,140,076 - 100,149,017 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_038849   ⟸   NM_013821
- UniProtKB: Q3UQN7 (UniProtKB/Swiss-Prot),   O35469 (UniProtKB/Swiss-Prot),   Q7TPU0 (UniProtKB/TrEMBL),   Q76CU3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000029463   ⟸   ENSMUST00000029463
Ensembl Acc Id: ENSMUSP00000129911   ⟸   ENSMUST00000170847
Protein Domains
3-beta hydroxysteroid dehydrogenase/isomerase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35469-F1-model_v2 AlphaFold O35469 1-373 view protein structure

Promoters
RGD ID:6881778
Promoter ID:EPDNEW_M4340
Type:initiation region
Name:Hsd3b6_1
Description:Mus musculus hydroxy-delta-5-steroid dehydrogenase, 3 beta- andsteroid delta-isomerase 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38398,814,443 - 98,814,503EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109598 AgrOrtholog
Ensembl Genes ENSMUSG00000027869 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000029463 ENTREZGENE
  ENSMUST00000029463.13 UniProtKB/Swiss-Prot
  ENSMUST00000170847.2 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 3Beta_OHSteriod_DH/Estase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipid_A_modif_metabolic_enz UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15497 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109598 ENTREZGENE
NCBI Gene 15497 ENTREZGENE
PANTHER BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 3Beta_HSD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsd3b6 PhenoGen
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 3BHS6_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UQN7 ENTREZGENE
  Q541Q1_MOUSE UniProtKB/TrEMBL
  Q76CU3 ENTREZGENE, UniProtKB/TrEMBL
  Q7TPU0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q3UQN7 UniProtKB/Swiss-Prot