Foxc2 (forkhead box C2) - Rat Genome Database

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Gene: Foxc2 (forkhead box C2) Mus musculus
Symbol: Foxc2
Name: forkhead box C2
RGD ID: 1614461
Description: Enables several functions, including DNA-binding transcription activator activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of vascular wound healing; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell surface receptor signaling pathway; circulatory system development; and kidney development. Predicted to be located in nuclear body. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; limb long bone; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including lymphedema; lymphedema-distichiasis syndrome; obesity; ptosis; and type 2 diabetes mellitus. Orthologous to human FOXC2 (forkhead box C2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BF-3; brain factor 3; Fkh14; forkhead box protein C2; forkhead homolog 14; forkhead-related protein FKHL14; Hfhbf3; mesenchyme fork head protein 1; MFH-1; Mfh1; transcription factor FKH-14
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm398121,842,910 - 121,845,634 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8121,842,910 - 121,845,634 (+)EnsemblGRCm39 Ensembl
GRCm388121,116,171 - 121,118,895 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,116,171 - 121,118,895 (+)EnsemblGRCm38mm10GRCm38
MGSCv378123,640,071 - 123,642,795 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368124,002,560 - 124,004,872 (+)NCBIMGSCv36mm8
Celera8125,334,251 - 125,336,975 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
abacavir  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldrin  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
CHIR 99021  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cocaine  (ISO)
copper(II) chloride  (ISO)
dabigatran  (ISO)
decabromodiphenyl ether  (ISO)
diallyl disulfide  (ISO)
dimethylselenide  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Doxylamine succinate  (ISO)
endosulfan  (ISO)
ethylene glycol  (ISO)
folic acid  (EXP)
genistein  (EXP)
hydrazines  (EXP)
hydroxyl  (ISO)
isotretinoin  (ISO)
L-methionine  (EXP)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (EXP)
nilotinib  (ISO)
nitrofen  (ISO)
ozone  (ISO)
panobinostat  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
pirinixic acid  (EXP)
rac-lactic acid  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
thalidomide  (ISO)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure morphogenesis  (IBA)
apoptotic process involved in outflow tract morphogenesis  (IGI)
artery morphogenesis  (IMP)
blood vessel development  (IGI)
blood vessel diameter maintenance  (IGI)
blood vessel remodeling  (IGI)
branching involved in blood vessel morphogenesis  (IGI)
camera-type eye development  (IMP)
cardiac muscle cell proliferation  (IGI)
cell differentiation  (IBA)
cell population proliferation  (IMP)
collagen fibril organization  (IMP)
embryonic cranial skeleton morphogenesis  (IMP)
embryonic heart tube development  (IGI)
embryonic skeletal system morphogenesis  (IMP)
embryonic viscerocranium morphogenesis  (IMP)
glomerular endothelium development  (IMP)
glomerular mesangial cell development  (IMP)
heart development  (IGI,IMP,ISO)
heart morphogenesis  (IGI)
insulin receptor signaling pathway  (ISO,ISS)
kidney development  (IMP)
lymph vessel development  (IGI)
lymphangiogenesis  (ISO,ISS)
metanephros development  (IMP)
negative regulation of apoptotic process involved in outflow tract morphogenesis  (IGI)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IDA)
neural crest cell development  (IGI)
Notch signaling pathway  (IGI)
ossification  (IMP)
paraxial mesoderm formation  (IGI)
paraxial mesodermal cell fate commitment  (IMP)
podocyte differentiation  (IMP)
positive regulation of cell adhesion mediated by integrin  (IDA)
positive regulation of cell migration involved in sprouting angiogenesis  (IDA)
positive regulation of DNA-templated transcription  (IDA,ISO,ISS)
positive regulation of endothelial cell migration  (IDA)
positive regulation of integrin activation  (IC)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
positive regulation of vascular wound healing  (IDA)
regulation of DNA-templated transcription  (IEA)
regulation of organ growth  (IGI)
regulation of transcription by RNA polymerase II  (IBA)
response to hormone  (ISO,ISS)
skeletal system development  (IGI,IMP)
somitogenesis  (IGI)
ureteric bud development  (IMP)
vascular endothelial growth factor receptor signaling pathway  (IGI)
ventricular cardiac muscle tissue morphogenesis  (IGI)

Cellular Component
nuclear body  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alisphenoid bone morphology  (IAGP)
abnormal aortic arch morphology  (IAGP)
abnormal aortic valve morphology  (IAGP)
abnormal basisphenoid bone morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal branching involved in ureteric bud morphogenesis  (IAGP)
abnormal canal of Schlemm morphology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal ciliary body morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal costovertebral joint morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal dermomyotome development  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal dorsal-ventral polarity of the somites  (IAGP)
abnormal eye morphology  (IAGP)
abnormal fourth pharyngeal arch artery morphology  (IAGP)
abnormal glomerular mesangium morphology  (IAGP)
abnormal gonial bone morphology  (IAGP)
abnormal head development  (IAGP)
abnormal heartbeat  (IAGP)
abnormal iridocorneal angle  (IAGP)
abnormal iris morphology  (IAGP)
abnormal iris pigment epithelium  (IAGP)
abnormal lymph circulation  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal mesangial cell morphology  (IAGP)
abnormal mesonephros morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal multipotent stem cell morphology  (IAGP)
abnormal muscle development  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal orbit morphology  (IAGP)
abnormal otic vesicle development  (IAGP)
abnormal palatine bone horizontal plate morphology  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal pharyngeal pouch morphology  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal presphenoid bone morphology  (IAGP)
abnormal pterygoid process morphology  (IAGP)
abnormal pulmonary valve morphology  (IAGP)
abnormal renal glomerulus basement membrane morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal sclerotome morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal somite shape  (IAGP)
abnormal sphenoid bone morphology  (IAGP)
abnormal subarachnoid space development  (IAGP)
abnormal superior vena cava morphology  (IAGP)
abnormal supraoccipital bone morphology  (IAGP)
abnormal third pharyngeal arch artery morphology  (IAGP)
abnormal thoracic duct morphology  (IAGP)
abnormal trabecular meshwork morphology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vertebrae development  (IAGP)
abnormal vertebral arch morphology  (IAGP)
abnormal vertebral body morphology  (IAGP)
abnormal vertebral lamina morphology  (IAGP)
abnormal vertebral pedicle morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
absent cartilage  (IAGP)
absent glomerular endothelium fenestra  (IAGP)
absent incus  (IAGP)
absent intervertebral disk  (IAGP)
absent kidney  (IAGP)
absent palatine bone  (IAGP)
absent palatine bone horizontal plate  (IAGP)
absent paraxial mesoderm  (IAGP)
absent podocyte foot process  (IAGP)
absent podocyte slit diaphragm  (IAGP)
absent presphenoid bone  (IAGP)
absent second pharyngeal arch  (IAGP)
absent soft palate  (IAGP)
absent somites  (IAGP)
absent stapes  (IAGP)
absent supraoccipital bone  (IAGP)
aortic arch coarctation  (IAGP)
atelectasis  (IAGP)
blepharoptosis  (IAGP)
cataract  (IAGP)
cleft palate  (IAGP)
cleft secondary palate  (IAGP)
cornea abrasion  (IAGP)
cornea ulcer  (IAGP)
cornea vascularization  (IAGP)
decreased angiogenesis  (IAGP)
decreased body length  (IAGP)
decreased embryo size  (IAGP)
decreased glomerular capillary number  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased rib number  (IAGP)
decreased somite size  (IAGP)
decreased tympanic ring size  (IAGP)
dilated dorsal aorta  (IAGP)
dilated glomerular capillary  (IAGP)
dilated heart atrium  (IAGP)
disorganized myocardium  (IAGP)
double ureter  (IAGP)
duplex kidney  (IAGP)
ectopic ureteric bud  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged pericardium  (IAGP)
enlarged third pharyngeal arch artery  (IAGP)
extremity edema  (IAGP)
eye opacity  (IAGP)
eyelids open at birth  (IAGP)
fusion of atlas and odontoid process  (IAGP)
glomerulus hemorrhage  (IAGP)
gonial bone hypoplasia  (IAGP)
head mesenchyme hypoplasia  (IAGP)
hydronephrosis  (IAGP)
hydrops fetalis  (IAGP)
hydroureter  (IAGP)
incomplete rostral neuropore closure  (IAGP)
increased brown adipose tissue amount  (IAGP)
increased lymph node number  (IAGP)
interrupted aortic arch, type b  (IAGP)
intracranial hemorrhage  (IAGP)
iris stroma hypoplasia  (IAGP)
kinked neural tube  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lymphangiectasis  (IAGP)
lymphatic vessel hyperplasia  (IAGP)
lymphedema  (IAGP)
malleus hypoplasia  (IAGP)
meningomyelocele  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular distichiasis  (IAGP)
pericardial edema  (IAGP)
pericardial effusion  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
periorbital edema  (IAGP)
persistent truncus arteriosus  (IAGP)
renal hypoplasia  (IAGP)
rib fusion  (IAGP)
short vertebral body  (IAGP)
short vertebral column  (IAGP)
small basioccipital bone  (IAGP)
small exoccipital bone  (IAGP)
small first pharyngeal arch  (IAGP)
small heart  (IAGP)
small interparietal bone  (IAGP)
small kidney  (IAGP)
small mandible  (IAGP)
small Meckel's cartilage  (IAGP)
small pterygoid bone  (IAGP)
small temporal bone squamous part  (IAGP)
small vertebral body  (IAGP)
spina bifida  (IAGP)
spina bifida occulta  (IAGP)
spinal hemorrhage  (IAGP)
thick aortic valve cusps  (IAGP)
thick pulmonary valve cusps  (IAGP)
thin myocardium  (IAGP)
trabecula carnea hypoplasia  (IAGP)
ventricle myocardium hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
vertebral fusion  (IAGP)

References - curated
# Reference Title Reference Citation
1. The FOXC2 C-512T polymorphism is associated with obesity and dyslipidemia. Carlsson E, etal., Obes Res. 2004 Nov;12(11):1738-43.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7683413   PMID:7689224   PMID:8325367   PMID:8375339   PMID:8661058   PMID:8666231   PMID:8674414   PMID:8889548   PMID:9106663   PMID:9169153   PMID:9409679   PMID:9545561  
PMID:9676429   PMID:10349636   PMID:10364424   PMID:10479458   PMID:10572046   PMID:10660670   PMID:10704385   PMID:10767326   PMID:10886375   PMID:10950932   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:11551504   PMID:11562355   PMID:11923482   PMID:11943768   PMID:12015277   PMID:12223415   PMID:12413905   PMID:12466851   PMID:12477932   PMID:12533514   PMID:12719382  
PMID:12812790   PMID:12925591   PMID:14512019   PMID:14648841   PMID:14681479   PMID:15107405   PMID:15196959   PMID:15277530   PMID:15322537   PMID:15342473   PMID:15465483   PMID:15618518  
PMID:15664398   PMID:16141072   PMID:16141073   PMID:16412416   PMID:16459152   PMID:16498405   PMID:16602821   PMID:16678147   PMID:16839542   PMID:17321697   PMID:17506979   PMID:17537911  
PMID:18187037   PMID:18233958   PMID:18287559   PMID:18367164   PMID:18424556   PMID:18545664   PMID:18579532   PMID:18582859   PMID:18621714   PMID:19369394   PMID:19398761   PMID:19475495  
PMID:19540201   PMID:19591821   PMID:19686679   PMID:19825936   PMID:19879845   PMID:19935708   PMID:20059953   PMID:20059958   PMID:20060810   PMID:20960542   PMID:21143873   PMID:21267068  
PMID:21270254   PMID:21515254   PMID:21614587   PMID:21640215   PMID:21731775   PMID:21873635   PMID:21909098   PMID:21931791   PMID:22012621   PMID:22306086   PMID:22365545   PMID:22511595  
PMID:22522965   PMID:22723296   PMID:22736606   PMID:22921202   PMID:22988430   PMID:23023706   PMID:23369715   PMID:23502673   PMID:23645207   PMID:23741013   PMID:23862012   PMID:23904126  
PMID:24055172   PMID:24146773   PMID:24310815   PMID:24361262   PMID:24370450   PMID:24590274   PMID:24705356   PMID:24785830   PMID:24927569   PMID:24952961   PMID:25044936   PMID:25202984  
PMID:25576926   PMID:25808752   PMID:26027726   PMID:26079578   PMID:26113535   PMID:26214525   PMID:26299482   PMID:26389677   PMID:26542011   PMID:26542959   PMID:26839363   PMID:26953188  
PMID:27193493   PMID:27214551   PMID:27313318   PMID:27606604   PMID:27771509   PMID:27783871   PMID:27819350   PMID:27991863   PMID:28179430   PMID:28223138   PMID:28250050   PMID:28253399  
PMID:28506991   PMID:28675425   PMID:28705793   PMID:28754980   PMID:28794157   PMID:29035278   PMID:29322554   PMID:29449451   PMID:29555813   PMID:29649409   PMID:29688375   PMID:30021842  
PMID:30104731   PMID:30332639   PMID:30352686   PMID:30355615   PMID:30376688   PMID:30482854   PMID:30633332   PMID:30796970   PMID:31062503   PMID:31319059   PMID:31461654   PMID:31582413  
PMID:31659103   PMID:31710307   PMID:32015493   PMID:32170602   PMID:32182215   PMID:32259372   PMID:32510325   PMID:32546759   PMID:33060128   PMID:33127760   PMID:33414188   PMID:33667029  
PMID:33681192   PMID:33934370   PMID:34256037   PMID:34263740   PMID:34272244   PMID:34331943   PMID:34403370   PMID:34446717   PMID:34731528   PMID:35108538   PMID:35177595   PMID:35236825  
PMID:35512705   PMID:36274060   PMID:36736300   PMID:37072887   PMID:37154714   PMID:37414529   PMID:37414855   PMID:37767708   PMID:38374152   PMID:38517430  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm398121,842,910 - 121,845,634 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8121,842,910 - 121,845,634 (+)EnsemblGRCm39 Ensembl
GRCm388121,116,171 - 121,118,895 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,116,171 - 121,118,895 (+)EnsemblGRCm38mm10GRCm38
MGSCv378123,640,071 - 123,642,795 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368124,002,560 - 124,004,872 (+)NCBIMGSCv36mm8
Celera8125,334,251 - 125,336,975 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.33NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381686,566,829 - 86,569,728 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1686,566,829 - 86,569,728 (+)EnsemblGRCh38hg38GRCh38
GRCh371686,600,435 - 86,603,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361685,158,443 - 85,159,948 (+)NCBINCBI36Build 36hg18NCBI36
Build 341685,158,442 - 85,159,948NCBI
Celera1670,901,820 - 70,903,503 (+)NCBICelera
Cytogenetic Map16q24.1NCBI
HuRef1672,340,749 - 72,342,345 (+)NCBIHuRef
CHM1_11688,012,585 - 88,014,267 (+)NCBICHM1_1
T2T-CHM13v2.01692,635,146 - 92,638,044 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81966,094,718 - 66,097,420 (+)NCBIGRCr8
mRatBN7.21949,186,034 - 49,188,736 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1949,185,662 - 49,188,737 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1955,977,317 - 55,980,018 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01956,661,030 - 56,663,732 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01958,875,485 - 58,878,187 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01953,044,379 - 53,047,081 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1953,044,379 - 53,047,081 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01963,788,037 - 63,790,739 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11228,513,040 - 228,513,088 (-)NCBI
Celera1948,432,333 - 48,435,035 (+)NCBICelera
Cytogenetic Map19q12NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21896,322,973 - 96,325,904 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116102,240,170 - 102,243,107 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01667,237,476 - 67,239,545 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11686,569,509 - 86,571,878 (+)NCBIpanpan1.1PanPan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1566,234,336 - 66,296,007 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl566,294,176 - 66,295,693 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha566,246,461 - 66,254,587 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0566,455,805 - 66,464,138 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1566,479,102 - 66,487,010 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0566,314,300 - 66,322,205 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0566,727,335 - 66,735,464 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934926,482,456 - 26,485,324 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366412,236,873 - 2,238,375 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366412,236,224 - 2,238,501 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl62,552,862 - 2,554,367 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.162,552,141 - 2,555,041 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.262,756,138 - 2,761,356 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1571,951,980 - 71,955,021 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl571,952,632 - 71,954,134 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660473,750,917 - 3,753,843 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247462,632,619 - 2,634,085 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247462,632,547 - 2,634,867 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Foxc2
136 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:223
Count of miRNA genes:199
Interacting mature miRNAs:209
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)897626632130127694Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined898563635130127694Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8103443553127781786Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8105033977130127694Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8105033977130127694Mouse
14746994Manh65_mmandible shape 65 (mouse)8106489629130127694Mouse
10412273Fcd1_mfunctional capillary density 1 (mouse)Not determined8110415083130127694Mouse
10412274Leci1_mleukocyte endothelial cell interactions 1 (mouse)Not determined8110415083130127694Mouse
12904938Edlmmq7_mextensor digitorum longus muscle mass QTL 7 (mouse)8111481497130127694Mouse
12904960Gmmq6_mgastrocnemius muscle mass QTL 6 (mouse)8111481497130127694Mouse
4141546Mrdq3_mmodifier of retinal degeneration QTL 3 (mouse)Not determined114439420126055880Mouse
26884375Skwq2_mskull length QTL 2, 5 week (mouse)8120726739130027694Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388121,118,476 - 121,118,660UniSTSGRCm38
MGSCv378123,642,376 - 123,642,560UniSTSGRCm37
Celera8125,336,556 - 125,336,740UniSTS
Cytogenetic Map8E1UniSTS
cM Map865.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388121,118,264 - 121,118,465UniSTSGRCm38
MGSCv378123,642,164 - 123,642,365UniSTSGRCm37
Celera8125,336,344 - 125,336,545UniSTS
Cytogenetic Map8E1UniSTS
cM Map865.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8E1UniSTS



RefSeq Acc Id: ENSMUST00000054691   ⟹   ENSMUSP00000055290
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8121,842,910 - 121,845,634 (+)Ensembl
GRCm38.p6 Ensembl8121,116,171 - 121,118,895 (+)Ensembl
RefSeq Acc Id: NM_013519   ⟹   NP_038547
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm398121,842,910 - 121,845,634 (+)NCBI
GRCm388121,116,171 - 121,118,895 (+)ENTREZGENE
MGSCv378123,640,071 - 123,642,795 (+)RGD
Celera8125,334,251 - 125,336,975 (+)RGD
RefSeq Acc Id: NP_038547   ⟸   NM_013519
- UniProtKB: Q63869 (UniProtKB/Swiss-Prot),   P97948 (UniProtKB/Swiss-Prot),   Q8C694 (UniProtKB/Swiss-Prot),   Q61850 (UniProtKB/Swiss-Prot),   B9EI61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000055290   ⟸   ENSMUST00000054691
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61850-F1-model_v2 AlphaFold Q61850 1-494 view protein structure

RGD ID:8668479
Promoter ID:EPDNEW_M12270
Type:initiation region
Description:Mus musculus forkhead box C2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm388121,116,171 - 121,116,231EPDNEW
RGD ID:6843168
Promoter ID:MM_KWN:55960
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_013519,   UC009NRR.1
Mouse AssemblyChrPosition (strand)Source
MGSCv368123,639,366 - 123,641,517 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1347481 AgrOrtholog
Ensembl Genes ENSMUSG00000046714 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000054691 ENTREZGENE
  ENSMUST00000054691.8 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fork_head_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FOXC1/C2-like_FH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_fork_head_CS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_fork_head_CS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14234 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Forkhead UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Foxc2 PhenoGen
  FORK_HEAD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FORK_HEAD_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00339 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FOXC2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P97948 UniProtKB/Swiss-Prot
  Q63869 UniProtKB/Swiss-Prot
  Q8C694 UniProtKB/Swiss-Prot