Foxf2 (forkhead box F2) - Rat Genome Database

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Gene: Foxf2 (forkhead box F2) Mus musculus
Analyze
Symbol: Foxf2
Name: forkhead box F2
RGD ID: 1614458
MGI Page MGI
Description: Enables DNA binding activity and DNA-binding transcription factor activity. Involved in embryonic camera-type eye morphogenesis. Acts upstream of or within several processes, including embryonic digestive tract development; establishment of planar polarity of embryonic epithelium; and negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; ear; embryo mesenchyme; genitourinary system; and limb digit. Orthologous to human FOXF2 (forkhead box F2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fkh20; forkhead box protein F2; forkhead homolog 20; FREA; FREAC2; L; LUN
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391331,809,686 - 31,815,390 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1331,809,799 - 31,815,386 (+)EnsemblGRCm39 Ensembl
GRCm381331,625,816 - 31,631,406 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1331,625,816 - 31,631,403 (+)EnsemblGRCm38mm10GRCm38
MGSCv371331,717,685 - 31,723,275 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361331,633,244 - 31,638,867 (+)NCBIMGSCv36mm8
Celera1331,834,722 - 31,840,312 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.48NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Stroke  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7957066   PMID:8626802   PMID:9676429   PMID:10349636   PMID:10822266   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11804790   PMID:12466851   PMID:12477932   PMID:12812790  
PMID:14681479   PMID:14745957   PMID:15107405   PMID:15457338   PMID:15618518   PMID:16141072   PMID:16141073   PMID:16439479   PMID:16691571   PMID:17261592   PMID:18023262   PMID:19304890  
PMID:19879143   PMID:20009030   PMID:20059953   PMID:20553735   PMID:20589901   PMID:20932939   PMID:21267068   PMID:21873635   PMID:22022403   PMID:22711520   PMID:23376422   PMID:23946491  
PMID:25356765   PMID:25631042   PMID:26120030   PMID:26238476   PMID:26745863   PMID:26930384   PMID:27180663   PMID:27425595   PMID:28069742   PMID:28286175   PMID:28506991   PMID:28797033  
PMID:30153454   PMID:30285803   PMID:30292786   PMID:30352852   PMID:30561639   PMID:30565344   PMID:30638444   PMID:32040930   PMID:32616504   PMID:32758357   PMID:33898467   PMID:34671097  
PMID:35668101   PMID:36196625   PMID:36227576   PMID:36314682   PMID:36369237   PMID:38110169  


Genomics

Comparative Map Data
Foxf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391331,809,686 - 31,815,390 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1331,809,799 - 31,815,386 (+)EnsemblGRCm39 Ensembl
GRCm381331,625,816 - 31,631,406 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1331,625,816 - 31,631,403 (+)EnsemblGRCm38mm10GRCm38
MGSCv371331,717,685 - 31,723,275 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361331,633,244 - 31,638,867 (+)NCBIMGSCv36mm8
Celera1331,834,722 - 31,840,312 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.48NCBI
FOXF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3861,389,576 - 1,395,603 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl61,389,576 - 1,395,603 (+)EnsemblGRCh38hg38GRCh38
GRCh3761,389,811 - 1,395,838 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3661,335,068 - 1,340,831 (+)NCBINCBI36Build 36hg18NCBI36
Build 3461,335,067 - 1,340,831NCBI
Celera62,618,774 - 2,624,536 (+)NCBICelera
Cytogenetic Map6p25.3NCBI
HuRef61,261,028 - 1,266,486 (+)NCBIHuRef
CHM1_161,392,174 - 1,397,939 (+)NCBICHM1_1
T2T-CHM13v2.061,252,762 - 1,258,791 (+)NCBIT2T-CHM13v2.0
Foxf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81733,044,446 - 33,051,259 (-)NCBIGRCr8
mRatBN7.21732,835,730 - 32,842,547 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1732,836,777 - 32,842,176 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1732,683,490 - 32,690,309 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01734,287,317 - 34,294,132 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01732,679,312 - 32,686,125 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01734,150,417 - 34,156,450 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
RGSC_v3.41739,255,027 - 39,259,442 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1732,397,527 - 32,399,176 (-)NCBICelera
Cytogenetic Map17p12NCBI
Foxf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546511,740,323 - 11,744,619 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546511,740,374 - 11,744,619 (-)NCBIChiLan1.0ChiLan1.0
FOXF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2516,005,506 - 16,012,048 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1612,001,152 - 12,007,248 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v061,209,899 - 1,215,970 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.161,327,682 - 1,332,813 (+)NCBIpanpan1.1PanPan1.1panPan2
FOXF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1351,841,165 - 1,846,649 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl351,841,123 - 1,846,663 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha351,853,322 - 1,858,844 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0351,799,867 - 1,805,405 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl351,799,867 - 1,805,402 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1351,774,904 - 1,780,415 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0351,795,973 - 1,801,502 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,130,940 - 3,136,459 (+)NCBIUU_Cfam_GSD_1.0
Foxf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494624,076,357 - 24,082,458 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366332,536,970 - 2,543,765 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366332,538,209 - 2,543,649 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7715,001 - 720,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17715,001 - 719,781 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27673,610 - 677,839 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FOXF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11770,744,989 - 70,750,860 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1770,745,011 - 70,750,652 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660441,334,730 - 1,340,793 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Foxf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475623,209,390 - 23,213,802 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475623,209,402 - 23,213,817 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Foxf2
135 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:250
Count of miRNA genes:217
Interacting mature miRNAs:231
Transcripts:ENSMUST00000042054
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1301984Pbd2_mpeak bone density 2 (mouse)Not determined131718950838947406Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse

Markers in Region
Foxf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381331,630,866 - 31,630,956UniSTSGRCm38
MGSCv371331,722,735 - 31,722,825UniSTSGRCm37
Celera1331,839,772 - 31,839,862UniSTS
Cytogenetic Map13A4UniSTS
cM Map13 UniSTS
Foxf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A4UniSTS


Expression


Sequence


Ensembl Acc Id: ENSMUST00000042054   ⟹   ENSMUSP00000046789
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1331,809,799 - 31,815,386 (+)Ensembl
GRCm38.p6 Ensembl1331,625,816 - 31,631,403 (+)Ensembl
RefSeq Acc Id: NM_010225   ⟹   NP_034355
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391331,809,686 - 31,815,390 (+)NCBI
GRCm381331,625,816 - 31,631,406 (+)ENTREZGENE
MGSCv371331,717,685 - 31,723,275 (+)RGD
Celera1331,834,722 - 31,840,312 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034355   ⟸   NM_010225
- UniProtKB: Q3V1L3 (UniProtKB/Swiss-Prot),   B2RQI5 (UniProtKB/Swiss-Prot),   Q78DW1 (UniProtKB/Swiss-Prot),   O54743 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000046789   ⟸   ENSMUST00000042054

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54743-F1-model_v2 AlphaFold O54743 1-446 view protein structure

Promoters
RGD ID:8680008
Promoter ID:EPDNEW_M18035
Type:initiation region
Name:Foxf2_1
Description:Mus musculus forkhead box F2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381331,625,912 - 31,625,972EPDNEW
RGD ID:6823912
Promoter ID:MM_KWN:13715
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:ENSMUST00000042054
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361331,718,781 - 31,719,281 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1347479 AgrOrtholog
Ensembl Genes ENSMUSG00000038402 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000042054 ENTREZGENE
  ENSMUST00000042054.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
InterPro Fork_head_dom UniProtKB/Swiss-Prot
  Forkhead_box_regulator UniProtKB/Swiss-Prot
  TF_fork_head_CS_1 UniProtKB/Swiss-Prot
  TF_fork_head_CS_2 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report mmu:14238 UniProtKB/Swiss-Prot
MGD MGI:1347479 ENTREZGENE
NCBI Gene 14238 ENTREZGENE
PANTHER FORKHEAD BOX PROTEIN BINIOU UniProtKB/Swiss-Prot
  FORKHEAD BOX PROTEIN F2 UniProtKB/Swiss-Prot
Pfam Forkhead UniProtKB/Swiss-Prot
PhenoGen Foxf2 PhenoGen
PRINTS FORKHEAD UniProtKB/Swiss-Prot
PROSITE FORK_HEAD_1 UniProtKB/Swiss-Prot
  FORK_HEAD_2 UniProtKB/Swiss-Prot
  FORK_HEAD_3 UniProtKB/Swiss-Prot
SMART SM00339 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt B2RQI5 ENTREZGENE
  FOXF2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3V1L3 ENTREZGENE
  Q78DW1 ENTREZGENE
UniProt Secondary B2RQI5 UniProtKB/Swiss-Prot
  Q3V1L3 UniProtKB/Swiss-Prot
  Q78DW1 UniProtKB/Swiss-Prot