Fpr3 (formyl peptide receptor 3) - Rat Genome Database

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Gene: Fpr3 (formyl peptide receptor 3) Mus musculus
Analyze
Symbol: Fpr3
Name: formyl peptide receptor 3
RGD ID: 1614455
MGI Page MGI
Description: Enables signaling receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to several human genes including FPR2 (formyl peptide receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ALX; FMLP-R-I; FMLP-related receptor I; formyl peptide receptor related sequence 1; formyl peptide receptor, related sequence 1; formyl peptide receptor-like 1; formyl peptide receptor-related sequence 1; Fp; Fpr; Fpr-rs1; Fpr-s1; Fprl1; lipoxin A4 receptor; Lx; LXA; LXA4 receptor; LXA4-R; Lxa4r; N-formyl peptide receptor 2; N-formyl peptide receptor 3; N-formylpeptide receptor-like 1
RGD Orthologs
Human
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm18307  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391718,190,720 - 18,191,939 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1718,108,114 - 18,191,939 (+)EnsemblGRCm39 Ensembl
GRCm381717,970,458 - 17,971,677 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1717,887,852 - 17,971,677 (+)EnsemblGRCm38mm10GRCm38
MGSCv371718,107,422 - 18,108,641 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361717,675,076 - 17,676,295 (+)NCBIMGSCv36mm8
Celera1718,910,966 - 18,912,175 (+)NCBICelera
Cytogenetic Map17A3.2NCBI
cM Map1710.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
plasma membrane  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9151906   PMID:9722950   PMID:12172542   PMID:12218158   PMID:12459252   PMID:12470609   PMID:12560218   PMID:12746227   PMID:15879124   PMID:17218541   PMID:19234121   PMID:19387439  
PMID:19497865   PMID:20435922   PMID:21501589   PMID:21873635   PMID:22859307   PMID:23733341   PMID:25512512   PMID:26957543   PMID:27207555   PMID:27317426   PMID:27626380   PMID:31585047  
PMID:31653840   PMID:31746387   PMID:32294408   PMID:32617132   PMID:36834844   PMID:37422776   PMID:38355793  


Genomics

Comparative Map Data
Fpr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391718,190,720 - 18,191,939 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1718,108,114 - 18,191,939 (+)EnsemblGRCm39 Ensembl
GRCm381717,970,458 - 17,971,677 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1717,887,852 - 17,971,677 (+)EnsemblGRCm38mm10GRCm38
MGSCv371718,107,422 - 18,108,641 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361717,675,076 - 17,676,295 (+)NCBIMGSCv36mm8
Celera1718,910,966 - 18,912,175 (+)NCBICelera
Cytogenetic Map17A3.2NCBI
cM Map1710.66NCBI
FPR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381951,795,157 - 51,826,190 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1951,795,157 - 51,826,190 (+)EnsemblGRCh38hg38GRCh38
GRCh371952,298,410 - 52,329,443 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,990,223 - 57,021,146 (+)NCBINCBI36Build 36hg18NCBI36
Build 341956,990,222 - 57,021,146NCBI
Celera1949,347,968 - 49,378,893 (+)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1948,629,161 - 48,659,996 (+)NCBIHuRef
CHM1_11952,300,223 - 52,331,168 (+)NCBICHM1_1
T2T-CHM13v2.01954,882,351 - 54,913,384 (+)NCBIT2T-CHM13v2.0
FPR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22057,838,728 - 57,868,198 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11959,763,039 - 59,792,514 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01948,739,357 - 48,768,833 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11957,618,692 - 57,647,489 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1957,645,054 - 57,646,115 (+)Ensemblpanpan1.1panPan2
FPR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1644,609,711 - 44,642,329 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl644,641,146 - 44,642,207 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607324,663,678 - 24,697,601 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:124
Interacting mature miRNAs:128
Transcripts:ENSMUST00000054871, ENSMUST00000115565
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558807Ceat1_mchronic experimental autoimmune thyroiditis 1 (mouse)Not determined171263668226401133Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
12910982Pifs2_mpeptide-induced fatal syndrome 2 (mouse)17126189355Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17129198453Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171683545533819843Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17129198453Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
4142507Obrq13_mobesity resistance QTL 13 (mouse)Not determined1219832925076769Mouse
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17127081639Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17787584329487423Mouse
1357452Vtbt18_mvertebral trabecular bone trait 18 (mouse)Not determined17120975022Mouse
1357902Obq19_mobesity QTL 19 (mouse)Not determined17125662076Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17485475227715939Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
1357680Idd23_minsulin dependent diabetes susceptibility 23 (mouse)Not determined17397489026401133Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
1302196Myaa1_mmodifier of Yaa 1 (mouse)Not determined17120975022Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1357743Lith3_mlithogenic gene 3 (mouse)Not determined17126194456Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17129198453Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17127081639Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17131030170Mouse

Markers in Region
UniSTS:490638  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381717,970,469 - 17,971,524UniSTSGRCm38
MGSCv371718,107,433 - 18,108,488UniSTSGRCm37
Celera1718,910,977 - 18,912,022UniSTS
Cytogenetic Map17A3.2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000054871   ⟹   ENSMUSP00000093316
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1718,108,114 - 18,191,939 (+)Ensembl
GRCm38.p6 Ensembl1717,887,852 - 17,971,677 (+)Ensembl
Ensembl Acc Id: ENSMUST00000115565   ⟹   ENSMUSP00000111227
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1718,190,720 - 18,191,939 (+)Ensembl
GRCm38.p6 Ensembl1717,970,458 - 17,971,677 (+)Ensembl
RefSeq Acc Id: NM_008042   ⟹   NP_032068
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391718,190,720 - 18,191,939 (+)NCBI
GRCm381717,970,458 - 17,971,677 (+)ENTREZGENE
MGSCv371718,107,422 - 18,108,641 (+)RGD
Celera1718,910,966 - 18,912,175 (+)RGD
cM Map17 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032068 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC34584 (Get FASTA)   NCBI Sequence Viewer  
  AAC53198 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000093316.3
  ENSMUSP00000111227
  ENSMUSP00000111227.2
GenBank Protein O08790 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032068   ⟸   NM_008042
- UniProtKB: O88535 (UniProtKB/Swiss-Prot),   O08790 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000093316   ⟸   ENSMUST00000054871
Ensembl Acc Id: ENSMUSP00000111227   ⟸   ENSMUST00000115565

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08790-F1-model_v2 AlphaFold O08790 1-351 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1194495 AgrOrtholog
Ensembl Genes ENSMUSG00000079700 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000054871.12 UniProtKB/Swiss-Prot
  ENSMUST00000115565 ENTREZGENE
  ENSMUST00000115565.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Formyl_rcpt-rel UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:14294 UniProtKB/Swiss-Prot
MGD MGI:1194495 ENTREZGENE
NCBI Gene 14294 ENTREZGENE
PANTHER N-FORMYL PEPTIDE RECEPTOR 2 UniProtKB/Swiss-Prot
  PTHR24225 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Fpr3 PhenoGen
PRINTS FMETLEUPHER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt FPRS1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  O88535 ENTREZGENE
UniProt Secondary O88535 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Fpr3  formyl peptide receptor 3  Fpr-rs1  formyl peptide receptor, related sequence 1  Data merged from RGD:1607550 737654 PROVISIONAL