Frat1 (frequently rearranged in advanced T cell lymphomas) - Rat Genome Database

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Gene: Frat1 (frequently rearranged in advanced T cell lymphomas) Mus musculus
Analyze
Symbol: Frat1
Name: frequently rearranged in advanced T cell lymphomas
RGD ID: 1614454
MGI Page MGI
Description: Predicted to enable molecular function inhibitor activity. Acts upstream of or within embryonic axis specification and protein export from nucleus. Located in cytoplasm and nucleus. Is expressed in several structures, including bronchiole; central nervous system; gut; hemolymphoid system gland; and sensory organ. Orthologous to human FRAT1 (FRAT regulator of WNT signaling pathway 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW060382; FRAT-1; frequently rearranged in advanced T-cell lymphomas 1; proto-oncogene FRAT1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391941,818,409 - 41,821,022 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1941,818,409 - 41,821,022 (+)EnsemblGRCm39 Ensembl
GRCm381941,829,970 - 41,832,583 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1941,829,970 - 41,832,583 (+)EnsemblGRCm38mm10GRCm38
MGSCv371941,904,460 - 41,907,073 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361941,883,427 - 41,885,894 (+)NCBIMGSCv36mm8
Celera1942,629,318 - 42,631,931 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1935.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9034327   PMID:10051411   PMID:10349636   PMID:10534617   PMID:10557087   PMID:10597256   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11779183   PMID:12223487  
PMID:12466851   PMID:12477932   PMID:14507779   PMID:15073180   PMID:15163367   PMID:15681612   PMID:15699046   PMID:16141072   PMID:16141073   PMID:16602821   PMID:19515997   PMID:19802005  
PMID:21267068   PMID:21873635   PMID:22064483   PMID:24319055   PMID:24952961  


Genomics

Comparative Map Data
Frat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391941,818,409 - 41,821,022 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1941,818,409 - 41,821,022 (+)EnsemblGRCm39 Ensembl
GRCm381941,829,970 - 41,832,583 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1941,829,970 - 41,832,583 (+)EnsemblGRCm38mm10GRCm38
MGSCv371941,904,460 - 41,907,073 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361941,883,427 - 41,885,894 (+)NCBIMGSCv36mm8
Celera1942,629,318 - 42,631,931 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1935.3NCBI
FRAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381097,319,271 - 97,321,915 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1097,319,271 - 97,321,915 (+)EnsemblGRCh38hg38GRCh38
GRCh371099,079,028 - 99,081,672 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361099,069,012 - 99,071,662 (+)NCBINCBI36Build 36hg18NCBI36
Celera1092,817,506 - 92,820,157 (+)NCBICelera
Cytogenetic Map10q24.1NCBI
HuRef1092,704,738 - 92,707,056 (+)NCBIHuRef
CHM1_11099,360,764 - 99,363,411 (+)NCBICHM1_1
T2T-CHM13v2.01098,199,470 - 98,202,113 (+)NCBIT2T-CHM13v2.0
Frat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81250,587,641 - 250,590,189 (+)NCBIGRCr8
mRatBN7.21240,638,309 - 240,640,857 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,638,296 - 240,640,945 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1248,783,574 - 248,786,144 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01255,480,727 - 255,483,297 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01248,133,737 - 248,136,307 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01261,071,965 - 261,075,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01268,509,986 - 268,527,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map1q54NCBI
Frat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555073,472,035 - 3,486,868 (+)NCBIChiLan1.0ChiLan1.0
FRAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28109,232,028 - 109,238,724 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110109,232,265 - 109,244,123 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01093,943,745 - 93,947,162 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FRAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12810,635,959 - 10,637,321 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2810,635,944 - 10,636,787 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2810,818,762 - 10,820,186 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02810,957,885 - 10,959,315 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12810,619,293 - 10,620,673 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02810,679,985 - 10,681,409 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02810,819,915 - 10,821,339 (+)NCBIUU_Cfam_GSD_1.0
Frat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721336,287,770 - 36,290,672 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366362,328,500 - 2,329,333 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366362,326,891 - 2,330,321 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FRAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14108,739,541 - 108,740,380 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114108,739,239 - 108,741,953 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FRAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1990,491,841 - 90,495,112 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl990,492,722 - 90,493,561 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604851,388,432 - 51,391,137 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Frat1
83 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:244
Count of miRNA genes:230
Interacting mature miRNAs:243
Transcripts:ENSMUST00000087155
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
13504736Ifvrq6_minfluenza virus resistance QTL 6 (mouse)193690291044913949Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
AW060382  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38563,117,675 - 63,117,817UniSTSGRCm38
GRCm381941,832,429 - 41,832,566UniSTSGRCm38
MGSCv37563,508,914 - 63,509,056UniSTSGRCm37
MGSCv371941,906,919 - 41,907,056UniSTSGRCm37
Celera560,420,278 - 60,420,420UniSTS
Celera1942,631,777 - 42,631,914UniSTS
Cytogenetic Map19C3UniSTS
cM Map1937.5UniSTS
Whitehead/MRC_RH19421.42UniSTS
UniSTS:237939  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381941,831,590 - 41,831,782UniSTSGRCm38
GRCm38762,462,779 - 62,462,969UniSTSGRCm38
MGSCv371941,906,080 - 41,906,272UniSTSGRCm37
MGSCv37769,607,665 - 69,607,855UniSTSGRCm37
Celera1942,630,938 - 42,631,130UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map19C3UniSTS
cM Map728.0UniSTS
cM Map1937.5UniSTS
Frat1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381941,831,369 - 41,832,184UniSTSGRCm38
MGSCv371941,906,713 - 41,906,897UniSTSGRCm37
MGSCv371941,905,311 - 41,906,163UniSTSGRCm37
Celera1942,630,717 - 42,631,532UniSTS
Cytogenetic Map19C3UniSTS
cM Map1937.5UniSTS
cM Map1937.5UniSTS
UniSTS:489053  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381941,830,118 - 41,831,101UniSTSGRCm38
MGSCv371941,904,608 - 41,905,591UniSTSGRCm37
Celera1942,629,466 - 42,630,449UniSTS
Cytogenetic Map19C3UniSTS
cM Map1937.5UniSTS
UniSTS:495468  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381941,830,116 - 41,831,299UniSTSGRCm38
MGSCv371941,904,606 - 41,905,789UniSTSGRCm37
Celera1942,629,464 - 42,630,647UniSTS
Cytogenetic Map19C3UniSTS
cM Map1937.5UniSTS
Frat1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381941,830,821 - 41,831,673UniSTSGRCm38
MGSCv371941,905,311 - 41,906,163UniSTSGRCm37
Celera1942,630,169 - 42,631,021UniSTS
Cytogenetic Map19C3UniSTS
cM Map1937.5UniSTS
Frat1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381941,832,223 - 41,832,407UniSTSGRCm38
MGSCv371941,906,713 - 41,906,897UniSTSGRCm37
Celera1942,631,571 - 42,631,755UniSTS
Cytogenetic Map19C3UniSTS


Expression


Sequence


Ensembl Acc Id: ENSMUST00000087155   ⟹   ENSMUSP00000147726
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1941,818,409 - 41,821,022 (+)Ensembl
GRCm38.p6 Ensembl1941,829,970 - 41,832,583 (+)Ensembl
RefSeq Acc Id: NM_008043   ⟹   NP_032069
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391941,818,409 - 41,821,022 (+)NCBI
GRCm381941,829,970 - 41,832,583 (+)ENTREZGENE
MGSCv371941,904,460 - 41,907,073 (+)RGD
Celera1942,629,318 - 42,631,931 (+)RGD
cM Map19 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032069 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB72010 (Get FASTA)   NCBI Sequence Viewer  
  AAI40988 (Get FASTA)   NCBI Sequence Viewer  
  EDL41862 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000147726
  ENSMUSP00000147726.2
GenBank Protein P70339 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032069   ⟸   NM_008043
- UniProtKB: P70339 (UniProtKB/Swiss-Prot),   B2RU64 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000147726   ⟸   ENSMUST00000087155

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70339-F1-model_v2 AlphaFold P70339 1-274 view protein structure

Promoters
RGD ID:6830003
Promoter ID:MM_KWN:27066
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000087155,   NM_008043,   NM_008043_FRAT1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361941,904,341 - 41,905,292 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109450 AgrOrtholog
Ensembl Genes ENSMUSG00000067199 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000087155 ENTREZGENE
  ENSMUST00000087155.5 UniProtKB/Swiss-Prot
InterPro GSK3-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109450 ENTREZGENE
NCBI Gene 14296 ENTREZGENE
PANTHER PROTO-ONCOGENE FRAT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR35154 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GSK-3_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Frat1 PhenoGen
UniProt B2RU64 ENTREZGENE, UniProtKB/TrEMBL
  FRAT1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Frat1  frequently rearranged in advanced T cell lymphomas  Frat1  frequently rearranged in advanced T-cell lymphomas  Symbol and/or name change 5135510 APPROVED