Sptlc2 (serine palmitoyltransferase, long chain base subunit 2) - Rat Genome Database

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Gene: Sptlc2 (serine palmitoyltransferase, long chain base subunit 2) Mus musculus
Analyze
Symbol: Sptlc2
Name: serine palmitoyltransferase, long chain base subunit 2
RGD ID: 1614415
MGI Page MGI
Description: Contributes to serine C-palmitoyltransferase activity. Involved in adipose tissue development and sphingolipid biosynthetic process. Acts upstream of or within sphingolipid biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study psoriasis. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1C. Orthologous to human SPTLC2 (serine palmitoyltransferase long chain base subunit 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AI173915; LCB; LCB 2; LCB2; LCB2a; long chain base biosynthesis protein 2; long chain base biosynthesis protein 2a; mKIAA0526; serine palmitoyltransferase 2; serine-palmitoyl-CoA transferase 2; Sp; SPT 2; Spt2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391287,351,832 - 87,435,129 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1287,351,832 - 87,435,129 (-)EnsemblGRCm39 Ensembl
GRCm381287,305,058 - 87,388,355 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1287,305,058 - 87,388,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv371288,648,839 - 88,729,180 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361288,196,992 - 88,277,333 (-)NCBIMGSCv36mm8
Celera1288,772,417 - 88,852,773 (-)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1241.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1-benzylpiperazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-carotene  (ISO)
butanal  (ISO)
calcitriol  (ISO)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (EXP,ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
divanadium pentaoxide  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
flutamide  (ISO)
folic acid  (EXP)
genistein  (EXP)
gentamycin  (ISO)
GW 4064  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
L-methionine  (EXP)
lithocholic acid  (EXP)
methapyrilene  (ISO)
methidathion  (EXP)
methotrexate  (EXP)
methoxychlor  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium fluoride  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
thiram  (ISO)
triclocarban  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal ceramide level  (IAGP)
abnormal circulating lipid level  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal dendritic epidermal T cell morphology  (IAGP)
abnormal epidermal lamellar body morphology  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal Langerhans cell morphology  (IAGP)
abnormal Langerhans cell physiology  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal lipid level  (IAGP)
abnormal liver physiology  (IAGP)
abnormal pancreatic acinar cell zymogen granule morphology  (IAGP)
abnormal small intestinal villus morphology  (IAGP)
abnormal small intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal sphingomyelin level  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal stomach mucosa morphology  (IAGP)
abnormal thymus morphology  (IAGP)
absent epidermis stratum granulosum  (IAGP)
acanthosis  (IAGP)
alopecia  (IAGP)
cellular necrosis  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased spleen weight  (IAGP)
decreased thymus weight  (IAGP)
dehydration  (IAGP)
delayed skin barrier formation  (IAGP)
dry skin  (IAGP)
embryonic lethality prior to organogenesis  (IEA)
epidermal hyperplasia  (IAGP)
hyperkeratosis  (IAGP)
impaired skin barrier function  (IAGP)
increased adrenal gland weight  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased cholesterol efflux  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating phospholipid level  (IAGP)
increased circulating serum albumin level  (IAGP)
increased dendritic cell number  (IAGP)
increased erythrocyte cell number  (IAGP)
increased gamma-delta T cell number  (IAGP)
increased hematocrit  (IAGP)
increased hemoglobin content  (IAGP)
increased neutrophil cell number  (IAGP)
increased T-helper 17 cell number  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
psoriasis  (IAGP)
reddish skin  (IAGP)
reticulocytopenia  (IAGP)
scaly skin  (IAGP)
sebaceous gland atrophy  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
sparse hair  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1317856   PMID:8000140   PMID:8921873   PMID:9363775   PMID:9405408   PMID:9858821   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932  
PMID:12520002   PMID:12782147   PMID:12819125   PMID:12904583   PMID:14610273   PMID:14681479   PMID:15368895   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16216550  
PMID:16602821   PMID:16960033   PMID:17070807   PMID:17194770   PMID:17967808   PMID:18614015   PMID:18799693   PMID:19648608   PMID:19897935   PMID:20211931   PMID:21167294   PMID:21267068  
PMID:21677750   PMID:21844222   PMID:21873635   PMID:22370449   PMID:22493506   PMID:23096701   PMID:23549085   PMID:23633022   PMID:23698380   PMID:24473265   PMID:24606881   PMID:25269881  
PMID:25332431   PMID:25602705   PMID:25691431   PMID:25978603   PMID:26438821   PMID:26496610   PMID:27113764   PMID:27818258   PMID:28378742   PMID:28698261   PMID:30550785   PMID:30952607  
PMID:31971349   PMID:32554809   PMID:34762852   PMID:35513574   PMID:37224999   PMID:38355793  


Genomics

Comparative Map Data
Sptlc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391287,351,832 - 87,435,129 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1287,351,832 - 87,435,129 (-)EnsemblGRCm39 Ensembl
GRCm381287,305,058 - 87,388,355 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1287,305,058 - 87,388,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv371288,648,839 - 88,729,180 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361288,196,992 - 88,277,333 (-)NCBIMGSCv36mm8
Celera1288,772,417 - 88,852,773 (-)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1241.52NCBI
SPTLC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381477,505,997 - 77,616,637 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1477,505,997 - 77,616,637 (-)EnsemblGRCh38hg38GRCh38
GRCh371477,972,340 - 78,082,980 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361477,043,023 - 77,152,863 (-)NCBINCBI36Build 36hg18NCBI36
Build 341477,043,024 - 77,152,863NCBI
Celera1458,011,851 - 58,121,636 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1458,138,337 - 58,249,054 (-)NCBIHuRef
CHM1_11477,911,814 - 78,022,586 (-)NCBICHM1_1
T2T-CHM13v2.01471,715,382 - 71,825,999 (-)NCBIT2T-CHM13v2.0
Sptlc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86112,679,623 - 112,762,470 (-)NCBIGRCr8
mRatBN7.26106,948,682 - 107,031,532 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6106,950,949 - 107,031,542 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6107,116,961 - 107,199,840 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06107,415,779 - 107,498,659 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06106,785,468 - 106,868,346 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06111,334,408 - 111,417,960 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6111,339,136 - 111,417,954 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06120,616,251 - 120,699,243 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46111,546,037 - 111,622,959 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16111,245,978 - 111,626,585 (-)NCBI
Celera6104,771,427 - 104,849,755 (-)NCBICelera
Cytogenetic Map6q31NCBI
Sptlc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554381,385,431 - 1,491,578 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554381,385,431 - 1,491,534 (-)NCBIChiLan1.0ChiLan1.0
SPTLC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21578,591,247 - 78,702,589 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11477,807,751 - 77,918,929 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01458,066,123 - 58,170,472 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11477,266,545 - 77,370,663 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1477,266,545 - 77,370,663 (-)Ensemblpanpan1.1panPan2
SPTLC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1850,291,797 - 50,401,202 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl850,271,010 - 50,401,313 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha849,979,477 - 50,088,850 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0850,525,698 - 50,635,391 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl850,530,838 - 50,635,427 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1850,188,135 - 50,297,514 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0850,211,301 - 50,320,641 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0850,609,185 - 50,719,362 (-)NCBIUU_Cfam_GSD_1.0
LOC101967158
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864025,664,744 - 25,778,794 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364886,315,715 - 6,419,882 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049364886,289,833 - 6,296,849 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364886,313,189 - 6,404,425 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPTLC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7100,544,478 - 100,638,905 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17100,545,360 - 100,638,973 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27106,672,604 - 106,730,716 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPTLC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12454,769,072 - 54,876,963 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605342,955,305 - 43,064,586 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sptlc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473424,281,482 - 24,400,870 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sptlc2
2750 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2253
Count of miRNA genes:815
Interacting mature miRNAs:1095
Transcripts:ENSMUST00000021424, ENSMUST00000167911, ENSMUST00000169845, ENSMUST00000170110, ENSMUST00000170720
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126064678692666774Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
25823169Hrsq8_mhost response to SARS QTL 8, log titer (mouse)1281696245108495368Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
1301046Par3_mpulmonary adenoma resistance 3 (mouse)Not determined126395670897956883Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
10043895Bw20_mbody weight QTL 20 (mouse)Not determined126230825296308252Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126214678699466259Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
10043948Pbft6_mpercent body fat 6 (mouse)Not determined126120542795205427Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
1301476Pbwg12_mpostnatal body weight growth 12 (mouse)Not determined126204016496040364Mouse
27226728Tibl20_mtibia length 20, 16 week (mouse)125914678693866774Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse

Markers in Region
D19271  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381287,309,748 - 87,309,906UniSTSGRCm38
MGSCv371288,650,698 - 88,650,856UniSTSGRCm37
Celera1288,774,276 - 88,774,434UniSTS
Cytogenetic Map12EUniSTS
Whitehead_YAC12 UniSTS
D12Mit178  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381287,376,578 - 87,376,727UniSTSGRCm38
MGSCv371288,717,528 - 88,717,677UniSTSGRCm37
Celera1288,841,121 - 88,841,270UniSTS
Cytogenetic Map12EUniSTS
cM Map1243.0UniSTS
Whitehead Genetic1238.3UniSTS
Whitehead/MRC_RH12822.74UniSTS
Whitehead_YAC12 UniSTS
AI173915  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381287,305,346 - 87,305,436UniSTSGRCm38
MGSCv371288,646,296 - 88,646,386UniSTSGRCm37
Celera1288,770,006 - 88,770,096UniSTS
Cytogenetic Map12EUniSTS
Whitehead/MRC_RH12822.74UniSTS
UniSTS:236912  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381287,307,194 - 87,307,550UniSTSGRCm38
MGSCv371288,648,144 - 88,648,500UniSTSGRCm37
Celera1288,771,722 - 88,772,078UniSTS
Cytogenetic Map12EUniSTS
BE115266  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381287,313,221 - 87,313,456UniSTSGRCm38
MGSCv371288,654,171 - 88,654,406UniSTSGRCm37
Celera1288,777,748 - 88,777,983UniSTS
Cytogenetic Map12EUniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK057644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY789607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF747116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT030249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U27455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X95642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000021424   ⟹   ENSMUSP00000021424
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1287,351,832 - 87,435,129 (-)Ensembl
GRCm38.p6 Ensembl1287,305,058 - 87,388,355 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167911
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1287,393,508 - 87,435,015 (-)Ensembl
GRCm38.p6 Ensembl1287,346,734 - 87,388,241 (-)Ensembl
Ensembl Acc Id: ENSMUST00000169845
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1287,354,844 - 87,390,622 (-)Ensembl
GRCm38.p6 Ensembl1287,308,070 - 87,343,848 (-)Ensembl
Ensembl Acc Id: ENSMUST00000170110
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1287,393,232 - 87,397,155 (-)Ensembl
GRCm38.p6 Ensembl1287,346,458 - 87,350,381 (-)Ensembl
Ensembl Acc Id: ENSMUST00000170720
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1287,356,413 - 87,375,387 (-)Ensembl
GRCm38.p6 Ensembl1287,309,639 - 87,328,613 (-)Ensembl
RefSeq Acc Id: NM_011479   ⟹   NP_035609
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391287,351,832 - 87,435,129 (-)NCBI
GRCm381287,305,058 - 87,388,355 (-)NCBI
MGSCv371288,648,839 - 88,729,180 (-)RGD
Celera1288,772,417 - 88,852,773 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035609   ⟸   NM_011479
- UniProtKB: P97356 (UniProtKB/Swiss-Prot),   P97363 (UniProtKB/Swiss-Prot),   Q542D6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000021424   ⟸   ENSMUST00000021424
Protein Domains
Aminotransferase class I/classII

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97363-F1-model_v2 AlphaFold P97363 1-560 view protein structure

Promoters
RGD ID:8678892
Promoter ID:EPDNEW_M17477
Type:initiation region
Name:Sptlc2_1
Description:Mus musculus serine palmitoyltransferase, long chain base subunit2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381287,388,266 - 87,388,326EPDNEW
RGD ID:6823446
Promoter ID:MM_KWN:12260
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Kidney,   Lung
Transcripts:UC007OIU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361288,669,941 - 88,670,441 (-)MPROMDB
RGD ID:6823445
Promoter ID:MM_KWN:12262
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000021424
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361288,729,081 - 88,729,727 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108074 AgrOrtholog
Ensembl Genes ENSMUSG00000021036 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021424 ENTREZGENE
  ENSMUST00000021424.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aminotrans_II_pyridoxalP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aminotransferase_I/II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AON_synthase_class-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20773 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108074 ENTREZGENE
NCBI Gene 20773 ENTREZGENE
PANTHER CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE PALMITOYLTRANSFERASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aminotran_1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sptlc2 PhenoGen
PROSITE AA_TRANSFER_CLASS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P97356 ENTREZGENE
  P97363 ENTREZGENE
  Q3UT78_MOUSE UniProtKB/TrEMBL
  Q3UZQ0_MOUSE UniProtKB/TrEMBL
  Q542D6 ENTREZGENE, UniProtKB/TrEMBL
  Q6A053_MOUSE UniProtKB/TrEMBL
  Q8C9F8_MOUSE UniProtKB/TrEMBL
  SPTC2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P97356 UniProtKB/Swiss-Prot