Mir146 (microRNA 146) - Rat Genome Database

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Gene: Mir146 (microRNA 146) Mus musculus
Analyze
Symbol: Mir146
Name: microRNA 146
RGD ID: 1608327
MGI Page MGI
Description: Acts upstream of or within several processes, including cellular response to estrogen stimulus; cellular response to leukemia inhibitory factor; and cellular response to lipopolysaccharide. Located in synapse. Is expressed in lung. Human ortholog(s) of this gene implicated in atrophic gastritis; carcinoma (multiple); coronary artery disease; fatal familial insomnia; and type 1 diabetes mellitus. Orthologous to human MIR146A (microRNA 146a).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: miR-1; miR-146a; Mirn; Mirn146; mmu-mir-1; mmu-mir-146
RGD Orthologs
Human
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,265,224 - 43,265,288 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,265,224 - 43,265,288 (-)EnsemblGRCm39 Ensembl
GRCm381143,374,397 - 43,374,461 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,374,397 - 43,374,461 (-)EnsemblGRCm38mm10GRCm38
MGSCv371143,187,899 - 43,187,963 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1148,002,809 - 48,002,873 (-)NCBICelera
Cytogenetic Map11A5NCBI
cM Map1125.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amyloid-beta  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to decreased oxygen levels  (IEP)
cellular response to estrogen stimulus  (IDA)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to leukemia inhibitory factor  (IEP)
cellular response to lipopolysaccharide  (IDA,ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (ISO)
cellular response to virus  (ISO)
innate immune response  (ISO)
interleukin-1-mediated signaling pathway  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (IMP,ISO)
myeloid cell differentiation  (IGI)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic DNA fragmentation  (ISO)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
negative regulation of cholesterol storage  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of dephosphorylation  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of interleukin-8 production  (ISO)
negative regulation of intracellular signal transduction  (ISO)
negative regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
negative regulation of matrix metallopeptidase secretion  (ISO)
negative regulation of membrane permeability  (ISO)
negative regulation of monocyte extravasation  (ISO)
negative regulation of non-canonical NF-kappaB signal transduction  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of tyrosine phosphorylation of STAT protein  (ISO)
negative regulation of vascular endothelial growth factor production  (ISO)
non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of gene expression  (IDA,IGI)
regulation of stem cell differentiation  (ISO)
regulation of toll-like receptor signaling pathway  (ISO)
response to Gram-positive bacterium  (ISO)
response to ischemia  (ISO)
response to oxygen levels  (IDA)
sensory perception of sound  (IEP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal hematopoietic stem cell morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal immune tolerance  (IAGP)
abnormal lymphocyte physiology  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal regulatory T cell physiology  (IAGP)
abnormal spleen B cell follicle morphology  (IAGP)
abnormal T cell activation  (IAGP)
anemia  (IAGP)
blepharitis  (IAGP)
conjunctivitis  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased monocyte cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
dermatitis  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
increased acute inflammation  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased bone marrow cell number  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-10 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased follicular lymphoma incidence  (IAGP)
increased germinal center B cell number  (IAGP)
increased hemolymphoid system tumor incidence  (IAGP)
increased IgG level  (IAGP)
increased IgG1 level  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased macrophage nitric oxide production  (IAGP)
increased myeloid sarcoma incidence  (IAGP)
increased plasma cell number  (IAGP)
increased regulatory T cell number  (IAGP)
increased spleen germinal center number  (IAGP)
increased spleen germinal center size  (IAGP)
increased spleen neoplasm incidence  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T follicular helper cell number  (IAGP)
increased tumor incidence  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
myelofibrosis  (IAGP)
myeloid hyperplasia  (IAGP)
premature aging  (IAGP)
premature death  (IAGP)
thrombocytopenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Up-regulation of circulating miRNA146a correlates with viral load via IRAK1 and TRAF6 in hepatitis C virus-infected patients. Abdel Motaleb FI, etal., Virus Res. 2017 Jun 15;238:24-28. doi: 10.1016/j.virusres.2017.05.026. Epub 2017 Jun 3.
2. MicroRNA-146a-deficient mice develop immune complex glomerulonephritis. Amrouche L, etal., Sci Rep. 2019 Oct 30;9(1):15597. doi: 10.1038/s41598-019-51985-1.
3. Polymorphisms in genes encoding miR-155 and miR-146a are associated with protection to type 1 diabetes mellitus. Assmann TS, etal., Acta Diabetol. 2017 May;54(5):433-441. doi: 10.1007/s00592-016-0961-y. Epub 2017 Jan 19.
4. Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis. Bandiera S, etal., J Virol. 2016 Jun 24;90(14):6387-6400. doi: 10.1128/JVI.00619-16. Print 2016 Jul 15.
5. MiRNA-Related Polymorphisms in miR-146a and TCF21 Are Associated with Increased Susceptibility to Coronary Artery Disease in an Iranian Population. Bastami M, etal., Genet Test Mol Biomarkers. 2016 May;20(5):241-8. doi: 10.1089/gtmb.2015.0253. Epub 2016 Feb 24.
6. Anti-Inflammatory Role of MicroRNA-146a in the Pathogenesis of Diabetic Nephropathy. Bhatt K, etal., J Am Soc Nephrol. 2016 Aug;27(8):2277-88. doi: 10.1681/ASN.2015010111. Epub 2015 Dec 8.
7. Serum Exosomal miRNAs for Grading Hepatic Fibrosis Due to Schistosomiasis. Cai P, etal., Int J Mol Sci. 2020 May 18;21(10). pii: ijms21103560. doi: 10.3390/ijms21103560.
8. miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain. Cannella D, etal., Cell Rep. 2014 Mar 13;6(5):928-37. doi: 10.1016/j.celrep.2014.02.002. Epub 2014 Feb 27.
9. miR-146a G>C polymorphisms and risk of hepatocellular carcinoma in a Chinese population. Cong N, etal., Tumour Biol. 2014 Jun;35(6):5669-73. doi: 10.1007/s13277-014-1750-2. Epub 2014 Mar 11.
10. MicroRNA-146a Deficiency Protects against Listeria monocytogenes Infection by Modulating the Gut Microbiota. Du CT, etal., Int J Mol Sci. 2018 Mar 26;19(4). pii: ijms19040993. doi: 10.3390/ijms19040993.
11. Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection. Fu Y, etal., PLoS Pathog. 2017 Sep 14;13(9):e1006611. doi: 10.1371/journal.ppat.1006611. eCollection 2017 Sep.
12. The associations of two SNPs in miRNA-146a and one SNP in ZBTB38-RASA2 with the disease susceptibility and the clinical features of the Chinese patients of sCJD and FFI. Gao C, etal., Prion. 2018 Jan 2;12(1):34-41. doi: 10.1080/19336896.2017.1405885. Epub 2018 Jan 2.
13. Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression. Gao M, etal., J Immunol. 2015 Jul 15;195(2):672-82. doi: 10.4049/jimmunol.1403155. Epub 2015 Jun 5.
14. Systemic Treatment with a miR-146a Mimic Suppresses Endotoxin Sensitivity and Partially Protects Mice from the Progression of Acute Graft-versus-Host Disease. Gartner JG, etal., Scand J Immunol. 2017 Nov;86(5):368-376. doi: 10.1111/sji.12597. Epub 2017 Sep 29.
15. NOD2-nitric oxide-responsive microRNA-146a activates Sonic hedgehog signaling to orchestrate inflammatory responses in murine model of inflammatory bowel disease. Ghorpade DS, etal., J Biol Chem. 2013 Nov 15;288(46):33037-48. doi: 10.1074/jbc.M113.492496. Epub 2013 Oct 3.
16. Micro RNA-320 as a novel potential biomarker in renal ischemia reperfusion. Güçlü A, etal., Ren Fail. 2016 Oct;38(9):1468-1475. doi: 10.1080/0886022X.2016.1227915. Epub 2016 Oct 19.
17. MicroR-146 blocks the activation of M1 macrophage by targeting signal transducer and activator of transcription 1 in hepatic schistosomiasis. He X, etal., EBioMedicine. 2016 Nov;13:339-347. doi: 10.1016/j.ebiom.2016.10.024. Epub 2016 Oct 19.
18. Activation of nuclear factor kappa B in the hepatic stellate cells of mice with schistosomiasis japonica. He X, etal., PLoS One. 2014 Aug 12;9(8):e104323. doi: 10.1371/journal.pone.0104323. eCollection 2014.
19. Combined effect of miR-146a rs2910164 G/C polymorphism and Toll-like receptor 4 +3725 G/C polymorphism on the risk of severe gastric atrophy in Japanese. Hishida A, etal., Dig Dis Sci. 2011 Apr;56(4):1131-7. doi: 10.1007/s10620-010-1376-1. Epub 2010 Aug 19.
20. Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon. Ho BC, etal., Nat Commun. 2014;5:3344. doi: 10.1038/ncomms4344.
21. Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a. Hou Z, etal., Sci Rep. 2016 May 23;6:26150. doi: 10.1038/srep26150.
22. Acute meningitis in rats is associated with decreased levels of miR132 and miR146a. Jagoo M, etal., Cent Eur J Immunol. 2014;39(3):316-22. doi: 10.5114/ceji.2014.45941. Epub 2014 Oct 14.
23. Association of a single-nucleotide polymorphism within the miR-146a gene with susceptibility for acute-on-chronic hepatitis B liver failure. Jiang H, etal., Immunogenetics. 2013 Apr;65(4):257-63. doi: 10.1007/s00251-012-0675-4. Epub 2013 Jan 6.
24. LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K/Akt/mTOR axis. Li H, etal., Life Sci. 2020 Aug 1;254:116801. doi: 10.1016/j.lfs.2019.116801. Epub 2019 Aug 28.
25. Upregulation of microRNA-146a by hepatitis B virus X protein contributes to hepatitis development by downregulating complement factor H. Li JF, etal., mBio. 2015 Mar 24;6(2). pii: mBio.02459-14. doi: 10.1128/mBio.02459-14.
26. microRNA-146a promotes mycobacterial survival in macrophages through suppressing nitric oxide production. Li M, etal., Sci Rep. 2016 Mar 30;6:23351. doi: 10.1038/srep23351.
27. MicroRNA‑146a inhibits the inflammatory responses induced by interleukin‑17A during the infection of Helicobacter pylori. Li N, etal., Mol Med Rep. 2019 Feb;19(2):1388-1395. doi: 10.3892/mmr.2018.9725. Epub 2018 Dec 5.
28. Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a. Li R and Wang L, Mol Med Rep. 2019 Dec;20(6):5041-5049. doi: 10.3892/mmr.2019.10743. Epub 2019 Oct 15.
29. MiR-146a-5p inhibits cell proliferation and cell cycle progression in NSCLC cell lines by targeting CCND1 and CCND2. Li YL, etal., Oncotarget. 2016 Sep 13;7(37):59287-59298. doi: 10.18632/oncotarget.11040.
30. MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. Lochhead RB, etal., PLoS Pathog. 2014 Jun 26;10(6):e1004212. doi: 10.1371/journal.ppat.1004212. eCollection 2014 Jun.
31. Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity. Okoye IS, etal., Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3081-90. doi: 10.1073/pnas.1406322111. Epub 2014 Jul 14.
32. Dysregulated Serum MiRNA Profile and Promising Biomarkers in Dengue-infected Patients. Ouyang X, etal., Int J Med Sci. 2016 Feb 18;13(3):195-205. doi: 10.7150/ijms.13996. eCollection 2016.
33. Rg6, a rare ginsenoside, inhibits systemic inflammation through the induction of interleukin-10 and microRNA-146a. Paik S, etal., Sci Rep. 2019 Mar 13;9(1):4342. doi: 10.1038/s41598-019-40690-8.
34. Mouse MP Annotation Import Pipeline RGD automated import pipeline
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. MicroRNA 146a (miR-146a) is over-expressed during prion disease and modulates the innate immune response and the microglial activation state. Saba R, etal., PLoS One. 2012;7(2):e30832. doi: 10.1371/journal.pone.0030832. Epub 2012 Feb 17.
37. MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1. Schmolka N, etal., Sci Immunol. 2018 May 4;3(23). pii: 3/23/eaao1392. doi: 10.1126/sciimmunol.aao1392.
38. MiRNA-146a polymorphism increases the odds of malaria in pregnancy. van Loon W, etal., Malar J. 2019 Jan 14;18(1):7. doi: 10.1186/s12936-019-2643-z.
39. [Expression characteristics of microRNA in mice with schistosomiasis and praziquantel treatment]. Wang CY, etal., Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2014 Apr;26(2):165-8, 174.
40. MicroRNA-146a feedback suppresses T cell immune function by targeting Stat1 in patients with chronic hepatitis B. Wang S, etal., J Immunol. 2013 Jul 1;191(1):293-301. doi: 10.4049/jimmunol.1202100. Epub 2013 May 22.
41. MicroRNA-146a enhances Helicobacter pylori induced cell apoptosis in human gastric cancer epithelial cells. Wu K, etal., Asian Pac J Cancer Prev. 2014;15(14):5583-6. doi: 10.7314/apjcp.2014.15.14.5583.
42. A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Xu T, etal., Carcinogenesis. 2008 Nov;29(11):2126-31. doi: 10.1093/carcin/bgn195. Epub 2008 Aug 18.
43. MicroRNA-146a regulates the transformation from liver fibrosis to cirrhosis in patients with hepatitis B via interleukin-6. Yang Z, etal., Exp Ther Med. 2019 Jun;17(6):4670-4676. doi: 10.3892/etm.2019.7490. Epub 2019 Apr 16.
44. Downregulation of miR-146a inhibits influenza A virus replication by enhancing the type I interferon response in vitro and in vivo. Zhang F, etal., Biomed Pharmacother. 2019 Mar;111:740-750. doi: 10.1016/j.biopha.2018.12.103. Epub 2019 Jan 3.
45. Involvement of TLR2-MyD88 in abnormal expression of miR-146a in peripheral blood monocytes of patients with chronic hepatitis C. Zhang WJ, etal., J Huazhong Univ Sci Technolog Med Sci. 2015 Apr;35(2):219-224. doi: 10.1007/s11596-015-1414-5. Epub 2015 Apr 16.
46. Association between miR-146aG>C and miR-196a2C>T polymorphisms and the risk of hepatocellular carcinoma in a Chinese population. Zhou B, etal., Tumour Biol. 2014 Aug;35(8):7775-80. doi: 10.1007/s13277-014-2020-z. Epub 2014 May 10.
47. Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients. Zhu GF, etal., J Interv Cardiol. 2019 Dec 1;2019:9723129. doi: 10.1155/2019/9723129. eCollection 2019.
48. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Zhu S, etal., Nat Med. 2012 Jul;18(7):1077-86. doi: 10.1038/nm.2815.
49. PECULIARITIES OF MIR-146A AND MIR-155 EXPRESSION IN PATIENTS WITH ALLERGOPATHY IN COMBINATION WITH CHRONIC EPSTEIN-BARR VIRUS INFECTION IN LATENT AND ACTIVE PHASES. Zubchenko S, etal., Georgian Med News. 2019 May;(290):69-73.
Additional References at PubMed
PMID:12007417   PMID:16381832   PMID:17369397   PMID:17604727   PMID:17613256   PMID:18452032   PMID:18723672   PMID:18791161   PMID:19026611   PMID:19147652   PMID:19559694   PMID:19596990  
PMID:19965651   PMID:20215419   PMID:20413612   PMID:20439489   PMID:20495188   PMID:20709800   PMID:20850013   PMID:20933052   PMID:20951969   PMID:21037258   PMID:21247879   PMID:21263019  
PMID:21267068   PMID:21555486   PMID:21557898   PMID:21576471   PMID:21730286   PMID:21822254   PMID:21885871   PMID:21975861   PMID:21981419   PMID:22113163   PMID:22210724   PMID:22415194  
PMID:22545247   PMID:22551553   PMID:22570807   PMID:22580216   PMID:22851573   PMID:22891274   PMID:22897173   PMID:23143100   PMID:23200854   PMID:23221399   PMID:23572509   PMID:23588407  
PMID:23589616   PMID:23619365   PMID:23645835   PMID:23646144   PMID:23699512   PMID:23705069   PMID:23733368   PMID:23744481   PMID:23952003   PMID:23974950   PMID:24184056   PMID:24277697  
PMID:24291840   PMID:24316060   PMID:24427314   PMID:24470395   PMID:24472607   PMID:24719463   PMID:24735967   PMID:24771509   PMID:24828499   PMID:24962817   PMID:24987958   PMID:25199827  
PMID:25205119   PMID:25311550   PMID:25367574   PMID:25406379   PMID:25515214   PMID:25697406   PMID:25712341   PMID:25743066   PMID:25896300   PMID:25904598   PMID:25906746   PMID:25957028  
PMID:26084661   PMID:26165466   PMID:26166175   PMID:26199426   PMID:26456940   PMID:26458771   PMID:26492575   PMID:26505653   PMID:26537990   PMID:26538391   PMID:26549232   PMID:26634350  
PMID:26681446   PMID:26700406   PMID:26800097   PMID:27163405   PMID:27221467   PMID:27250735   PMID:27444565   PMID:27568078   PMID:27635087   PMID:27733775   PMID:27908889   PMID:27913625  
PMID:28190197   PMID:28219659   PMID:28279663   PMID:28346483   PMID:28399410   PMID:28484267   PMID:28510617   PMID:28595995   PMID:28596252   PMID:28611091   PMID:28637783   PMID:28784800  
PMID:28810531   PMID:28811005   PMID:28872459   PMID:28882869   PMID:28963073   PMID:28975995   PMID:29021573   PMID:29101850   PMID:29107863   PMID:29133238   PMID:29181576   PMID:29263441  
PMID:29288795   PMID:29437577   PMID:29441948   PMID:29505740   PMID:29544526   PMID:29550454   PMID:29575548   PMID:29593734   PMID:29902229   PMID:29925839   PMID:30013024   PMID:30015963  
PMID:30018336   PMID:30103197   PMID:30134242   PMID:30337925   PMID:30355233   PMID:30387844   PMID:30425059   PMID:30610163   PMID:30613275   PMID:30633643   PMID:30651631   PMID:30768595  
PMID:30777858   PMID:30972735   PMID:30979483   PMID:31156641   PMID:31356686   PMID:31412923   PMID:31434993   PMID:31477775   PMID:31479774   PMID:31486503   PMID:31511497   PMID:31682635  
PMID:31798643   PMID:31894315   PMID:31957545   PMID:32092902   PMID:32107471   PMID:32125286   PMID:32153557   PMID:32161096   PMID:32228681   PMID:32384151   PMID:32388802   PMID:32438838  
PMID:32582192   PMID:32586906   PMID:32612165   PMID:32633138   PMID:32958516   PMID:33002743   PMID:33085187   PMID:33166004   PMID:33185814   PMID:33206203   PMID:33436554   PMID:33664736  
PMID:33725320   PMID:33819341   PMID:33880591   PMID:33893298   PMID:33985523   PMID:34114724   PMID:34185416   PMID:34675187   PMID:34774846   PMID:34808293   PMID:34825304   PMID:34868004  
PMID:34877498   PMID:34968770   PMID:35311564   PMID:35359143   PMID:35410468   PMID:35531876   PMID:35548775   PMID:35562117   PMID:35604113   PMID:35660690   PMID:35676454   PMID:35679261  
PMID:35705996   PMID:35764020   PMID:35781746   PMID:35900794   PMID:36028828   PMID:36096257   PMID:36172375   PMID:36736750   PMID:36902041   PMID:37072613   PMID:37433841   PMID:37659839  


Genomics

Comparative Map Data
Mir146
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,265,224 - 43,265,288 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,265,224 - 43,265,288 (-)EnsemblGRCm39 Ensembl
GRCm381143,374,397 - 43,374,461 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,374,397 - 43,374,461 (-)EnsemblGRCm38mm10GRCm38
MGSCv371143,187,899 - 43,187,963 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1148,002,809 - 48,002,873 (-)NCBICelera
Cytogenetic Map11A5NCBI
cM Map1125.68NCBI
MIR146A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385160,485,352 - 160,485,450 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5160,485,352 - 160,485,450 (+)EnsemblGRCh38hg38GRCh38
GRCh375159,912,359 - 159,912,457 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365159,844,936 - 159,845,034 (+)NCBINCBI36Build 36hg18NCBI36
Celera5155,944,832 - 155,944,930 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5155,005,782 - 155,005,880 (+)NCBIHuRef
CHM1_15159,345,261 - 159,345,359 (+)NCBICHM1_1
T2T-CHM13v2.05161,013,850 - 161,013,948 (+)NCBIT2T-CHM13v2.0
Mir146a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21027,848,516 - 27,848,610 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1027,848,516 - 27,848,610 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1032,609,206 - 32,609,300 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0101,147,600 - 1,147,694 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01027,581,111 - 27,581,205 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01028,962,476 - 28,962,570 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1028,962,476 - 28,962,570 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01028,806,739 - 28,806,833 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1027,342,093 - 27,342,187 (-)NCBICelera
Cytogenetic Map10q21NCBI

Variants

.
Variants in Mir146
5 total Variants
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:21623
Count of gene targets:8644
Count of transcripts:14011
Interacting mature miRNAs:mmu-miR-146a-3p, mmu-miR-146a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1301814Bbaa7_mB.burgdorferi-associated arthritis 7 (mouse)Not determined112601178044264695Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
10043922Alcw9_malcohol withdrawal 9 (mouse)Not determined113557861644065931Mouse
1301718Pbw3_mpentobarbital withdrawal QTL 3 (mouse)Not determined113557861644065931Mouse
1558769Zolw1_mzolpidem withdrawal 1 (mouse)Not determined113557861644065931Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000083667
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1143,265,224 - 43,265,288 (-)Ensembl
GRCm38.p6 Ensembl1143,374,397 - 43,374,461 (-)Ensembl
RefSeq Acc Id: NR_029558
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391143,265,224 - 43,265,288 (-)NCBI
GRCm381143,374,397 - 43,374,461 (-)ENTREZGENE
MGSCv371143,187,899 - 43,187,963 (-)RGD
Celera1148,002,809 - 48,002,873 (-)RGD
cM Map11 ENTREZGENE
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2676831 AgrOrtholog
Ensembl Genes ENSMUSG00000065601 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083667 ENTREZGENE
MGD MGI:2676831 ENTREZGENE
miRBase MI0000170 ENTREZGENE
NCBI Gene 387164 ENTREZGENE
PhenoGen Mir146 PhenoGen
RNAcentral URS0000121576 RNACentral
  URS000050B527 RNACentral
  URS000075DF9E RNACentral