UBE2Z (ubiquitin conjugating enzyme E2 Z) - Rat Genome Database

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Gene: UBE2Z (ubiquitin conjugating enzyme E2 Z) Homo sapiens
Analyze
Symbol: UBE2Z
Name: ubiquitin conjugating enzyme E2 Z
RGD ID: 1606510
HGNC Page HGNC:25847
Description: Enables molecular adaptor activity. Involved in positive regulation of apoptotic process. Located in cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E2 ubiquitin-conjugating enzyme Z; FLJ13855; HOYS7; uba6-specific E2 conjugating enzyme 1; UBA6-specific enzyme E2; ubiquitin carrier protein Z; ubiquitin conjugating enzyme E2Z; ubiquitin-conjugating enzyme E2 Z; ubiquitin-conjugating enzyme E2Z; ubiquitin-protein ligase Z; USE1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381748,908,407 - 48,929,056 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1748,908,407 - 48,929,056 (+)EnsemblGRCh38hg38GRCh38
GRCh371746,985,769 - 47,006,418 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,340,766 - 44,361,421 (+)NCBINCBI36Build 36hg18NCBI36
Celera1743,440,014 - 43,460,620 (+)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1742,353,370 - 42,374,100 (+)NCBIHuRef
CHM1_11747,051,462 - 47,072,170 (+)NCBICHM1_1
T2T-CHM13v2.01749,772,123 - 49,792,776 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IDA,TAS)
nucleoplasm  (IDA)
nucleus  (IBA,IDA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:15489334   PMID:15761153   PMID:16169070   PMID:16189514   PMID:16344560   PMID:17160626   PMID:17464193   PMID:17597759   PMID:18029348   PMID:18976975  
PMID:19250909   PMID:19549727   PMID:19690564   PMID:20975683   PMID:21378990   PMID:21816346   PMID:21873635   PMID:22321011   PMID:22427669   PMID:22658674   PMID:22939629   PMID:23824909  
PMID:24528925   PMID:24647965   PMID:25416956   PMID:25768649   PMID:26555268   PMID:26602883   PMID:27182664   PMID:27425610   PMID:27569286   PMID:28376205   PMID:28840129   PMID:29791485  
PMID:30718280   PMID:31332168   PMID:31575873   PMID:31831168   PMID:32127821   PMID:32296183   PMID:32392439   PMID:32687490   PMID:33730565   PMID:33961781   PMID:35256949   PMID:35671810  
PMID:35831314   PMID:35944360   PMID:35970836   PMID:35987950   PMID:36215168  


Genomics

Comparative Map Data
UBE2Z
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381748,908,407 - 48,929,056 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1748,908,407 - 48,929,056 (+)EnsemblGRCh38hg38GRCh38
GRCh371746,985,769 - 47,006,418 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,340,766 - 44,361,421 (+)NCBINCBI36Build 36hg18NCBI36
Celera1743,440,014 - 43,460,620 (+)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1742,353,370 - 42,374,100 (+)NCBIHuRef
CHM1_11747,051,462 - 47,072,170 (+)NCBICHM1_1
T2T-CHM13v2.01749,772,123 - 49,792,776 (+)NCBIT2T-CHM13v2.0
Ube2z
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,938,257 - 95,956,190 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1195,938,258 - 95,956,214 (-)EnsemblGRCm39 Ensembl
GRCm381196,047,431 - 96,065,364 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1196,047,432 - 96,065,388 (-)EnsemblGRCm38mm10GRCm38
MGSCv371195,908,745 - 95,926,678 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361195,863,520 - 95,881,451 (-)NCBIMGSCv36mm8
Celera11105,697,733 - 105,715,651 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.28NCBI
Ube2z
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,494,522 - 81,513,641 (-)NCBIGRCr8
mRatBN7.21080,997,816 - 81,016,936 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,997,817 - 81,016,936 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1085,946,050 - 85,965,184 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,444,086 - 85,463,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,836,783 - 80,855,935 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,869,703 - 83,888,823 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,869,704 - 83,888,823 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,674,572 - 83,693,693 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41084,762,405 - 84,781,526 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11084,778,519 - 84,796,326 (-)NCBI
Celera1079,765,580 - 79,784,755 (-)NCBICelera
Cytogenetic Map10q26NCBI
Ube2z
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,408,043 - 12,413,996 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545112,406,555 - 12,416,543 (-)NCBIChiLan1.0ChiLan1.0
UBE2Z
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21916,174,109 - 16,196,000 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11718,139,699 - 18,160,389 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0178,611,033 - 8,631,716 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1178,795,899 - 8,816,212 (-)NCBIpanpan1.1PanPan1.1panPan2
UBE2Z
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,134,715 - 25,150,694 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,139,253 - 25,149,027 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha924,595,585 - 24,615,238 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0925,929,673 - 25,947,267 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl925,929,673 - 25,945,959 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1924,697,532 - 24,715,103 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0924,955,784 - 24,973,369 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,084,709 - 25,102,297 (+)NCBIUU_Cfam_GSD_1.0
Ube2z
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560224,535,675 - 24,557,002 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649012,523,293 - 12,540,166 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649012,518,137 - 12,540,272 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBE2Z
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,122,098 - 25,142,753 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,122,072 - 25,141,144 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,078,088 - 25,097,171 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UBE2Z
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,322,433 - 69,342,217 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1669,322,453 - 69,340,309 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607740,424,548 - 40,445,600 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ube2z
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247955,305,728 - 5,318,222 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247955,306,072 - 5,318,220 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in UBE2Z
18 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q21.31-21.33(chr17:44955325-49381173)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052480]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052480]|See cases [RCV000052480] Chr17:44955325..49381173 [GRCh38]
Chr17:43032693..47458535 [GRCh37]
Chr17:40388219..44813534 [NCBI36]
Chr17:17q21.31-21.33
pathogenic
GRCh38/hg38 17q21.32-21.33(chr17:48520885-49511208)x1 copy number loss See cases [RCV000053431] Chr17:48520885..49511208 [GRCh38]
Chr17:46598247..47588570 [GRCh37]
Chr17:43953246..44943569 [NCBI36]
Chr17:17q21.32-21.33
pathogenic
NM_023079.4(UBE2Z):c.799C>T (p.Leu267=) single nucleotide variant Malignant melanoma [RCV000071543] Chr17:48921268 [GRCh38]
Chr17:46998630 [GRCh37]
Chr17:44353629 [NCBI36]
Chr17:17q21.32
not provided
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
NM_023079.4(UBE2Z):c.390+403G>A single nucleotide variant Lung cancer [RCV000100489] Chr17:48911283 [GRCh38]
Chr17:46988645 [GRCh37]
Chr17:17q21.32
uncertain significance
GRCh38/hg38 17q21.32-21.33(chr17:47986886-49329397)x1 copy number loss See cases [RCV000142900] Chr17:47986886..49329397 [GRCh38]
Chr17:46064252..47406759 [GRCh37]
Chr17:43419251..44761758 [NCBI36]
Chr17:17q21.32-21.33
pathogenic
GRCh38/hg38 17q21.32-21.33(chr17:48450628-49552921)x3 copy number gain See cases [RCV000143451] Chr17:48450628..49552921 [GRCh38]
Chr17:46527990..47630283 [GRCh37]
Chr17:43882989..44985282 [NCBI36]
Chr17:17q21.32-21.33
uncertain significance
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q21.32-22(chr17:46481089-51396368)x1 copy number loss not provided [RCV000513510] Chr17:46481089..51396368 [GRCh37]
Chr17:17q21.32-22
likely pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_023079.5(UBE2Z):c.170G>C (p.Gly57Ala) single nucleotide variant Inborn genetic diseases [RCV003266654] Chr17:48908673 [GRCh38]
Chr17:46986035 [GRCh37]
Chr17:17q21.32
uncertain significance
GRCh37/hg19 17q21.32-21.33(chr17:46899690-47540874)x3 copy number gain not provided [RCV000849505] Chr17:46899690..47540874 [GRCh37]
Chr17:17q21.32-21.33
uncertain significance
GRCh37/hg19 17q21.32(chr17:46874271-47158974)x3 copy number gain not provided [RCV000848908] Chr17:46874271..47158974 [GRCh37]
Chr17:17q21.32
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_023079.5(UBE2Z):c.94G>A (p.Gly32Ser) single nucleotide variant Inborn genetic diseases [RCV002748807] Chr17:48908597 [GRCh38]
Chr17:46985959 [GRCh37]
Chr17:17q21.32
uncertain significance
GRCh37/hg19 17q21.32-21.33(chr17:46753824-47577721)x3 copy number gain not provided [RCV002472415] Chr17:46753824..47577721 [GRCh37]
Chr17:17q21.32-21.33
uncertain significance
NM_023079.5(UBE2Z):c.892C>A (p.Gln298Lys) single nucleotide variant Inborn genetic diseases [RCV002893329] Chr17:48922935 [GRCh38]
Chr17:47000297 [GRCh37]
Chr17:17q21.32
uncertain significance
NM_023079.5(UBE2Z):c.80T>G (p.Val27Gly) single nucleotide variant Inborn genetic diseases [RCV002850097] Chr17:48908583 [GRCh38]
Chr17:46985945 [GRCh37]
Chr17:17q21.32
uncertain significance
NM_023079.5(UBE2Z):c.793G>A (p.Glu265Lys) single nucleotide variant Inborn genetic diseases [RCV002712495] Chr17:48921262 [GRCh38]
Chr17:46998624 [GRCh37]
Chr17:17q21.32
uncertain significance
Single allele deletion Tricho-dento-osseous syndrome [RCV003494599] Chr17:46740736..48853218 [GRCh37]
Chr17:17q21.32-21.33
pathogenic
NM_023079.5(UBE2Z):c.245A>G (p.His82Arg) single nucleotide variant Inborn genetic diseases [RCV003360396] Chr17:48908748 [GRCh38]
Chr17:46986110 [GRCh37]
Chr17:17q21.32
uncertain significance
NM_023079.5(UBE2Z):c.394C>G (p.His132Asp) single nucleotide variant Inborn genetic diseases [RCV003294838] Chr17:48912837 [GRCh38]
Chr17:46990199 [GRCh37]
Chr17:17q21.32
uncertain significance
NM_023079.5(UBE2Z):c.143C>T (p.Ala48Val) single nucleotide variant Inborn genetic diseases [RCV002687905] Chr17:48908646 [GRCh38]
Chr17:46986008 [GRCh37]
Chr17:17q21.32
uncertain significance
NM_023079.5(UBE2Z):c.538A>G (p.Asn180Asp) single nucleotide variant Inborn genetic diseases [RCV002826883] Chr17:48912981 [GRCh38]
Chr17:46990343 [GRCh37]
Chr17:17q21.32
uncertain significance
NM_023079.5(UBE2Z):c.866G>A (p.Arg289His) single nucleotide variant Inborn genetic diseases [RCV002724479] Chr17:48922909 [GRCh38]
Chr17:47000271 [GRCh37]
Chr17:17q21.32
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2682
Count of miRNA genes:1039
Interacting mature miRNAs:1317
Transcripts:ENST00000360943, ENST00000504684, ENST00000506271, ENST00000506498, ENST00000508468, ENST00000511373, ENST00000513342, ENST00000514948
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
A009L01  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,005,435 - 47,005,676UniSTSGRCh37
Build 361744,360,434 - 44,360,675RGDNCBI36
Celera1743,459,633 - 43,459,874RGD
Cytogenetic Map17q21.32UniSTS
HuRef1742,373,113 - 42,373,354UniSTS
GeneMap99-GB4 RH Map17340.04UniSTS
NCBI RH Map17638.1UniSTS
RH17824  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,005,510 - 47,005,630UniSTSGRCh37
Build 361744,360,509 - 44,360,629RGDNCBI36
Celera1743,459,708 - 43,459,828RGD
Cytogenetic Map17q21.32UniSTS
HuRef1742,373,188 - 42,373,308UniSTS
GeneMap99-GB4 RH Map17340.78UniSTS
NCBI RH Map17638.1UniSTS
RH48263  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371746,989,599 - 46,989,725UniSTSGRCh37
Build 361744,344,598 - 44,344,724RGDNCBI36
Celera1743,443,796 - 43,443,922RGD
Cytogenetic Map17q21.32UniSTS
HuRef1742,357,272 - 42,357,398UniSTS
GeneMap99-GB4 RH Map17340.78UniSTS
NCBI RH Map17604.8UniSTS
G32634  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,005,435 - 47,005,676UniSTSGRCh37
Celera1743,459,633 - 43,459,874UniSTS
Cytogenetic Map17q21.32UniSTS
HuRef1742,373,113 - 42,373,354UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 2432 2767 1685 585 1825 427 4326 2068 3529 412 1447 1607 171 1204 2759 4
Low 217 38 37 123 37 30 125 187 6 1 1 1 29
Below cutoff 2 2 1 14 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_023079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA843379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AA845421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB025426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK024030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK091644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL713782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA928380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF623992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000360943   ⟹   ENSP00000354201
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1748,908,407 - 48,929,056 (+)Ensembl
RefSeq Acc Id: ENST00000504684   ⟹   ENSP00000460759
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1748,910,690 - 48,927,054 (+)Ensembl
RefSeq Acc Id: ENST00000506271
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1748,915,720 - 48,927,155 (+)Ensembl
RefSeq Acc Id: ENST00000506498   ⟹   ENSP00000425398
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1748,908,716 - 48,927,103 (+)Ensembl
RefSeq Acc Id: ENST00000508468   ⟹   ENSP00000424543
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1748,908,473 - 48,921,272 (+)Ensembl
RefSeq Acc Id: ENST00000511373   ⟹   ENSP00000461147
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1748,910,348 - 48,916,123 (+)Ensembl
RefSeq Acc Id: ENST00000513342
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1748,911,179 - 48,929,054 (+)Ensembl
RefSeq Acc Id: ENST00000514948   ⟹   ENSP00000459473
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1748,921,202 - 48,923,097 (+)Ensembl
RefSeq Acc Id: NM_023079   ⟹   NP_075567
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381748,908,407 - 48,929,056 (+)NCBI
GRCh371746,985,731 - 47,006,422 (+)RGD
Build 361744,340,766 - 44,361,421 (+)NCBI Archive
Celera1743,440,014 - 43,460,620 (+)RGD
HuRef1742,353,370 - 42,374,100 (+)RGD
CHM1_11747,051,462 - 47,072,170 (+)NCBI
T2T-CHM13v2.01749,772,123 - 49,792,776 (+)NCBI
Sequence:
RefSeq Acc Id: NP_075567   ⟸   NM_023079
- UniProtKB: Q8TCM4 (UniProtKB/Swiss-Prot),   Q7L354 (UniProtKB/Swiss-Prot),   A6NC60 (UniProtKB/Swiss-Prot),   A6N8M6 (UniProtKB/Swiss-Prot),   Q9H893 (UniProtKB/Swiss-Prot),   Q9H832 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000460759   ⟸   ENST00000504684
RefSeq Acc Id: ENSP00000425398   ⟸   ENST00000506498
RefSeq Acc Id: ENSP00000354201   ⟸   ENST00000360943
RefSeq Acc Id: ENSP00000424543   ⟸   ENST00000508468
RefSeq Acc Id: ENSP00000461147   ⟸   ENST00000511373
RefSeq Acc Id: ENSP00000459473   ⟸   ENST00000514948
Protein Domains
UBC core

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9H832-F1-model_v2 AlphaFold Q9H832 1-354 view protein structure

Promoters
RGD ID:6794674
Promoter ID:HG_KWN:26516
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000360943,   ENST00000405215
Position:
Human AssemblyChrPosition (strand)Source
Build 361744,340,501 - 44,341,001 (+)MPROMDB
RGD ID:6811383
Promoter ID:HG_ACW:35140
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:UBE2Z.DAPR07,   UBE2Z.GAPR07,   UBE2Z.HAPR07,   UBE2Z.IAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 361744,343,926 - 44,344,426 (+)MPROMDB
RGD ID:6811381
Promoter ID:HG_ACW:35142
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:UBE2Z.EAPR07,   UBE2Z.FAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361744,348,166 - 44,348,666 (+)MPROMDB
RGD ID:7235545
Promoter ID:EPDNEW_H23519
Type:initiation region
Name:UBE2Z_1
Description:ubiquitin conjugating enzyme E2 Z
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381748,908,407 - 48,908,467EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:25847 AgrOrtholog
COSMIC UBE2Z COSMIC
Ensembl Genes ENSG00000159202 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000360943 ENTREZGENE
  ENST00000360943.10 UniProtKB/Swiss-Prot
  ENST00000504684.5 UniProtKB/TrEMBL
  ENST00000506498.5 UniProtKB/TrEMBL
  ENST00000508468.2 UniProtKB/TrEMBL
  ENST00000511373.1 UniProtKB/TrEMBL
  ENST00000514948.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000159202 GTEx
HGNC ID HGNC:25847 ENTREZGENE
Human Proteome Map UBE2Z Human Proteome Map
InterPro UBQ-conjugat_E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-conjugating_enzyme/RWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:65264 UniProtKB/Swiss-Prot
NCBI Gene 65264 ENTREZGENE
OMIM 611362 OMIM
PANTHER (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN-CONJUGATING ENZYME E2 Z UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam UQ_con UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142670659 PharmGKB
PROSITE UBIQUITIN_CONJUGAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART UBCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54495 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6N8M6 ENTREZGENE
  A6NC60 ENTREZGENE
  D6RB11_HUMAN UniProtKB/TrEMBL
  H0Y9X8_HUMAN UniProtKB/TrEMBL
  I3L286_HUMAN UniProtKB/TrEMBL
  I3L3V3_HUMAN UniProtKB/TrEMBL
  I3L4C5_HUMAN UniProtKB/TrEMBL
  Q7L354 ENTREZGENE
  Q8TCM4 ENTREZGENE
  Q9H832 ENTREZGENE
  Q9H893 ENTREZGENE
  UBE2Z_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A6N8M6 UniProtKB/Swiss-Prot
  A6NC60 UniProtKB/Swiss-Prot
  Q7L354 UniProtKB/Swiss-Prot
  Q8TCM4 UniProtKB/Swiss-Prot
  Q9H893 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-21 UBE2Z  ubiquitin conjugating enzyme E2 Z    ubiquitin conjugating enzyme E2Z  Symbol and/or name change 5135510 APPROVED
2015-11-24 UBE2Z  ubiquitin conjugating enzyme E2Z    ubiquitin-conjugating enzyme E2Z  Symbol and/or name change 5135510 APPROVED