ATM (ATM serine/threonine kinase) - Rat Genome Database

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Gene: ATM (ATM serine/threonine kinase) Homo sapiens
Symbol: ATM
Name: ATM serine/threonine kinase
RGD ID: 1606040
HGNC Page HGNC:795
Description: Enables 1-phosphatidylinositol-3-kinase activity; DNA-dependent protein kinase activity; and identical protein binding activity. Involved in several processes, including cellular response to ionizing radiation; regulation of chromosome organization; and regulation of intracellular signal transduction. Located in nucleolus and nucleoplasm. Part of DNA repair complex. Is active in peroxisomal matrix. Colocalizes with chromosome, telomeric region. Implicated in several diseases, including breast cancer (multiple); endometrial cancer; lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Biomarker of several diseases, including gastrointestinal system cancer (multiple); human immunodeficiency virus infectious disease; lung non-small cell carcinoma; oral mucosa leukoplakia; and prostate carcinoma in situ.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A-T mutated; AT mutated; AT1; ATA; ataxia telangiectasia mutated; ataxia telangiectasia mutated (includes complementation groups A, C and D); ATC; ATD; ATDC; ATE; DKFZp781A0353; human phosphatidylinositol 3-kinase homolog; MGC74674; serine-protein kinase ATM; serine/threonine kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1; truncated ATM serine/threonine kinase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3811108,223,067 - 108,369,102 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11108,223,044 - 108,369,102 (+)EnsemblGRCh38hg38GRCh38
GRCh3711108,093,794 - 108,239,829 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611107,598,769 - 107,745,036 (+)NCBINCBI36Build 36hg18NCBI36
Celera11105,248,510 - 105,394,764 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11104,019,183 - 104,165,444 (+)NCBIHuRef
CHM1_111107,976,660 - 108,122,959 (+)NCBICHM1_1
T2T-CHM13v2.011108,230,362 - 108,376,596 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)