ZNF668 (zinc finger protein 668) - Rat Genome Database

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Gene: ZNF668 (zinc finger protein 668) Homo sapiens
Analyze
Symbol: ZNF668
Name: zinc finger protein 668
RGD ID: 1605939
HGNC Page HGNC:25821
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in DNA repair. Predicted to be active in nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FLJ13479; FLJ14492; NEDGEF
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,060,847 - 31,074,240 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,060,843 - 31,074,240 (-)EnsemblGRCh38hg38GRCh38
GRCh371631,072,168 - 31,085,561 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,979,672 - 30,993,005 (-)NCBINCBI36Build 36hg18NCBI36
Celera1629,211,862 - 29,225,335 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,633,854 - 28,647,340 (-)NCBIHuRef
CHM1_11632,389,459 - 32,402,942 (-)NCBICHM1_1
T2T-CHM13v2.01631,448,267 - 31,461,668 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:15489334   PMID:16344560   PMID:19322201   PMID:21852383   PMID:21873635   PMID:23777805   PMID:26186194   PMID:26496610   PMID:28514442   PMID:29117863  
PMID:29180619   PMID:29509190   PMID:29511261   PMID:29721183   PMID:30209976   PMID:30804502   PMID:32296183   PMID:32867128   PMID:33961781   PMID:34313816   PMID:35013218   PMID:35205757  
PMID:35563538   PMID:35819319   PMID:35915203   PMID:36543142   PMID:36724073  


Genomics

Comparative Map Data
ZNF668
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,060,847 - 31,074,240 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,060,843 - 31,074,240 (-)EnsemblGRCh38hg38GRCh38
GRCh371631,072,168 - 31,085,561 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,979,672 - 30,993,005 (-)NCBINCBI36Build 36hg18NCBI36
Celera1629,211,862 - 29,225,335 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,633,854 - 28,647,340 (-)NCBIHuRef
CHM1_11632,389,459 - 32,402,942 (-)NCBICHM1_1
T2T-CHM13v2.01631,448,267 - 31,461,668 (-)NCBIT2T-CHM13v2.0
Zfp668
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,460,197 - 127,476,008 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,462,219 - 127,476,000 (-)EnsemblGRCm39 Ensembl
GRCm387127,861,025 - 127,876,836 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,863,047 - 127,876,828 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,008,873 - 135,020,337 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,656,507 - 127,667,971 (-)NCBIMGSCv36mm8
Celera7127,700,354 - 127,711,818 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.79NCBI
Zfp668
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,905,112 - 191,915,436 (-)NCBIGRCr8
mRatBN7.21182,474,633 - 182,484,957 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,474,633 - 182,492,878 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,825,175 - 190,834,974 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,011,270 - 198,021,069 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,681,673 - 190,691,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,310,935 - 199,321,231 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,310,935 - 199,320,727 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,333,359 - 206,343,642 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,148,888 - 187,158,687 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,299,878 - 187,302,104 (-)NCBI
Celera1180,125,759 - 180,135,373 (-)NCBICelera
Cytogenetic Map1q37NCBI
Znf668
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,902,527 - 7,905,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554937,902,527 - 7,911,616 (-)NCBIChiLan1.0ChiLan1.0
ZNF668
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,268,367 - 34,281,300 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,069,774 - 39,082,702 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,893,617 - 23,906,552 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,429,002 - 31,443,072 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,425,412 - 31,442,494 (-)Ensemblpanpan1.1panPan2
ZNF668
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,157,767 - 17,166,397 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,158,384 - 17,166,174 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,732,997 - 18,741,757 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,288,529 - 17,297,296 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,288,824 - 17,297,549 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,088,922 - 17,097,681 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,007,782 - 17,016,534 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,320,167 - 17,328,929 (+)NCBIUU_Cfam_GSD_1.0
Znf668
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,324,740 - 125,344,567 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,422,989 - 13,426,060 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,423,491 - 13,442,329 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF668
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,406,273 - 17,416,795 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,406,263 - 17,417,115 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,737,178 - 17,747,460 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF668
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,749,292 - 27,761,905 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,749,164 - 27,752,954 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,706,070 - 1,718,532 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf668
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,116,605 - 14,121,994 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,114,438 - 14,125,715 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ZNF668
31 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p11.2-11.1(chr16:30691912-36160463)x3 copy number gain See cases [RCV000133811] Chr16:30691912..36160463 [GRCh38]
Chr16:30703233..35147508 [GRCh37]
Chr16:30610734..35005009 [NCBI36]
Chr16:16p11.2-11.1		 pathogenic
GRCh38/hg38 16p11.2(chr16:29909613-31438697)x3 copy number gain See cases [RCV000135339] Chr16:29909613..31438697 [GRCh38]
Chr16:29920934..31450018 [GRCh37]
Chr16:29828435..31357519 [NCBI36]
Chr16:16p11.2		 pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:27311746-31193406)x3 copy number gain See cases [RCV000140341] Chr16:27311746..31193406 [GRCh38]
Chr16:27323067..31204727 [GRCh37]
Chr16:27230568..31112228 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic
GRCh38/hg38 16p11.2(chr16:30960404-31066796)x1 copy number loss See cases [RCV000139523] Chr16:30960404..31066796 [GRCh38]
Chr16:30971725..31078117 [GRCh37]
Chr16:30879226..30985618 [NCBI36]
Chr16:16p11.2		 likely benign
GRCh38/hg38 16p12.2-11.2(chr16:23752047-31943755)x3 copy number gain See cases [RCV000141141] Chr16:23752047..31943755 [GRCh38]
Chr16:23763368..31955076 [GRCh37]
Chr16:23670869..31862577 [NCBI36]
Chr16:16p12.2-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:30391304-31122666)x3 copy number gain Breast ductal adenocarcinoma [RCV000207028] Chr16:30391304..31122666 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Breast ductal adenocarcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2		 uncertain significance
Single allele deletion Branched-chain keto acid dehydrogenase kinase deficiency [RCV000735205] Chr16:30554158..31536880 [GRCh37]
Chr16:16p11.2		 uncertain significance
NC_000016.10:g.(?_30992801)_(31068051_?)del deletion Generalized epilepsy with febrile seizures plus, type 9 [RCV000558002] Chr16:30992801..31068051 [GRCh38]
Chr16:31004122..31079372 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:30943854-31171177)x1 copy number loss See cases [RCV000446201] Chr16:30943854..31171177 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p11.2(chr16:30830287-31827011)x4 copy number gain See cases [RCV000447708] Chr16:30830287..31827011 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p11.2(chr16:28826162-29043901)x1 copy number loss See cases [RCV000448084] Chr16:28826162..29043901 [GRCh37]
Chr16:16p11.2		 likely pathogenic
GRCh37/hg19 16p11.2(chr16:30952806-31177641)x1 copy number loss See cases [RCV000511906] Chr16:30952806..31177641 [GRCh37]
Chr16:16p11.2		 likely pathogenic
GRCh37/hg19 16p11.2(chr16:30607048-31117069)x1 copy number loss See cases [RCV000511454] Chr16:30607048..31117069 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
NM_024706.5(ZNF668):c.142G>A (p.Asp48Asn) single nucleotide variant not specified [RCV004313419] Chr16:31064318 [GRCh38]
Chr16:31075639 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
NM_024706.5(ZNF668):c.1009A>G (p.Lys337Glu) single nucleotide variant not provided [RCV000677298] Chr16:31061919 [GRCh38]
Chr16:31073240 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p11.2(chr16:30738551-34194635)x3 copy number gain not provided [RCV000739123] Chr16:30738551..34194635 [GRCh37]
Chr16:16p11.2		 benign
NM_024706.5(ZNF668):c.1859G>A (p.Ter620=) single nucleotide variant ZNF668-related disorder [RCV003916253]|not provided [RCV000968327] Chr16:31061069 [GRCh38]
Chr16:31072390 [GRCh37]
Chr16:16p11.2		 benign|likely benign
NM_024706.5(ZNF668):c.1763G>A (p.Arg588His) single nucleotide variant not specified [RCV004289116] Chr16:31061165 [GRCh38]
Chr16:31072486 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p11.2(chr16:30851860-31156762)x1 copy number loss not provided [RCV000848082] Chr16:30851860..31156762 [GRCh37]
Chr16:16p11.2		 pathogenic
NM_024706.5(ZNF668):c.148T>G (p.Ser50Ala) single nucleotide variant not specified [RCV004317862] Chr16:31064312 [GRCh38]
Chr16:31075633 [GRCh37]
Chr16:16p11.2		 likely benign
NM_024706.5(ZNF668):c.955C>T (p.Gln319Ter) single nucleotide variant Failure to thrive [RCV001542806]|Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies [RCV003222335]|Severe short-limb dwarfism [RCV001844298] Chr16:31061973 [GRCh38]
Chr16:31073294 [GRCh37]
Chr16:16p11.2		 pathogenic
NM_024706.5(ZNF668):c.1111C>T (p.Arg371Ter) single nucleotide variant Failure to thrive [RCV001542807]|Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies [RCV003222336] Chr16:31061817 [GRCh38]
Chr16:31073138 [GRCh37]
Chr16:16p11.2		 pathogenic
NM_024706.5(ZNF668):c.546G>A (p.Val182=) single nucleotide variant not provided [RCV000957404] Chr16:31063914 [GRCh38]
Chr16:31075235 [GRCh37]
Chr16:16p11.2		 benign
GRCh37/hg19 16p13.3-11.2(chr16:5805001-34230001) copy number gain Microcephaly [RCV001252948] Chr16:5805001..34230001 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:30350747-31905898)x3 copy number gain not provided [RCV001258619] Chr16:30350747..31905898 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.606C>T (p.Gly202=) single nucleotide variant not provided [RCV001754182] Chr16:31063854 [GRCh38]
Chr16:31075175 [GRCh37]
Chr16:16p11.2		 benign
GRCh37/hg19 16p11.2(chr16:30943854-31171177) copy number loss not specified [RCV002052525] Chr16:30943854..31171177 [GRCh37]
Chr16:16p11.2		 likely pathogenic
Q319* single nucleotide variant Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies [RCV003152348]   pathogenic
R371* single nucleotide variant Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies [RCV003152349]   pathogenic
NM_024706.5(ZNF668):c.1549G>C (p.Val517Leu) single nucleotide variant Myoepithelial tumor [RCV002463958] Chr16:31061379 [GRCh38]
Chr16:31072700 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.1288G>T (p.Val430Leu) single nucleotide variant not specified [RCV004314496] Chr16:31061640 [GRCh38]
Chr16:31072961 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.1762C>T (p.Arg588Cys) single nucleotide variant not specified [RCV004192229] Chr16:31061166 [GRCh38]
Chr16:31072487 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.1666C>T (p.Arg556Trp) single nucleotide variant not specified [RCV004179132] Chr16:31061262 [GRCh38]
Chr16:31072583 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.156G>C (p.Glu52Asp) single nucleotide variant not specified [RCV004120241] Chr16:31064304 [GRCh38]
Chr16:31075625 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.1220T>G (p.Leu407Arg) single nucleotide variant not specified [RCV004136037] Chr16:31061708 [GRCh38]
Chr16:31073029 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.211G>A (p.Gly71Arg) single nucleotide variant not specified [RCV004089166] Chr16:31064249 [GRCh38]
Chr16:31075570 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.1102G>C (p.Glu368Gln) single nucleotide variant not specified [RCV004176617] Chr16:31061826 [GRCh38]
Chr16:31073147 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.634C>T (p.Arg212Cys) single nucleotide variant not specified [RCV004103992] Chr16:31063826 [GRCh38]
Chr16:31075147 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.1465G>A (p.Ala489Thr) single nucleotide variant not specified [RCV004143834] Chr16:31061463 [GRCh38]
Chr16:31072784 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.1634C>G (p.Pro545Arg) single nucleotide variant not specified [RCV004166121] Chr16:31061294 [GRCh38]
Chr16:31072615 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.493G>A (p.Glu165Lys) single nucleotide variant not specified [RCV004159877] Chr16:31063967 [GRCh38]
Chr16:31075288 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.1276C>T (p.Gln426Ter) single nucleotide variant not provided [RCV002581685] Chr16:31061652 [GRCh38]
Chr16:31072973 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.270del (p.Lys91fs) deletion not provided [RCV002581686] Chr16:31064190 [GRCh38]
Chr16:31075511 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.382C>T (p.Arg128Cys) single nucleotide variant not specified [RCV004076368] Chr16:31064078 [GRCh38]
Chr16:31075399 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.617C>T (p.Ala206Val) single nucleotide variant not specified [RCV004187382] Chr16:31063843 [GRCh38]
Chr16:31075164 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.1606C>G (p.Arg536Gly) single nucleotide variant not specified [RCV004145145] Chr16:31061322 [GRCh38]
Chr16:31072643 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.664C>T (p.Arg222Cys) single nucleotide variant not specified [RCV004131944] Chr16:31062264 [GRCh38]
Chr16:31073585 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.721T>A (p.Cys241Ser) single nucleotide variant not specified [RCV004098599] Chr16:31062207 [GRCh38]
Chr16:31073528 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.559C>T (p.Arg187Trp) single nucleotide variant not specified [RCV004270350] Chr16:31063901 [GRCh38]
Chr16:31075222 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.-22-106A>T single nucleotide variant not specified [RCV004337883] Chr16:31064587 [GRCh38]
Chr16:31075908 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.298C>T (p.Arg100Cys) single nucleotide variant not specified [RCV004363987] Chr16:31064162 [GRCh38]
Chr16:31075483 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.46A>G (p.Lys16Glu) single nucleotide variant not specified [RCV004339576] Chr16:31064414 [GRCh38]
Chr16:31075735 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.-22-107G>A single nucleotide variant ZNF668-related disorder [RCV003939327] Chr16:31064588 [GRCh38]
Chr16:31075909 [GRCh37]
Chr16:16p11.2		 likely benign
NM_024706.5(ZNF668):c.1112G>A (p.Arg371Gln) single nucleotide variant not specified [RCV004489912] Chr16:31061816 [GRCh38]
Chr16:31073137 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.868T>G (p.Ser290Ala) single nucleotide variant not specified [RCV004489919] Chr16:31062060 [GRCh38]
Chr16:31073381 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.273G>A (p.Lys91=) single nucleotide variant ZNF668-related disorder [RCV003899384] Chr16:31064187 [GRCh38]
Chr16:31075508 [GRCh37]
Chr16:16p11.2		 likely benign
NM_024706.5(ZNF668):c.77C>A (p.Ser26Tyr) single nucleotide variant not specified [RCV004489914] Chr16:31064383 [GRCh38]
Chr16:31075704 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.550C>T (p.Arg184Cys) single nucleotide variant not specified [RCV004489917] Chr16:31063910 [GRCh38]
Chr16:31075231 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.791T>A (p.Leu264His) single nucleotide variant not specified [RCV004489918] Chr16:31062137 [GRCh38]
Chr16:31073458 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.1625G>A (p.Arg542Gln) single nucleotide variant not specified [RCV004489916] Chr16:31061303 [GRCh38]
Chr16:31072624 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.1590G>C (p.Leu530=) single nucleotide variant ZNF668-related disorder [RCV003911679] Chr16:31061338 [GRCh38]
Chr16:31072659 [GRCh37]
Chr16:16p11.2		 likely benign
NM_024706.5(ZNF668):c.1041G>A (p.Ala347=) single nucleotide variant ZNF668-related disorder [RCV003936838] Chr16:31061887 [GRCh38]
Chr16:31073208 [GRCh37]
Chr16:16p11.2		 likely benign
NM_024706.5(ZNF668):c.1149C>G (p.Ser383Arg) single nucleotide variant not specified [RCV004489913] Chr16:31061779 [GRCh38]
Chr16:31073100 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.14C>T (p.Ala5Val) single nucleotide variant not specified [RCV004614699] Chr16:31064446 [GRCh38]
Chr16:31075767 [GRCh37]
Chr16:16p11.2		 uncertain significance
NC_000016.9:g.(?_28889993)_(31202759_?)del deletion Dilated Cardiomyopathy, Dominant [RCV004582801] Chr16:28889993..31202759 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_024706.5(ZNF668):c.124G>A (p.Ala42Thr) single nucleotide variant not specified [RCV004601651] Chr16:31064336 [GRCh38]
Chr16:31075657 [GRCh37]
Chr16:16p11.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2742
Count of miRNA genes:725
Interacting mature miRNAs:848
Transcripts:ENST00000300849, ENST00000394983, ENST00000414399, ENST00000417935, ENST00000426488, ENST00000442862, ENST00000535577, ENST00000538906, ENST00000539836, ENST00000564456
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407362591GWAS1011567_Hmathematical ability QTL GWAS1011567 (human)2e-09mathematical ability163106608831066089Human
406978574GWAS627550_Hcigarettes per day measurement QTL GWAS627550 (human)2e-09cigarettes per day measurement163107414931074150Human

Markers in Region
SHGC-63580  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371631,075,595 - 31,075,720UniSTSGRCh37
Build 361630,983,096 - 30,983,221RGDNCBI36
Celera1629,221,777 - 29,221,902RGD
Cytogenetic Map16p11.2UniSTS
HuRef1628,637,287 - 28,637,412UniSTS
TNG Radiation Hybrid Map1617335.0UniSTS
RH47854  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371631,075,574 - 31,075,705UniSTSGRCh37
Build 361630,983,075 - 30,983,206RGDNCBI36
Celera1629,221,792 - 29,221,923RGD
Cytogenetic Map16p11.2UniSTS
HuRef1628,637,266 - 28,637,397UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001172668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001172669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001172670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_024706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC135050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA450347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC412389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF459566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000300849   ⟹   ENSP00000300849
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,060,847 - 31,074,240 (-)Ensembl
Ensembl Acc Id: ENST00000394983   ⟹   ENSP00000378434
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,060,850 - 31,073,502 (-)Ensembl
Ensembl Acc Id: ENST00000414399   ⟹   ENSP00000412340
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,062,122 - 31,073,712 (-)Ensembl
Ensembl Acc Id: ENST00000417935   ⟹   ENSP00000390671
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,064,184 - 31,072,827 (-)Ensembl
Ensembl Acc Id: ENST00000426488   ⟹   ENSP00000403975
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,060,848 - 31,064,969 (-)Ensembl
Ensembl Acc Id: ENST00000442862   ⟹   ENSP00000416853
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,063,969 - 31,065,088 (-)Ensembl
Ensembl Acc Id: ENST00000535577   ⟹   ENSP00000441349
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,060,843 - 31,065,088 (-)Ensembl
Ensembl Acc Id: ENST00000538906   ⟹   ENSP00000440149
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,060,848 - 31,073,502 (-)Ensembl
Ensembl Acc Id: ENST00000539836   ⟹   ENSP00000442573
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,060,851 - 31,065,055 (-)Ensembl
Ensembl Acc Id: ENST00000564456
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,064,650 - 31,074,184 (-)Ensembl
RefSeq Acc Id: NM_001172668   ⟹   NP_001166139
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,060,847 - 31,073,502 (-)NCBI
GRCh371631,072,164 - 31,085,641 (-)RGD
Celera1629,211,862 - 29,225,335 (+)RGD
HuRef1628,633,854 - 28,647,340 (-)RGD
CHM1_11632,389,464 - 32,402,124 (-)NCBI
T2T-CHM13v2.01631,448,267 - 31,460,930 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001172669   ⟹   NP_001166140
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,060,847 - 31,065,029 (-)NCBI
GRCh371631,072,164 - 31,085,641 (-)RGD
Celera1629,211,862 - 29,225,335 (+)RGD
HuRef1628,633,854 - 28,647,340 (-)RGD
CHM1_11632,389,459 - 32,393,706 (-)NCBI
T2T-CHM13v2.01631,448,267 - 31,452,451 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001172670   ⟹   NP_001166141
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,060,847 - 31,065,029 (-)NCBI
GRCh371631,072,164 - 31,085,641 (-)RGD
Celera1629,211,862 - 29,225,335 (+)RGD
HuRef1628,633,854 - 28,647,340 (-)RGD
CHM1_11632,389,459 - 32,393,706 (-)NCBI
T2T-CHM13v2.01631,448,267 - 31,452,451 (-)NCBI
Sequence:
RefSeq Acc Id: NM_024706   ⟹   NP_078982
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,060,847 - 31,074,240 (-)NCBI
GRCh371631,072,164 - 31,085,641 (-)RGD
Build 361630,979,672 - 30,993,005 (-)NCBI Archive
Celera1629,211,862 - 29,225,335 (+)RGD
HuRef1628,633,854 - 28,647,340 (-)RGD
CHM1_11632,389,459 - 32,402,942 (-)NCBI
T2T-CHM13v2.01631,448,267 - 31,461,668 (-)NCBI
Sequence:
RefSeq Acc Id: NP_078982   ⟸   NM_024706
- Peptide Label: isoform a
- UniProtKB: Q8N669 (UniProtKB/Swiss-Prot),   Q59EV1 (UniProtKB/Swiss-Prot),   F5H7E7 (UniProtKB/Swiss-Prot),   C9JHH8 (UniProtKB/Swiss-Prot),   Q9H8L4 (UniProtKB/Swiss-Prot),   Q96K58 (UniProtKB/Swiss-Prot),   A8K1I4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001166140   ⟸   NM_001172669
- Peptide Label: isoform b
- UniProtKB: A8K1I4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001166141   ⟸   NM_001172670
- Peptide Label: isoform a
- UniProtKB: Q8N669 (UniProtKB/Swiss-Prot),   Q59EV1 (UniProtKB/Swiss-Prot),   F5H7E7 (UniProtKB/Swiss-Prot),   C9JHH8 (UniProtKB/Swiss-Prot),   Q9H8L4 (UniProtKB/Swiss-Prot),   Q96K58 (UniProtKB/Swiss-Prot),   A8K1I4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001166139   ⟸   NM_001172668
- Peptide Label: isoform a
- UniProtKB: Q8N669 (UniProtKB/Swiss-Prot),   Q59EV1 (UniProtKB/Swiss-Prot),   F5H7E7 (UniProtKB/Swiss-Prot),   C9JHH8 (UniProtKB/Swiss-Prot),   Q9H8L4 (UniProtKB/Swiss-Prot),   Q96K58 (UniProtKB/Swiss-Prot),   A8K1I4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000403975   ⟸   ENST00000426488
Ensembl Acc Id: ENSP00000412340   ⟸   ENST00000414399
Ensembl Acc Id: ENSP00000441349   ⟸   ENST00000535577
Ensembl Acc Id: ENSP00000416853   ⟸   ENST00000442862
Ensembl Acc Id: ENSP00000390671   ⟸   ENST00000417935
Ensembl Acc Id: ENSP00000440149   ⟸   ENST00000538906
Ensembl Acc Id: ENSP00000300849   ⟸   ENST00000300849
Ensembl Acc Id: ENSP00000442573   ⟸   ENST00000539836
Ensembl Acc Id: ENSP00000378434   ⟸   ENST00000394983
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96K58-F1-model_v2 AlphaFold Q96K58 1-619 view protein structure

Promoters
RGD ID:6793643
Promoter ID:HG_KWN:23595
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000394983,   NM_001172668,   NM_024706,   OTTHUMT00000108508,   OTTHUMT00000108509,   OTTHUMT00000108520,   OTTHUMT00000108521
Position:
Human AssemblyChrPosition (strand)Source
Build 361630,991,451 - 30,993,382 (+)MPROMDB
RGD ID:7232055
Promoter ID:EPDNEW_H21772
Type:initiation region
Name:ZNF668_1
Description:zinc finger protein 668
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21773  EPDNEW_H21774  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,065,029 - 31,065,089EPDNEW
RGD ID:7232053
Promoter ID:EPDNEW_H21773
Type:initiation region
Name:ZNF668_3
Description:zinc finger protein 668
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21772  EPDNEW_H21774  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,073,529 - 31,073,589EPDNEW
RGD ID:7232057
Promoter ID:EPDNEW_H21774
Type:initiation region
Name:ZNF668_2
Description:zinc finger protein 668
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21773  EPDNEW_H21772  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,074,240 - 31,074,300EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:25821 AgrOrtholog
COSMIC ZNF668 COSMIC
Ensembl Genes ENSG00000167394 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000300849 ENTREZGENE
  ENST00000300849.5 UniProtKB/Swiss-Prot
  ENST00000394983.6 UniProtKB/Swiss-Prot
  ENST00000414399.1 UniProtKB/TrEMBL
  ENST00000417935.1 UniProtKB/TrEMBL
  ENST00000426488.6 UniProtKB/Swiss-Prot
  ENST00000442862.2 UniProtKB/TrEMBL
  ENST00000535577 ENTREZGENE
  ENST00000535577.5 UniProtKB/Swiss-Prot
  ENST00000538906 ENTREZGENE
  ENST00000538906.5 UniProtKB/Swiss-Prot
  ENST00000539836 ENTREZGENE
  ENST00000539836.3 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000167394 GTEx
HGNC ID HGNC:25821 ENTREZGENE
Human Proteome Map ZNF668 Human Proteome Map
InterPro Zinc_finger UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:79759 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 79759 ENTREZGENE
OMIM 617103 OMIM
PANTHER FI23536P1-RELATED UniProtKB/Swiss-Prot
  FINGER PROTEIN, PUTATIVE-RELATED UniProtKB/TrEMBL
  LOW QUALITY PROTEIN: ZINC FINGER PROTEIN 595-LIKE-RELATED UniProtKB/TrEMBL
  PR DOMAIN ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/Swiss-Prot
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142670515 PharmGKB
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K1I4 ENTREZGENE, UniProtKB/TrEMBL
  C9J092_HUMAN UniProtKB/TrEMBL
  C9JCJ0_HUMAN UniProtKB/TrEMBL
  C9JG35_HUMAN UniProtKB/TrEMBL
  C9JHH8 ENTREZGENE
  F5H7E7 ENTREZGENE
  Q4G0L6_HUMAN UniProtKB/TrEMBL
  Q59EV1 ENTREZGENE
  Q8N669 ENTREZGENE
  Q96K58 ENTREZGENE
  Q9H8L4 ENTREZGENE
  ZN668_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary C9JHH8 UniProtKB/Swiss-Prot
  F5H7E7 UniProtKB/Swiss-Prot
  Q59EV1 UniProtKB/Swiss-Prot
  Q8N669 UniProtKB/Swiss-Prot
  Q9H8L4 UniProtKB/Swiss-Prot