DRD3 (dopamine receptor D3) - Rat Genome Database

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Gene: DRD3 (dopamine receptor D3) Homo sapiens
Analyze
Symbol: DRD3
Name: dopamine receptor D3
RGD ID: 1605735
HGNC Page HGNC:3024
Description: Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including G protein-coupled dopamine receptor signaling pathway; arachidonate secretion; and behavioral response to cocaine. Located in plasma membrane. Implicated in essential tremor; essential tremor 1; and schizophrenia. Biomarker of Alzheimer's disease and Parkinson's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: D(3) dopamine receptor; D3DR; dopamine D3 receptor; essential tremor 1; ETM1; FET1; MGC149204; MGC149205
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383114,127,580 - 114,199,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3114,127,580 - 114,199,407 (-)EnsemblGRCh38hg38GRCh38
GRCh373113,846,427 - 113,918,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363115,330,247 - 115,380,589 (-)NCBINCBI36Build 36hg18NCBI36
Celera3112,255,976 - 112,306,017 (-)NCBICelera
Cytogenetic Map3q13.31NCBI
HuRef3111,221,547 - 111,271,509 (-)NCBIHuRef
CHM1_13113,810,902 - 113,860,923 (-)NCBICHM1_1
T2T-CHM13v2.03116,848,840 - 116,920,342 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-butaclamol  (EXP)
(1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin  (EXP)
(R,R)-tramadol  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,2,3,4-tetrahydroisoquinoline  (EXP)
17beta-estradiol  (ISO)
2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP)
amitriptyline  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
apomorphine  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
baclofen  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bromocriptine  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
CGP 52608  (EXP)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
dieldrin  (ISO)
diiodine  (ISO)
dimethylarsinic acid  (ISO)
dizocilpine maleate  (ISO)
dopamine  (EXP,ISO)
ethanol  (ISO)
eticlopride(1+)  (EXP)
fenvalerate  (ISO)
fluoxetine  (EXP)
folic acid  (EXP)
FPL 64176  (ISO)
fucoxanthin  (EXP)
gamma-aminobutyric acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (EXP,ISO)
ionomycin  (ISO)
KN-93  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP,ISO)
methylarsonic acid  (ISO)
Methylazoxymethanol acetate  (ISO)
methylmercury chloride  (ISO)
mirtazapine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (ISO)
N-Methylspiperone  (ISO)
nafadotride  (EXP)
nicotine  (ISO)
nifedipine  (ISO)
olanzapine  (EXP)
oxidopamine  (ISO)
piperidines  (EXP)
pramipexole  (EXP)
propanal  (EXP)
quercetin  (ISO)
quinpirole  (EXP,ISO)
risperidone  (EXP)
ropinirole  (EXP)
SCH 23390  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
spiperone  (EXP)
tetrahydropalmatine  (ISO)
tramadol  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
U-73122  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acid secretion  (ISS)
adenylate cyclase-activating dopamine receptor signaling pathway  (IDA,ISO)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (IBA,IDA,IEA)
arachidonate secretion  (IDA)
autophagy  (ISO)
behavioral response to cocaine  (IEP,ISO,ISS)
circadian regulation of gene expression  (ISO,ISS)
dopamine metabolic process  (IC)
G protein-coupled dopamine receptor signaling pathway  (ISO)
G protein-coupled receptor internalization  (IDA,ISO)
G protein-coupled receptor signaling pathway  (IDA,IEA,ISO)
intracellular calcium ion homeostasis  (IDA)
learning  (NAS)
learning or memory  (NAS)
locomotory behavior  (ISO,ISS)
musculoskeletal movement, spinal reflex action  (ISO,ISS)
negative regulation of apoptotic process  (ISO)
negative regulation of blood pressure  (ISO,ISS)
negative regulation of cytosolic calcium ion concentration  (IBA)
negative regulation of dopamine receptor signaling pathway  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO,ISS)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
negative regulation of protein secretion  (IDA)
negative regulation of sodium:proton antiporter activity  (ISO)
negative regulation of synaptic transmission, glutamatergic  (IBA)
negative regulation of transcription by RNA polymerase II  (ISO)
oligodendrocyte differentiation  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IBA)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokinesis  (IMP)
positive regulation of dopamine receptor signaling pathway  (ISO,ISS)
positive regulation of mitotic nuclear division  (ISS)
positive regulation of transcription by RNA polymerase II  (ISO)
prepulse inhibition  (IMP)
regulation of blood volume by renin-angiotensin  (ISO)
regulation of circadian sleep/wake cycle, sleep  (ISO)
regulation of dopamine secretion  (IBA,ISO,ISS)
regulation of dopamine uptake involved in synaptic transmission  (IC)
regulation of lipid metabolic process  (ISO)
regulation of locomotion involved in locomotory behavior  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of neurotransmitter uptake  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of potassium ion transport  (IBA)
response to amphetamine  (ISO)
response to cocaine  (IEP,ISO)
response to ethanol  (ISO,ISS)
response to histamine  (IDA)
response to morphine  (ISO,ISS)
response to xenobiotic stimulus  (ISS)
signal transduction  (IEA)
social behavior  (NAS)
synaptic transmission, dopaminergic  (IEA)
visual learning  (ISO,ISS)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Striatal neurochemical changes in transgenic models of Huntington's disease. Ariano MA, etal., J Neurosci Res. 2002 Jun 15;68(6):716-29.
2. Increased expression of dopamine receptors on lymphocytes in Parkinson's disease. Barbanti P, etal., Mov Disord. 1999 Sep;14(5):764-71.
3. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
4. Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. Crocq MA, etal., J Med Genet. 1992 Dec;29(12):858-60.
5. Up-regulation of D3 dopaminergic receptor mRNA in the core of the nucleus accumbens accompanies the development of seizures in a genetic model of absence-epilepsy in the rat. Deransart C, etal., Brain Res Mol Brain Res. 2001 Oct 19;94(1-2):166-77.
6. Impulsivity and Concussion in Juvenile Rats: Examining Molecular and Structural Aspects of the Frontostriatal Pathway. Hehar H, etal., PLoS One. 2015 Oct 8;10(10):e0139842. doi: 10.1371/journal.pone.0139842. eCollection 2015.
7. Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats. Kosmowska B, etal., CNS Neurosci Ther. 2016 Jan;22(1):53-62. doi: 10.1111/cns.12467. Epub 2015 Oct 13.
8. Immunohistochemical localization of dopamine receptor subtypes (D1R-D5R) in Alzheimer's disease brain. Kumar U and Patel SC, Brain Res. 2007 Feb 2;1131(1):187-96. Epub 2006 Dec 19.
9. Dopamine D3 receptor antagonists improve the learning performance in memory-impaired rats. Laszy J, etal., Psychopharmacology (Berl). 2005 May;179(3):567-75. Epub 2004 Dec 24.
10. The usefulness of the spontaneously hypertensive rat to model attention-deficit/hyperactivity disorder (ADHD) may be explained by the differential expression of dopamine-related genes in the brain. Li Q, etal., Neurochem Int. 2007 May;50(6):848-57. Epub 2007 Mar 1.
11. Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. Li Y, etal., Med Sci Monit. 2017 Jun 9;23:2805-2815.
12. Linkage with the Ser9Gly DRD3 polymorphism in essential tremor families. Lucotte G, etal., Clin Genet. 2006 May;69(5):437-40.
13. Decrease of the D3 dopamine receptor mRNA expression in lymphocytes from patients with Parkinson's disease. Nagai Y, etal., Neurology. 1996 Mar;46(3):791-5.
14. A study of the association between schizophrenia and the dopamine D3 receptor gene. Nanko S, etal., Hum Genet. 1993 Oct;92(4):336-8.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Dopamine D3 receptor modulation of dopamine efflux in the rat nucleus accumbens. Roberts C, etal., Eur J Pharmacol. 2006 Mar 18;534(1-3):108-14. Epub 2006 Feb 21.
19. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
20. Effects of oligonucleotide antisense to dopamine D3 receptor mRNA in a rodent model of behavioural sensitization to levodopa. van Kampen JM and Stoessl AJ, Neuroscience 2003;116(1):307-14.
21. Stimulation of Dopamine D3 Receptor Attenuates Renal Ischemia-Reperfusion Injury via Increased Linkage With Ga12. Wang Z, etal., Transplantation. 2015 Nov;99(11):2274-84. doi: 10.1097/TP.0000000000000762.
22. Interaction between polymorphisms of the dopamine D3 receptor and manganese superoxide dismutase genes in susceptibility to tardive dyskinesia. Zhang ZJ, etal., Psychiatr Genet. 2003 Sep;13(3):187-92.
23. Prenatal Exposure to Methamphetamine: Up-Regulation of Brain Receptor Genes. Zoubková H, etal., Front Neurosci. 2019 Aug 1;13:771. doi: 10.3389/fnins.2019.00771. eCollection 2019.
Additional References at PubMed
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PMID:39187246   PMID:39300138  


Genomics

Comparative Map Data
DRD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383114,127,580 - 114,199,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3114,127,580 - 114,199,407 (-)EnsemblGRCh38hg38GRCh38
GRCh373113,846,427 - 113,918,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363115,330,247 - 115,380,589 (-)NCBINCBI36Build 36hg18NCBI36
Celera3112,255,976 - 112,306,017 (-)NCBICelera
Cytogenetic Map3q13.31NCBI
HuRef3111,221,547 - 111,271,509 (-)NCBIHuRef
CHM1_13113,810,902 - 113,860,923 (-)NCBICHM1_1
T2T-CHM13v2.03116,848,840 - 116,920,342 (-)NCBIT2T-CHM13v2.0
Drd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391643,574,285 - 43,646,353 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1643,574,389 - 43,643,295 (+)EnsemblGRCm39 Ensembl
GRCm381643,754,015 - 43,825,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1643,754,026 - 43,822,932 (+)EnsemblGRCm38mm10GRCm38
MGSCv371643,762,355 - 43,822,952 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361643,681,574 - 43,742,171 (+)NCBIMGSCv36mm8
Celera1644,116,581 - 44,178,828 (+)NCBICelera
Cytogenetic Map16B4NCBI
cM Map1628.44NCBI
Drd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81170,385,586 - 70,437,793 (-)NCBIGRCr8
mRatBN7.21156,879,689 - 56,931,901 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,879,689 - 56,940,596 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1165,692,856 - 65,745,058 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01158,355,096 - 58,407,302 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01157,403,823 - 57,463,424 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01161,819,102 - 61,883,223 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1161,822,077 - 61,874,327 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,955,136 - 61,016,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,446,901 - 58,520,589 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11158,504,489 - 58,578,178 (-)NCBI
Celera1156,432,639 - 56,484,538 (-)NCBICelera
Cytogenetic Map11q21NCBI
Drd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542714,219,594 - 14,252,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542714,219,519 - 14,252,178 (-)NCBIChiLan1.0ChiLan1.0
DRD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22112,119,170 - 112,171,040 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13112,123,944 - 112,175,818 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03111,265,834 - 111,317,176 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13118,187,636 - 118,237,403 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3118,187,636 - 118,237,403 (-)Ensemblpanpan1.1panPan2
DRD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13318,369,362 - 18,414,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3318,372,865 - 18,412,277 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3318,479,435 - 18,522,131 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03318,617,139 - 18,660,020 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3318,616,976 - 18,660,045 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13318,420,282 - 18,463,050 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03318,472,599 - 18,515,180 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03319,017,562 - 19,060,421 (-)NCBIUU_Cfam_GSD_1.0
Drd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602135,897,271 - 135,945,568 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365361,580,732 - 1,616,725 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365361,580,732 - 1,616,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13145,771,774 - 145,819,168 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113145,769,294 - 145,817,997 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213155,329,068 - 155,375,118 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12266,683,987 - 66,737,645 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2266,691,177 - 66,736,690 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604199,729,580 - 99,781,727 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473134,319,130 - 34,363,184 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473134,318,733 - 34,369,111 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DRD3
56 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000796.6(DRD3):c.25G>A (p.Gly9Ser) single nucleotide variant DRD3-related disorder [RCV003974838]|Essential tremor, susceptibility to [RCV000018258]|Schizophrenia, susceptibility to [RCV000018257]|Tremor, hereditary essential, 1 [RCV000381906]|not provided [RCV004710442]|not specified [RCV000613256] Chr3:114171968 [GRCh38]
Chr3:113890815 [GRCh37]
Chr3:3q13.31		 risk factor|benign|likely benign
GRCh38/hg38 3q13.2-13.31(chr3:112168829-117393356)x1 copy number loss See cases [RCV000050766] Chr3:112168829..117393356 [GRCh38]
Chr3:111887676..117112203 [GRCh37]
Chr3:113370366..118594893 [NCBI36]
Chr3:3q13.2-13.31		 pathogenic
GRCh38/hg38 3q11.1-21.1(chr3:93886671-123216683)x1 copy number loss See cases [RCV000051543] Chr3:93886671..123216683 [GRCh38]
Chr3:93605515..122935530 [GRCh37]
Chr3:95088205..124418220 [NCBI36]
Chr3:3q11.1-21.1		 pathogenic
GRCh38/hg38 3q13.13-13.31(chr3:108242572-116169331)x1 copy number loss See cases [RCV000051544] Chr3:108242572..116169331 [GRCh38]
Chr3:107961419..115888178 [GRCh37]
Chr3:109444109..117370868 [NCBI36]
Chr3:3q13.13-13.31		 pathogenic
GRCh38/hg38 3q13.2-13.31(chr3:112479482-115774102)x1 copy number loss See cases [RCV000051545] Chr3:112479482..115774102 [GRCh38]
Chr3:112198329..115492949 [GRCh37]
Chr3:113681019..116975639 [NCBI36]
Chr3:3q13.2-13.31		 pathogenic
GRCh38/hg38 3q13.11-13.31(chr3:104621220-116093884)x3 copy number gain See cases [RCV000051722] Chr3:104621220..116093884 [GRCh38]
Chr3:104340064..115812731 [GRCh37]
Chr3:105822754..117295421 [NCBI36]
Chr3:3q13.11-13.31		 pathogenic
NM_000796.6(DRD3):c.117C>T (p.Leu39=) single nucleotide variant not provided [RCV004721751] Chr3:114171876 [GRCh38]
Chr3:113890723 [GRCh37]
Chr3:115373413 [NCBI36]
Chr3:3q13.31		 likely benign|not provided
GRCh38/hg38 3q11.1-13.31(chr3:93819623-116887056)x1 copy number loss See cases [RCV000135320] Chr3:93819623..116887056 [GRCh38]
Chr3:93538467..116605903 [GRCh37]
Chr3:95021157..118088593 [NCBI36]
Chr3:3q11.1-13.31		 pathogenic
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29		 pathogenic
GRCh38/hg38 3q13.2-13.31(chr3:112465096-115774102)x1 copy number loss See cases [RCV000135592] Chr3:112465096..115774102 [GRCh38]
Chr3:112183943..115492949 [GRCh37]
Chr3:113666633..116975639 [NCBI36]
Chr3:3q13.2-13.31		 likely pathogenic
GRCh38/hg38 3q11.2-13.31(chr3:97795369-115663349)x1 copy number loss See cases [RCV000138186] Chr3:97795369..115663349 [GRCh38]
Chr3:97514213..115382196 [GRCh37]
Chr3:98996903..116864886 [NCBI36]
Chr3:3q11.2-13.31		 pathogenic|uncertain significance
GRCh38/hg38 3q13.2-13.31(chr3:112465094-115774111)x1 copy number loss See cases [RCV000138434] Chr3:112465094..115774111 [GRCh38]
Chr3:112183941..115492958 [GRCh37]
Chr3:113666631..116975648 [NCBI36]
Chr3:3q13.2-13.31		 pathogenic
GRCh38/hg38 3q13.2-21.3(chr3:112620977-128734134)x1 copy number loss See cases [RCV000139033] Chr3:112620977..128734134 [GRCh38]
Chr3:112339824..128452977 [GRCh37]
Chr3:113822514..129935667 [NCBI36]
Chr3:3q13.2-21.3		 pathogenic
GRCh38/hg38 3q13.31-21.2(chr3:114122562-124532374)x1 copy number loss See cases [RCV000142009] Chr3:114122562..124532374 [GRCh38]
Chr3:113841409..124251221 [GRCh37]
Chr3:115324099..125733911 [NCBI36]
Chr3:3q13.31-21.2		 pathogenic
GRCh38/hg38 3q11.1-24(chr3:93800620-145695381)x3 copy number gain See cases [RCV000142340] Chr3:93800620..145695381 [GRCh38]
Chr3:93519464..145413168 [GRCh37]
Chr3:95002154..146895858 [NCBI36]
Chr3:3q11.1-24		 pathogenic
GRCh38/hg38 3q13.2-13.31(chr3:112425234-115795585)x1 copy number loss See cases [RCV000142219] Chr3:112425234..115795585 [GRCh38]
Chr3:112144081..115514432 [GRCh37]
Chr3:113626771..116997122 [NCBI36]
Chr3:3q13.2-13.31		 pathogenic
GRCh38/hg38 3q13.2-13.33(chr3:112520553-120031022)x1 copy number loss See cases [RCV000142725] Chr3:112520553..120031022 [GRCh38]
Chr3:112239400..119749869 [GRCh37]
Chr3:113722090..121232559 [NCBI36]
Chr3:3q13.2-13.33		 pathogenic
NM_000796.6(DRD3):c.987A>G (p.Gln329=) single nucleotide variant Tremor, hereditary essential, 1 [RCV000260664]|not provided [RCV000953478] Chr3:114131137 [GRCh38]
Chr3:113849984 [GRCh37]
Chr3:3q13.31		 benign|likely benign
NM_000796.6(DRD3):c.-153T>G single nucleotide variant Tremor, hereditary essential, 1 [RCV000284814] Chr3:114178774 [GRCh38]
Chr3:113897621 [GRCh37]
Chr3:3q13.31		 likely benign|uncertain significance
NM_000796.6(DRD3):c.-286A>C single nucleotide variant Tremor, hereditary essential, 1 [RCV000281412] Chr3:114178907 [GRCh38]
Chr3:113897754 [GRCh37]
Chr3:3q13.31		 likely benign
NM_000796.6(DRD3):c.691T>A (p.Cys231Ser) single nucleotide variant DRD3-related disorder [RCV003972443]|Tremor, hereditary essential, 1 [RCV000275832] Chr3:114139532 [GRCh38]
Chr3:113858379 [GRCh37]
Chr3:3q13.31		 likely benign|uncertain significance
NM_000796.6(DRD3):c.270+14A>G single nucleotide variant Hereditary essential tremor [RCV000272180] Chr3:114171709 [GRCh38]
Chr3:113890556 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.-281A>G single nucleotide variant Hereditary essential tremor [RCV000397000] Chr3:114178902 [GRCh38]
Chr3:113897749 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.-333G>A single nucleotide variant Tremor, hereditary essential, 1 [RCV000398553]|not provided [RCV004715997] Chr3:114178954 [GRCh38]
Chr3:113897801 [GRCh37]
Chr3:3q13.31		 benign|likely benign
NM_000796.6(DRD3):c.-318C>T single nucleotide variant Hereditary essential tremor [RCV000336537] Chr3:114178939 [GRCh38]
Chr3:113897786 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.1077C>T (p.His359=) single nucleotide variant Tremor, hereditary essential, 1 [RCV000355960]|not provided [RCV000953477] Chr3:114128842 [GRCh38]
Chr3:113847689 [GRCh37]
Chr3:3q13.31		 benign|likely benign|uncertain significance
NM_000796.6(DRD3):c.-252C>T single nucleotide variant Tremor, hereditary essential, 1 [RCV000340085] Chr3:114178873 [GRCh38]
Chr3:113897720 [GRCh37]
Chr3:3q13.31		 likely benign
NM_000796.6(DRD3):c.-38A>C single nucleotide variant Hereditary essential tremor [RCV000288465] Chr3:114178659 [GRCh38]
Chr3:113897506 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.-105G>A single nucleotide variant Tremor, hereditary essential, 1 [RCV000324870]|not provided [RCV004710915] Chr3:114178726 [GRCh38]
Chr3:113897573 [GRCh37]
Chr3:3q13.31		 likely benign
NM_000796.6(DRD3):c.51A>G (p.Ala17=) single nucleotide variant DRD3-related disorder [RCV003972444]|Tremor, hereditary essential, 1 [RCV000327367]|not provided [RCV004715996] Chr3:114171942 [GRCh38]
Chr3:113890789 [GRCh37]
Chr3:3q13.31		 benign|likely benign
NM_000796.6(DRD3):c.720G>A (p.Gln240=) single nucleotide variant Tremor, hereditary essential, 1 [RCV000370469]|not provided [RCV004715995] Chr3:114139503 [GRCh38]
Chr3:113858350 [GRCh37]
Chr3:3q13.31		 benign|likely benign
NM_000796.6(DRD3):c.821G>A (p.Gly274Glu) single nucleotide variant Hereditary essential tremor [RCV000297108] Chr3:114131303 [GRCh38]
Chr3:113850150 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.383+7C>T single nucleotide variant Hereditary essential tremor [RCV000330956] Chr3:114159748 [GRCh38]
Chr3:113878595 [GRCh37]
Chr3:3q13.31		 uncertain significance
GRCh37/hg19 3q13.12-13.31(chr3:106598767-115704696) copy number loss Chromosome 3q13.31 deletion syndrome [RCV002280741] Chr3:106598767..115704696 [GRCh37]
Chr3:3q13.12-13.31		 pathogenic
NM_000796.6(DRD3):c.-388T>A single nucleotide variant Hereditary essential tremor [RCV000315005] Chr3:114179009 [GRCh38]
Chr3:113897856 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.302T>G (p.Ile101Ser) single nucleotide variant Hereditary essential tremor [RCV000366836] Chr3:114159836 [GRCh38]
Chr3:113878683 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.1151C>A (p.Thr384Asn) single nucleotide variant Hereditary essential tremor [RCV000301133] Chr3:114128768 [GRCh38]
Chr3:113847615 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.-114A>G single nucleotide variant Hereditary essential tremor [RCV000379475] Chr3:114178735 [GRCh38]
Chr3:113897582 [GRCh37]
Chr3:3q13.31		 uncertain significance
GRCh37/hg19 3q13.2-13.31(chr3:112144081-115514432)x1 copy number loss See cases [RCV000446223] Chr3:112144081..115514432 [GRCh37]
Chr3:3q13.2-13.31		 pathogenic
GRCh37/hg19 3q13.11-13.32(chr3:105094834-117441953)x1 copy number loss See cases [RCV000448410] Chr3:105094834..117441953 [GRCh37]
Chr3:3q13.11-13.32		 pathogenic
GRCh37/hg19 3q13.2-13.31(chr3:112590339-116461450)x1 copy number loss See cases [RCV000511086] Chr3:112590339..116461450 [GRCh37]
Chr3:3q13.2-13.31		 pathogenic
NM_000796.6(DRD3):c.44G>C (p.Cys15Ser) single nucleotide variant not specified [RCV004285674] Chr3:114171949 [GRCh38]
Chr3:113890796 [GRCh37]
Chr3:3q13.31		 uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
NM_000796.6(DRD3):c.383+2327C>T single nucleotide variant not specified [RCV000607974] Chr3:114157428 [GRCh38]
Chr3:113876275 [GRCh37]
Chr3:3q13.31		 benign
NM_000796.6(DRD3):c.25= (p.Gly9=) single nucleotide variant not specified [RCV000606074] Chr3:114171968 [GRCh38]
Chr3:113890815 [GRCh37]
Chr3:3q13.31		 benign
GRCh37/hg19 3q13.13-13.31(chr3:110645295-115103586)x1 copy number loss not provided [RCV000682294] Chr3:110645295..115103586 [GRCh37]
Chr3:3q13.13-13.31		 pathogenic
GRCh37/hg19 3q13.2-13.31(chr3:111894832-116930109)x1 copy number loss not provided [RCV000682296] Chr3:111894832..116930109 [GRCh37]
Chr3:3q13.2-13.31		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
NM_000796.6(DRD3):c.405C>T (p.Pro135=) single nucleotide variant not provided [RCV000925042] Chr3:114147536 [GRCh38]
Chr3:113866383 [GRCh37]
Chr3:3q13.31		 likely benign
NM_000796.6(DRD3):c.1047T>C (p.His349=) single nucleotide variant not provided [RCV000900426] Chr3:114128872 [GRCh38]
Chr3:113847719 [GRCh37]
Chr3:3q13.31		 likely benign
NM_000796.6(DRD3):c.954G>A (p.Arg318=) single nucleotide variant not provided [RCV000925299] Chr3:114131170 [GRCh38]
Chr3:113850017 [GRCh37]
Chr3:3q13.31		 likely benign
NM_000796.6(DRD3):c.324C>A (p.Thr108=) single nucleotide variant not provided [RCV000915643] Chr3:114159814 [GRCh38]
Chr3:113878661 [GRCh37]
Chr3:3q13.31		 likely benign
GRCh37/hg19 3q13.2-13.31(chr3:112183943-115492949)x1 copy number loss not provided [RCV000856645] Chr3:112183943..115492949 [GRCh37]
Chr3:3q13.2-13.31		 pathogenic
NM_000796.6(DRD3):c.921G>T (p.Ser307=) single nucleotide variant not provided [RCV000938300] Chr3:114131203 [GRCh38]
Chr3:113850050 [GRCh37]
Chr3:3q13.31		 likely benign
GRCh37/hg19 3q13.31(chr3:113594376-114060961)x3 copy number gain not provided [RCV000848094] Chr3:113594376..114060961 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.406G>A (p.Val136Ile) single nucleotide variant Tremor, hereditary essential, 1 [RCV001144425] Chr3:114147535 [GRCh38]
Chr3:113866382 [GRCh37]
Chr3:3q13.31		 likely benign
NC_000003.11:g.(?_113503051)_(114070745_?)dup duplication not provided [RCV003105597] Chr3:113503051..114070745 [GRCh37]
Chr3:3q13.31		 uncertain significance
NC_000003.11:g.(?_113010404)_(114099634_?)del deletion not provided [RCV003105596] Chr3:113010404..114099634 [GRCh37]
Chr3:3q13.2-13.31		 pathogenic|uncertain significance
NM_000796.6(DRD3):c.112G>A (p.Ala38Thr) single nucleotide variant Tremor, hereditary essential, 1 [RCV001144426]|not provided [RCV004711541] Chr3:114171881 [GRCh38]
Chr3:113890728 [GRCh37]
Chr3:3q13.31		 likely benign
NM_000796.6(DRD3):c.720= (p.Gln240=) variation not provided [RCV000956126] Chr3:114139503 [GRCh38]
Chr3:113858350 [GRCh37]
Chr3:3q13.31		 benign
GRCh37/hg19 3q13.2-13.32(chr3:113233952-118525556)x1 copy number loss See cases [RCV001194596] Chr3:113233952..118525556 [GRCh37]
Chr3:3q13.2-13.32		 pathogenic
GRCh37/hg19 3q13.2-13.31(chr3:112135341-115509260)x3 copy number gain not provided [RCV001259226] Chr3:112135341..115509260 [GRCh37]
Chr3:3q13.2-13.31		 pathogenic
NM_000796.6(DRD3):c.129C>T (p.Ile43=) single nucleotide variant not provided [RCV001311602] Chr3:114171864 [GRCh38]
Chr3:113890711 [GRCh37]
Chr3:3q13.31		 likely benign
GRCh37/hg19 3q13.31(chr3:113623035-114368128)x1 copy number loss Chromosome 3q13.31 deletion syndrome [RCV001391300] Chr3:113623035..114368128 [GRCh37]
Chr3:3q13.31		 pathogenic
GRCh37/hg19 3q13.2-13.31(chr3:112144081-115514432) copy number loss not specified [RCV002053367] Chr3:112144081..115514432 [GRCh37]
Chr3:3q13.2-13.31		 pathogenic
NM_000796.6(DRD3):c.404C>A (p.Pro135His) single nucleotide variant Tremor, hereditary essential, 1 [RCV002293395] Chr3:114147537 [GRCh38]
Chr3:113866384 [GRCh37]
Chr3:3q13.31		 uncertain significance
GRCh37/hg19 3q13.12-13.31(chr3:107059705-115005256)x1 copy number loss not provided [RCV002472579] Chr3:107059705..115005256 [GRCh37]
Chr3:3q13.12-13.31		 pathogenic
NM_000796.6(DRD3):c.940C>A (p.Pro314Thr) single nucleotide variant not specified [RCV004087258] Chr3:114131184 [GRCh38]
Chr3:113850031 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.41C>T (p.Thr14Ile) single nucleotide variant not specified [RCV004152407] Chr3:114171952 [GRCh38]
Chr3:113890799 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.172C>T (p.Arg58Trp) single nucleotide variant not specified [RCV004174948] Chr3:114171821 [GRCh38]
Chr3:113890668 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.1018G>T (p.Val340Phe) single nucleotide variant not specified [RCV004104371] Chr3:114128901 [GRCh38]
Chr3:113847748 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.299G>A (p.Arg100His) single nucleotide variant not specified [RCV004177918] Chr3:114159839 [GRCh38]
Chr3:113878686 [GRCh37]
Chr3:3q13.31		 uncertain significance
GRCh37/hg19 3q13.13-13.31(chr3:110966195-115843176)x1 copy number loss Chromosome 3q13.31 deletion syndrome [RCV003222552] Chr3:110966195..115843176 [GRCh37]
Chr3:3q13.13-13.31		 pathogenic
NM_000796.6(DRD3):c.676C>G (p.Arg226Gly) single nucleotide variant not specified [RCV004262062] Chr3:114139547 [GRCh38]
Chr3:113858394 [GRCh37]
Chr3:3q13.31		 uncertain significance
GRCh38/hg38 3q11.1-21.2(chr3:93979547-124774010)x1 copy number loss Chromosome 3q13.31 deletion syndrome [RCV003327614] Chr3:93979547..124774010 [GRCh38]
Chr3:3q11.1-21.2		 pathogenic
NM_000796.6(DRD3):c.659G>A (p.Arg220Gln) single nucleotide variant not specified [RCV004338728] Chr3:114139564 [GRCh38]
Chr3:113858411 [GRCh37]
Chr3:3q13.31		 uncertain significance
GRCh37/hg19 3q13.13-13.31(chr3:110398276-113879363)x1 copy number loss not provided [RCV003485398] Chr3:110398276..113879363 [GRCh37]
Chr3:3q13.13-13.31		 uncertain significance
NM_000796.6(DRD3):c.1110G>T (p.Trp370Cys) single nucleotide variant DRD3-related disorder [RCV003400123] Chr3:114128809 [GRCh38]
Chr3:113847656 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.155T>C (p.Met52Thr) single nucleotide variant not provided [RCV003434763]|not specified [RCV004364591] Chr3:114171838 [GRCh38]
Chr3:113890685 [GRCh37]
Chr3:3q13.31		 likely benign|uncertain significance
NM_000796.6(DRD3):c.723+4A>G single nucleotide variant not provided [RCV003437953] Chr3:114139496 [GRCh38]
Chr3:113858343 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.114G>A (p.Ala38=) single nucleotide variant DRD3-related disorder [RCV003981357] Chr3:114171879 [GRCh38]
Chr3:113890726 [GRCh37]
Chr3:3q13.31		 likely benign
NM_000796.6(DRD3):c.365G>A (p.Cys122Tyr) single nucleotide variant not specified [RCV004377091] Chr3:114159773 [GRCh38]
Chr3:113878620 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.529G>A (p.Asp177Asn) single nucleotide variant not specified [RCV004377093] Chr3:114139694 [GRCh38]
Chr3:113858541 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.47G>A (p.Gly16Glu) single nucleotide variant not specified [RCV004377092] Chr3:114171946 [GRCh38]
Chr3:113890793 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.623A>G (p.Tyr208Cys) single nucleotide variant not specified [RCV004377094] Chr3:114139600 [GRCh38]
Chr3:113858447 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.745C>T (p.His249Tyr) single nucleotide variant not specified [RCV004377095] Chr3:114131379 [GRCh38]
Chr3:113850226 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.323C>G (p.Thr108Ser) single nucleotide variant not specified [RCV004619845] Chr3:114159815 [GRCh38]
Chr3:113878662 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.941C>T (p.Pro314Leu) single nucleotide variant not specified [RCV004914355] Chr3:114131183 [GRCh38]
Chr3:113850030 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.893T>G (p.Val298Gly) single nucleotide variant not specified [RCV004914356] Chr3:114131231 [GRCh38]
Chr3:113850078 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.1036T>C (p.Phe346Leu) single nucleotide variant not specified [RCV004914357] Chr3:114128883 [GRCh38]
Chr3:113847730 [GRCh37]
Chr3:3q13.31		 uncertain significance
NM_000796.6(DRD3):c.1172G>A (p.Arg391Gln) single nucleotide variant not specified [RCV004914354] Chr3:114128747 [GRCh38]
Chr3:113847594 [GRCh37]
Chr3:3q13.31		 uncertain significance
GRCh37/hg19 3q13.2-13.31(chr3:112144082-115514432)x1 copy number loss not provided [RCV004819338] Chr3:112144082..115514432 [GRCh37]
Chr3:3q13.2-13.31		 pathogenic
NM_000796.6(DRD3):c.1130C>A (p.Ala377Asp) single nucleotide variant not specified [RCV004920337] Chr3:114128789 [GRCh38]
Chr3:113847636 [GRCh37]
Chr3:3q13.31		 uncertain significance
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIRLET7Dhsa-let-7d-5pMirecordsexternal_info{changed}NA19703567

Predicted Target Of
Summary Value
Count of predictions:1062
Count of miRNA genes:403
Interacting mature miRNAs:431
Transcripts:ENST00000295881, ENST00000383673, ENST00000460779, ENST00000467632
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597491212GWAS1587286_Hbreast density QTL GWAS1587286 (human)0.0000002breast density3114197063114197064Human
597466511GWAS1562585_Hfeeling emotionally hurt measurement QTL GWAS1562585 (human)3e-08feeling emotionally hurt measurement3114198525114198526Human
597226590GWAS1322664_Hchronotype measurement QTL GWAS1322664 (human)2e-08sleep behavior trait (VT:0001501)3114172702114172703Human
597206127GWAS1302201_Hghrelin measurement QTL GWAS1302201 (human)3e-08blood ghrelin amount (VT:0010695)3114175357114175358Human
597164548GWAS1260622_Hlipid measurement QTL GWAS1260622 (human)0.000002lipid measurementblood lipid measurement (CMO:0000050)3114151231114151232Human
407060909GWAS709885_Hchronotype measurement QTL GWAS709885 (human)5e-09sleep behavior trait (VT:0001501)3114172702114172703Human
407025117GWAS674093_Hsmooth surface dental caries QTL GWAS674093 (human)0.000009smooth surface dental caries3114171942114171943Human

Markers in Region
GDB:197934  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373113,890,558 - 113,891,020UniSTSGRCh37
Build 363115,373,248 - 115,373,710RGDNCBI36
Celera3112,298,676 - 112,299,138RGD
Cytogenetic Map3q13.3UniSTS
HuRef3111,264,168 - 111,264,630UniSTS
GDB:512205  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373113,890,765 - 113,890,842UniSTSGRCh37
Build 363115,373,455 - 115,373,532RGDNCBI36
Celera3112,298,883 - 112,298,960RGD
Cytogenetic Map3q13.3UniSTS
HuRef3111,264,375 - 111,264,452UniSTS
RH71216  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373113,847,564 - 113,847,741UniSTSGRCh37
Build 363115,330,254 - 115,330,431RGDNCBI36
Celera3112,255,983 - 112,256,160RGD
Cytogenetic Map3q13.3UniSTS
HuRef3111,221,554 - 111,221,731UniSTS
GeneMap99-GB4 RH Map3412.11UniSTS
NCBI RH Map3928.3UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
216 368 394 255 1979 307 412 53 543 31 510 1088 1091 3 1701 100 627 343 24

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001290809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017005829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A19667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC092896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC093010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF033621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY228454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY228455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY228456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY228457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY228458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY228459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ534829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ535032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L20469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U25441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000295881   ⟹   ENSP00000295881
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3114,128,710 - 114,179,052 (-)Ensembl
Ensembl Acc Id: ENST00000383673   ⟹   ENSP00000373169
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3114,127,580 - 114,179,052 (-)Ensembl
Ensembl Acc Id: ENST00000460779   ⟹   ENSP00000419402
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3114,128,652 - 114,199,407 (-)Ensembl
Ensembl Acc Id: ENST00000467632   ⟹   ENSP00000420662
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3114,128,710 - 114,178,698 (-)Ensembl
Ensembl Acc Id: ENST00000698213   ⟹   ENSP00000513607
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3114,127,580 - 114,179,052 (-)Ensembl
RefSeq Acc Id: NM_000796   ⟹   NP_000787
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383114,127,580 - 114,179,052 (-)NCBI
GRCh373113,847,499 - 113,918,254 (-)NCBI
Build 363115,330,247 - 115,380,589 (-)NCBI Archive
HuRef3111,221,547 - 111,291,849 (-)NCBI
CHM1_13113,810,844 - 113,860,923 (-)NCBI
T2T-CHM13v2.03116,848,840 - 116,900,027 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001282563   ⟹   NP_001269492
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383114,128,652 - 114,199,407 (-)NCBI
HuRef3111,221,547 - 111,291,849 (-)NCBI
CHM1_13113,810,844 - 113,881,272 (-)NCBI
T2T-CHM13v2.03116,849,912 - 116,920,342 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001290809   ⟹   NP_001277738
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383114,128,652 - 114,178,776 (-)NCBI
CHM1_13113,810,844 - 113,860,647 (-)NCBI
T2T-CHM13v2.03116,849,912 - 116,899,751 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033663   ⟹   NP_387512
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383114,127,580 - 114,179,052 (-)NCBI
GRCh373113,847,499 - 113,918,254 (-)NCBI
Build 363115,330,247 - 115,380,589 (-)NCBI Archive
HuRef3111,221,547 - 111,291,849 (-)NCBI
CHM1_13113,810,844 - 113,860,923 (-)NCBI
T2T-CHM13v2.03116,848,840 - 116,900,027 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_000787 (Get FASTA)   NCBI Sequence Viewer  
  NP_001269492 (Get FASTA)   NCBI Sequence Viewer  
  NP_001277738 (Get FASTA)   NCBI Sequence Viewer  
  NP_387512 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA03543 (Get FASTA)   NCBI Sequence Viewer  
  AAA64369 (Get FASTA)   NCBI Sequence Viewer  
  AAA73929 (Get FASTA)   NCBI Sequence Viewer  
  AAB08750 (Get FASTA)   NCBI Sequence Viewer  
  AAH95510 (Get FASTA)   NCBI Sequence Viewer  
  AAI28123 (Get FASTA)   NCBI Sequence Viewer  
  AAI28124 (Get FASTA)   NCBI Sequence Viewer  
  AAK28307 (Get FASTA)   NCBI Sequence Viewer  
  AHW56469 (Get FASTA)   NCBI Sequence Viewer  
  AHW56671 (Get FASTA)   NCBI Sequence Viewer  
  BAF84998 (Get FASTA)   NCBI Sequence Viewer  
  CAA01483 (Get FASTA)   NCBI Sequence Viewer  
  CAB70095 (Get FASTA)   NCBI Sequence Viewer  
  EAW79605 (Get FASTA)   NCBI Sequence Viewer  
  EAW79606 (Get FASTA)   NCBI Sequence Viewer  
  EAW79607 (Get FASTA)   NCBI Sequence Viewer  
  EAW79608 (Get FASTA)   NCBI Sequence Viewer  
  EAW79609 (Get FASTA)   NCBI Sequence Viewer  
  EAW79610 (Get FASTA)   NCBI Sequence Viewer  
  EAW79611 (Get FASTA)   NCBI Sequence Viewer  
  EAW79612 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000295881
  ENSP00000295881.6
  ENSP00000373169
  ENSP00000373169.2
  ENSP00000419402
  ENSP00000419402.1
  ENSP00000420662
  ENSP00000420662.1
  ENSP00000513607.1
GenBank Protein P35462 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_387512   ⟸   NM_033663
- Peptide Label: isoform e
- UniProtKB: A8K8E4 (UniProtKB/TrEMBL),   E9PCM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_000787   ⟸   NM_000796
- Peptide Label: isoform a
- UniProtKB: A1A4V5 (UniProtKB/Swiss-Prot),   Q4VBM8 (UniProtKB/Swiss-Prot),   P35462 (UniProtKB/Swiss-Prot),   A8K8E4 (UniProtKB/TrEMBL),   X5D2G4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001269492   ⟸   NM_001282563
- Peptide Label: isoform a
- UniProtKB: A1A4V5 (UniProtKB/Swiss-Prot),   Q4VBM8 (UniProtKB/Swiss-Prot),   P35462 (UniProtKB/Swiss-Prot),   A8K8E4 (UniProtKB/TrEMBL),   X5D2G4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277738   ⟸   NM_001290809
- Peptide Label: isoform a
- UniProtKB: A1A4V5 (UniProtKB/Swiss-Prot),   Q4VBM8 (UniProtKB/Swiss-Prot),   P35462 (UniProtKB/Swiss-Prot),   A8K8E4 (UniProtKB/TrEMBL),   X5D2G4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000295881   ⟸   ENST00000295881
Ensembl Acc Id: ENSP00000420662   ⟸   ENST00000467632
Ensembl Acc Id: ENSP00000419402   ⟸   ENST00000460779
Ensembl Acc Id: ENSP00000373169   ⟸   ENST00000383673
Ensembl Acc Id: ENSP00000513607   ⟸   ENST00000698213
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35462-F1-model_v2 AlphaFold P35462 1-400 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3024 AgrOrtholog
COSMIC DRD3 COSMIC
Ensembl Genes ENSG00000151577 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000295881 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000295881.9 UniProtKB/Swiss-Prot
  ENST00000383673 ENTREZGENE
  ENST00000383673.5 UniProtKB/Swiss-Prot
  ENST00000460779 ENTREZGENE
  ENST00000460779.5 UniProtKB/Swiss-Prot
  ENST00000467632 ENTREZGENE
  ENST00000467632.5 UniProtKB/Swiss-Prot
  ENST00000698213.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000151577 GTEx
HGNC ID HGNC:3024 ENTREZGENE
Human Proteome Map DRD3 Human Proteome Map
InterPro Dopamine_D3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1814 ENTREZGENE
OMIM 126451 OMIM
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  D(3) DOPAMINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DRD3 RGD, PharmGKB
PRINTS DOPAMINED3R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOPAMINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8V8TLH3_HUMAN UniProtKB/TrEMBL
  A1A4V4_HUMAN UniProtKB/TrEMBL
  A1A4V5 ENTREZGENE
  A8K8E4 ENTREZGENE, UniProtKB/TrEMBL
  DRD3_HUMAN UniProtKB/Swiss-Prot
  E9PCM4 ENTREZGENE, UniProtKB/TrEMBL
  P35462 ENTREZGENE
  Q13167_HUMAN UniProtKB/TrEMBL
  Q4VBM8 ENTREZGENE
  Q9BXX6_HUMAN UniProtKB/TrEMBL
  Q9NY31_HUMAN UniProtKB/TrEMBL
  X5D2G4 ENTREZGENE, UniProtKB/TrEMBL
  X5DP70_HUMAN UniProtKB/TrEMBL
UniProt Secondary A1A4V5 UniProtKB/Swiss-Prot
  Q4VBM8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 DRD3  dopamine receptor D3  ETM1  essential tremor 1  Data merged from RGD:1348511 737654 PROVISIONAL