KEAP1 Human (+)-albicanol multiple interactions ISO Keap1 (Mus musculus) 6480464 albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 mRNA] and albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 protein] CTD PMID:33761044 KEAP1 Human (-)-ephedrine multiple interactions EXP 6480464 Ephedrine inhibits the reaction [Bleomycin results in increased expression of KEAP1 protein] CTD PMID:37778983 KEAP1 Human (-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 epigallocatechin gallate promotes the reaction [arsenite results in increased expression of KEAP1 mRNA] CTD PMID:29572906 KEAP1 Human (-)-epigallocatechin 3-gallate increases expression EXP 6480464 epigallocatechin gallate results in increased expression of KEAP1 protein CTD PMID:35218280 KEAP1 Human (R)-lipoic acid increases expression EXP 6480464 Thioctic Acid results in increased expression of KEAP1 protein CTD PMID:19033392 KEAP1 Human (R)-lipoic acid multiple interactions ISO Keap1 (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein] CTD PMID:34252510 KEAP1 Human (R,R,R)-alpha-tocopherol multiple interactions EXP 6480464 alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 mRNA] and alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:36058301 KEAP1 Human 1,2-dimethylhydrazine multiple interactions ISO Keap1 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KEAP1 mRNA CTD PMID:22206623 KEAP1 Human 1,2-naphthoquinone affects response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the susceptibility to 1 and 2-naphthoquinone CTD PMID:21384861 KEAP1 Human 1,2-naphthoquinone increases metabolic processing ISO Keap1 (Mus musculus) 6480464 1 and 2-naphthoquinone results in increased metabolism of KEAP1 protein CTD PMID:21384861 and PMID:25807370 KEAP1 Human 1-chloro-2,4-dinitrobenzene multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of KEAP1 protein] more ... CTD PMID:19033392 and PMID:25742418 KEAP1 Human 1-chloro-2,4-dinitrobenzene decreases expression ISO Keap1 (Mus musculus) 6480464 Dinitrochlorobenzene results in decreased expression of KEAP1 mRNA CTD PMID:28219650 KEAP1 Human 1-chloro-2,4-dinitrobenzene increases expression EXP 6480464 Dinitrochlorobenzene results in increased expression of KEAP1 protein CTD PMID:19033392 KEAP1 Human 1-chloro-2,4-dinitrobenzene affects metabolic processing ISO Keap1 (Mus musculus) 6480464 Dinitrochlorobenzene affects the metabolism of KEAP1 protein CTD PMID:18785192 KEAP1 Human 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO Keap1 (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:33368846 KEAP1 Human 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression ISO Keap1 (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:38016618 KEAP1 Human 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO Keap1 (Mus musculus) 6480464 1 more ... CTD PMID:33368846 and PMID:38016618 KEAP1 Human 1-naphthyl isothiocyanate decreases expression ISO Keap1 (Mus musculus) 6480464 1-Naphthylisothiocyanate results in decreased expression of KEAP1 mRNA and 1-Naphthylisothiocyanate results in decreased expression of KEAP1 protein CTD PMID:36008890 and PMID:37348807 KEAP1 Human 1-naphthyl isothiocyanate multiple interactions ISO Keap1 (Mus musculus) 6480464 liquiritin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of KEAP1 protein] CTD PMID:36008890 KEAP1 Human 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole decreases export EXP 6480464 KEAP1 protein results in decreased export of bisbenzimide ethoxide trihydrochloride CTD PMID:25841332 KEAP1 Human 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Keap1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of KEAP1 mRNA CTD PMID:21570461 KEAP1 Human 2,4-di-tert-butylphenol multiple interactions EXP 6480464 [SAG compound co-treated with 2 and 4-di-tert-butylphenol co-treated with Fibroblast Growth Factor 2] results in increased expression of KEAP1 mRNA CTD PMID:36682590 KEAP1 Human 2,4-dinitrotoluene affects expression ISO Keap1 (Rattus norvegicus) 6480464 2 and 4-dinitrotoluene affects the expression of KEAP1 mRNA CTD PMID:21346803 KEAP1 Human 2,5-dihydroxybenzoic acid multiple interactions ISO Keap1 (Mus musculus) 6480464 2 and 5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of KEAP1 mRNA] CTD PMID:37120126 KEAP1 Human 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO Keap1 (Mus musculus) 6480464 8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased degradation of KEAP1 protein] more ... CTD PMID:35691465 KEAP1 Human 2-tert-butylhydroquinone increases expression EXP 6480464 2-tert-butylhydroquinone results in increased expression of KEAP1 protein CTD PMID:19033392 KEAP1 Human 2-tert-butylhydroquinone increases expression ISO Keap1 (Rattus norvegicus) 6480464 2-tert-butylhydroquinone results in increased expression of KEAP1 protein CTD PMID:31726083 KEAP1 Human 2-tert-butylhydroquinone multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 2-tert-butylhydroquinone promotes the reaction [thallium nitrate results in decreased expression of KEAP1 protein] CTD PMID:31726083 KEAP1 Human 2-tert-butylhydroquinone decreases response to substance EXP 6480464 KEAP1 protein mutant form results in decreased susceptibility to 2-tert-butylhydroquinone CTD PMID:23589329 KEAP1 Human 2-tert-butylhydroquinone multiple interactions EXP 6480464 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein] more ... CTD PMID:18417180 and PMID:23589329 KEAP1 Human 2-tert-butylhydroquinone affects binding ISO Keap1 (Mus musculus) 6480464 2-tert-butylhydroquinone binds to KEAP1 protein CTD PMID:19808700 KEAP1 Human 2-tert-butylhydroquinone multiple interactions ISO Keap1 (Mus musculus) 6480464 2-tert-butylhydroquinone inhibits the reaction [2 more ... CTD PMID:18512965 more ... KEAP1 Human 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:24709675 KEAP1 Human 3,3',4,4',5-pentachlorobiphenyl affects expression ISO Keap1 (Mus musculus) 6480464 3 more ... CTD PMID:31563530 KEAP1 Human 3,3',4,4',5-pentachlorobiphenyl multiple interactions EXP 6480464 3 more ... CTD PMID:24709675 KEAP1 Human 3,4-methylenedioxymethamphetamine decreases expression ISO Keap1 (Mus musculus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of KEAP1 mRNA CTD PMID:26251327 KEAP1 Human 3,4-methylenedioxymethamphetamine increases methylation ISO Keap1 (Mus musculus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of KEAP1 promoter CTD PMID:26251327 KEAP1 Human 3,5-diethoxycarbonyl-1,4-dihydrocollidine decreases response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 gene mutant form results in decreased susceptibility to 3 more ... CTD PMID:30825315 KEAP1 Human 3,5-diethoxycarbonyl-1,4-dihydrocollidine multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 gene mutant form promotes the reaction [3 more ... CTD PMID:30825315 KEAP1 Human 3,5-diethoxycarbonyl-1,4-dihydrocollidine affects response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 gene affects the susceptibility to 3 more ... CTD PMID:30215777 KEAP1 Human 3-chloropropane-1,2-diol increases expression ISO Keap1 (Rattus norvegicus) 6480464 alpha-Chlorohydrin results in increased expression of KEAP1 protein CTD PMID:34915118 KEAP1 Human 3-methyladenine decreases expression EXP 6480464 3-methyladenine results in decreased expression of KEAP1 protein CTD PMID:29781141 KEAP1 Human 3-methylcholanthrene increases expression ISO Keap1 (Mus musculus) 6480464 Methylcholanthrene results in increased expression of KEAP1 mRNA CTD PMID:23712962 KEAP1 Human 3-phenylprop-2-enal affects expression ISO Keap1 (Mus musculus) 6480464 cinnamaldehyde affects the expression of KEAP1 mRNA CTD PMID:28219650 KEAP1 Human 3-phenylprop-2-enal increases expression EXP 6480464 cinnamaldehyde results in increased expression of KEAP1 protein CTD PMID:19033392 KEAP1 Human 4,4'-diaminodiphenylmethane decreases expression ISO Keap1 (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of KEAP1 mRNA CTD PMID:18648102 KEAP1 Human 4,4'-dipyridyl disulfide multiple interactions ISO Keap1 (Mus musculus) 6480464 4 more ... CTD PMID:15865434 KEAP1 Human 4,4'-sulfonyldiphenol increases expression ISO Keap1 (Mus musculus) 6480464 bisphenol S results in increased expression of KEAP1 mRNA and bisphenol S results in increased expression of KEAP1 protein CTD PMID:36541330 KEAP1 Human 4,4'-sulfonyldiphenol decreases methylation EXP 6480464 bisphenol S results in decreased methylation of KEAP1 gene CTD PMID:31601247 KEAP1 Human 4-amino-2,6-dinitrotoluene affects expression ISO Keap1 (Rattus norvegicus) 6480464 4-amino-2 and 6-dinitrotoluene affects the expression of KEAP1 mRNA CTD PMID:21346803 KEAP1 Human 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 [Decitabine affects the methylation of KEAP1 promoter] which affects the expression of KEAP1 mRNA more ... CTD PMID:18555005 and PMID:26409248 KEAP1 Human 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of KEAP1 mRNA CTD PMID:20124447 KEAP1 Human 5-fluorouracil affects response to substance EXP 6480464 KEAP1 protein affects the susceptibility to Fluorouracil CTD PMID:18692501 KEAP1 Human 7,12-dimethyltetraphene multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 betulin inhibits the reaction [9 more ... CTD PMID:24995432 and PMID:33759307 KEAP1 Human 7,12-dimethyltetraphene increases expression ISO Keap1 (Rattus norvegicus) 6480464 9 more ... CTD PMID:24995432 and PMID:33759307 KEAP1 Human 7,8-dihydroxycoumarin decreases expression EXP 6480464 daphnetin results in decreased expression of KEAP1 protein CTD PMID:30738023 KEAP1 Human [6]-Shogaol decreases expression EXP 6480464 shogaol metabolite results in decreased expression of KEAP1 protein and shogaol results in decreased expression of KEAP1 protein CTD PMID:25148906 KEAP1 Human [6]-Shogaol multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the reaction [shogaol analog results in increased expression of HMOX1 protein] more ... CTD PMID:23899529 KEAP1 Human [6]-Shogaol increases alkylation EXP 6480464 shogaol results in increased alkylation of KEAP1 protein CTD PMID:25148906 KEAP1 Human acrolein multiple interactions EXP 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein and Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein] CTD PMID:19608619 KEAP1 Human acrolein multiple interactions ISO Keap1 (Mus musculus) 6480464 [Ovalbumin co-treated with Acrolein] results in increased expression of KEAP1 protein CTD PMID:30608172 KEAP1 Human acrolein increases expression ISO Keap1 (Mus musculus) 6480464 Acrolein results in increased expression of KEAP1 protein CTD PMID:30608172 KEAP1 Human acrylamide multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [Acrylamide co-treated with INS protein] results in increased expression of KEAP1 mRNA CTD PMID:38604440 KEAP1 Human acrylamide multiple interactions ISO Keap1 (Mus musculus) 6480464 [NLRP3 gene mutant form affects the susceptibility to Acrylamide] which results in increased expression of KEAP1 protein and Acrylamide inhibits the reaction [Streptozocin results in increased expression of KEAP1 mRNA] CTD PMID:32014472 and PMID:34896238 KEAP1 Human acrylamide increases expression ISO Keap1 (Rattus norvegicus) 6480464 Acrylamide results in increased expression of KEAP1 mRNA CTD PMID:38604440 KEAP1 Human acrylamide increases expression ISO Keap1 (Mus musculus) 6480464 Acrylamide results in increased expression of KEAP1 mRNA CTD PMID:34896238 KEAP1 Human acrylamide affects expression ISO Keap1 (Rattus norvegicus) 6480464 Acrylamide affects the expression of KEAP1 protein CTD PMID:29426002 KEAP1 Human Aescin multiple interactions ISO Keap1 (Mus musculus) 6480464 Escin inhibits the reaction [Dietary Fats results in increased expression of KEAP1 protein] more ... CTD PMID:36905866 KEAP1 Human Aescin multiple interactions EXP 6480464 Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of KEAP1 protein] CTD PMID:36905866 KEAP1 Human Aescin increases expression ISO Keap1 (Mus musculus) 6480464 Escin results in increased expression of KEAP1 protein CTD PMID:36905866 KEAP1 Human aflatoxin B1 multiple interactions ISO Keap1 (Mus musculus) 6480464 Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 mRNA] and Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 protein] CTD PMID:35063475 KEAP1 Human aflatoxin B1 multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [Aflatoxin B1 co-treated with caryophyllene] results in increased expression of KEAP1 protein CTD PMID:34506763 KEAP1 Human aflatoxin B1 decreases expression ISO Keap1 (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of KEAP1 mRNA and Aflatoxin B1 results in decreased expression of KEAP1 protein CTD PMID:35063475 KEAP1 Human aldehydo-D-glucose multiple interactions ISO Keap1 (Mus musculus) 6480464 [NFE2L2 protein co-treated with KEAP1 protein] affects the abundance of Glucose CTD PMID:23017736 KEAP1 Human aldehydo-D-glucose multiple interactions EXP 6480464 solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 mRNA] and solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 protein] CTD PMID:37586544 KEAP1 Human aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of KEAP1 mRNA and Glucose results in increased expression of KEAP1 protein CTD PMID:37586544 KEAP1 Human aldehydo-D-glucose multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of KEAP1 protein more ... CTD PMID:35191607 KEAP1 Human all-trans-retinoic acid multiple interactions EXP 6480464 [Tretinoin co-treated with arsenic trioxide] results in increased expression of KEAP1 mRNA CTD PMID:15894607 KEAP1 Human all-trans-retinoic acid increases expression ISO Keap1 (Rattus norvegicus) 6480464 Tretinoin results in increased expression of KEAP1 protein CTD PMID:30267739 KEAP1 Human alpha,alpha-trehalose multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Trehalose inhibits the reaction [cadmium acetate results in decreased expression of KEAP1 protein] CTD PMID:29140578 KEAP1 Human alpha-D-galactose multiple interactions ISO Keap1 (Mus musculus) 6480464 albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 mRNA] and albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 protein] CTD PMID:33761044 KEAP1 Human alpha-D-galactose increases expression ISO Keap1 (Mus musculus) 6480464 Galactose results in increased expression of KEAP1 mRNA and Galactose results in increased expression of KEAP1 protein CTD PMID:33761044 KEAP1 Human Altertoxin II multiple interactions EXP 6480464 altertoxin II results in increased expression of and affects the localization of KEAP1 protein CTD PMID:27178040 KEAP1 Human amiodarone decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Amiodarone results in decreased expression of KEAP1 mRNA CTD PMID:17991464 KEAP1 Human amitraz multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 KEAP1 protein affects the reaction [amitraz results in decreased expression of CAT protein] more ... CTD PMID:31029719 KEAP1 Human amitraz increases expression ISO Keap1 (Rattus norvegicus) 6480464 amitraz results in increased expression of KEAP1 protein CTD PMID:31029719 KEAP1 Human ammonium chloride affects expression ISO Keap1 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of KEAP1 mRNA CTD PMID:16483693 KEAP1 Human Ammothamnine multiple interactions ISO Keap1 (Mus musculus) 6480464 [oxymatrine inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in increased stability of and results in increased localization of NFE2L2 protein and oxymatrine inhibits the reaction [KEAP1 protein binds to NFE2L2 protein] CTD PMID:37196756 KEAP1 Human andrographolide decreases expression EXP 6480464 andrographolide results in decreased expression of KEAP1 mRNA and andrographolide results in decreased expression of KEAP1 protein CTD PMID:29355602 and PMID:35724838 KEAP1 Human anethole multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 anethole inhibits the reaction [Isoproterenol results in increased expression of KEAP1 mRNA] and anethole inhibits the reaction [Isoproterenol results in increased expression of KEAP1 protein] CTD PMID:35430261 KEAP1 Human anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [pachastrissamine analog promotes the reaction [KEAP1 protein binds to SQSTM1 protein]] CTD PMID:35123989 KEAP1 Human aristolochic acid A increases expression ISO Keap1 (Mus musculus) 6480464 aristolochic acid I results in increased expression of KEAP1 protein CTD PMID:24530882 KEAP1 Human aristolochic acid A multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 mRNA] and Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 protein] CTD PMID:36037877 KEAP1 Human aristolochic acid A decreases expression ISO Keap1 (Rattus norvegicus) 6480464 aristolochic acid I results in decreased expression of KEAP1 mRNA and aristolochic acid I results in decreased expression of KEAP1 protein CTD PMID:36037877 KEAP1 Human aristolochic acid A increases expression EXP 6480464 aristolochic acid I results in increased expression of KEAP1 mRNA CTD PMID:33212167 KEAP1 Human aristolochic acid A multiple interactions ISO Keap1 (Mus musculus) 6480464 bardoxolone methyl inhibits the reaction [aristolochic acid I results in increased expression of KEAP1 protein] CTD PMID:24530882 KEAP1 Human arotinoid acid multiple interactions EXP 6480464 [4-(2-(5 more ... CTD PMID:34480604 KEAP1 Human arsane affects response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the susceptibility to Arsenic CTD PMID:19808700 KEAP1 Human arsane increases methylation EXP 6480464 Arsenic results in increased methylation of KEAP1 promoter CTD PMID:29247444 KEAP1 Human arsane affects binding ISO Keap1 (Mus musculus) 6480464 Arsenic binds to KEAP1 protein CTD PMID:19808700 KEAP1 Human arsane increases expression EXP 6480464 Arsenic results in increased expression of KEAP1 mRNA and Arsenic results in increased expression of KEAP1 protein CTD PMID:14567983 KEAP1 Human arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of KEAP1 mRNA and Arsenic results in increased expression of KEAP1 protein CTD PMID:14567983 KEAP1 Human arsenic atom increases methylation EXP 6480464 Arsenic results in increased methylation of KEAP1 promoter CTD PMID:29247444 KEAP1 Human arsenic atom affects response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the susceptibility to Arsenic CTD PMID:19808700 KEAP1 Human arsenic atom affects binding ISO Keap1 (Mus musculus) 6480464 Arsenic binds to KEAP1 protein CTD PMID:19808700 KEAP1 Human arsenite(3-) decreases expression EXP 6480464 arsenite results in decreased expression of KEAP1 mRNA and arsenite results in decreased expression of KEAP1 protein CTD PMID:22476201 KEAP1 Human arsenite(3-) affects response to substance EXP 6480464 KEAP1 protein affects the susceptibility to arsenite CTD PMID:22476201 KEAP1 Human arsenite(3-) multiple interactions EXP 6480464 epigallocatechin gallate promotes the reaction [arsenite results in increased expression of KEAP1 mRNA] more ... CTD PMID:22476201 and PMID:29572906 KEAP1 Human arsenite(3-) increases expression EXP 6480464 arsenite results in increased expression of KEAP1 mRNA and arsenite results in increased expression of KEAP1 protein CTD PMID:22476201 and PMID:29572906 KEAP1 Human arsenous acid decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Arsenic Trioxide results in decreased expression of KEAP1 protein CTD PMID:24634002 and PMID:32920515 KEAP1 Human arsenous acid multiple interactions ISO Keap1 (Mus musculus) 6480464 18alpha and 20beta-hydroxy-11-oxo-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranurosyl-alpha-D-glucopyranosiduronate magnesium tetrahydrate inhibits the reaction [Arsenic Trioxide results in increased expression of KEAP1 protein] CTD PMID:33846815 KEAP1 Human arsenous acid increases expression ISO Keap1 (Mus musculus) 6480464 Arsenic Trioxide results in increased expression of KEAP1 protein CTD PMID:33846815 KEAP1 Human arsenous acid multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein] CTD PMID:32920515 KEAP1 Human arsenous acid affects response to substance EXP 6480464 KEAP1 gene mutant form affects the susceptibility to Arsenic Trioxide CTD PMID:30815697 KEAP1 Human arsenous acid increases response to substance EXP 6480464 KEAP1 mRNA results in increased susceptibility to Arsenic Trioxide CTD PMID:26708503 KEAP1 Human arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of KEAP1 mRNA and Arsenic Trioxide results in increased expression of KEAP1 protein CTD PMID:15894607 more ... KEAP1 Human arsenous acid decreases response to substance EXP 6480464 KEAP1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:22684020 KEAP1 Human arsenous acid increases expression ISO Keap1 (Rattus norvegicus) 6480464 Arsenic Trioxide results in increased expression of KEAP1 mRNA CTD PMID:29223816 KEAP1 Human arsenous acid multiple interactions EXP 6480464 [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of KEAP1 mRNA more ... CTD PMID:15894607 more ... KEAP1 Human atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of KEAP1 mRNA CTD PMID:22378314 KEAP1 Human atrazine decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Atrazine results in decreased expression of KEAP1 mRNA and Atrazine results in decreased expression of KEAP1 protein CTD PMID:34624533 KEAP1 Human atrazine decreases expression ISO Keap1 (Mus musculus) 6480464 Atrazine results in decreased expression of KEAP1 mRNA and Atrazine results in decreased expression of KEAP1 protein CTD PMID:30360616 more ... KEAP1 Human atrazine multiple interactions ISO Keap1 (Mus musculus) 6480464 Lycopene inhibits the reaction [Atrazine results in decreased expression of KEAP1 mRNA] and Lycopene inhibits the reaction [Atrazine results in decreased expression of KEAP1 protein] CTD PMID:30360616 and PMID:36216167 KEAP1 Human aureusidin decreases expression ISO Keap1 (Rattus norvegicus) 6480464 aureusidin results in decreased expression of KEAP1 mRNA and aureusidin results in decreased expression of KEAP1 protein CTD PMID:31790703 KEAP1 Human azathioprine affects response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the susceptibility to Azathioprine CTD PMID:21803983 KEAP1 Human bafilomycin A1 multiple interactions EXP 6480464 bafilomycin A1 promotes the reaction [pachastrissamine analog promotes the reaction [KEAP1 protein binds to SQSTM1 protein]] CTD PMID:35123989 KEAP1 Human baicalin multiple interactions ISO Keap1 (Mus musculus) 6480464 baicalin inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:38016618 KEAP1 Human Bardoxolone methyl increases expression EXP 6480464 bardoxolone methyl results in increased expression of KEAP1 protein CTD PMID:27358234 KEAP1 Human Bardoxolone methyl decreases expression EXP 6480464 bardoxolone methyl results in decreased expression of KEAP1 mRNA CTD PMID:35724838 KEAP1 Human Bardoxolone methyl multiple interactions ISO Keap1 (Mus musculus) 6480464 bardoxolone methyl inhibits the reaction [aristolochic acid I results in increased expression of KEAP1 protein] CTD PMID:24530882 KEAP1 Human belinostat decreases expression EXP 6480464 belinostat results in decreased expression of KEAP1 mRNA CTD PMID:19606018 KEAP1 Human benzene decreases expression EXP 6480464 Benzene results in decreased expression of KEAP1 mRNA CTD PMID:33064461 KEAP1 Human benzene increases expression ISO Keap1 (Mus musculus) 6480464 Benzene results in increased expression of KEAP1 protein CTD PMID:36306860 KEAP1 Human benzene-1,2,4-triol increases expression EXP 6480464 hydroxyhydroquinone results in increased expression of KEAP1 mRNA CTD PMID:17572062 KEAP1 Human benzo[a]pyrene increases expression ISO Keap1 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of KEAP1 mRNA CTD PMID:21569818 and PMID:22228805 KEAP1 Human benzo[a]pyrene decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Benzo(a)pyrene results in decreased expression of KEAP1 protein CTD PMID:36736873 KEAP1 Human benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of KEAP1 mRNA CTD PMID:20106945 more ... KEAP1 Human benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of KEAP1 mRNA and Benzo(a)pyrene results in decreased expression of KEAP1 protein CTD PMID:20498004 and PMID:25946486 KEAP1 Human benzo[a]pyrene diol epoxide I decreases expression EXP 6480464 7 more ... CTD PMID:19150397 KEAP1 Human benzoquinones multiple interactions ISO Keap1 (Mus musculus) 6480464 Benzoquinones analog binds to and results in increased metabolism of KEAP1 protein CTD PMID:21651925 KEAP1 Human betulin multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 betulin inhibits the reaction [9 more ... CTD PMID:33759307 KEAP1 Human bis(2-ethylhexyl) phthalate multiple interactions ISO Keap1 (Mus musculus) 6480464 Lycopene inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of KEAP1 mRNA] more ... CTD PMID:35917956 and PMID:36610486 KEAP1 Human bis(2-ethylhexyl) phthalate increases expression ISO Keap1 (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of KEAP1 protein CTD PMID:36610486 KEAP1 Human bis(2-ethylhexyl) phthalate decreases expression ISO Keap1 (Mus musculus) 6480464 Diethylhexyl Phthalate results in decreased expression of KEAP1 mRNA and Diethylhexyl Phthalate results in decreased expression of KEAP1 protein CTD PMID:35917956 KEAP1 Human bisdemethoxycurcumin multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 protein inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA] CTD PMID:17535857 KEAP1 Human bisphenol A affects expression ISO Keap1 (Rattus norvegicus) 6480464 bisphenol A affects the expression of KEAP1 mRNA CTD PMID:25181051 KEAP1 Human bisphenol A decreases expression ISO Keap1 (Rattus norvegicus) 6480464 bisphenol A analog results in decreased expression of KEAP1 mRNA and bisphenol A analog results in decreased expression of KEAP1 protein CTD PMID:35427877 KEAP1 Human bisphenol A increases expression ISO Keap1 (Mus musculus) 6480464 bisphenol A results in increased expression of KEAP1 mRNA CTD PMID:32156529 KEAP1 Human bisphenol A multiple interactions EXP 6480464 [[ginger extract results in increased abundance of Oils and Volatile] which co-treated with bisphenol A] affects the expression of KEAP1 protein CTD PMID:33376534 KEAP1 Human bisphenol A increases methylation ISO Keap1 (Rattus norvegicus) 6480464 bisphenol A results in increased methylation of KEAP1 gene CTD PMID:28505145 KEAP1 Human bleomycin A2 multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 celastrol inhibits the reaction [Bleomycin results in decreased expression of KEAP1 protein] CTD PMID:26768587 KEAP1 Human bleomycin A2 increases expression EXP 6480464 Bleomycin results in increased expression of KEAP1 protein CTD PMID:37778983 KEAP1 Human bleomycin A2 multiple interactions EXP 6480464 Ephedrine inhibits the reaction [Bleomycin results in increased expression of KEAP1 protein] CTD PMID:37778983 KEAP1 Human bleomycin A2 decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Bleomycin results in decreased expression of KEAP1 protein CTD PMID:26768587 KEAP1 Human bromosulfophthalein decreases glutathionylation ISO Keap1 (Mus musculus) 6480464 KEAP1 protein results in decreased glutathionylation of Sulfobromophthalein CTD PMID:19246623 KEAP1 Human bromosulfophthalein decreases transport ISO Keap1 (Mus musculus) 6480464 KEAP1 protein results in decreased transport of Sulfobromophthalein CTD PMID:19246623 KEAP1 Human Brusatol multiple interactions EXP 6480464 [KEAP1 protein results in decreased expression of NFE2L2 protein] which results in decreased susceptibility to brusatol more ... CTD PMID:21205897 and PMID:32682831 KEAP1 Human Brusatol multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 brusatol inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KEAP1 protein] CTD PMID:34695510 KEAP1 Human buspirone multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Buspirone inhibits the reaction [Methotrexate results in increased expression of KEAP1 mRNA] CTD PMID:37341015 KEAP1 Human C60 fullerene increases expression ISO Keap1 (Rattus norvegicus) 6480464 fullerene C60 results in increased expression of KEAP1 mRNA CTD PMID:19167457 KEAP1 Human cadmium atom increases degradation ISO Keap1 (Rattus norvegicus) 6480464 Cadmium results in increased degradation of KEAP1 protein CTD PMID:27658547 KEAP1 Human cadmium atom increases expression ISO Keap1 (Mus musculus) 6480464 Cadmium results in increased expression of KEAP1 mRNA CTD PMID:37270049 KEAP1 Human cadmium atom multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KEAP1 mRNA more ... CTD PMID:34695510 and PMID:36718047 KEAP1 Human cadmium dichloride decreases expression ISO Keap1 (Mus musculus) 6480464 Cadmium Chloride results in decreased expression of KEAP1 mRNA CTD PMID:20061341 KEAP1 Human cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of KEAP1 mRNA and Cadmium Chloride results in decreased expression of KEAP1 protein CTD PMID:35122928 and PMID:38568856 KEAP1 Human cadmium dichloride decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Cadmium Chloride results in decreased expression of KEAP1 protein CTD PMID:35122928 KEAP1 Human cadmium dichloride affects folding ISO Keap1 (Mus musculus) 6480464 Cadmium Chloride affects the folding of KEAP1 protein CTD PMID:30261176 KEAP1 Human cadmium dichloride multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KEAP1 mRNA more ... CTD PMID:34695510 and PMID:36718047 KEAP1 Human cadmium dichloride affects binding ISO Keap1 (Mus musculus) 6480464 Cadmium Chloride binds to KEAP1 protein CTD PMID:19808700 and PMID:26827822 KEAP1 Human cadmium dichloride multiple interactions ISO Keap1 (Mus musculus) 6480464 [Cadmium Chloride affects the reaction [NFE2L2 protein binds to KEAP1 protein]] affects the localization of [NFE2L2 protein binds to KEAP1 protein] more ... CTD PMID:18512965 more ... KEAP1 Human carbendazim multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Chitosan inhibits the reaction [carbendazim results in increased expression of KEAP1 mRNA] CTD PMID:35705592 KEAP1 Human carbendazim increases expression ISO Keap1 (Rattus norvegicus) 6480464 carbendazim results in increased expression of KEAP1 mRNA CTD PMID:35705592 KEAP1 Human carbon disulfide decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Carbon Disulfide results in decreased expression of KEAP1 protein CTD PMID:27530093 KEAP1 Human carbon monoxide multiple interactions ISO Keap1 (Mus musculus) 6480464 Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:18845810 KEAP1 Human CCCP multiple interactions EXP 6480464 [[Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in decreased activity of NFE2L2 protein more ... CTD PMID:30715550 KEAP1 Human celastrol multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 celastrol inhibits the reaction [Bleomycin results in decreased expression of KEAP1 protein] CTD PMID:26768587 KEAP1 Human CGP 52608 multiple interactions EXP 6480464 CGP 52608 promotes the reaction [RORA protein binds to KEAP1 gene] CTD PMID:28238834 KEAP1 Human chalcones decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Chalcones analog results in decreased expression of KEAP1 protein CTD PMID:23963778 KEAP1 Human CHIR 99021 multiple interactions EXP 6480464 [4-(2-(5 more ... CTD PMID:34480604 KEAP1 Human chitosan multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Chitosan inhibits the reaction [carbendazim results in increased expression of KEAP1 mRNA] CTD PMID:35705592 KEAP1 Human chlorambucil multiple interactions EXP 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil and Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil] CTD PMID:19608619 KEAP1 Human chloroacetaldehyde increases expression EXP 6480464 chloroacetaldehyde results in increased expression of KEAP1 mRNA CTD PMID:25596134 KEAP1 Human choline multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of CD36 mRNA] more ... CTD PMID:20350562 KEAP1 Human cidofovir anhydrous increases expression EXP 6480464 Cidofovir results in increased expression of KEAP1 mRNA CTD PMID:25596134 KEAP1 Human cisplatin multiple interactions EXP 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of KEAP1 mRNA and [KEAP1 protein results in decreased stability of NFE2L2 protein] which results in increased susceptibility to Cisplatin CTD PMID:20530669 and PMID:27392435 KEAP1 Human cisplatin affects expression ISO Keap1 (Rattus norvegicus) 6480464 Cisplatin affects the expression of KEAP1 protein CTD PMID:30125553 KEAP1 Human cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of KEAP1 mRNA CTD PMID:25596134 and PMID:27594783 KEAP1 Human cisplatin increases response to substance EXP 6480464 KEAP1 protein results in increased susceptibility to Cisplatin CTD PMID:25841332 KEAP1 Human Clivoline increases expression EXP 6480464 clivorine results in increased expression of KEAP1 mRNA CTD PMID:25881548 KEAP1 Human clodronic acid increases expression EXP 6480464 Clodronic Acid results in increased expression of KEAP1 mRNA CTD PMID:25596134 KEAP1 Human clofibric acid multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KEAP1 mRNA CTD PMID:17602206 KEAP1 Human cobalt atom affects binding ISO Keap1 (Mus musculus) 6480464 Cobalt binds to KEAP1 protein CTD PMID:15865434 KEAP1 Human cobalt atom multiple interactions ISO Keap1 (Mus musculus) 6480464 Zinc inhibits the reaction [Cobalt binds to KEAP1 protein] CTD PMID:15865434 KEAP1 Human cobalt dichloride increases expression ISO Keap1 (Rattus norvegicus) 6480464 cobaltous chloride results in increased expression of KEAP1 mRNA CTD PMID:24386269 KEAP1 Human cobalt dichloride affects response to substance EXP 6480464 KEAP1 protein affects the susceptibility to cobaltous chloride CTD PMID:29966676 KEAP1 Human cobalt dichloride multiple interactions EXP 6480464 KEAP1 protein inhibits the reaction [cobaltous chloride results in increased expression of GCLC mRNA] more ... CTD PMID:29966676 KEAP1 Human colistin increases expression ISO Keap1 (Mus musculus) 6480464 Colistin results in increased expression of KEAP1 mRNA and Colistin results in increased expression of KEAP1 protein CTD PMID:34560125 KEAP1 Human copper atom multiple interactions EXP 6480464 [Chelating Agents binds to Copper] which affects the expression of KEAP1 mRNA and [Chelating Agents binds to Copper] which results in increased expression of KEAP1 mRNA CTD PMID:30911355 KEAP1 Human copper(0) multiple interactions EXP 6480464 [Chelating Agents binds to Copper] which affects the expression of KEAP1 mRNA and [Chelating Agents binds to Copper] which results in increased expression of KEAP1 mRNA CTD PMID:30911355 KEAP1 Human copper(II) sulfate multiple interactions ISO Keap1 (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Copper Sulfate results in decreased expression of KEAP1 mRNA] more ... CTD PMID:37353053 KEAP1 Human copper(II) sulfate decreases expression ISO Keap1 (Mus musculus) 6480464 Copper Sulfate results in decreased expression of KEAP1 mRNA and Copper Sulfate results in decreased expression of KEAP1 protein CTD PMID:37353053 KEAP1 Human cortisol multiple interactions EXP 6480464 [4-(2-(5 more ... CTD PMID:34480604 KEAP1 Human crocin-1 multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein] CTD PMID:32920515 KEAP1 Human CU-O LINKAGE decreases expression EXP 6480464 cupric oxide results in decreased expression of KEAP1 mRNA CTD PMID:32285662 KEAP1 Human cumene hydroperoxide multiple interactions EXP 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide and Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide] CTD PMID:19608619 KEAP1 Human curcumin multiple interactions ISO Keap1 (Mus musculus) 6480464 Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 mRNA] more ... CTD PMID:17535857 and PMID:35063475 KEAP1 Human curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of KEAP1 mRNA] and Curcumin inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein] CTD PMID:31521693 and PMID:34758851 KEAP1 Human curcumin decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Curcumin analog results in decreased expression of KEAP1 protein and Curcumin results in decreased expression of KEAP1 protein CTD PMID:30946834 KEAP1 Human curcumin multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein] more ... CTD PMID:30946834 more ... KEAP1 Human curcumin decreases expression EXP 6480464 Curcumin results in decreased expression of KEAP1 mRNA CTD PMID:31521693 KEAP1 Human curcumin increases expression EXP 6480464 Curcumin results in increased expression of KEAP1 mRNA CTD PMID:23710286 KEAP1 Human curcumin decreases expression ISO Keap1 (Mus musculus) 6480464 Curcumin analog results in decreased expression of KEAP1 protein CTD PMID:26991801 KEAP1 Human cyclophosphamide multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Quercetin inhibits the reaction [Cyclophosphamide results in decreased expression of KEAP1 mRNA] CTD PMID:37419146 KEAP1 Human cyclophosphamide decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Cyclophosphamide results in decreased expression of KEAP1 mRNA CTD PMID:37419146 KEAP1 Human cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of KEAP1 mRNA CTD PMID:25596134 KEAP1 Human cyclosporin A decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Cyclosporine results in decreased expression of KEAP1 mRNA CTD PMID:25596134 KEAP1 Human D-glucose multiple interactions ISO Keap1 (Mus musculus) 6480464 [NFE2L2 protein co-treated with KEAP1 protein] affects the abundance of Glucose CTD PMID:23017736 KEAP1 Human D-glucose increases expression EXP 6480464 Glucose results in increased expression of KEAP1 mRNA and Glucose results in increased expression of KEAP1 protein CTD PMID:37586544 KEAP1 Human D-glucose multiple interactions EXP 6480464 solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 mRNA] and solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 protein] CTD PMID:37586544 KEAP1 Human D-glucose multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of KEAP1 protein more ... CTD PMID:35191607 KEAP1 Human decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of KEAP1 protein CTD PMID:33675858 KEAP1 Human decabromodiphenyl ether multiple interactions EXP 6480464 Luteolin inhibits the reaction [decabromobiphenyl ether results in decreased expression of KEAP1 protein] CTD PMID:33675858 KEAP1 Human decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of KEAP1 mRNA and decabromobiphenyl ether results in increased expression of KEAP1 protein CTD PMID:34571075 and PMID:35266255 KEAP1 Human deguelin increases expression EXP 6480464 deguelin results in increased expression of KEAP1 mRNA CTD PMID:33512557 KEAP1 Human demethoxycurcumin multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 protein inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA] CTD PMID:17535857 KEAP1 Human Dendrobine multiple interactions EXP 6480464 dendrobine inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 mRNA] more ... CTD PMID:36058301 KEAP1 Human deoxynivalenol increases expression ISO Keap1 (Mus musculus) 6480464 deoxynivalenol results in increased expression of KEAP1 protein CTD PMID:38040082 KEAP1 Human deoxynivalenol multiple interactions ISO Keap1 (Mus musculus) 6480464 Selenomethionine inhibits the reaction [deoxynivalenol results in increased expression of KEAP1 protein] CTD PMID:38040082 KEAP1 Human deoxynivalenol decreases expression ISO Keap1 (Mus musculus) 6480464 deoxynivalenol results in decreased expression of KEAP1 mRNA CTD PMID:34400200 KEAP1 Human diallyl disulfide multiple interactions ISO Keap1 (Mus musculus) 6480464 diallyl disulfide promotes the reaction [lipopolysaccharide and Escherichia coli O111 B4 results in decreased expression of KEAP1 protein] CTD PMID:34896185 KEAP1 Human diallyl disulfide decreases expression ISO Keap1 (Mus musculus) 6480464 diallyl disulfide results in decreased expression of KEAP1 protein CTD PMID:34896185 KEAP1 Human diallyl trisulfide decreases expression ISO Keap1 (Rattus norvegicus) 6480464 diallyl trisulfide results in decreased expression of KEAP1 protein CTD PMID:23453443 KEAP1 Human diallyl trisulfide affects binding EXP 6480464 diallyl trisulfide binds to KEAP1 protein CTD PMID:24489685 KEAP1 Human diallyl trisulfide multiple interactions EXP 6480464 diallyl trisulfide promotes the reaction [KEAP1 mutant form affects the localization of NFE2L2 protein] CTD PMID:24489685 KEAP1 Human diarsenic trioxide multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein] CTD PMID:32920515 KEAP1 Human diarsenic trioxide increases expression ISO Keap1 (Mus musculus) 6480464 Arsenic Trioxide results in increased expression of KEAP1 protein CTD PMID:33846815 KEAP1 Human diarsenic trioxide multiple interactions ISO Keap1 (Mus musculus) 6480464 18alpha and 20beta-hydroxy-11-oxo-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranurosyl-alpha-D-glucopyranosiduronate magnesium tetrahydrate inhibits the reaction [Arsenic Trioxide results in increased expression of KEAP1 protein] CTD PMID:33846815 KEAP1 Human diarsenic trioxide increases expression ISO Keap1 (Rattus norvegicus) 6480464 Arsenic Trioxide results in increased expression of KEAP1 mRNA CTD PMID:29223816 KEAP1 Human diarsenic trioxide multiple interactions EXP 6480464 [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of KEAP1 mRNA more ... CTD PMID:15894607 more ... KEAP1 Human diarsenic trioxide affects response to substance EXP 6480464 KEAP1 gene mutant form affects the susceptibility to Arsenic Trioxide CTD PMID:30815697 KEAP1 Human diarsenic trioxide decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Arsenic Trioxide results in decreased expression of KEAP1 protein CTD PMID:24634002 and PMID:32920515 KEAP1 Human diarsenic trioxide increases response to substance EXP 6480464 KEAP1 mRNA results in increased susceptibility to Arsenic Trioxide CTD PMID:26708503 KEAP1 Human diarsenic trioxide decreases response to substance EXP 6480464 KEAP1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:22684020 KEAP1 Human diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of KEAP1 mRNA and Arsenic Trioxide results in increased expression of KEAP1 protein CTD PMID:15894607 more ... KEAP1 Human Dibutyl phosphate affects expression EXP 6480464 di-n-butylphosphoric acid affects the expression of KEAP1 mRNA CTD PMID:37042841 KEAP1 Human dibutyl phthalate decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Dibutyl Phthalate results in decreased expression of KEAP1 mRNA CTD PMID:21266533 KEAP1 Human dibutyl phthalate decreases expression ISO Keap1 (Mus musculus) 6480464 Dibutyl Phthalate results in decreased expression of KEAP1 mRNA CTD PMID:17361019 KEAP1 Human dichloroacetyl chloride multiple interactions ISO Keap1 (Mus musculus) 6480464 2-tert-butylhydroquinone inhibits the reaction [2 more ... CTD PMID:32073640 KEAP1 Human dichloroacetyl chloride increases expression ISO Keap1 (Mus musculus) 6480464 2 more ... CTD PMID:32073640 KEAP1 Human diethyl maleate increases expression EXP 6480464 diethyl maleate results in increased expression of KEAP1 mRNA and diethyl maleate results in increased expression of KEAP1 protein CTD PMID:27358234 more ... KEAP1 Human diethyl phthalate increases expression ISO Keap1 (Mus musculus) 6480464 diethyl phthalate results in increased expression of KEAP1 protein CTD PMID:37942807 KEAP1 Human diethylstilbestrol increases expression ISO Keap1 (Rattus norvegicus) 6480464 Diethylstilbestrol results in increased expression of KEAP1 mRNA CTD PMID:37077353 KEAP1 Human dihydroartemisinin affects binding EXP 6480464 artenimol analog binds to KEAP1 protein CTD PMID:26340163 KEAP1 Human dimercaprol affects binding ISO Keap1 (Mus musculus) 6480464 Dimercaprol binds to KEAP1 protein CTD PMID:19808700 KEAP1 Human dioscin multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:28082111 KEAP1 Human diosmetin multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 diosmetin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of KEAP1 protein] more ... CTD PMID:35191607 KEAP1 Human dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of KEAP1 mRNA and Oxygen deficiency results in decreased expression of KEAP1 protein CTD PMID:25596134 and PMID:34023435 KEAP1 Human dioxygen multiple interactions EXP 6480464 [Ozone co-treated with Oxygen] inhibits the reaction [KEAP1 protein results in increased degradation of NFE2L2 protein] and [Ozone co-treated with Oxygen] results in increased expression of KEAP1 protein CTD PMID:26270818 and PMID:29864481 KEAP1 Human dioxygen multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of KEAP1 protein more ... CTD PMID:29139225 and PMID:35191607 KEAP1 Human dioxygen increases expression ISO Keap1 (Rattus norvegicus) 6480464 Oxygen deficiency results in increased expression of KEAP1 protein CTD PMID:29139225 KEAP1 Human diquat multiple interactions ISO Keap1 (Mus musculus) 6480464 [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA more ... CTD PMID:22762311 KEAP1 Human diquat decreases expression ISO Keap1 (Mus musculus) 6480464 Diquat results in decreased expression of KEAP1 protein CTD PMID:36851058 KEAP1 Human disodium selenite multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Sodium Selenite inhibits the reaction [Sodium Fluoride results in decreased expression of KEAP1 mRNA] CTD PMID:36736877 KEAP1 Human divanadium pentaoxide decreases expression EXP 6480464 vanadium pentoxide results in decreased expression of KEAP1 mRNA CTD PMID:17459161 KEAP1 Human dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 KEAP1 Human doxorubicin increases expression ISO Keap1 (Rattus norvegicus) 6480464 Doxorubicin results in increased expression of KEAP1 protein CTD PMID:28082111 and PMID:37030624 KEAP1 Human doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of KEAP1 mRNA CTD PMID:29803840 KEAP1 Human doxorubicin multiple interactions ISO Keap1 (Mus musculus) 6480464 indole-3-carbinol inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] and naringin inhibits the reaction [Doxorubicin results in decreased expression of KEAP1 protein] CTD PMID:29775573 and PMID:36811345 KEAP1 Human doxorubicin increases expression ISO Keap1 (Mus musculus) 6480464 Doxorubicin results in increased expression of KEAP1 protein CTD PMID:29775573 and PMID:36811345 KEAP1 Human doxorubicin multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] and SIRT1 protein affects the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:28082111 and PMID:37030624 KEAP1 Human doxorubicin increases response to substance EXP 6480464 KEAP1 mRNA results in increased susceptibility to Doxorubicin CTD PMID:26708503 KEAP1 Human doxorubicin multiple interactions EXP 6480464 KEAP1 protein results in decreased export of and results in increased susceptibility to Doxorubicin CTD PMID:25841332 KEAP1 Human doxorubicin affects response to substance ISO Keap1 (Rattus norvegicus) 6480464 KEAP1 protein affects the susceptibility to Doxorubicin CTD PMID:24211725 KEAP1 Human doxorubicin increases degradation ISO Keap1 (Rattus norvegicus) 6480464 Doxorubicin results in increased degradation of KEAP1 protein CTD PMID:24211725 KEAP1 Human doxorubicin decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Doxorubicin results in decreased expression of KEAP1 protein CTD PMID:24211725 KEAP1 Human doxorubicin decreases response to substance EXP 6480464 KEAP1 protein results in decreased susceptibility to Doxorubicin CTD PMID:22684020 KEAP1 Human elemental selenium increases expression EXP 6480464 Selenium results in increased expression of KEAP1 mRNA CTD PMID:19244175 KEAP1 Human ethanol multiple interactions ISO Keap1 (Mus musculus) 6480464 [dihydromyricetin co-treated with Ethanol] results in decreased expression of KEAP1 protein CTD PMID:28419832 KEAP1 Human ethanol affects splicing ISO Keap1 (Mus musculus) 6480464 Ethanol affects the splicing of KEAP1 mRNA CTD PMID:30319688 KEAP1 Human ethionamide multiple interactions EXP 6480464 KEAP1 mRNA inhibits the reaction [Ethionamide results in increased susceptibility to arsenic trioxide] CTD PMID:26708503 KEAP1 Human ethylene glycol bis(2-aminoethyl)tetraacetic acid multiple interactions ISO Keap1 (Mus musculus) 6480464 Egtazic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein] CTD PMID:15865434 KEAP1 Human ethylenediaminetetraacetic acid multiple interactions ISO Keap1 (Mus musculus) 6480464 Edetic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein] CTD PMID:15865434 KEAP1 Human etoposide decreases response to substance EXP 6480464 KEAP1 protein results in decreased susceptibility to Etoposide CTD PMID:22684020 KEAP1 Human etoposide multiple interactions EXP 6480464 KEAP1 protein affects the reaction [Etoposide results in increased expression of CDKN1A protein] CTD PMID:27982581 KEAP1 Human etoposide increases response to substance EXP 6480464 KEAP1 mRNA results in increased susceptibility to Etoposide CTD PMID:26708503 KEAP1 Human falcarindiol multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 falcarindiol binds to and results in increased alkylation of KEAP1 protein more ... CTD PMID:20026152 KEAP1 Human falcarindiol affects folding ISO Keap1 (Rattus norvegicus) 6480464 falcarindiol affects the folding of KEAP1 protein CTD PMID:20026152 KEAP1 Human falcarindiol decreases activity ISO Keap1 (Rattus norvegicus) 6480464 falcarindiol results in decreased activity of KEAP1 protein CTD PMID:20026152 KEAP1 Human farrerol decreases expression ISO Keap1 (Mus musculus) 6480464 farrerol results in decreased expression of KEAP1 protein CTD PMID:26111761 KEAP1 Human fenofibrate multiple interactions ISO Keap1 (Mus musculus) 6480464 Fenofibrate inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein] CTD PMID:36905866 KEAP1 Human finasteride increases expression ISO Keap1 (Rattus norvegicus) 6480464 Finasteride results in increased expression of KEAP1 mRNA CTD PMID:24136188 KEAP1 Human flavonoids decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Flavonoids results in decreased expression of KEAP1 mRNA CTD PMID:18035473 KEAP1 Human flutamide increases expression ISO Keap1 (Rattus norvegicus) 6480464 Flutamide results in increased expression of KEAP1 mRNA CTD PMID:24136188 KEAP1 Human folic acid multiple interactions ISO Keap1 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KEAP1 mRNA CTD PMID:22206623 KEAP1 Human fumonisin B1 decreases expression EXP 6480464 fumonisin B1 results in decreased expression of KEAP1 mRNA and fumonisin B1 results in decreased expression of KEAP1 protein CTD PMID:33496827 KEAP1 Human fumonisin B1 decreases expression ISO Keap1 (Mus musculus) 6480464 fumonisin B1 results in decreased expression of KEAP1 mRNA CTD PMID:35697133 KEAP1 Human fumonisin B1 multiple interactions EXP 6480464 [fumonisin B1 results in increased methylation of KEAP1 promoter] which results in decreased expression of KEAP1 mRNA CTD PMID:33496827 KEAP1 Human fumonisin B1 increases methylation EXP 6480464 fumonisin B1 results in increased methylation of KEAP1 promoter CTD PMID:33496827 KEAP1 Human galactose multiple interactions ISO Keap1 (Mus musculus) 6480464 albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 mRNA] and albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 protein] CTD PMID:33761044 KEAP1 Human galactose increases expression ISO Keap1 (Mus musculus) 6480464 Galactose results in increased expression of KEAP1 mRNA and Galactose results in increased expression of KEAP1 protein CTD PMID:33761044 KEAP1 Human gefitinib increases expression EXP 6480464 gefitinib results in increased expression of KEAP1 mRNA CTD PMID:27639429 KEAP1 Human gentamycin multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [Gentamicins results in increased expression of KEAP1 mRNA] CTD PMID:38056816 KEAP1 Human gentamycin decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Gentamicins results in decreased expression of KEAP1 mRNA CTD PMID:33387578 KEAP1 Human gentamycin increases expression ISO Keap1 (Rattus norvegicus) 6480464 Gentamicins results in increased expression of KEAP1 mRNA CTD PMID:38056816 KEAP1 Human ginsenoside Rg1 multiple interactions ISO Keap1 (Mus musculus) 6480464 ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of KEAP1 protein] CTD PMID:29964319 KEAP1 Human gliclazide multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA] and Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein] CTD PMID:21439372 KEAP1 Human glucose multiple interactions ISO Keap1 (Mus musculus) 6480464 [NFE2L2 protein co-treated with KEAP1 protein] affects the abundance of Glucose CTD PMID:23017736 KEAP1 Human glucose increases expression EXP 6480464 Glucose results in increased expression of KEAP1 mRNA and Glucose results in increased expression of KEAP1 protein CTD PMID:37586544 KEAP1 Human glucose multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of KEAP1 protein more ... CTD PMID:35191607 KEAP1 Human glucose multiple interactions EXP 6480464 solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 mRNA] and solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 protein] CTD PMID:37586544 KEAP1 Human glutathione multiple interactions EXP 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione more ... CTD PMID:19608619 and PMID:21972102 KEAP1 Human glutathione increases abundance ISO Keap1 (Mus musculus) 6480464 KEAP1 gene mutant form results in increased abundance of Glutathione CTD PMID:26827822 KEAP1 Human glutathione multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Glutathione inhibits the reaction [falcarindiol binds to and results in increased alkylation of KEAP1 protein] CTD PMID:20026152 KEAP1 Human glutathione multiple interactions ISO Keap1 (Mus musculus) 6480464 [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA more ... CTD PMID:20800667 more ... KEAP1 Human glyburide multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of KEAP1 mRNA] and Glyburide inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 and PMID:36510688 KEAP1 Human glyphosate increases expression EXP 6480464 Glyphosate results in increased expression of KEAP1 mRNA CTD PMID:36625791 KEAP1 Human hemin decreases expression ISO Keap1 (Mus musculus) 6480464 Hemin results in decreased expression of KEAP1 protein CTD PMID:27777014 KEAP1 Human hesperetin affects binding EXP 6480464 hesperetin binds to KEAP1 protein CTD PMID:37487865 KEAP1 Human hexadecanoic acid multiple interactions EXP 6480464 [Palmitic Acid co-treated with Oleic Acid] results in increased expression of KEAP1 protein and Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of KEAP1 protein] CTD PMID:36905866 KEAP1 Human hexaflumuron decreases expression ISO Keap1 (Rattus norvegicus) 6480464 hexafluoron results in decreased expression of KEAP1 mRNA CTD PMID:34993831 KEAP1 Human homocysteine increases expression EXP 6480464 Homocysteine results in increased expression of KEAP1 protein CTD PMID:22964297 KEAP1 Human hydrogen peroxide multiple interactions ISO Keap1 (Mus musculus) 6480464 Hydrogen Peroxide promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]] CTD PMID:15865434 KEAP1 Human hydrogen peroxide increases expression ISO Keap1 (Rattus norvegicus) 6480464 Hydrogen Peroxide results in increased expression of KEAP1 protein CTD PMID:30104959 KEAP1 Human hydrogen peroxide decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Hydrogen Peroxide results in decreased expression of KEAP1 protein CTD PMID:32275923 KEAP1 Human hydrogen peroxide multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] more ... CTD PMID:30104959 and PMID:32275923 KEAP1 Human hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of KEAP1 mRNA and Hydrogen Peroxide results in increased expression of KEAP1 protein CTD PMID:31705858 and PMID:36058301 KEAP1 Human hydrogen peroxide multiple interactions EXP 6480464 (+)-JQ1 compound promotes the reaction [Hydrogen Peroxide results in decreased expression of KEAP1 protein] more ... CTD PMID:25742418 more ... KEAP1 Human hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of KEAP1 mRNA and Hydrogen Peroxide results in decreased expression of KEAP1 protein CTD PMID:23410634 more ... KEAP1 Human hydrogen sulfide multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat promotes the reaction [KEAP1 protein binds to NFE2L2 protein]] and [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in increased expression of KEAP1 protein] CTD PMID:32064027 KEAP1 Human hydroquinone decreases expression ISO Keap1 (Mus musculus) 6480464 hydroquinone results in decreased expression of KEAP1 protein CTD PMID:23290930 KEAP1 Human hydroquinone decreases expression EXP 6480464 hydroquinone results in decreased expression of KEAP1 protein CTD PMID:36646296 KEAP1 Human hypochlorous acid increases expression ISO Keap1 (Mus musculus) 6480464 Hypochlorous Acid results in increased expression of KEAP1 mRNA CTD PMID:17980396 KEAP1 Human ifosfamide increases expression EXP 6480464 Ifosfamide results in increased expression of KEAP1 mRNA CTD PMID:25596134 KEAP1 Human imidacloprid decreases expression ISO Keap1 (Rattus norvegicus) 6480464 imidacloprid results in decreased expression of KEAP1 mRNA CTD PMID:34993831 KEAP1 Human indole-3-methanol multiple interactions ISO Keap1 (Mus musculus) 6480464 indole-3-carbinol inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:29775573 KEAP1 Human indometacin multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] more ... CTD PMID:11909699 KEAP1 Human iron(III) citrate multiple interactions EXP 6480464 [trigonelline co-treated with ferric citrate] results in decreased expression of KEAP1 mRNA CTD PMID:29959986 KEAP1 Human isoniazide decreases expression ISO Keap1 (Mus musculus) 6480464 Isoniazid results in decreased expression of KEAP1 mRNA CTD PMID:33771660 KEAP1 Human isoprenaline multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [Isoproterenol co-treated with POSTN protein] results in decreased expression of KEAP1 mRNA more ... CTD PMID:30303030 and PMID:35430261 KEAP1 Human isoprenaline increases expression ISO Keap1 (Rattus norvegicus) 6480464 Isoproterenol results in increased expression of KEAP1 mRNA and Isoproterenol results in increased expression of KEAP1 protein CTD PMID:35430261 KEAP1 Human isoprenaline decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Isoproterenol results in decreased expression of KEAP1 mRNA CTD PMID:30303030 KEAP1 Human ketoconazole increases expression ISO Keap1 (Rattus norvegicus) 6480464 Ketoconazole results in increased expression of KEAP1 mRNA CTD PMID:37077353 KEAP1 Human L-ascorbic acid multiple interactions EXP 6480464 [[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in decreased expression of KEAP1 mRNA more ... CTD PMID:28285367 more ... KEAP1 Human L-ascorbic acid decreases expression EXP 6480464 Ascorbic Acid results in decreased expression of KEAP1 protein CTD PMID:31610155 KEAP1 Human L-ascorbic acid 2-phosphate multiple interactions EXP 6480464 [[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of KEAP1 mRNA CTD PMID:34480604 KEAP1 Human L-methionine multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of CD36 mRNA] more ... CTD PMID:20350562 KEAP1 Human lansoprazole increases oxidation ISO Keap1 (Rattus norvegicus) 6480464 Lansoprazole results in increased oxidation of KEAP1 protein CTD PMID:19628634 KEAP1 Human lanthanum trichloride increases expression ISO Keap1 (Mus musculus) 6480464 lanthanum chloride results in increased expression of KEAP1 protein CTD PMID:33098623 KEAP1 Human lead diacetate multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein more ... CTD PMID:31610155 KEAP1 Human lead diacetate multiple interactions ISO Keap1 (Mus musculus) 6480464 [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of KEAP1 mRNA more ... CTD PMID:38180308 KEAP1 Human lead diacetate decreases expression ISO Keap1 (Rattus norvegicus) 6480464 lead acetate results in decreased expression of KEAP1 mRNA CTD PMID:33862172 KEAP1 Human lead(0) multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein more ... CTD PMID:31610155 KEAP1 Human lead(0) multiple interactions ISO Keap1 (Mus musculus) 6480464 [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of KEAP1 mRNA more ... CTD PMID:38180308 KEAP1 Human leflunomide increases expression ISO Keap1 (Rattus norvegicus) 6480464 leflunomide results in increased expression of KEAP1 mRNA CTD PMID:24136188 KEAP1 Human Liensinine multiple interactions ISO Keap1 (Mus musculus) 6480464 liensinine inhibits the reaction [Lipopolysaccharides results in increased expression of KEAP1 protein] CTD PMID:38692452 KEAP1 Human Liensinine multiple interactions EXP 6480464 liensinine inhibits the reaction [Lipopolysaccharides results in increased expression of KEAP1 protein] CTD PMID:38692452 KEAP1 Human linsidomine affects response to substance EXP 6480464 KEAP1 mRNA affects the susceptibility to linsidomine CTD PMID:16092930 KEAP1 Human lipoic acid increases expression EXP 6480464 Thioctic Acid results in increased expression of KEAP1 protein CTD PMID:19033392 KEAP1 Human lipoic acid multiple interactions ISO Keap1 (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein] CTD PMID:34252510 KEAP1 Human lipopolysaccharide increases expression ISO Keap1 (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of KEAP1 protein CTD PMID:38692452 KEAP1 Human lipopolysaccharide multiple interactions ISO Keap1 (Mus musculus) 6480464 8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased degradation of KEAP1 protein] more ... CTD PMID:35691465 and PMID:38692452 KEAP1 Human lipopolysaccharide multiple interactions EXP 6480464 liensinine inhibits the reaction [Lipopolysaccharides results in increased expression of KEAP1 protein] CTD PMID:38692452 KEAP1 Human lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of KEAP1 protein CTD PMID:38692452 KEAP1 Human liproxstatin-1 increases expression EXP 6480464 liproxstatin-1 results in increased expression of KEAP1 protein CTD PMID:37507096 KEAP1 Human liquiritin multiple interactions ISO Keap1 (Mus musculus) 6480464 liquiritin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of KEAP1 protein] CTD PMID:36008890 KEAP1 Human luteolin multiple interactions EXP 6480464 Luteolin inhibits the reaction [decabromobiphenyl ether results in decreased expression of KEAP1 protein] CTD PMID:33675858 KEAP1 Human lycopene multiple interactions ISO Keap1 (Mus musculus) 6480464 Lycopene inhibits the reaction [Atrazine results in decreased expression of KEAP1 mRNA] more ... CTD PMID:30360616 more ... KEAP1 Human lycopene increases expression ISO Keap1 (Mus musculus) 6480464 Lycopene results in increased expression of KEAP1 mRNA CTD PMID:36216167 KEAP1 Human manganese(II) chloride affects expression ISO Keap1 (Mus musculus) 6480464 manganese chloride affects the expression of KEAP1 protein CTD PMID:25288107 KEAP1 Human manganese(II) chloride multiple interactions ISO Keap1 (Mus musculus) 6480464 Melatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein] CTD PMID:25288107 KEAP1 Human melatonin decreases expression ISO Keap1 (Mus musculus) 6480464 Melatonin results in decreased expression of KEAP1 protein CTD PMID:25288107 KEAP1 Human melatonin multiple interactions ISO Keap1 (Mus musculus) 6480464 Melatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein] CTD PMID:25288107 KEAP1 Human menadione multiple interactions EXP 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Vitamin K 3 CTD PMID:19608619 KEAP1 Human menadione decreases expression EXP 6480464 Vitamin K 3 results in decreased expression of KEAP1 mRNA CTD PMID:23410634 KEAP1 Human mercury dibromide increases expression EXP 6480464 mercuric bromide results in increased expression of KEAP1 mRNA CTD PMID:26272509 KEAP1 Human mercury dibromide multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA CTD PMID:27188386 KEAP1 Human metformin multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Metformin inhibits the reaction [Streptozocin results in increased expression of KEAP1 mRNA] and Metformin inhibits the reaction [Streptozocin results in increased expression of KEAP1 protein] CTD PMID:33639173 KEAP1 Human metformin multiple interactions ISO Keap1 (Mus musculus) 6480464 Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of KEAP1 mRNA] CTD PMID:37120126 KEAP1 Human metformin decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Metformin results in decreased expression of KEAP1 mRNA CTD PMID:25596134 KEAP1 Human methotrexate multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Buspirone inhibits the reaction [Methotrexate results in increased expression of KEAP1 mRNA] CTD PMID:37341015 KEAP1 Human methotrexate increases expression ISO Keap1 (Rattus norvegicus) 6480464 Methotrexate results in increased expression of KEAP1 mRNA CTD PMID:37341015 KEAP1 Human microcystin-LR affects binding EXP 6480464 cyanoginosin LR binds to KEAP1 protein CTD PMID:20722399 KEAP1 Human monascin multiple interactions EXP 6480464 monascin inhibits the reaction [S100B protein results in increased expression of KEAP1 protein] CTD PMID:23331247 KEAP1 Human N'-(2,4-dimethylphenyl)-N-methylformamidine increases expression ISO Keap1 (Rattus norvegicus) 6480464 U 40481 results in increased expression of KEAP1 protein CTD PMID:31029719 KEAP1 Human N'-(2,4-dimethylphenyl)-N-methylformamidine multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 KEAP1 protein affects the reaction [U 40481 results in decreased expression of CAT protein] more ... CTD PMID:31029719 KEAP1 Human N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine multiple interactions ISO Keap1 (Mus musculus) 6480464 N more ... CTD PMID:15865434 KEAP1 Human N-acetyl-1,4-benzoquinone imine multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine] CTD PMID:19246624 KEAP1 Human N-acetyl-1,4-benzoquinone imine affects metabolic processing ISO Keap1 (Mus musculus) 6480464 N-acetyl-4-benzoquinoneimine affects the metabolism of KEAP1 protein CTD PMID:18785192 KEAP1 Human N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of KEAP1 protein] and Acetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] CTD PMID:11909699 and PMID:19033392 KEAP1 Human N-acetyl-L-cysteine multiple interactions ISO Keap1 (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Copper Sulfate results in decreased expression of KEAP1 mRNA] more ... CTD PMID:37353053 and PMID:37369159 KEAP1 Human N-acetyl-L-cysteine multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:30104959 KEAP1 Human N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO Keap1 (Mus musculus) 6480464 [2-tert-butylhydroquinone co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [NFE2L2 protein binds to KEAP1 protein] and benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:18512965 KEAP1 Human N-methyl-4-phenylpyridinium multiple interactions ISO Keap1 (Mus musculus) 6480464 [1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in decreased expression of KEAP1 protein and baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in decreased expression of KEAP1 protein] CTD PMID:38016618 KEAP1 Human N-methylnicotinate multiple interactions EXP 6480464 [trigonelline co-treated with ferric citrate] results in decreased expression of KEAP1 mRNA CTD PMID:29959986 KEAP1 Human N-nitrosodiethylamine multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KEAP1 mRNA CTD PMID:17602206 KEAP1 Human NADP zwitterion affects abundance ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the abundance of NADP CTD PMID:21775727 KEAP1 Human NADP(+) affects abundance ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the abundance of NADP CTD PMID:21775727 KEAP1 Human naphthalene-1,2-diol increases metabolic processing ISO Keap1 (Mus musculus) 6480464 1 and 2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein CTD PMID:25807370 KEAP1 Human naphthalene-1,2-diol multiple interactions ISO Keap1 (Mus musculus) 6480464 Glutathione inhibits the reaction [1 and 2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein] CTD PMID:25807370 KEAP1 Human naringin multiple interactions ISO Keap1 (Mus musculus) 6480464 naringin inhibits the reaction [Doxorubicin results in decreased expression of KEAP1 protein] CTD PMID:36811345 KEAP1 Human nefazodone increases expression ISO Keap1 (Rattus norvegicus) 6480464 nefazodone results in increased expression of KEAP1 mRNA CTD PMID:24136188 KEAP1 Human nickel atom increases expression EXP 6480464 Nickel results in increased expression of KEAP1 protein CTD PMID:19033392 KEAP1 Human nicotinamide multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA more ... CTD PMID:21439372 KEAP1 Human nicotinamide multiple interactions ISO Keap1 (Mus musculus) 6480464 2 more ... CTD PMID:33949241 and PMID:37120126 KEAP1 Human ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of KEAP1 mRNA CTD PMID:32905824 KEAP1 Human oleic acid multiple interactions EXP 6480464 [Palmitic Acid co-treated with Oleic Acid] results in increased expression of KEAP1 protein and Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of KEAP1 protein] CTD PMID:36905866 KEAP1 Human oxidopamine affects response to substance EXP 6480464 KEAP1 mRNA affects the susceptibility to Oxidopamine CTD PMID:16092930 KEAP1 Human ozone multiple interactions EXP 6480464 [Ozone co-treated with Oxygen] inhibits the reaction [KEAP1 protein results in increased degradation of NFE2L2 protein] and [Ozone co-treated with Oxygen] results in increased expression of KEAP1 protein CTD PMID:26270818 and PMID:29864481 KEAP1 Human ozone increases expression ISO Keap1 (Mus musculus) 6480464 [Ozone results in increased expression of HIF1A] which results in increased expression of KEAP1 CTD PMID:24040961 KEAP1 Human p-chloromercuribenzoic acid increases expression EXP 6480464 p-Chloromercuribenzoic Acid results in increased expression of KEAP1 mRNA CTD PMID:26272509 KEAP1 Human p-chloromercuribenzoic acid multiple interactions EXP 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA CTD PMID:27188386 KEAP1 Human paclitaxel multiple interactions EXP 6480464 [KEAP1 protein results in decreased stability of NFE2L2 protein] which results in increased susceptibility to Paclitaxel CTD PMID:20530669 KEAP1 Human paeoniflorin multiple interactions ISO Keap1 (Mus musculus) 6480464 peoniflorin inhibits the reaction [Particulate Matter results in increased expression of KEAP1 protein] CTD PMID:38705442 KEAP1 Human paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of KEAP1 mRNA CTD PMID:25881548 KEAP1 Human paracetamol increases expression ISO Keap1 (Mus musculus) 6480464 Acetaminophen results in increased expression of KEAP1 protein CTD PMID:33949241 KEAP1 Human paracetamol decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Acetaminophen results in decreased expression of KEAP1 mRNA CTD PMID:33387578 KEAP1 Human paracetamol affects expression ISO Keap1 (Mus musculus) 6480464 Acetaminophen affects the expression of KEAP1 protein CTD PMID:29331651 KEAP1 Human paracetamol decreases response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 gene mutant form results in decreased susceptibility to Acetaminophen CTD PMID:16293230 and PMID:25499718 KEAP1 Human paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of KEAP1 mRNA CTD PMID:21420995 KEAP1 Human paracetamol increases response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 results in increased susceptibility to Acetaminophen CTD PMID:20404090 KEAP1 Human paracetamol affects sulfation ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the sulfation of Acetaminophen CTD PMID:19246624 KEAP1 Human paracetamol affects glucuronidation ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the glucuronidation of Acetaminophen CTD PMID:19246624 KEAP1 Human paracetamol multiple interactions ISO Keap1 (Mus musculus) 6480464 ABCC3 protein affects the reaction [KEAP1 protein affects the glucuronidation of Acetaminophen] and Niacinamide inhibits the reaction [Acetaminophen results in increased expression of KEAP1 protein] CTD PMID:19246624 and PMID:33949241 KEAP1 Human paracetamol affects glutathionylation ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the glutathionylation of Acetaminophen CTD PMID:19246624 KEAP1 Human paraquat multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat promotes the reaction [KEAP1 protein binds to NFE2L2 protein]] more ... CTD PMID:32064027 KEAP1 Human paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of KEAP1 protein CTD PMID:37507096 KEAP1 Human paraquat increases expression ISO Keap1 (Rattus norvegicus) 6480464 Paraquat results in increased expression of KEAP1 protein CTD PMID:32064027 KEAP1 Human pentachlorophenol increases expression ISO Keap1 (Mus musculus) 6480464 Pentachlorophenol results in increased expression of KEAP1 mRNA CTD PMID:23892564 KEAP1 Human perfluorohexanesulfonic acid decreases expression ISO Keap1 (Mus musculus) 6480464 perfluorohexanesulfonic acid results in decreased expression of KEAP1 mRNA CTD PMID:37995155 KEAP1 Human perfluorooctane-1-sulfonic acid decreases expression ISO Keap1 (Rattus norvegicus) 6480464 perfluorooctane sulfonic acid results in decreased expression of KEAP1 mRNA CTD PMID:20621739 KEAP1 Human perillyl aldehyde multiple interactions EXP 6480464 KEAP1 protein inhibits the reaction [perillaldehyde results in increased expression of TXN mRNA] CTD PMID:19123792 KEAP1 Human phalloidin multiple interactions ISO Keap1 (Mus musculus) 6480464 [KEAP1 gene mutant form results in decreased susceptibility to Phalloidine] which results in decreased expression of CXCL1 mRNA more ... CTD PMID:25280775 KEAP1 Human phalloidin decreases response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 gene mutant form results in decreased susceptibility to Phalloidine CTD PMID:25280775 KEAP1 Human phenobarbital multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the reaction [Phenobarbital results in increased expression of CYP2A5 mRNA] CTD PMID:22859313 KEAP1 Human phenylarsine oxide affects binding ISO Keap1 (Mus musculus) 6480464 oxophenylarsine binds to KEAP1 protein CTD PMID:19786557 and PMID:19808700 KEAP1 Human phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of KEAP1 mRNA CTD PMID:26272509 KEAP1 Human phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA CTD PMID:27188386 KEAP1 Human phlorizin increases expression ISO Keap1 (Mus musculus) 6480464 Phlorhizin results in increased expression of KEAP1 mRNA CTD PMID:22538082 KEAP1 Human pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KEAP1 mRNA CTD PMID:19710929 KEAP1 Human poly(ethylene) multiple interactions ISO Keap1 (Mus musculus) 6480464 [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of KEAP1 mRNA more ... CTD PMID:38180308 KEAP1 Human poly(vinyl chloride) multiple interactions ISO Keap1 (Mus musculus) 6480464 [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of KEAP1 mRNA more ... CTD PMID:38180308 KEAP1 Human porphyrins increases expression EXP 6480464 Porphyrins results in increased expression of KEAP1 mRNA CTD PMID:31385236 KEAP1 Human potassium dichromate multiple interactions ISO Keap1 (Mus musculus) 6480464 Potassium Dichromate affects the localization of and results in decreased ubiquitination of KEAP1 protein and Potassium Dichromate inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:17420218 KEAP1 Human pterostilbene multiple interactions ISO Keap1 (Mus musculus) 6480464 pterostilbene inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:26700463 KEAP1 Human quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KEAP1 protein] and Quercetin results in increased metabolism of and results in increased degradation of and results in decreased expression of KEAP1 protein CTD PMID:17462537 and PMID:27050144 KEAP1 Human quercetin multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Quercetin inhibits the reaction [Cyclophosphamide results in decreased expression of KEAP1 mRNA] CTD PMID:37419146 KEAP1 Human quercetin decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Quercetin results in decreased expression of KEAP1 protein CTD PMID:25339115 KEAP1 Human quercetin increases expression ISO Keap1 (Mus musculus) 6480464 Quercetin results in increased expression of KEAP1 mRNA CTD PMID:23295412 KEAP1 Human quercetin 3-O-beta-D-glucofuranoside multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 isoquercitrin inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 KEAP1 Human quercetin 3-O-beta-D-glucopyranoside multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 isoquercitrin inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 KEAP1 Human quercitrin increases expression EXP 6480464 quercitrin results in increased expression of KEAP1 mRNA CTD PMID:25193878 KEAP1 Human quinolinic acid multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein] more ... CTD PMID:30876764 KEAP1 Human reactive oxygen species increases expression EXP 6480464 Reactive Oxygen Species results in increased expression of KEAP1 mRNA CTD PMID:25800948 KEAP1 Human resveratrol multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA] more ... CTD PMID:21439372 and PMID:23551926 KEAP1 Human resveratrol multiple interactions ISO Keap1 (Mus musculus) 6480464 Resveratrol inhibits the reaction [Rotenone results in increased expression of KEAP1 protein] CTD PMID:34391968 KEAP1 Human resveratrol multiple interactions EXP 6480464 [Resveratrol co-treated with Plant Extracts] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of KEAP1 protein] more ... CTD PMID:16948474 more ... KEAP1 Human rosmarinic acid decreases expression EXP 6480464 Rosmarinic Acid results in decreased expression of KEAP1 protein CTD PMID:31610155 KEAP1 Human rosmarinic acid multiple interactions EXP 6480464 Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein] CTD PMID:31610155 KEAP1 Human rotenone decreases response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 gene mutant form results in decreased susceptibility to Rotenone CTD PMID:19167360 KEAP1 Human rotenone multiple interactions ISO Keap1 (Mus musculus) 6480464 Resveratrol inhibits the reaction [Rotenone results in increased expression of KEAP1 protein] CTD PMID:34391968 KEAP1 Human rotenone increases expression ISO Keap1 (Mus musculus) 6480464 Rotenone results in increased expression of KEAP1 protein CTD PMID:34391968 and PMID:35919817 KEAP1 Human rotenone decreases expression ISO Keap1 (Mus musculus) 6480464 Rotenone results in decreased expression of KEAP1 mRNA CTD PMID:23186747 KEAP1 Human S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein] more ... CTD PMID:19608619 KEAP1 Human SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 KEAP1 Human SCH772984 multiple interactions EXP 6480464 SCH772984 inhibits the reaction [pachastrissamine analog promotes the reaction [KEAP1 protein binds to SQSTM1 protein]] CTD PMID:35123989 KEAP1 Human scutellarin multiple interactions ISO Keap1 (Mus musculus) 6480464 scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of KEAP1 mRNA] and scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of KEAP1 protein] CTD PMID:34610774 KEAP1 Human selenium atom increases expression EXP 6480464 Selenium results in increased expression of KEAP1 mRNA CTD PMID:19244175 KEAP1 Human selenomethionine multiple interactions ISO Keap1 (Mus musculus) 6480464 Selenomethionine inhibits the reaction [deoxynivalenol results in increased expression of KEAP1 protein] CTD PMID:38040082 KEAP1 Human silibinin multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Silybin inhibits the reaction [sodium arsenite results in increased expression of KEAP1] CTD PMID:24062023 KEAP1 Human silicon atom multiple interactions ISO Keap1 (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein] CTD PMID:34252510 KEAP1 Human silicon atom increases expression ISO Keap1 (Mus musculus) 6480464 Silicon results in increased expression of KEAP1 protein CTD PMID:34252510 KEAP1 Human silicon dioxide multiple interactions EXP 6480464 tanshinone promotes the reaction [Silicon Dioxide results in decreased expression of KEAP1 protein] CTD PMID:32097614 KEAP1 Human silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of KEAP1 protein CTD PMID:32097614 KEAP1 Human sirolimus increases expression EXP 6480464 Sirolimus results in increased expression of KEAP1 protein CTD PMID:29781141 KEAP1 Human sirolimus multiple interactions EXP 6480464 Sirolimus inhibits the reaction [Resveratrol inhibits the reaction [Particulate Matter affects the expression of KEAP1 protein]] CTD PMID:29781141 KEAP1 Human sodium arsenite multiple interactions EXP 6480464 Decitabine inhibits the reaction [sodium arsenite results in decreased expression of KEAP1 protein] more ... CTD PMID:18417180 more ... KEAP1 Human sodium arsenite increases methylation EXP 6480464 sodium arsenite results in increased methylation of KEAP1 promoter CTD PMID:26409248 KEAP1 Human sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of KEAP1 mRNA CTD PMID:38568856 KEAP1 Human sodium arsenite affects folding ISO Keap1 (Mus musculus) 6480464 sodium arsenite affects the folding of KEAP1 protein CTD PMID:30261176 KEAP1 Human sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of KEAP1 protein CTD PMID:26409248 and PMID:28229933 KEAP1 Human sodium arsenite affects expression ISO Keap1 (Rattus norvegicus) 6480464 sodium arsenite affects the expression of KEAP1 mRNA CTD PMID:25625412 KEAP1 Human sodium arsenite increases expression ISO Keap1 (Rattus norvegicus) 6480464 sodium arsenite results in increased expression of KEAP1 CTD PMID:24062023 KEAP1 Human sodium arsenite multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 silybin inhibits the reaction [sodium arsenite results in increased expression of KEAP1] CTD PMID:24062023 KEAP1 Human sodium arsenite increases expression ISO Keap1 (Mus musculus) 6480464 sodium arsenite results in increased expression of KEAP1 mRNA and sodium arsenite results in increased expression of KEAP1 protein CTD PMID:26371860 and PMID:35679981 KEAP1 Human sodium arsenite multiple interactions ISO Keap1 (Mus musculus) 6480464 ATG7 gene mutant form inhibits the reaction [sodium arsenite results in increased degradation of KEAP1 protein] more ... CTD PMID:16785233 more ... KEAP1 Human sodium arsenite affects localization EXP 6480464 sodium arsenite affects the localization of KEAP1 protein CTD PMID:23589329 KEAP1 Human sodium dichromate decreases expression ISO Keap1 (Mus musculus) 6480464 sodium bichromate results in decreased expression of KEAP1 mRNA CTD PMID:22155349 KEAP1 Human sodium fluoride multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 Sodium Selenite inhibits the reaction [Sodium Fluoride results in decreased expression of KEAP1 mRNA] CTD PMID:36736877 KEAP1 Human sodium fluoride decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Sodium Fluoride results in decreased expression of KEAP1 mRNA CTD PMID:36736877 KEAP1 Human solanesol multiple interactions EXP 6480464 solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 mRNA] more ... CTD PMID:25645596 and PMID:37586544 KEAP1 Human sterigmatocystin affects expression ISO Keap1 (Rattus norvegicus) 6480464 Sterigmatocystin affects the expression of KEAP1 mRNA CTD PMID:34126181 KEAP1 Human streptozocin multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 [Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of KEAP1 mRNA more ... CTD PMID:21439372 more ... KEAP1 Human streptozocin increases expression ISO Keap1 (Mus musculus) 6480464 Streptozocin results in increased expression of KEAP1 mRNA CTD PMID:34896238 KEAP1 Human streptozocin multiple interactions ISO Keap1 (Mus musculus) 6480464 2 more ... CTD PMID:34610774 more ... KEAP1 Human streptozocin increases expression ISO Keap1 (Rattus norvegicus) 6480464 Streptozocin results in increased expression of KEAP1 mRNA and Streptozocin results in increased expression of KEAP1 protein CTD PMID:32662907 and PMID:33639173 KEAP1 Human streptozocin decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Streptozocin results in decreased expression of KEAP1 mRNA CTD PMID:30817903 KEAP1 Human sulforaphane increases expression EXP 6480464 sulforaphane results in increased expression of KEAP1 protein CTD PMID:19033392 KEAP1 Human sulforaphane decreases expression EXP 6480464 sulforaphane results in decreased expression of KEAP1 mRNA CTD PMID:35724838 KEAP1 Human sulforaphane decreases response to substance EXP 6480464 KEAP1 protein mutant form results in decreased susceptibility to sulforaphane CTD PMID:23589329 KEAP1 Human sulforaphane multiple interactions ISO Keap1 (Mus musculus) 6480464 sulforaphane inhibits the reaction [Carbon Tetrachloride results in increased expression of KEAP1 protein] more ... CTD PMID:15865434 more ... KEAP1 Human sulforaphane multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 sulforaphane promotes the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:22558124 KEAP1 Human sulforaphane increases response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 protein results in increased susceptibility to sulforaphane CTD PMID:22558124 KEAP1 Human sulforaphane increases response to substance EXP 6480464 KEAP1 protein results in increased susceptibility to sulforaphane CTD PMID:22558124 KEAP1 Human sulforaphane increases metabolic processing EXP 6480464 sulforaphane results in increased metabolism of KEAP1 protein CTD PMID:21391649 KEAP1 Human sulforaphane multiple interactions EXP 6480464 Iodoacetamide inhibits the reaction [sulforaphane results in increased metabolism of KEAP1 protein] more ... CTD PMID:18417180 more ... KEAP1 Human sulindac decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Sulindac results in decreased expression of KEAP1 mRNA CTD PMID:24136188 KEAP1 Human T-2 toxin decreases expression EXP 6480464 T-2 Toxin results in decreased expression of KEAP1 mRNA and T-2 Toxin results in decreased expression of KEAP1 protein CTD PMID:35842139 KEAP1 Human tangeretin multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 tangeretin inhibits the reaction [9 more ... CTD PMID:24995432 KEAP1 Human Tanshinone I multiple interactions EXP 6480464 tanshinone promotes the reaction [Silicon Dioxide results in decreased expression of KEAP1 protein] CTD PMID:32097614 KEAP1 Human temozolomide increases expression EXP 6480464 Temozolomide results in increased expression of KEAP1 mRNA CTD PMID:31758290 KEAP1 Human tert-butyl hydroperoxide multiple interactions EXP 6480464 Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KEAP1 protein] and Quercetin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KEAP1 protein] CTD PMID:27050144 KEAP1 Human tert-butyl hydroperoxide increases expression EXP 6480464 tert-Butylhydroperoxide results in increased expression of KEAP1 protein CTD PMID:27050144 KEAP1 Human tetrachloromethane increases expression ISO Keap1 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of KEAP1 protein CTD PMID:29964319 KEAP1 Human tetrachloromethane multiple interactions ISO Keap1 (Mus musculus) 6480464 ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of KEAP1 protein] and sulforaphane inhibits the reaction [Carbon Tetrachloride results in increased expression of KEAP1 protein] CTD PMID:29964319 KEAP1 Human thapsigargin increases expression EXP 6480464 Thapsigargin results in increased expression of KEAP1 protein CTD PMID:27358234 KEAP1 Human thioacetamide decreases expression ISO Keap1 (Rattus norvegicus) 6480464 Thioacetamide results in decreased expression of KEAP1 mRNA CTD PMID:34492290 KEAP1 Human thiophenes multiple interactions EXP 6480464 Thiophenes inhibits the reaction [KEAP1 gene mutant form promotes the reaction [lipopolysaccharide and E coli O55-B5 results in increased expression of IL6 mRNA]] CTD PMID:23906629 KEAP1 Human Tiron multiple interactions ISO Keap1 (Mus musculus) 6480464 1 more ... CTD PMID:33368846 KEAP1 Human titanium dioxide increases methylation ISO Keap1 (Mus musculus) 6480464 titanium dioxide results in increased methylation of KEAP1 gene CTD PMID:35295148 KEAP1 Human titanium dioxide decreases methylation ISO Keap1 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of KEAP1 gene CTD PMID:35295148 KEAP1 Human trabectedin increases expression EXP 6480464 Trabectedin results in increased expression of KEAP1 protein CTD PMID:36396105 KEAP1 Human trans-anethole multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 anethole inhibits the reaction [Isoproterenol results in increased expression of KEAP1 mRNA] and anethole inhibits the reaction [Isoproterenol results in increased expression of KEAP1 protein] CTD PMID:35430261 KEAP1 Human trans-piceid multiple interactions EXP 6480464 polydatin inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:31705858 KEAP1 Human trans-piceid multiple interactions ISO Keap1 (Mus musculus) 6480464 polydatin inhibits the reaction [TSHR protein results in increased expression of KEAP1 protein] CTD PMID:31705858 KEAP1 Human trans-rhaponticin multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 rhapontin inhibits the reaction [Streptozocin results in increased expression of KEAP1 mRNA] and rhapontin inhibits the reaction [Streptozocin results in increased expression of KEAP1 protein] CTD PMID:32662907 KEAP1 Human tributylstannane decreases expression ISO Keap1 (Mus musculus) 6480464 tributyltin results in decreased expression of KEAP1 protein CTD PMID:36858641 KEAP1 Human Tributyltin oxide affects localization EXP 6480464 bis(tri-n-butyltin)oxide affects the localization of KEAP1 protein CTD PMID:21601586 KEAP1 Human tricetin increases expression EXP 6480464 tricetin results in increased expression of KEAP1 mRNA and tricetin results in increased expression of KEAP1 protein CTD PMID:31176653 KEAP1 Human trichloroethene multiple interactions ISO Keap1 (Mus musculus) 6480464 sulforaphane inhibits the reaction [Trichloroethylene results in increased expression of KEAP1 mRNA] CTD PMID:32073640 KEAP1 Human trichloroethene increases expression ISO Keap1 (Rattus norvegicus) 6480464 Trichloroethylene results in increased expression of KEAP1 mRNA CTD PMID:33387578 KEAP1 Human trichloroethene increases expression ISO Keap1 (Mus musculus) 6480464 Trichloroethylene results in increased expression of KEAP1 mRNA CTD PMID:32073640 KEAP1 Human trichostatin A affects expression EXP 6480464 trichostatin A affects the expression of KEAP1 mRNA CTD PMID:28542535 KEAP1 Human trilobatin multiple interactions ISO Keap1 (Rattus norvegicus) 6480464 trilobatin inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:30104959 KEAP1 Human Triptolide decreases expression EXP 6480464 triptolide results in decreased expression of KEAP1 protein CTD PMID:30682494 and PMID:36990132 KEAP1 Human triptonide decreases expression ISO Keap1 (Mus musculus) 6480464 triptonide results in decreased expression of KEAP1 mRNA CTD PMID:33045310 KEAP1 Human troglitazone multiple interactions EXP 6480464 KEAP1 protein promotes the reaction [troglitazone results in increased susceptibility to arsenic trioxide] CTD PMID:22684020 KEAP1 Human tyloxapol multiple interactions ISO Keap1 (Mus musculus) 6480464 Escin inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein] and Fenofibrate inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein] CTD PMID:36905866 KEAP1 Human tyloxapol increases expression ISO Keap1 (Mus musculus) 6480464 tyloxapol results in increased expression of KEAP1 protein CTD PMID:36905866 KEAP1 Human valdecoxib increases expression ISO Keap1 (Rattus norvegicus) 6480464 valdecoxib results in increased expression of KEAP1 mRNA CTD PMID:24136188 KEAP1 Human valproic acid decreases expression ISO Keap1 (Mus musculus) 6480464 Valproic Acid results in decreased expression of KEAP1 mRNA CTD PMID:21427059 KEAP1 Human valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of KEAP1 mRNA CTD PMID:25979313 KEAP1 Human valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of KEAP1 mRNA CTD PMID:22083351 and PMID:29154799 KEAP1 Human vitamin D decreases expression EXP 6480464 Vitamin D results in decreased expression of KEAP1 protein CTD PMID:30698894 KEAP1 Human XAV939 multiple interactions EXP 6480464 [[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of KEAP1 mRNA and [[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in decreased expression of KEAP1 mRNA CTD PMID:34480604 KEAP1 Human zinc atom multiple interactions ISO Keap1 (Mus musculus) 6480464 4 more ... CTD PMID:15865434 KEAP1 Human zinc atom affects binding ISO Keap1 (Mus musculus) 6480464 Zinc binds to KEAP1 protein CTD PMID:15865434 KEAP1 Human zinc dichloride affects folding ISO Keap1 (Mus musculus) 6480464 zinc chloride affects the folding of KEAP1 protein CTD PMID:30261176 KEAP1 Human zinc dichloride multiple interactions ISO Keap1 (Mus musculus) 6480464 zinc chloride promotes the reaction [KEAP1 protein binds to KEAP1 protein] CTD PMID:30261176 KEAP1 Human zinc(0) multiple interactions ISO Keap1 (Mus musculus) 6480464 4 more ... CTD PMID:15865434 KEAP1 Human zinc(0) affects binding ISO Keap1 (Mus musculus) 6480464 Zinc binds to KEAP1 protein CTD PMID:15865434
