CD86 (CD86 molecule) - Rat Genome Database

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Gene: CD86 (CD86 molecule) Homo sapiens
Analyze
Symbol: CD86
Name: CD86 molecule
RGD ID: 1604658
HGNC Page HGNC:1705
Description: Enables receptor ligand activity. Involved in T cell activation. Located in centriolar satellite; extracellular exosome; and plasma membrane. Implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Biomarker of several diseases, including autoimmune disease (multiple); cryoglobulinemia; hematologic cancer (multiple); lung disease (multiple); and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: activation B7-2 antigen; B-lymphocyte activation antigen B7-2; B-lymphocyte antigen B7-2; B7-2; B7-2 antigen; B7.2; B70; BU63; CD28 antigen ligand 2; CD28LG2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CTLA-4 counter-receptor B7.2; FUN-1; LAB72; MGC34413; T-lymphocyte activation antigen CD86
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383122,055,362 - 122,121,136 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3122,055,362 - 122,121,139 (+)EnsemblGRCh38hg38GRCh38
GRCh373121,774,209 - 121,839,983 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363123,256,911 - 123,322,673 (+)NCBINCBI36Build 36hg18NCBI36
Celera3120,183,894 - 120,249,657 (+)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3119,148,000 - 119,213,630 (+)NCBIHuRef
CHM1_13121,738,233 - 121,803,970 (+)NCBICHM1_1
T2T-CHM13v2.03124,775,351 - 124,841,114 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(R)-lipoic acid  (EXP)
(S)-nicotine  (ISO)
1,10-phenanthroline  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (EXP)
1,4-benzoquinone  (EXP)
1,4-phenylenediamine  (EXP)
1-aminobenzotriazole  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
2-Methoxy-4-methylphenol  (EXP)
2-tert-butylhydroquinone  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-octylphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP)
9-cis-retinoic acid  (EXP)
acetamide  (ISO)
adenosine 5'-[gamma-thio]triphosphate  (ISO)
albendazole  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (EXP)
alternariol  (EXP,ISO)
aluminium hydroxide  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (EXP)
arachidonyl-2'-chloroethylamide  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
asbestos  (EXP)
atorvastatin calcium  (EXP)
Azoxymethane  (ISO)
Bandrowski's base  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzoyl chloride  (EXP)
benzyl benzoate  (EXP)
benzyl cinnamate  (EXP)
benzylpenicillin  (EXP)
beryllium sulfate  (EXP)
beta-D-glucan  (ISO)
beta-naphthoflavone  (EXP)
betamethasone valerate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
calcitriol  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
cefaloridine  (ISO)
CGP 52608  (EXP)
chloramine T  (EXP)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (EXP)
cisplatin  (EXP)
citral  (EXP)
citric acid  (EXP)
clobetasol  (ISO)
clodronic acid  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (EXP,ISO)
cordycepin  (ISO)
cortisol  (EXP,ISO)
Cyclopamine  (EXP)
daidzein  (ISO)
DDE  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dicoumarol  (EXP)
diethyl maleate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
diiodine  (ISO)
diisononyl phthalate  (ISO)
dimethoate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diphenylmethane-4,4'-diisocyanate  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
equol  (ISO)
estriol  (ISO)
ethylene glycol dimethacrylate  (EXP)
ethylmercuric chloride  (EXP)
eugenol  (EXP)
fluorescein 5-isothiocyanate  (EXP)
flutamide  (EXP)
formaldehyde  (EXP)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
geranial  (EXP)
geraniol  (EXP)
glucuronoxylomannan  (EXP)
glutaraldehyde  (EXP)
glutathione  (EXP)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
graphite  (ISO)
Harpagide  (ISO)
helenalin  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP,ISO)
hydroxycitronellal  (EXP)
imidurea  (EXP)
imiquimod  (ISO)
immunological adjuvant  (EXP)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (EXP,ISO)
ionomycin  (EXP,ISO)
kanamycin A  (EXP)
L-cysteine  (EXP)
lead diacetate  (ISO)
lead nitrate  (ISO)
levonorgestrel  (EXP)
lidocaine  (ISO)
linalool  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lupane  (EXP)
manganese(II) chloride  (EXP)
mercury dichloride  (EXP)
methotrexate  (EXP)
methoxychlor  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
mifepristone  (EXP)
MK-2206  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
muramyl dipeptide  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
n-propyl gallate  (EXP)
nandrolone  (EXP)
neomycin  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (EXP)
nonanoic acid  (EXP)
nystatin  (ISO)
ochratoxin A  (ISO)
octanoic acid  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenanthridone  (EXP)
phenethyl caffeate  (ISO)
phenyl benzoate  (EXP)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
polymyxin B2  (EXP,ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
pyridine  (EXP)
pyrithione  (ISO)
quercetin  (ISO)
rac-lactic acid  (EXP)
raloxifene  (ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
S-nitrosoglutathione  (EXP)
SB 203580  (EXP)
SCH 23390  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sirolimus  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
Soman  (ISO)
streptozocin  (ISO)
succimer  (EXP)
sulpiride  (ISO)
tacrolimus hydrate  (EXP)
testosterone  (ISO)
testosterone undecanoate  (EXP)
tetrachloromethane  (ISO)
thimerosal  (EXP)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
Tributyltin oxide  (ISO)
tributyrin  (ISO)
trimethyltin  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
ursolic acid  (ISO)
vincristine  (EXP)
vitamin E  (EXP)
Y-27632  (ISO)
zearalenone  (EXP)
zinc dichloride  (ISO)
zinc protoporphyrin  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Activated microglial cells acquire an immature dendritic cell phenotype and may terminate the immune response in an acute model of EAE. Almolda B, etal., J Neuroimmunol. 2010 Jun;223(1-2):39-54. Epub 2010 May 6.
2. Altered phenotype and function of dendritic cells in children with type 1 diabetes. Angelini F, etal., Clin Exp Immunol. 2005 Nov;142(2):341-6.
3. Small interfering RNA against CD86 during allergen challenge blocks experimental allergic asthma. Asai-Tajiri Y, etal., Respir Res. 2014 Oct 27;15:132. doi: 10.1186/s12931-014-0132-z.
4. A role for dendritic cells in bleomycin-induced pulmonary fibrosis in mice? Bantsimba-Malanda C, etal., Am J Respir Crit Care Med. 2010 Aug 1;182(3):385-95. Epub 2010 Apr 15.
5. Francisella tularensis induces aberrant activation of pulmonary dendritic cells. Bosio CM and Dow SW, J Immunol. 2005 Nov 15;175(10):6792-801.
6. CD86+ or HLA-G+ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis. Brown R, etal., Blood. 2012 Sep 6;120(10):2055-63. doi: 10.1182/blood-2012-03-416792. Epub 2012 Jun 15.
7. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. Chang TT, etal., J Exp Med. 1999 Sep 6;190(5):733-40.
8. Cauterization of central cornea induces recruitment of major histocompatibility complex class II+ Langerhans cells from limbal basal epithelium. Chen W, etal., Cornea. 2010 Jan;29(1):73-9.
9. Anti-tumor immunity in a model of acute myeloid leukemia. Cheuk AT, etal., Leuk Lymphoma. 2009 Mar;50(3):447-54.
10. Increased gene expression of Toll-like receptors and antigen-presenting cell-related molecules in the onset of experimentally induced furcation lesions of endodontic origin in rat molars. Chokechanachaisakul U, etal., J Endod. 2010 Feb;36(2):251-5. Epub 2009 Dec 4.
11. Dexamethasone inhibits immunoreactivity of dendritic cells in patients with chronic idiopathic thrombocytopenic purpura. Chu XX, etal., Blood Coagul Fibrinolysis. 2010 Sep;21(6):564-7. doi: 10.1097/MBC.0b013e32833c2b8c.
12. A functional CD86 polymorphism associated with asthma and related allergic disorders. Corydon TJ, etal., J Med Genet. 2007 Aug;44(8):509-15. Epub 2007 May 18.
13. Low CD86 expression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation. Dahlen E, etal., J Immunol. 2000 Mar 1;164(5):2444-56.
14. Low expression of antigen-presenting and costimulatory molecules by lung cells from tuberculosis patients. Flores-Batista VC, etal., Braz J Med Biol Res. 2007 Dec;40(12):1671-9. Epub 2007 Oct 29.
15. Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease. Freeman CM, etal., Am J Respir Crit Care Med. 2009 Dec 15;180(12):1179-88. Epub 2009 Sep 3.
16. Mature CD11c(+) cells are enhanced in hypersensitivity pneumonitis. Girard M, etal., Eur Respir J. 2009 Sep;34(3):749-56. Epub 2009 Mar 12.
17. Development of human T-cell leukemia virus type 1-transformed tumors in rats following suppression of T-cell immunity by CD80 and CD86 blockade. Hanabuchi S, etal., J Virol. 2000 Jan;74(1):428-35.
18. CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin. Herold KC, etal., J Immunol. 1997 Jan 15;158(2):984-91.
19. Streptococcus pneumoniae Infection aggravates experimental autoimmune encephalomyelitis via Toll-like receptor 2. Herrmann I, etal., Infect Immun. 2006 Aug;74(8):4841-8.
20. Upregulation of B7.2, but not B7.1, on B cells from patients with allergic asthma. Hofer MF, etal., J Allergy Clin Immunol. 1998 Jan;101(1 Pt 1):96-102.
21. House dust mite regulate the lung inflammation of asthmatic mice through TLR4 pathway in airway epithelial cells. Hongjia L, etal., Cell Biochem Funct. 2010 Oct;28(7):597-603.
22. A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis. Hu X, etal., PLoS One. 2016 Mar 31;11(3):e0152368. doi: 10.1371/journal.pone.0152368. eCollection 2016.
23. AID induces intraclonal diversity and genomic damage in CD86(+) chronic lymphocytic leukemia cells. Huemer M, etal., Eur J Immunol. 2014 Dec;44(12):3747-57. doi: 10.1002/eji.201344421. Epub 2014 Oct 18.
24. Islet-infiltrating t lymphocytes in insulin-dependent diabetic patients express CD80 (B7-1) and CD86 (B7-2). Imagawa A, etal., J Autoimmun. 1996 Jun;9(3):391-6.
25. Distinct transcriptional control in major immunogenetic subsets of chronic lymphocytic leukemia exhibiting subset-biased global DNA methylation profiles. Kanduri M, etal., Epigenetics. 2012 Dec 1;7(12):1435-42. doi: 10.4161/epi.22901. Epub 2012 Nov 15.
26. Artificial dental pulp exposure injury up-regulates antigen-presenting cell-related molecules in rat central nervous system. Kaneko T, etal., J Endod. 2010 Mar;36(3):459-64.
27. Development of murine allergic asthma is dependent upon B7-2 costimulation. Keane-Myers AM, etal., J Immunol. 1998 Jan 15;160(2):1036-43.
28. An essential role for dendritic cells in human and experimental allergic rhinitis. KleinJan A, etal., J Allergy Clin Immunol. 2006 Nov;118(5):1117-25. Epub 2006 Aug 28.
29. CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease. Liu Y, etal., Hum Immunol. 2010 Nov;71(11):1141-6. Epub 2010 Aug 21.
30. [Expression of co-stimulatory molecules in peripheral blood of patients with idiopathic thrombocytopenic purpura in relation with platelet antibodies]. Ma XR, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Apr;17(2):483-6.
31. Fc gamma receptors regulate immune activation and susceptibility during Mycobacterium tuberculosis infection. Maglione PJ, etal., J Immunol. 2008 Mar 1;180(5):3329-38.
32. Increased expression of costimulatory molecules CD86 and sCTLA-4 in patients with acute lymphoblastic leukemia. Mansour A, etal., Leuk Lymphoma. 2014 Sep;55(9):2120-4. doi: 10.3109/10428194.2013.869328. Epub 2014 Mar 7.
33. Low expression of T-cell co-stimulatory molecules in bone marrow-derived dendritic cells in a mouse model of chronic respiratory infection with Pseudomonas aeruginosa. Mukae H, etal., Tohoku J Exp Med. 2010 Jan;220(1):59-65.
34. A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes. Phillips B, etal., Diabetes. 2008 Jun;57(6):1544-55. Epub 2008 Mar 3.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion. Rau FC, etal., J Immunol. 2009 Dec 15;183(12):7661-71. Epub .
37. Arming parvoviruses with CpG motifs to improve their oncosuppressive capacity. Raykov Z, etal., Int J Cancer. 2008 Jun 15;122(12):2880-4.
38. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Functional and phenotypic characteristics of testicular macrophages in experimental autoimmune orchitis. Rival C, etal., J Pathol. 2008 Jun;215(2):108-17.
41. CpG-ODN and MPLA prevent mortality in a murine model of post-hemorrhage-Staphyloccocus aureus pneumonia. Roquilly A, etal., PLoS One. 2010 Oct 7;5(10):e13228.
42. Appearance of cells expressing CD80 and CD86 costimulatory antigens in the pancreas of nonobese diabetic mice. Sainio-Pollanen S, etal., Pancreas. 1996 Nov;13(4):388-94.
43. Enhanced activation of memory, but not naive, B cells in chronic hepatitis C virus-infected patients with cryoglobulinemia and advanced liver fibrosis. Santer DM, etal., PLoS One. 2013 Jun 28;8(6):e68308. doi: 10.1371/journal.pone.0068308. Print 2013.
44. Effects of in vivo administration of anti-B7-1/B7-2 monoclonal antibodies on the survival of mice with chronic ongoing myocarditis caused by Coxsackievirus B3. Seko Y, etal., J Pathol. 1999 May;188(1):107-12. doi: 10.1002/(SICI)1096-9896(199905)188:1<107::AID-PATH319>3.0.CO;2-7.
45. High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection. Silveira-Lemos D, etal., Mem Inst Oswaldo Cruz. 2006 Sep;101 Suppl 1:345-51.
46. Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. Spatz M, etal., Cell Immunol. 2003 Jan;221(1):15-26.
47. Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control. Strickland DH, etal., Mucosal Immunol. 2011 Jan;4(1):43-52. Epub 2010 Jul 28.
48. Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia. Tamura H, etal., Clin Cancer Res. 2005 Aug 15;11(16):5708-17.
49. CD86 has sustained costimulatory effects on CD8 T cells. Thomas IJ, etal., J Immunol. 2007 Nov 1;179(9):5936-46.
50. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Thored P, etal., Glia. 2009 Jun;57(8):835-49.
51. CD28-B7-2 but not CD28-B7-1 interaction is required for T cell costimulation in experimental obliterative bronchiolitis in the rat. Tikkanen JM, etal., Transplant Proc. 2001 Feb-Mar;33(1-2):535.
52. Polymorphisms in CD28, CTLA-4, CD80 and CD86 genes may influence the risk of multiple sclerosis and its age of onset. Wagner M, etal., J Neuroimmunol. 2015 Nov 15;288:79-86. doi: 10.1016/j.jneuroim.2015.09.004. Epub 2015 Sep 18.
53. Impairment of monocyte-derived dendritic cells in idiopathic pulmonary arterial hypertension. Wang W, etal., J Clin Immunol. 2009 Nov;29(6):705-13. Epub 2009 Aug 20.
54. In vivo role of dendritic cells in a murine model of pulmonary cryptococcosis. Wozniak KL, etal., Infect Immun. 2006 Jul;74(7):3817-24.
55. B7-2 (CD86) controls the priming of autoreactive CD4 T cell response against pancreatic islets. Yadav D, etal., J Immunol. 2004 Sep 15;173(6):3631-9.
56. Association between high-mobility group box-1 protein release and immune function of dendritic cells in thermal injury. Zhang LT, etal., J Interferon Cytokine Res. 2010 Jul;30(7):487-95.
57. Circulating myeloid dendritic cells are increased in individuals with severe aplastic anemia. Zonghong S, etal., Int J Hematol. 2011 Feb;93(2):156-62. doi: 10.1007/s12185-010-0761-z. Epub 2011 Jan 14.
Additional References at PubMed
PMID:7489738   PMID:7495740   PMID:7513726   PMID:7520767   PMID:7527824   PMID:7541777   PMID:7542604   PMID:7694153   PMID:7694363   PMID:9032261   PMID:9250865   PMID:9573027  
PMID:9915850   PMID:10464129   PMID:10606960   PMID:10886401   PMID:11021528   PMID:11029388   PMID:11123305   PMID:11162656   PMID:11169444   PMID:11196673   PMID:11207262   PMID:11238115  
PMID:11279501   PMID:11496240   PMID:11702979   PMID:11714768   PMID:11726649   PMID:11751963   PMID:11823047   PMID:11826754   PMID:11986949   PMID:12015893   PMID:12071705   PMID:12097397  
PMID:12100033   PMID:12187923   PMID:12213904   PMID:12372936   PMID:12477932   PMID:12486098   PMID:12513711   PMID:12582153   PMID:12606712   PMID:12660731   PMID:12672403   PMID:12829914  
PMID:12878356   PMID:12905492   PMID:14692664   PMID:14727087   PMID:14871408   PMID:14975605   PMID:14978077   PMID:15019278   PMID:15034022   PMID:15045639   PMID:15059478   PMID:15110532  
PMID:15163715   PMID:15280476   PMID:15489334   PMID:15611322   PMID:15623548   PMID:15628695   PMID:15895390   PMID:15908444   PMID:15942292   PMID:15956545   PMID:16002699   PMID:16177101  
PMID:16223675   PMID:16272310   PMID:16339520   PMID:16344560   PMID:16690948   PMID:16712644   PMID:16818765   PMID:17077296   PMID:17386046   PMID:17524139   PMID:17605869   PMID:17622942  
PMID:17703412   PMID:17919231   PMID:17925605   PMID:17963596   PMID:17977894   PMID:17989345   PMID:18005680   PMID:18069758   PMID:18301333   PMID:18322188   PMID:18506362   PMID:18577795  
PMID:18580477   PMID:18676680   PMID:18941200   PMID:18945465   PMID:19012493   PMID:19086656   PMID:19149577   PMID:19170196   PMID:19257981   PMID:19258923   PMID:19275586   PMID:19299714  
PMID:19430862   PMID:19550123   PMID:19625176   PMID:19692168   PMID:19735272   PMID:19828628   PMID:19852851   PMID:19913121   PMID:20012528   PMID:20019769   PMID:20066438   PMID:20067533  
PMID:20100932   PMID:20118277   PMID:20212510   PMID:20230296   PMID:20237496   PMID:20331378   PMID:20380573   PMID:20388394   PMID:20433886   PMID:20458337   PMID:20503287   PMID:20601595  
PMID:20628086   PMID:20802378   PMID:20884055   PMID:20971123   PMID:20979791   PMID:21048031   PMID:21469977   PMID:21474713   PMID:21525579   PMID:21540807   PMID:21563968   PMID:21628959  
PMID:21778700   PMID:21833088   PMID:21870962   PMID:21873635   PMID:21896490   PMID:21911468   PMID:21922073   PMID:21982860   PMID:21988832   PMID:22074996   PMID:22103833   PMID:22142817  
PMID:22182632   PMID:22190364   PMID:22199280   PMID:22246628   PMID:22371880   PMID:22379101   PMID:22558273   PMID:22659416   PMID:22732586   PMID:22808111   PMID:22821131   PMID:22962607  
PMID:23175469   PMID:23246582   PMID:23289444   PMID:23470321   PMID:23661460   PMID:23867827   PMID:23981064   PMID:24023945   PMID:24162774   PMID:24202305   PMID:24298899   PMID:24378263  
PMID:24415757   PMID:24505475   PMID:24531620   PMID:24632372   PMID:24696476   PMID:24845157   PMID:24897540   PMID:24930629   PMID:24951814   PMID:24981893   PMID:25129060   PMID:25241761  
PMID:25248333   PMID:25261932   PMID:25279986   PMID:25369324   PMID:25482673   PMID:25892855   PMID:25896473   PMID:25912130   PMID:26416278   PMID:26795594   PMID:26901523   PMID:27348308  
PMID:27708164   PMID:27718302   PMID:28056587   PMID:28067225   PMID:28074067   PMID:28079472   PMID:28274366   PMID:28338767   PMID:28904313   PMID:29217299   PMID:29277562   PMID:29577049  
PMID:29599775   PMID:30343689   PMID:30406401   PMID:31114583   PMID:31485639   PMID:31575740   PMID:31651850   PMID:31755324   PMID:32197584   PMID:32513696   PMID:32580776   PMID:33363541  
PMID:33771483   PMID:34149691   PMID:34157285   PMID:34191384   PMID:34486997   PMID:34656742   PMID:34738707   PMID:35000467   PMID:35022089   PMID:35380688   PMID:36051533   PMID:36796620  
PMID:37614091   PMID:37918715  


Genomics

Comparative Map Data
CD86
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383122,055,362 - 122,121,136 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3122,055,362 - 122,121,139 (+)EnsemblGRCh38hg38GRCh38
GRCh373121,774,209 - 121,839,983 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363123,256,911 - 123,322,673 (+)NCBINCBI36Build 36hg18NCBI36
Celera3120,183,894 - 120,249,657 (+)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3119,148,000 - 119,213,630 (+)NCBIHuRef
CHM1_13121,738,233 - 121,803,970 (+)NCBICHM1_1
T2T-CHM13v2.03124,775,351 - 124,841,114 (+)NCBIT2T-CHM13v2.0
Cd86
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391636,389,318 - 36,486,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1636,424,231 - 36,486,443 (-)EnsemblGRCm39 Ensembl
GRCm381636,568,956 - 36,666,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1636,603,869 - 36,666,081 (-)EnsemblGRCm38mm10GRCm38
MGSCv371636,603,955 - 36,666,163 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361636,523,113 - 36,585,290 (-)NCBIMGSCv36mm8
Celera1637,019,467 - 37,081,856 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1625.72NCBI
Cd86
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81177,647,565 - 77,706,178 (+)NCBIGRCr8
mRatBN7.21164,142,193 - 64,200,816 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,163,828 - 64,200,818 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1172,976,468 - 73,012,708 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01165,638,701 - 65,674,935 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,669,718 - 64,705,519 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,060,305 - 67,117,990 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,082,193 - 67,118,795 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,150,748 - 70,208,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,215,233 - 66,238,882 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11166,272,821 - 66,296,468 (-)NCBI
Celera1163,635,203 - 63,670,914 (+)NCBICelera
Cytogenetic Map11q22NCBI
Cd86
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542721,375,794 - 21,435,874 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542721,375,820 - 21,436,767 (+)NCBIChiLan1.0ChiLan1.0
CD86
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22120,006,752 - 120,072,511 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13120,011,537 - 120,077,290 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03119,151,884 - 119,217,641 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13126,059,008 - 126,124,339 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3126,059,008 - 126,124,339 (+)Ensemblpanpan1.1panPan2
CD86
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13325,256,267 - 25,318,855 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3325,256,267 - 25,318,087 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3325,281,506 - 25,343,086 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03325,491,858 - 25,554,625 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3325,491,761 - 25,553,455 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13325,289,910 - 25,351,816 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03325,332,469 - 25,394,248 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03325,890,298 - 25,952,478 (+)NCBIUU_Cfam_GSD_1.0
Cd86
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602129,038,128 - 129,107,520 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365368,414,491 - 8,481,712 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD86
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13138,427,533 - 138,504,310 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113138,427,573 - 138,504,307 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213148,055,863 - 148,130,754 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD86
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12258,741,534 - 58,805,417 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2258,741,525 - 58,805,366 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041107,540,631 - 107,604,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd86
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624912350,157 - 426,712 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624912350,201 - 432,410 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CD86
36 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q13.33-21.2(chr3:121644209-125676353)x1 copy number loss See cases [RCV000051569] Chr3:121644209..125676353 [GRCh38]
Chr3:121363056..125395197 [GRCh37]
Chr3:122845746..126877887 [NCBI36]
Chr3:3q13.33-21.2
pathogenic
GRCh38/hg38 3q11.1-21.1(chr3:93886671-123216683)x1 copy number loss See cases [RCV000051543] Chr3:93886671..123216683 [GRCh38]
Chr3:93605515..122935530 [GRCh37]
Chr3:95088205..124418220 [NCBI36]
Chr3:3q11.1-21.1
pathogenic
GRCh38/hg38 3q13.32-21.2(chr3:119117166-125920734)x1 copy number loss See cases [RCV000051546] Chr3:119117166..125920734 [GRCh38]
Chr3:118836013..125639577 [GRCh37]
Chr3:120318703..127122267 [NCBI36]
Chr3:3q13.32-21.2
pathogenic
NM_175862.4(CD86):c.743G>A (p.Trp248Ter) single nucleotide variant Malignant melanoma [RCV000065802] Chr3:122109304 [GRCh38]
Chr3:121828151 [GRCh37]
Chr3:123310841 [NCBI36]
Chr3:3q13.33
not provided
NM_175862.4(CD86):c.951G>A (p.Ser317=) single nucleotide variant Malignant melanoma [RCV000065803] Chr3:122119495 [GRCh38]
Chr3:121838342 [GRCh37]
Chr3:123321032 [NCBI36]
Chr3:3q13.33
not provided
NM_175862.4(CD86):c.804G>A (p.Trp268Ter) single nucleotide variant Malignant melanoma [RCV000060680] Chr3:122109365 [GRCh38]
Chr3:121828212 [GRCh37]
Chr3:123310902 [NCBI36]
Chr3:3q13.33
not provided
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29
pathogenic
GRCh38/hg38 3q13.31-21.1(chr3:115019074-122513398)x1 copy number loss See cases [RCV000135961] Chr3:115019074..122513398 [GRCh38]
Chr3:114737921..122232245 [GRCh37]
Chr3:116220611..123714935 [NCBI36]
Chr3:3q13.31-21.1
pathogenic
GRCh38/hg38 3q13.2-21.3(chr3:112620977-128734134)x1 copy number loss See cases [RCV000139033] Chr3:112620977..128734134 [GRCh38]
Chr3:112339824..128452977 [GRCh37]
Chr3:113822514..129935667 [NCBI36]
Chr3:3q13.2-21.3
pathogenic
GRCh38/hg38 3q13.33-21.3(chr3:121925147-126782249)x1 copy number loss See cases [RCV000140814] Chr3:121925147..126782249 [GRCh38]
Chr3:121643994..126501092 [GRCh37]
Chr3:123126684..127983782 [NCBI36]
Chr3:3q13.33-21.3
pathogenic
GRCh38/hg38 3q13.31-21.2(chr3:114122562-124532374)x1 copy number loss See cases [RCV000142009] Chr3:114122562..124532374 [GRCh38]
Chr3:113841409..124251221 [GRCh37]
Chr3:115324099..125733911 [NCBI36]
Chr3:3q13.31-21.2
pathogenic
GRCh38/hg38 3q11.1-24(chr3:93800620-145695381)x3 copy number gain See cases [RCV000142340] Chr3:93800620..145695381 [GRCh38]
Chr3:93519464..145413168 [GRCh37]
Chr3:95002154..146895858 [NCBI36]
Chr3:3q11.1-24
pathogenic
GRCh38/hg38 3q13.32-21.3(chr3:118673898-126540730)x1 copy number loss See cases [RCV000143695] Chr3:118673898..126540730 [GRCh38]
Chr3:118392745..126259573 [GRCh37]
Chr3:119875435..127742263 [NCBI36]
Chr3:3q13.32-21.3
pathogenic
GRCh37/hg19 3q13.33-21.1(chr3:119749810-122459323)x3 copy number gain See cases [RCV000240473] Chr3:119749810..122459323 [GRCh37]
Chr3:3q13.33-21.1
likely pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3q13.31-21.1(chr3:115518341-122129283)x1 copy number loss not provided [RCV000682298] Chr3:115518341..122129283 [GRCh37]
Chr3:3q13.31-21.1
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_175862.5(CD86):c.967G>A (p.Asp323Asn) single nucleotide variant not provided [RCV000894318] Chr3:122119511 [GRCh38]
Chr3:121838358 [GRCh37]
Chr3:3q13.33
benign
GRCh37/hg19 3q13.33-21.1(chr3:121384741-123672180)x3 copy number gain not provided [RCV000848663] Chr3:121384741..123672180 [GRCh37]
Chr3:3q13.33-21.1
uncertain significance
NM_175862.5(CD86):c.508A>G (p.Ser170Gly) single nucleotide variant not specified [RCV004315097] Chr3:122106305 [GRCh38]
Chr3:121825152 [GRCh37]
Chr3:3q13.33
uncertain significance
NM_175862.5(CD86):c.928G>A (p.Ala310Thr) single nucleotide variant not provided [RCV001608900] Chr3:122119472 [GRCh38]
Chr3:121838319 [GRCh37]
Chr3:3q13.33
benign
Single allele deletion Deafness-lymphedema-leukemia syndrome [RCV001541924] Chr3:120247726..128319968 [GRCh37]
Chr3:3q13.33-21.3
pathogenic
GRCh37/hg19 3q13.31-26.31(chr3:116620308-172042292)x3 copy number gain not provided [RCV002472621] Chr3:116620308..172042292 [GRCh37]
Chr3:3q13.31-26.31
pathogenic
NM_175862.5(CD86):c.931C>G (p.Gln311Glu) single nucleotide variant not specified [RCV004609949] Chr3:122119475 [GRCh38]
Chr3:121838322 [GRCh37]
Chr3:3q13.33
uncertain significance
NC_000003.11:g.(?_120365818)_(133465047_?)del deletion Alkaptonuria [RCV002035459] Chr3:120365818..133465047 [GRCh37]
Chr3:3q13.33-22.1
pathogenic
NC_000003.11:g.(?_121489192)_(125313644_?)dup duplication Familial hypocalciuric hypercalcemia [RCV003111142] Chr3:121489192..125313644 [GRCh37]
Chr3:3q13.33-21.2
uncertain significance
NM_175862.5(CD86):c.611C>G (p.Ser204Cys) single nucleotide variant not specified [RCV004218219] Chr3:122106408 [GRCh38]
Chr3:121825255 [GRCh37]
Chr3:3q13.33
uncertain significance
NM_175862.5(CD86):c.935G>A (p.Arg312His) single nucleotide variant not specified [RCV004225597] Chr3:122119479 [GRCh38]
Chr3:121838326 [GRCh37]
Chr3:3q13.33
likely benign
NM_175862.5(CD86):c.457A>C (p.Ile153Leu) single nucleotide variant not specified [RCV004222175] Chr3:122106254 [GRCh38]
Chr3:121825101 [GRCh37]
Chr3:3q13.33
uncertain significance
NM_175862.5(CD86):c.247A>G (p.Met83Val) single nucleotide variant not specified [RCV004200259] Chr3:122103694 [GRCh38]
Chr3:121822541 [GRCh37]
Chr3:3q13.33
uncertain significance
NM_175862.5(CD86):c.677G>A (p.Arg226Gln) single nucleotide variant not specified [RCV004195129] Chr3:122106474 [GRCh38]
Chr3:121825321 [GRCh37]
Chr3:3q13.33
likely benign
NM_175862.5(CD86):c.820A>C (p.Lys274Gln) single nucleotide variant not specified [RCV004102725] Chr3:122109381 [GRCh38]
Chr3:121828228 [GRCh37]
Chr3:3q13.33
uncertain significance
NM_175862.5(CD86):c.454T>C (p.Tyr152His) single nucleotide variant not specified [RCV004225148] Chr3:122106251 [GRCh38]
Chr3:121825098 [GRCh37]
Chr3:3q13.33
uncertain significance
NM_175862.5(CD86):c.71C>T (p.Ala24Val) single nucleotide variant not specified [RCV004243868] Chr3:122103518 [GRCh38]
Chr3:121822365 [GRCh37]
Chr3:3q13.33
uncertain significance
NM_175862.5(CD86):c.830G>A (p.Arg277His) single nucleotide variant not specified [RCV004094051] Chr3:122109391 [GRCh38]
Chr3:121828238 [GRCh37]
Chr3:3q13.33
uncertain significance
NM_175862.5(CD86):c.424G>T (p.Val142Leu) single nucleotide variant not specified [RCV004184529] Chr3:122106221 [GRCh38]
Chr3:121825068 [GRCh37]
Chr3:3q13.33
uncertain significance
NM_175862.5(CD86):c.551G>T (p.Gly184Val) single nucleotide variant not specified [RCV004149463] Chr3:122106348 [GRCh38]
Chr3:121825195 [GRCh37]
Chr3:3q13.33
uncertain significance
NM_175862.5(CD86):c.452T>C (p.Val151Ala) single nucleotide variant not specified [RCV004301959] Chr3:122106249 [GRCh38]
Chr3:121825096 [GRCh37]
Chr3:3q13.33
uncertain significance
GRCh38/hg38 3q11.1-21.2(chr3:93979547-124774010)x1 copy number loss Chromosome 3q13.31 deletion syndrome [RCV003327614] Chr3:93979547..124774010 [GRCh38]
Chr3:3q11.1-21.2
pathogenic
NM_175862.5(CD86):c.919T>G (p.Ser307Ala) single nucleotide variant not specified [RCV004347989] Chr3:122119463 [GRCh38]
Chr3:121838310 [GRCh37]
Chr3:3q13.33
uncertain significance
NM_175862.5(CD86):c.230G>A (p.Ser77Asn) single nucleotide variant not specified [RCV004435569] Chr3:122103677 [GRCh38]
Chr3:121822524 [GRCh37]
Chr3:3q13.33
likely benign
NM_175862.5(CD86):c.394G>A (p.Val132Met) single nucleotide variant not specified [RCV004435570] Chr3:122103841 [GRCh38]
Chr3:121822688 [GRCh37]
Chr3:3q13.33
uncertain significance
NM_175862.5(CD86):c.218A>G (p.Glu73Gly) single nucleotide variant not specified [RCV004435568] Chr3:122103665 [GRCh38]
Chr3:121822512 [GRCh37]
Chr3:3q13.33
uncertain significance
NM_175862.5(CD86):c.824G>A (p.Arg275Gln) single nucleotide variant not specified [RCV004435572] Chr3:122109385 [GRCh38]
Chr3:121828232 [GRCh37]
Chr3:3q13.33
likely benign
NM_175862.5(CD86):c.934C>T (p.Arg312Cys) single nucleotide variant not specified [RCV004435573] Chr3:122119478 [GRCh38]
Chr3:121838325 [GRCh37]
Chr3:3q13.33
likely benign
NM_175862.5(CD86):c.217G>C (p.Glu73Gln) single nucleotide variant not specified [RCV004435567] Chr3:122103664 [GRCh38]
Chr3:121822511 [GRCh37]
Chr3:3q13.33
uncertain significance
NM_175862.5(CD86):c.863A>G (p.Glu288Gly) single nucleotide variant not specified [RCV004606606] Chr3:122118063 [GRCh38]
Chr3:121836910 [GRCh37]
Chr3:3q13.33
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2609
Count of miRNA genes:752
Interacting mature miRNAs:854
Transcripts:ENST00000264468, ENST00000330540, ENST00000393627, ENST00000469710, ENST00000478390, ENST00000478741, ENST00000482356, ENST00000483949, ENST00000493101
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407181057GWAS830033_Hcalcium measurement QTL GWAS830033 (human)9e-11calcium measurementblood calcium level (CMO:0000502)3122120353122120354Human
407111521GWAS760497_Heosinophil count QTL GWAS760497 (human)6e-10eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)3122062876122062877Human
407181056GWAS830032_Hcalcium measurement QTL GWAS830032 (human)2e-11calcium measurementblood calcium level (CMO:0000502)3122083447122083448Human
406989156GWAS638132_Hselective IgA deficiency disease QTL GWAS638132 (human)0.0000002selective IgA deficiency disease3122081640122081641Human
407251648GWAS900624_Hlymphocyte count QTL GWAS900624 (human)2e-10lymphocyte countblood lymphocyte count (CMO:0000031)3122102059122102060Human
407156429GWAS805405_Hblood phosphate measurement QTL GWAS805405 (human)6e-11blood phosphate amount (VT:0001565)blood phosphate level (CMO:0000504)3122077921122077922Human
407042347GWAS691323_Hneoplasm of mature B-cells QTL GWAS691323 (human)0.0000002neoplasm of mature B-cells3122098766122098767Human
407076233GWAS725209_Htotal blood protein measurement QTL GWAS725209 (human)4e-08total blood protein measurementblood protein measurement (CMO:0000028)3122098766122098767Human
406950157GWAS599133_Hdiffuse large B-cell lymphoma QTL GWAS599133 (human)8e-08diffuse large B-cell lymphoma3122098766122098767Human
407168820GWAS817796_Hgut microbiome measurement QTL GWAS817796 (human)0.000002gut microbiome measurement3122077921122077922Human
407309590GWAS958566_Hblood phosphate measurement QTL GWAS958566 (human)7e-10blood phosphate amount (VT:0001565)blood phosphate level (CMO:0000504)3122108877122108878Human
406945683GWAS594659_Heosinophil percentage of leukocytes QTL GWAS594659 (human)7e-15eosinophil percentage of leukocytesblood eosinophil count to total leukocyte count ratio (CMO:0000369)3122062842122062843Human
406941107GWAS590083_Hautoimmune thyroid disease QTL GWAS590083 (human)3e-08autoimmune thyroid disease3122106350122106351Human
407184918GWAS833894_Hcalcium measurement QTL GWAS833894 (human)4e-13calcium measurementblood calcium level (CMO:0000502)3122118003122118004Human
407298227GWAS947203_Ht-lymphocyte activation antigen CD86 measurement QTL GWAS947203 (human)1e-64t-lymphocyte activation antigen CD86 measurement3122110727122110728Human
407181084GWAS830060_Hcalcium measurement QTL GWAS830060 (human)4e-09calcium measurementblood calcium level (CMO:0000502)3122069850122069851Human
407212924GWAS861900_Ht-lymphocyte activation antigen CD86 measurement QTL GWAS861900 (human)2e-37t-lymphocyte activation antigen CD86 measurement3122108896122108897Human
406943259GWAS592235_Heosinophil count QTL GWAS592235 (human)4e-13eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)3122062842122062843Human
407129592GWAS778568_Hmultiple sclerosis QTL GWAS778568 (human)6e-08multiple sclerosis3122074340122074341Human
406948061GWAS597037_HHodgkins lymphoma, multiple myeloma, non-Hodgkins lymphoma QTL GWAS597037 (human)7e-10Hodgkins lymphoma, multiple myeloma, non-Hodgkins lymphoma3122081640122081641Human
407152441GWAS801417_Hcalcium measurement QTL GWAS801417 (human)3e-13calcium measurementblood calcium level (CMO:0000502)3122077921122077922Human
406983932GWAS632908_Hmultiple sclerosis QTL GWAS632908 (human)1e-11multiple sclerosis3122077921122077922Human
407183002GWAS831978_Hcalcium measurement QTL GWAS831978 (human)1e-15calcium measurementblood calcium level (CMO:0000502)3122108877122108878Human

Markers in Region
G31041  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373121,839,827 - 121,839,959UniSTSGRCh37
Build 363123,322,517 - 123,322,649RGDNCBI36
Celera3120,249,501 - 120,249,633RGD
Cytogenetic Map3q21UniSTS
HuRef3119,213,467 - 119,213,599UniSTS
SGC35242  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373121,838,433 - 121,838,632UniSTSGRCh37
Build 363123,321,123 - 123,321,322RGDNCBI36
Celera3120,248,109 - 120,248,308RGD
Cytogenetic Map3q21UniSTS
HuRef3119,212,075 - 119,212,274UniSTS
GeneMap99-GB4 RH Map3430.17UniSTS
Whitehead-RH Map3527.0UniSTS
NCBI RH Map3929.8UniSTS
RH11462  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373121,838,339 - 121,838,550UniSTSGRCh37
Build 363123,321,029 - 123,321,240RGDNCBI36
Celera3120,248,015 - 120,248,226RGD
Cytogenetic Map3q21UniSTS
HuRef3119,211,981 - 119,212,192UniSTS
GeneMap99-GB4 RH Map3423.87UniSTS
NCBI RH Map3929.8UniSTS
RH102182  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373121,839,591 - 121,839,741UniSTSGRCh37
Build 363123,322,281 - 123,322,431RGDNCBI36
Celera3120,249,265 - 120,249,415RGD
Cytogenetic Map3q21UniSTS
HuRef3119,213,231 - 119,213,381UniSTS
GeneMap99-GB4 RH Map3423.87UniSTS
SHGC-147993  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373121,812,512 - 121,812,860UniSTSGRCh37
Build 363123,295,202 - 123,295,550RGDNCBI36
Celera3120,222,182 - 120,222,530RGD
Cytogenetic Map3q21UniSTS
HuRef3119,186,140 - 119,186,488UniSTS
TNG Radiation Hybrid Map369386.0UniSTS
CD86_510  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373121,839,218 - 121,840,080UniSTSGRCh37
Build 363123,321,908 - 123,322,770RGDNCBI36
Celera3120,248,892 - 120,249,754RGD
HuRef3119,212,858 - 119,213,720UniSTS
D3S2989  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373121,777,615 - 121,777,790UniSTSGRCh37
Build 363123,260,305 - 123,260,480RGDNCBI36
Celera3120,187,288 - 120,187,463RGD
Cytogenetic Map3q21UniSTS
HuRef3119,151,406 - 119,151,581UniSTS
Whitehead-RH Map3530.1UniSTS
Whitehead-YAC Contig Map3 UniSTS
NCBI RH Map31038.8UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2337 2780 2243 4830 1699 2185 3 609 1924 448 2198 7115 6412 22 3655 808 1660 1473 171

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001206924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001206925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_175862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_176892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC068630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF099105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX093060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD705810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA619360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF064748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC231874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU284848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L25259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000264468   ⟹   ENSP00000264468
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3122,077,849 - 122,121,139 (+)Ensembl
Ensembl Acc Id: ENST00000330540   ⟹   ENSP00000332049
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3122,055,362 - 122,121,136 (+)Ensembl
Ensembl Acc Id: ENST00000393627   ⟹   ENSP00000377248
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3122,077,903 - 122,119,820 (+)Ensembl
Ensembl Acc Id: ENST00000469710   ⟹   ENSP00000418988
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3122,055,366 - 122,120,074 (+)Ensembl
Ensembl Acc Id: ENST00000478390
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3122,055,377 - 122,092,162 (+)Ensembl
Ensembl Acc Id: ENST00000478741   ⟹   ENSP00000417195
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3122,091,601 - 122,119,593 (+)Ensembl
Ensembl Acc Id: ENST00000482356   ⟹   ENSP00000419116
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3122,077,857 - 122,106,318 (+)Ensembl
Ensembl Acc Id: ENST00000483949
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3122,077,844 - 122,103,657 (+)Ensembl
Ensembl Acc Id: ENST00000493101   ⟹   ENSP00000420230
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3122,055,366 - 122,120,328 (+)Ensembl
RefSeq Acc Id: NM_001206924   ⟹   NP_001193853
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383122,055,362 - 122,121,136 (+)NCBI
GRCh373121,774,209 - 121,839,990 (+)ENTREZGENE
HuRef3119,148,000 - 119,213,630 (+)ENTREZGENE
CHM1_13121,738,233 - 121,803,970 (+)NCBI
T2T-CHM13v2.03124,775,351 - 124,841,114 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001206925   ⟹   NP_001193854
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383122,055,362 - 122,121,136 (+)NCBI
GRCh373121,774,209 - 121,839,990 (+)ENTREZGENE
HuRef3119,148,000 - 119,213,630 (+)ENTREZGENE
CHM1_13121,738,233 - 121,803,970 (+)NCBI
T2T-CHM13v2.03124,775,351 - 124,841,114 (+)NCBI
Sequence:
RefSeq Acc Id: NM_006889   ⟹   NP_008820
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383122,077,784 - 122,121,136 (+)NCBI
GRCh373121,774,209 - 121,839,990 (+)ENTREZGENE
Build 363123,279,440 - 123,322,673 (+)NCBI Archive
HuRef3119,148,000 - 119,213,630 (+)ENTREZGENE
CHM1_13121,760,717 - 121,803,970 (+)NCBI
T2T-CHM13v2.03124,797,770 - 124,841,114 (+)NCBI
Sequence:
RefSeq Acc Id: NM_175862   ⟹   NP_787058
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383122,055,362 - 122,121,136 (+)NCBI
GRCh373121,774,209 - 121,839,990 (+)ENTREZGENE
Build 363123,256,911 - 123,322,673 (+)NCBI Archive
HuRef3119,148,000 - 119,213,630 (+)ENTREZGENE
CHM1_13121,738,233 - 121,803,970 (+)NCBI
T2T-CHM13v2.03124,775,351 - 124,841,114 (+)NCBI
Sequence:
RefSeq Acc Id: NM_176892   ⟹   NP_795711
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383122,077,784 - 122,121,136 (+)NCBI
GRCh373121,774,209 - 121,839,990 (+)ENTREZGENE
HuRef3119,148,000 - 119,213,630 (+)ENTREZGENE
CHM1_13121,760,717 - 121,803,970 (+)NCBI
T2T-CHM13v2.03124,797,770 - 124,841,114 (+)NCBI
Sequence:
RefSeq Acc Id: NP_787058   ⟸   NM_175862
- Peptide Label: isoform 1 precursor
- UniProtKB: Q6GTS4 (UniProtKB/Swiss-Prot),   Q6FHB1 (UniProtKB/Swiss-Prot),   Q13655 (UniProtKB/Swiss-Prot),   P42081 (UniProtKB/Swiss-Prot),   E9PC27 (UniProtKB/Swiss-Prot),   E7ETN5 (UniProtKB/Swiss-Prot),   B7Z702 (UniProtKB/Swiss-Prot),   B7Z2F3 (UniProtKB/Swiss-Prot),   A0N0P0 (UniProtKB/Swiss-Prot),   Q7M4L5 (UniProtKB/Swiss-Prot),   A8K632 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001193853   ⟸   NM_001206924
- Peptide Label: isoform 4 precursor
- Sequence:
RefSeq Acc Id: NP_001193854   ⟸   NM_001206925
- Peptide Label: isoform 5
- Sequence:
RefSeq Acc Id: NP_008820   ⟸   NM_006889
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A0X9R4E0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_795711   ⟸   NM_176892
- Peptide Label: isoform 3 precursor
- UniProtKB: H7C4F8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000417195   ⟸   ENST00000478741
Ensembl Acc Id: ENSP00000420230   ⟸   ENST00000493101
Ensembl Acc Id: ENSP00000418988   ⟸   ENST00000469710
Ensembl Acc Id: ENSP00000419116   ⟸   ENST00000482356
Ensembl Acc Id: ENSP00000377248   ⟸   ENST00000393627
Ensembl Acc Id: ENSP00000264468   ⟸   ENST00000264468
Ensembl Acc Id: ENSP00000332049   ⟸   ENST00000330540
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42081-F1-model_v2 AlphaFold P42081 1-329 view protein structure

Promoters
RGD ID:6865410
Promoter ID:EPDNEW_H5870
Type:initiation region
Name:CD86_1
Description:CD86 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5867  EPDNEW_H5871  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383122,055,366 - 122,055,426EPDNEW
RGD ID:6865412
Promoter ID:EPDNEW_H5871
Type:initiation region
Name:CD86_2
Description:CD86 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5867  EPDNEW_H5870  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383122,077,876 - 122,077,936EPDNEW
RGD ID:6800913
Promoter ID:HG_KWN:45973
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:ENST00000264468,   NM_175862
Position:
Human AssemblyChrPosition (strand)Source
Build 363123,256,711 - 123,257,211 (+)MPROMDB
RGD ID:6800752
Promoter ID:HG_KWN:45974
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:NM_006889
Position:
Human AssemblyChrPosition (strand)Source
Build 363123,278,671 - 123,279,927 (+)MPROMDB
RGD ID:6800911
Promoter ID:HG_KWN:45975
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:ENST00000383662
Position:
Human AssemblyChrPosition (strand)Source
Build 363123,287,321 - 123,288,382 (+)MPROMDB
RGD ID:6814704
Promoter ID:HG_XEF:5589
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NM_001042644,   NM_001082208,   NM_001112636,   NM_214222
Position:
Human AssemblyChrPosition (strand)Source
Build 363123,292,991 - 123,293,491 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1705 AgrOrtholog
COSMIC CD86 COSMIC
Ensembl Genes ENSG00000114013 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000264468 ENTREZGENE
  ENST00000264468.9 UniProtKB/Swiss-Prot
  ENST00000330540 ENTREZGENE
  ENST00000330540.7 UniProtKB/Swiss-Prot
  ENST00000393627 ENTREZGENE
  ENST00000393627.6 UniProtKB/Swiss-Prot
  ENST00000469710 ENTREZGENE
  ENST00000469710.5 UniProtKB/Swiss-Prot
  ENST00000478741.1 UniProtKB/TrEMBL
  ENST00000482356.5 UniProtKB/TrEMBL
  ENST00000493101 ENTREZGENE
  ENST00000493101.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000114013 GTEx
HGNC ID HGNC:1705 ENTREZGENE
Human Proteome Map CD86 Human Proteome Map
InterPro CD86_IgV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-cell_Activation_Regulation UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:942 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 942 ENTREZGENE
OMIM 601020 OMIM
PANTHER T-LYMPHOCYTE ACTIVATION ANTIGEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-LYMPHOCYTE ACTIVATION ANTIGEN CD86 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26243 PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0X9R4E0 ENTREZGENE, UniProtKB/TrEMBL
  A0N0P0 ENTREZGENE
  A8K632 ENTREZGENE, UniProtKB/TrEMBL
  B7Z2F3 ENTREZGENE
  B7Z702 ENTREZGENE
  C9JXS1_HUMAN UniProtKB/TrEMBL
  CD86_HUMAN UniProtKB/Swiss-Prot
  E7ETN5 ENTREZGENE
  E9PC27 ENTREZGENE
  H7C4F8 ENTREZGENE, UniProtKB/TrEMBL
  P42081 ENTREZGENE
  Q13655 ENTREZGENE
  Q6FHB1 ENTREZGENE
  Q6GTS4 ENTREZGENE
  Q7M4L5 ENTREZGENE
UniProt Secondary A0N0P0 UniProtKB/Swiss-Prot
  B7Z2F3 UniProtKB/Swiss-Prot
  B7Z702 UniProtKB/Swiss-Prot
  E7ETN5 UniProtKB/Swiss-Prot
  E9PC27 UniProtKB/Swiss-Prot
  Q13655 UniProtKB/Swiss-Prot
  Q6FHB1 UniProtKB/Swiss-Prot
  Q6GTS4 UniProtKB/Swiss-Prot
  Q7M4L5 UniProtKB/Swiss-Prot