FRAT1 (FRAT regulator of WNT signaling pathway 1)

Advanced Search (OLGA)

Gene: FRAT1 (FRAT regulator of WNT signaling pathway 1) Homo sapiens

Analyze

Symbol:

FRAT1

Name:

FRAT regulator of WNT signaling pathway 1

RGD ID:

1604648

HGNC Page

HGNC:3944

Description:

Enables molecular function inhibitor activity. Involved in beta-catenin destruction complex disassembly; positive regulation of canonical Wnt signaling pathway; and regulation of protein export from nucleus. Located in cytosol and nucleus.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

FLJ97193; FRAT-1; FRAT1, WNT signaling pathway regulator; frequently rearranged in advanced T-cell lymphomas 1; proto-oncogene FRAT1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	97,319,271 - 97,321,915 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	97,319,271 - 97,321,915 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	99,079,028 - 99,081,672 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	99,069,012 - 99,071,662 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	10	92,817,506 - 92,820,157 (+)	NCBI		Celera
Cytogenetic Map	10	q24.1	NCBI
HuRef	10	92,704,738 - 92,707,056 (+)	NCBI		HuRef
CHM1_1	10	99,360,764 - 99,363,411 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	98,199,470 - 98,202,113 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

17beta-hydroxy-5alpha-androstan-3-one (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (EXP)

4,4'-diaminodiphenylmethane (ISO)

5-aza-2'-deoxycytidine (ISO)

afimoxifene (EXP)

aflatoxin B1 (EXP)

arsenous acid (EXP)

atrazine (EXP)

benzo[a]pyrene (EXP,ISO)

butanal (EXP)

carbamazepine (EXP)

carbon nanotube (ISO)

cisplatin (EXP)

copper atom (EXP)

copper(0) (EXP)

cyclosporin A (EXP)

diarsenic trioxide (EXP)

dorsomorphin (EXP)

elemental selenium (EXP)

ethyl methanesulfonate (EXP)

folic acid (ISO)

gamma-hexachlorocyclohexane (EXP)

iron dichloride (EXP)

lipopolysaccharide (EXP)

maneb (ISO)

ochratoxin A (EXP)

paracetamol (EXP)

paraquat (ISO)

pentanal (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (EXP)

propanal (EXP)

quercetin (EXP)

rac-lactic acid (EXP)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (EXP)

SB 431542 (EXP)

selenium atom (EXP)

sirolimus (EXP)

sunitinib (EXP)

triphenyl phosphate (EXP)

triptonide (ISO)

urethane (EXP)

valproic acid (EXP,ISO)

vitamin E (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

canonical Wnt signaling pathway (IDA,IGI)

embryonic axis specification (ISO)

positive regulation of canonical Wnt signaling pathway (IBA,IGI)

protein export from nucleus (ISO)

regulation of protein export from nucleus (IDA)

Wnt signaling pathway (IEA,ISO)

Cellular Component

cytoplasm (IBA,IDA,IEA)

cytosol (IDA,TAS)

intracellular membrane-bounded organelle (IDA)

nucleus (IDA,ISO)

Molecular Function

molecular function inhibitor activity (IDA)

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9034327	PMID:10428961	PMID:10481074	PMID:11445844	PMID:11738041	PMID:11894125	PMID:12095675	PMID:12223487	PMID:12477932	PMID:12556519	PMID:12805274	PMID:15164054
PMID:15489334	PMID:16385451	PMID:16479254	PMID:16982607	PMID:18498136	PMID:20041315	PMID:20096670	PMID:21818639	PMID:21873635	PMID:21988832	PMID:22528942	PMID:23455922
PMID:23602568	PMID:23613813	PMID:24135036	PMID:24829151	PMID:25387569	PMID:25922553	PMID:26178481	PMID:26496610	PMID:27599661	PMID:27666874	PMID:29568061	PMID:33961781
PMID:34319909	PMID:35059733	PMID:36153370	PMID:37704626

Genomics

Comparative Map Data

FRAT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	97,319,271 - 97,321,915 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	97,319,271 - 97,321,915 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	99,079,028 - 99,081,672 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	99,069,012 - 99,071,662 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	10	92,817,506 - 92,820,157 (+)	NCBI		Celera
Cytogenetic Map	10	q24.1	NCBI
HuRef	10	92,704,738 - 92,707,056 (+)	NCBI		HuRef
CHM1_1	10	99,360,764 - 99,363,411 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	98,199,470 - 98,202,113 (+)	NCBI		T2T-CHM13v2.0

Frat1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	41,818,409 - 41,821,022 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	41,818,409 - 41,821,022 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	41,829,970 - 41,832,583 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	41,829,970 - 41,832,583 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	41,904,460 - 41,907,073 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	41,883,427 - 41,885,894 (+)	NCBI		MGSCv36	mm8
Celera	19	42,629,318 - 42,631,931 (+)	NCBI		Celera
Cytogenetic Map	19	C3	NCBI
cM Map	19	35.3	NCBI

Frat1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	250,587,641 - 250,590,189 (+)	NCBI		GRCr8
mRatBN7.2	1	240,638,309 - 240,640,857 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	240,638,296 - 240,640,945 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	248,783,574 - 248,786,144 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	255,480,727 - 255,483,297 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	248,133,737 - 248,136,307 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	261,071,965 - 261,075,244 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	268,509,986 - 268,527,716 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Cytogenetic Map	1	q54	NCBI

Frat1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955507	3,472,035 - 3,486,868 (+)	NCBI	ChiLan1.0	ChiLan1.0

FRAT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	109,232,028 - 109,238,724 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	109,232,265 - 109,244,123 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	93,943,745 - 93,947,162 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

FRAT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	10,635,959 - 10,637,321 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	10,635,944 - 10,636,787 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	10,818,762 - 10,820,186 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	10,957,885 - 10,959,315 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	28	10,619,293 - 10,620,673 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	10,679,985 - 10,681,409 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	10,819,915 - 10,821,339 (+)	NCBI		UU_Cfam_GSD_1.0

Frat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	36,287,770 - 36,290,672 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936636	2,328,500 - 2,329,333 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936636	2,326,891 - 2,330,321 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FRAT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	108,739,541 - 108,740,380 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	108,739,239 - 108,741,953 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

FRAT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	90,491,841 - 90,495,112 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	90,492,722 - 90,493,561 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	51,388,432 - 51,391,137 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in FRAT1
10 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3	copy number gain	See cases [RCV000050747]	Chr10:95112607..116776637 [GRCh38] Chr10:96872364..118383651 [GRCh37] Chr10:96862354..118526138 [NCBI36] Chr10:10q23.33-25.3	pathogenic
GRCh38/hg38 10q23.33-24.2(chr10:92626680-97755102)x1	copy number loss	See cases [RCV000052564]	Chr10:92626680..97755102 [GRCh38] Chr10:94386437..99514859 [GRCh37] Chr10:94376417..99504849 [NCBI36] Chr10:10q23.33-24.2	pathogenic
GRCh38/hg38 10q23.33-24.32(chr10:93181201-101356779)x1	copy number loss	See cases [RCV000052565]	Chr10:93181201..101356779 [GRCh38] Chr10:94940958..103116536 [GRCh37] Chr10:94930948..103106526 [NCBI36] Chr10:10q23.33-24.32	pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]\|See cases [RCV000053560]	Chr10:91048545..133620674 [GRCh38] Chr10:92808302..135434178 [GRCh37] Chr10:92798282..135284168 [NCBI36] Chr10:10q23.31-26.3	pathogenic
GRCh38/hg38 10q24.1(chr10:96601018-97382040)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053561]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053561]\|See cases [RCV000053561]	Chr10:96601018..97382040 [GRCh38] Chr10:98360775..99141797 [GRCh37] Chr10:98350765..99131787 [NCBI36] Chr10:10q24.1	pathogenic
GRCh37/hg19 10q24.1(chr10:98941691-99153357)x3	copy number gain	See cases [RCV000240430]	Chr10:98941691..99153357 [GRCh37] Chr10:10q24.1	uncertain significance
GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143)	copy number loss	Distal 10q deletion syndrome [RCV003319583]	Chr10:12829206..135427143 [GRCh37] Chr10:10p13-q26.3	pathogenic
GRCh37/hg19 10q23.1-25.1(chr10:85557432-105804295)x1	copy number loss	Poly (ADP-Ribose) polymerase inhibitor response [RCV000431909]	Chr10:85557432..105804295 [GRCh37] Chr10:10q23.1-25.1	pathogenic\|drug response
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3	copy number gain	See cases [RCV000448750]	Chr10:93297..135378918 [GRCh37] Chr10:10p15.3-q26.3	pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)	copy number gain	See cases [RCV000511389]	Chr10:100027..135427143 [GRCh37] Chr10:10p15.3-q26.3	pathogenic\|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3	copy number gain	See cases [RCV000510861]	Chr10:100027..135427143 [GRCh37] Chr10:10p15.3-q26.3	pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3	copy number gain	See cases [RCV000510972]	Chr10:93283493..135427143 [GRCh37] Chr10:10q23.32-26.3	pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1	copy number loss	Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438]	Chr10:42347406..135534747 [GRCh37] Chr10:10q11.21-26.3	drug response
GRCh37/hg19 10q23.32-24.2(chr10:93908171-101809723)x1	copy number loss	See cases [RCV000512315]	Chr10:93908171..101809723 [GRCh37] Chr10:10q23.32-24.2	pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3	copy number gain	not provided [RCV000683291]	Chr10:94346520..135427143 [GRCh37] Chr10:10q23.33-26.3	pathogenic
GRCh37/hg19 10q24.1(chr10:98974462-99135215)x3	copy number gain	not provided [RCV000737280]	Chr10:98974462..99135215 [GRCh37] Chr10:10q24.1	benign
GRCh37/hg19 10q24.1(chr10:98903394-99097191)x1	copy number loss	not provided [RCV000749794]	Chr10:98903394..99097191 [GRCh37] Chr10:10q24.1	benign
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3	copy number gain	not provided [RCV000749464]	Chr10:73232..135524321 [GRCh37] Chr10:10p15.3-q26.3	pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3	copy number gain	not provided [RCV000749465]	Chr10:98087..135477883 [GRCh37] Chr10:10p15.3-q26.3	pathogenic
GRCh37/hg19 10q24.1-24.2(chr10:99070594-99445724)	copy number gain	not specified [RCV002052884]	Chr10:99070594..99445724 [GRCh37] Chr10:10q24.1-24.2	uncertain significance
GRCh37/hg19 10q24.1-24.2(chr10:99027360-99300723)x1	copy number loss	not provided [RCV002472884]	Chr10:99027360..99300723 [GRCh37] Chr10:10q24.1-24.2	uncertain significance
NM_005479.4(FRAT1):c.322C>G (p.Pro108Ala)	single nucleotide variant	not specified [RCV004224641]	Chr10:97319775 [GRCh38] Chr10:99079532 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.544C>G (p.Leu182Val)	single nucleotide variant	not specified [RCV004166784]	Chr10:97319997 [GRCh38] Chr10:99079754 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.521G>A (p.Arg174Gln)	single nucleotide variant	not specified [RCV004143573]	Chr10:97319974 [GRCh38] Chr10:99079731 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.179C>G (p.Pro60Arg)	single nucleotide variant	not specified [RCV004155592]	Chr10:97319632 [GRCh38] Chr10:99079389 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.832G>C (p.Gly278Arg)	single nucleotide variant	not specified [RCV004140145]	Chr10:97320285 [GRCh38] Chr10:99080042 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.775G>A (p.Asp259Asn)	single nucleotide variant	not specified [RCV004106068]	Chr10:97320228 [GRCh38] Chr10:99079985 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.245C>G (p.Pro82Arg)	single nucleotide variant	not specified [RCV004183497]	Chr10:97319698 [GRCh38] Chr10:99079455 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.370C>T (p.Arg124Cys)	single nucleotide variant	not specified [RCV004075435]	Chr10:97319823 [GRCh38] Chr10:99079580 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.740C>A (p.Pro247His)	single nucleotide variant	not specified [RCV004269565]	Chr10:97320193 [GRCh38] Chr10:99079950 [GRCh37] Chr10:10q24.1	uncertain significance
GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143)	copy number gain	Distal trisomy 10q [RCV003319593]	Chr10:11138692..135427143 [GRCh37] Chr10:10p14-q26.3	pathogenic
NM_005479.4(FRAT1):c.202G>A (p.Gly68Arg)	single nucleotide variant	not specified [RCV004356629]	Chr10:97319655 [GRCh38] Chr10:99079412 [GRCh37] Chr10:10q24.1	uncertain significance
GRCh37/hg19 10q11.21-24.2(chr10:42709645-100834951)x3	copy number gain	not provided [RCV003484798]	Chr10:42709645..100834951 [GRCh37] Chr10:10q11.21-24.2	pathogenic
GRCh37/hg19 10q23.31-24.2(chr10:90796994-100067505)x1	copy number loss	not specified [RCV003986861]	Chr10:90796994..100067505 [GRCh37] Chr10:10q23.31-24.2	pathogenic
GRCh37/hg19 10q23.33-24.2(chr10:94283369-101820913)x1	copy number loss	not specified [RCV003986912]	Chr10:94283369..101820913 [GRCh37] Chr10:10q23.33-24.2	pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:95078198-135427143)x3	copy number gain	not specified [RCV003986893]	Chr10:95078198..135427143 [GRCh37] Chr10:10q23.33-26.3	pathogenic
NM_005479.4(FRAT1):c.224G>A (p.Gly75Glu)	single nucleotide variant	not specified [RCV004394584]	Chr10:97319677 [GRCh38] Chr10:99079434 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.256G>A (p.Ala86Thr)	single nucleotide variant	not specified [RCV004394585]	Chr10:97319709 [GRCh38] Chr10:99079466 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.269C>A (p.Ala90Glu)	single nucleotide variant	not specified [RCV004394586]	Chr10:97319722 [GRCh38] Chr10:99079479 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.160G>A (p.Asp54Asn)	single nucleotide variant	not specified [RCV004394583]	Chr10:97319613 [GRCh38] Chr10:99079370 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.66G>C (p.Glu22Asp)	single nucleotide variant	not specified [RCV004394587]	Chr10:97319519 [GRCh38] Chr10:99079276 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.814G>A (p.Asp272Asn)	single nucleotide variant	not specified [RCV004394588]	Chr10:97320267 [GRCh38] Chr10:99080024 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.394G>C (p.Glu132Gln)	single nucleotide variant	not specified [RCV004621386]	Chr10:97319847 [GRCh38] Chr10:99079604 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.241G>A (p.Val81Met)	single nucleotide variant	not specified [RCV004621388]	Chr10:97319694 [GRCh38] Chr10:99079451 [GRCh37] Chr10:10q24.1	uncertain significance
NM_005479.4(FRAT1):c.734A>T (p.His245Leu)	single nucleotide variant	not specified [RCV004621387]	Chr10:97320187 [GRCh38] Chr10:99079944 [GRCh37] Chr10:10q24.1	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	788
Count of miRNA genes:	578
Interacting mature miRNAs:	636
Transcripts:	ENST00000371021, ENST00000490980
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2314551	GLUCO52_H	Glucose level QTL 52 (human)	1.4		Glucose level		10	77605006	103605006	Human

Markers in Region

RH99329

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	10	99,081,145 - 99,081,330	UniSTS	GRCh37
Build 36	10	99,071,135 - 99,071,320	RGD	NCBI36
Celera	10	92,819,630 - 92,819,815	RGD
Cytogenetic Map	10	q24.1	UniSTS
HuRef	10	92,706,529 - 92,706,714	UniSTS
GeneMap99-GB4 RH Map	10	460.07	UniSTS

RH71241

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	10	99,080,010 - 99,080,133	UniSTS	GRCh37
Build 36	10	99,070,000 - 99,070,123	RGD	NCBI36
Celera	10	92,818,496 - 92,818,619	RGD
Cytogenetic Map	10	q24.1	UniSTS
HuRef	10	92,705,395 - 92,705,518	UniSTS
GeneMap99-GB4 RH Map	10	457.44	UniSTS

FRAT1_113

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	10	99,080,813 - 99,081,710	UniSTS	GRCh37
Build 36	10	99,070,803 - 99,071,700	RGD	NCBI36
Celera	10	92,819,298 - 92,820,195	RGD
HuRef	10	92,706,197 - 92,707,094	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
1204	2439	2788	2252	4972	1726	2351	6	624	1944	465	2270	7297	6463	53	3733	1	852	1744	1617	173	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_005479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB074890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK307245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL355490	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY271248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC034476	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BE041458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068268	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U58975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000371021 ⟹ ENSP00000360060

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	10	97,319,271 - 97,321,915 (+)	Ensembl

Ensembl Acc Id:

ENST00000490980

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	10	97,320,741 - 97,321,823 (+)	Ensembl

RefSeq Acc Id:

NM_005479 ⟹ NP_005470

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	10	97,319,271 - 97,321,915 (+)	NCBI
GRCh37	10	99,079,022 - 99,081,672 (+)	ENTREZGENE
GRCh37	10	99,079,022 - 99,081,672 (+)	NCBI
Build 36	10	99,069,012 - 99,071,662 (+)	NCBI Archive
HuRef	10	92,704,738 - 92,707,056 (+)	ENTREZGENE
CHM1_1	10	99,360,764 - 99,363,411 (+)	NCBI
T2T-CHM13v2.0	10	98,199,470 - 98,202,113 (+)	NCBI

Sequence:

show sequence

CGGCTCCCGCGGCTGCAGGCGCGCGGCTAGAGTGCCTGGCGGGCTCCGGCTTCCGCGTCCGCCC
CGGCCCCGGTCCAGACTTAGTCTTCAGCTCCGCGCCCGCTCCGCCGCGGCCCACCGCGCCCGCC
GGCAGCCGAGCCCCCAGCGACGCCCGCACAGCTCCGGGTGCCCAGACAGGGGGCCATGCCGTGC
CGGAGGGAGGAGGAAGAGGAAGCCGGCGAGGAGGCGGAGGGGGAGGAAGAGGAGGAGGACAGCT
TCCTCCTACTGCAGCAGTCAGTGGCGCTGGGCAGCTCGGGCGAGGTGGACCGGCTGGTGGCCCA
GATCGGCGAGACGCTGCAGCTGGACGCGGCGCAGCACAGCCCGGCCTCGCCGTGCGGGCCCCCG
GGGGCGCCGCTGCGGGCCCCGGGGCCCCTGGCTGCGGCGGTGCCGGCGGACAAGGCCAGGTCCC
CGGCGGTGCCGCTGCTGCTGCCGCCCGCGTTGGCGGAGACTGTGGGCCCGGCGCCCCCTGGGGT
CCTGCGCTGCGCCCTGGGGGACCGCGGCCGCGTGCGGGGCCGCGCTGCGCCCTACTGCGTGGCC
GAGCTCGCCACAGGCCCCAGCGCGCTGTCCCCACTGCCCCCTCAGGCCGACCTTGATGGGCCTC
CGGGAGCTGGCAAGCAGGGCATCCCGCAGCCGCTGTCGGGTCCGTGCCGGCGAGGATGGCTCCG
GGGCGCCGCCGCCTCCCGCCGCCTGCAGCAGCGACGCGGGTCCCAACCAGAAACCCGCACAGGC
GACGACGACCCGCACCGGCTTCTGCAGCAGCTAGTGCTCTCTGGAAACCTCATCAAGGAGGCCG
TGCGAAGGCTTCATTCGCGACGGCTGCAGTTACGTGCAAAGCTTCCCCAACGCCCGCTCCTGGG
ACCTCTGTCGGCCCCGGTGCATGAACCCCCTTCGCCTCGCAGCCCTCGCGCGGCCTGCAGTGAC
CCTGGCGCCTCCGGGAGGGCGCAGCTCAGAACTGGCGACGGCGTTCTTGTGCCTGGCAGCTAAC
ACGCCCGGGGTGGCCACAGCGCCAGCCTCAGACTGGAGGGCAAGGGGTTCCCTTGAGGGCTGCA
GTTCTACTCAGGCTGGTGGAGAACTCTGGCTTTTGGAAGCGAGAGTAAAAAGCTAATGACGAGG
AACCGAAAAATCGCGAGTGTTTCGCGGGTAACTGGGGTTGAGGGCCAAAATATTTGGAATGAAG
GACTTTGGCCCTATTTAAGGCAGATTTTACAGAGCGCACCTCAAACGTACAAGTCAGTAGGACT
CCTTATTTGGCGTGACCCGACCTGGCCGCGGAGCCTGCATTTCCTCGCAGCCTCTCAGTGCCCT
CCAGCCCCGCGACCATGTGGCCACAATCCACGCTTCTCCGGATCGCGGTGCGCCGGAACCACGG
AGGATGATGCCAGTTACTTGCTTTACCTTTTCAGGGCTGGCTCCTGATCCACTTTGGGGGAGGA
GAACATGAGTAGATAATTTCAGGGTGCAGCCCAATCTGCCAGACTTAAAAAAACCATCTTGTGT
CTTTGGAGGTGCTGCTTAATACCAAACATGCGGTGCCATGAAGGGACCCTTTGGGGGTTGAATA
GGAGTTAACCCCTGCGCTCTCTTTGCAACTGTCTCTCTTCTCAGAGTGGTGGGGGAAGGCTGTA
CGACACGGGTGGGGAAAGGAGGTGGGGGCGGGGAGTATTGAATGGTGGTGGAAGGGTAGAGAGG
CGCGGAGTGAACCCCACGCCCTGTCTAAAGTGTATTTTCAGAGCCGGCCCGCCTCTCCTCGGTT
CAAGGTCACTGTTTCCTGGGCACGCACTGGGTTGCGGGACAGAGTAGCCAGGTTCTGCCGGTGC
TCGGAGAAGAGCGCAGTGTTTTGCAAGTGCTGGAGTCTCCTGAGGACACGCGCGTCGCCGCCAC
CGCGGGTGTGGGAAAGCGCGGACGTGCTGGGCGGCTGTGCTTCGGTAGGCGACCACCGCCCCTG
GCCGCGCTCCGGGCTTTCACGGAAACTCCCGAGACCGGGCCCTGGGTTCCTCCTCTCCTACTCG
GCTCTGCAGTCCTACTCAAGCGGGTGGCTCTGGGATCCTGGGGGCCTGGGTTGGGGGCTAGGGA
GACGCCATGTGATGGACACTCCAGGGACACACAGCCTAGCACAGCAGCTTATAATGGGCTCTCC
GGGGCCATTTGCAATAACAGCTGCAATTCCCTGGATAGACGAGTTGATTTCCTCCCTCTGCCCC
TCCCCCAGCCATGCCAGCTGGCCTTTGTAAGTGCAGGAAACCGAGTAGAAAATGTGACCCTCCA
AATGGAGAAGCTGCAGGCTTTGCCATTGTGAACCATGGTGAAGTGCTTGGAACATACTGTTCAC
TCACTCTAAAGGCGCTGAGACTGTGCTGTTGTTCTCGTTTTTATAGTCAATGGCTTGTTCATCA
TCCAGATGTGGCTACTGACATATCTACACTTCGCACCGGAGTGTCTGGAATTGTGGCTATCCTG
ATTATAGGATTTTAACTTAACTGAAATGCCTGCTTTGAATAAATGTGTTGGGTTTTTTGTTTGG
TTTTATTTTATACTTGCCATCAGTGAAAAAGATGTACAGAACACATTTCTCTGATCTCCATAAA
CATGAAAACACTTGAAATCTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_005470	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB97096	(Get FASTA)	NCBI Sequence Viewer
	AAH34476	(Get FASTA)	NCBI Sequence Viewer
	BAB86352	(Get FASTA)	NCBI Sequence Viewer
	EAW49950	(Get FASTA)	NCBI Sequence Viewer
	EAW49951	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000360060
	ENSP00000360060.3
GenBank Protein	Q92837	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_005470 ⟸ NM_005479

- UniProtKB:

Q8NE74 (UniProtKB/Swiss-Prot), Q5JTI1 (UniProtKB/Swiss-Prot), Q8TDW9 (UniProtKB/Swiss-Prot), Q92837 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MPCRREEEEEAGEEAEGEEEEEDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQHSPASPC
GPPGAPLRAPGPLAAAVPADKARSPAVPLLLPPALAETVGPAPPGVLRCALGDRGRVRGRAAPY
CVAELATGPSALSPLPPQADLDGPPGAGKQGIPQPLSGPCRRGWLRGAAASRRLQQRRGSQPET
RTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGPLSAPVHEPPSPRSPRAA
CSDPGASGRAQLRTGDGVLVPGS

hide sequence

Ensembl Acc Id:

ENSP00000360060 ⟸ ENST00000371021

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q92837-F1-model_v2	AlphaFold	Q92837	1-279	view protein structure

Promoters

RGD ID:

6814483

Promoter ID:

HG_XEF:1060

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, K562, Lymphoblastoid, NB4

Transcripts:

NM_001170562, NM_008043, NM_013788

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	10	99,068,694 - 99,069,194 (+)	MPROMDB

RGD ID:

6787718

Promoter ID:

HG_KWN:10739

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Lymphoblastoid, NB4

Transcripts:

OTTHUMT00000049674

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	10	99,069,604 - 99,070,104 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:3944	AgrOrtholog
COSMIC	FRAT1	COSMIC
Ensembl Genes	ENSG00000165879	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000371021	ENTREZGENE
	ENST00000371021.5	UniProtKB/Swiss-Prot
GTEx	ENSG00000165879	GTEx
HGNC ID	HGNC:3944	ENTREZGENE
Human Proteome Map	FRAT1	Human Proteome Map
InterPro	GSK3-bd	UniProtKB/Swiss-Prot
KEGG Report	hsa:10023	UniProtKB/Swiss-Prot
NCBI Gene	10023	ENTREZGENE
OMIM	602503	OMIM
PANTHER	PROTO-ONCOGENE FRAT1	UniProtKB/Swiss-Prot
	PTHR35154	UniProtKB/Swiss-Prot
Pfam	GSK-3_bind	UniProtKB/Swiss-Prot
PharmGKB	PA28361	PharmGKB
UniProt	FRAT1_HUMAN	UniProtKB/Swiss-Prot
	Q5JTI1	ENTREZGENE
	Q8NE74	ENTREZGENE
	Q8TDW9	ENTREZGENE
	Q92837	ENTREZGENE
UniProt Secondary	Q5JTI1	UniProtKB/Swiss-Prot
	Q8NE74	UniProtKB/Swiss-Prot
	Q8TDW9	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-01-29	FRAT1	FRAT regulator of WNT signaling pathway 1	FRAT1	FRAT1, WNT signaling pathway regulator	Symbol and/or name change	5135510	APPROVED
2016-11-22	FRAT1	FRAT1, WNT signaling pathway regulator	FRAT1	frequently rearranged in advanced T-cell lymphomas 1	Symbol and/or name change	5135510	APPROVED
2014-05-21	FRAT1	frequently rearranged in advanced T-cell lymphomas 1	FRAT1	frequently rearranged in advanced T-cell lymphomas	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Annotations - KEGG (archival)