CCR2 (C-C motif chemokine receptor 2) - Rat Genome Database

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Gene: CCR2 (C-C motif chemokine receptor 2) Homo sapiens
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Symbol: CCR2
Name: C-C motif chemokine receptor 2
RGD ID: 1603716
HGNC Page HGNC:1603
Description: Enables CCR2 chemokine receptor binding activity. Involved in positive regulation of astrocyte chemotaxis and positive regulation of monocyte chemotaxis. Acts upstream of or within cytokine-mediated signaling pathway. Located in cytoplasm; fibrillar center; and plasma membrane. Implicated in several diseases, including Kawasaki disease; aggressive periodontitis; coronary artery disease (multiple); glucose metabolism disease (multiple); and uveitis (multiple). Biomarker of several diseases, including lung disease (multiple); macular degeneration (multiple); myeloid sarcoma; myositis (multiple); and periapical granuloma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; chemokine (C-C motif) receptor 2; chemokine (C-C) receptor 2; CKR2; CKR2A; CKR2B; CMKBR2; FLJ78302; MCP-1 receptor; MCP-1-R; MGC103828; MGC111760; MGC168006; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor; PCLUD
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,354,111 - 46,360,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,353,864 - 46,360,940 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,395,602 - 46,402,431 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,370,364 - 46,377,432 (+)NCBINCBI36Build 36hg18NCBI36
Celera346,332,557 - 46,339,734 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,438,874 - 46,446,051 (+)NCBIHuRef
CHM1_1346,345,233 - 46,352,410 (+)NCBICHM1_1
T2T-CHM13v2.0346,369,948 - 46,376,777 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
age related macular degeneration  (ISS)
aggressive periodontitis  (IAGP)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (EXP,ISO)
allergic disease  (EXP)
Alveolar Bone Loss  (ISO)
amyotrophic lateral sclerosis  (IEP)
Animal Toxoplasmosis  (ISO)
anxiety disorder  (ISO)
asthma  (IAGP,ISO)
atopic dermatitis  (IEP)
bacterial pneumonia  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
Chemical and Drug Induced Liver Injury  (EXP)
Choroidal Neovascularization  (ISO)
Chronic Periodontitis  (IEP)
congestive heart failure  (IAGP)
corneal neovascularization  (ISO)
coronary artery disease  (IAGP)
Coronavirus infectious disease  (ISS)
COVID-19  (EXP,HEP)
cutaneous leishmaniasis  (ISO)
Cystic Disease of Lung  (IAGP)
demyelinating disease  (ISO)
dermatomyositis  (IEP)
Diabetic Nephropathies  (IAGP,ISO)
dry eye syndrome  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
fungal infectious disease  (IEP)
Geographic Atrophy  (IEP)
Hearing Loss, Noise-Induced  (ISO)
Herpes Simplex Encephalitis  (ISO)
Herpesviridae Infections  (ISO)
human immunodeficiency virus infectious disease  (EXP,IAGP)
Hyperalgesia  (ISO)
ileitis  (ISO)
inclusion body myositis  (IEP)
intermediate uveitis  (IAGP)
interstitial lung disease  (IEP)
Intervertebral Disc Disease  (ISO)
Intimal Hyperplasia  (ISO)
Kawasaki disease  (IAGP)
Knee Osteoarthritis  (ISO)
Kuhnt-Junius degeneration  (IEP)
leishmaniasis  (ISO)
limited scleroderma  (ISO)
lipoatrophic diabetes mellitus  (ISO)
liver disease  (EXP)
Liver Reperfusion Injury  (ISO)
lung disease  (IEP,ISO)
macular degeneration  (IEP)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IAGP)
Mouth Neoplasms  (IAGP)
myeloid sarcoma  (IEP)
myocardial infarction  (IAGP)
Myocardial Reperfusion Injury  (IEP)
Nasal Polyps  (IEP)
oral squamous cell carcinoma  (IAGP)
Pain  (ISO)
Perennial Allergic Rhinitis  (IEP)
Peri-Implantitis  (IEP)
Periapical Diseases  (ISO)
periapical granuloma  (IEP)
periapical periodontitis  (ISO)
Periodontal Cyst  (IEP)
pleural tuberculosis  (IDA)
pneumonia  (EXP,ISO)
polymyositis  (IEP)
posterior uveitis  (IAGP)
prediabetes syndrome  (IAGP)
Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy  (IAGP)
psoriasis  (IEP)
psoriatic arthritis  (IAGP)
pulmonary fibrosis  (EXP,ISO)
pulmonary tuberculosis  (ISO)
retinal degeneration  (ISO)
retinitis  (ISO)
rhinitis  (IAGP)
sarcoidosis  (IAGP)
sciatic neuropathy  (ISO)
sialadenitis  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (EXP)
systemic scleroderma  (ISO)
Thoracic Injuries  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (IAGP)
type 2 diabetes mellitus  (IEP)
urticaria  (IAGP)
vasculitis  (ISO)
visceral leishmaniasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (ISO)
1,3-benzothiazole-2-thiol  (EXP)
1,4-phenylenediamine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-butoxyethanol  (ISO)
3-chlorophenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
9-cis-retinoic acid  (EXP)
acetaldehyde  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (EXP)
all-trans-retinoic acid  (EXP)
AM6545  (ISO)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (EXP)
amphetamine  (ISO)
amphotericin B  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
asbestos  (EXP)
asperentin  (ISO)
Azoxymethane  (ISO)
barium sulfate  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzylpenicillin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bleomycin A2  (ISO)
Brevianamide A  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
ceric oxide  (ISO)
chenodeoxycholic acid  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
cocaine  (ISO)
crocidolite asbestos  (EXP)
curcumin  (ISO)
cyclosporin A  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
Didecyldimethylammonium  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
disulfiram  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
edaravone  (ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
eugenol  (EXP)
flumequine  (ISO)
folic acid  (ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
isoniazide  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP)
losartan  (ISO)
LY294002  (EXP)
mechlorethamine  (ISO)
MeIQx  (ISO)
mercury atom  (EXP)
mercury dichloride  (ISO)
mercury(0)  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
mevalonic acid  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
nefazodone  (EXP)
neoechinulin A  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
olaparib  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
PCB138  (EXP)
pentachlorophenol  (EXP)
perindopril  (ISO)
picrotoxin  (ISO)
piperidines  (EXP)
proanthocyanidin  (EXP)
protein kinase inhibitor  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 203580  (EXP)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chlorate  (EXP)
sodium fluoride  (ISO)
sterigmatocystin  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
telmisartan  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trans-caffeic acid  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc sulfate  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel remodeling  (IEA,ISO,ISS)
calcium-mediated signaling  (IBA)
cell chemotaxis  (IBA)
cell surface receptor signaling pathway via JAK-STAT  (TAS)
cellular defense response  (IEA,ISO,TAS)
cellular homeostasis  (IEA,ISS)
chemokine-mediated signaling pathway  (IEA,ISO,ISS)
chemotaxis  (IEA,TAS)
cytokine-mediated signaling pathway  (IDA,ISO)
dendritic cell chemotaxis  (TAS)
G protein-coupled receptor signaling pathway  (IEA,ISO)
hemopoiesis  (IEA,ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
humoral immune response  (IEA,ISO)
immune response  (IBA,IEA,ISO,TAS)
inflammatory response  (IBA,IEA,ISO,TAS)
inflammatory response to antigenic stimulus  (ISO)
inflammatory response to wounding  (IEA,ISS)
intracellular calcium ion homeostasis  (ISO,ISS)
leukocyte adhesion to vascular endothelial cell  (IEA,ISO)
macrophage migration  (IEA,ISS)
monocyte chemotaxis  (IEA,ISO)
monocyte extravasation  (IEA,ISS)
negative regulation of adenylate cyclase activity  (TAS)
negative regulation of angiogenesis  (IEA,ISS)
negative regulation of eosinophil degranulation  (IEA,ISS)
negative regulation of type 2 immune response  (IEA,ISS)
neutrophil clearance  (IEA,ISO)
positive regulation of alpha-beta T cell proliferation  (IEA,ISS)
positive regulation of astrocyte chemotaxis  (IDA)
positive regulation of CD8-positive, alpha-beta T cell extravasation  (IEA,ISS)
positive regulation of cold-induced thermogenesis  (IEA,ISS)
positive regulation of cytosolic calcium ion concentration  (IBA,TAS)
positive regulation of hematopoietic stem cell migration  (IEA,ISS)
positive regulation of immune complex clearance by monocytes and macrophages  (IEA,ISS)
positive regulation of inflammatory response  (IEA,ISS)
positive regulation of interleukin-2 production  (IEA,ISS)
positive regulation of leukocyte tethering or rolling  (IEA,ISO)
positive regulation of monocyte chemotaxis  (IDA,IEA,ISS)
positive regulation of monocyte extravasation  (IEA,ISS)
positive regulation of NMDA glutamate receptor activity  (ISS)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of synaptic transmission, glutamatergic  (IEA,ISS)
positive regulation of T cell activation  (IEA,ISS)
positive regulation of T cell chemotaxis  (IEA,ISS)
positive regulation of T-helper 1 type immune response  (IEA,ISS)
positive regulation of thymocyte migration  (IEA,ISS)
positive regulation of tumor necrosis factor production  (IEA,ISO,ISS)
positive regulation of type II interferon production  (IEA,ISS)
regulation of inflammatory response  (IEA,ISS)
regulation of macrophage migration  (IEA,ISO)
regulation of mononuclear cell migration  (IEA,ISO)
regulation of T cell cytokine production  (IEA,ISS)
regulation of T cell differentiation  (IEA,ISS)
regulation of T cell migration  (IEA,ISO)
regulation of vascular endothelial growth factor production  (IEA,ISS)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to wounding  (TAS)
sensory perception of pain  (IEA,ISO,ISS)
T-helper 17 cell chemotaxis  (IEA,ISS)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Polymorphisms of chemokine and chemokine receptor genes in idiopathic immune-mediated posterior segment uveitis. Ahad MA, etal., Mol Vis. 2007 Mar 23;13:388-96.
2. Inhibition of corneal neovascularization by genetic ablation of CCR2. Ambati BK, etal., Cornea. 2003 Jul;22(5):465-7.
3. Immunohistochemical detection of CCR2 and CX3CR1 in sepsis-induced lung injury. An JL, etal., Forensic Sci Int. 2009 Nov 20;192(1-3):e21-5. Epub 2009 Sep 4.
4. Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis. Arai M, etal., J Dermatol Sci. 2013 Mar;69(3):250-8. doi: 10.1016/j.jdermsci.2012.10.010. Epub 2012 Oct 24.
5. Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Ayers CM, etal., Int Forum Allergy Rhinol. 2011 Jul-Aug;1(4):296-302. doi: 10.1002/alr.20046. Epub 2011 Apr 11.
6. Therapeutic effect of a topical CCR2 antagonist on induced alveolar bone loss in mice. Barros SP, etal., J Periodontal Res. 2011 Apr;46(2):246-51. doi: 10.1111/j.1600-0765.2010.01340.x. Epub 2011 Jan 18.
7. MCP-1 and CCR2 gene variants in oral squamous cell carcinoma. Bektas-Kayhan K, etal., Oral Dis. 2012 Jan;18(1):55-9. doi: 10.1111/j.1601-0825.2011.01843.x. Epub 2011 Aug 24.
8. Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. Belperio JA, etal., J Clin Invest. 2001 Aug;108(4):547-56.
9. Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. Bhangoo S, etal., Mol Pain. 2007 Dec 12;3:38.
10. Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice. Blease K, etal., J Immunol. 2000 Sep 1;165(5):2603-11.
11. Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis. Boivin N, etal., J Gen Virol. 2012 Jun;93(Pt 6):1294-304. doi: 10.1099/vir.0.041046-0. Epub 2012 Feb 29.
12. Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease. Breunis WB, etal., Clin Exp Immunol. 2007 Oct;150(1):83-90. Epub 2007 Aug 2.
13. Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria. Brzoza Z, etal., Allergol Immunopathol (Madr). 2013 May 30. pii: S0301-0546(13)00103-1. doi: 10.1016/j.aller.2013.02.003.
14. Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. Campbell EM, etal., J Immunol. 1999 Aug 15;163(4):2160-7.
15. CCR2-64I gene polymorphism increase susceptibility to oral cancer. Chen MK, etal., Oral Oncol. 2011 Jul;47(7):577-82. doi: 10.1016/j.oraloncology.2011.04.008. Epub 2011 May 12.
16. Spontaneous Development of Autoimmune Uveitis Is CCR2 Dependent. Chen YF, etal., Am J Pathol. 2014 Jun;184(6):1695-705. doi: 10.1016/j.ajpath.2014.02.024. Epub 2014 Apr 13.
17. Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease. Craven M, etal., PLoS One. 2012;7(7):e41594. doi: 10.1371/journal.pone.0041594. Epub 2012 Jul 25.
18. Development of experimental autoimmune uveitis: efficient recruitment of monocytes is independent of CCR2. Dagkalis A, etal., Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4288-94. doi: 10.1167/iovs.09-3434. Epub 2009 Apr 8.
19. Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. Dansereau MA, etal., J Neurochem. 2008 Jul;106(2):757-69. Epub 2008 Apr 17.
20. Beta-chemokine receptor expression in idiopathic inflammatory myopathies. De Paepe B and De Bleecker JL, Muscle Nerve. 2005 May;31(5):621-7.
21. Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration. Despriet DD, etal., Invest Ophthalmol Vis Sci. 2008 Jan;49(1):364-71. doi: 10.1167/iovs.07-0656.
22. MCP-1, CCR2 and CCR5 polymorphisms in Tunisian patients with atopic asthma. Dhaouadi T, etal., Iran J Allergy Asthma Immunol. 2013 Mar;12(1):29-36. doi: 012.01/ijaai.2936.
23. CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection. Egan CE, etal., Mucosal Immunol. 2009 Nov;2(6):527-35. doi: 10.1038/mi.2009.105. Epub 2009 Sep 9.
24. Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: differential roles for CCR2, CCR5, CXCR4 and CXCR7. Faaij CM, etal., Pediatr Blood Cancer. 2010 Aug;55(2):344-8. doi: 10.1002/pbc.22500.
25. [Expression of chemokine receptor CCR2 in cerebral tissue of newborn rat with experimental hypoxic-ischemic brain damage] Feng X and Yao YJ, Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Nov;38(6):942-4, 964.
26. Lack of association of CCR2-64I and CCR5-Delta 32 with type 1 diabetes and latent autoimmune diabetes in adults. Gambelunghe G, etal., Hum Immunol. 2003 Jun;64(6):629-32.
27. CCR2 deficiency results in increased osteolysis in experimental periapical lesions in mice. Garlet TP, etal., J Endod. 2010 Feb;36(2):244-50. doi: 10.1016/j.joen.2009.09.004. Epub 2009 Oct 23.
28. Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection. Goodyear A, etal., J Immunol. 2010 Feb 1;184(3):1445-54. Epub 2009 Dec 30.
29. Amelioration of murine dry eye disease by topical antagonist to chemokine receptor 2. Goyal S, etal., Arch Ophthalmol. 2009 Jul;127(7):882-7. doi: 10.1001/archophthalmol.2009.125.
30. Chemokine receptor expression in peripheral blood monocytes from patients with neovascular age-related macular degeneration. Grunin M, etal., Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5292-300. doi: 10.1167/iovs.11-9165.
31. Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa. Guo C, etal., Exp Eye Res. 2012 Nov;104:39-47. doi: 10.1016/j.exer.2012.08.013. Epub 2012 Sep 26.
32. Chemokine receptor expression in rat adjuvant-induced arthritis. Haas CS, etal., Arthritis Rheum. 2005 Dec;52(12):3718-30.
33. A role for MCP-1/CCR2 in interstitial lung disease in children. Hartl D, etal., Respir Res. 2005 Aug 11;6:93.
34. Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+ regulatory T cells in MRL/lpr mice. Hasegawa H, etal., Arthritis Res Ther. 2007;9(1):R15.
35. A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Hildebrandt GC, etal., Blood. 2004 Mar 15;103(6):2417-26. Epub 2003 Nov 13.
36. Changes in protein expression and distribution of spinal CCR2 in a rat model of bone cancer pain. Hu JH, etal., Brain Res. 2013 May 6;1509:1-7. doi: 10.1016/j.brainres.2013.03.002. Epub 2013 Mar 17.
37. Deficiency of lymph node resident dendritic cells and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection. Ibrahim MK, etal., Infect Immun. 2014 May 12.
38. Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation. Jerath MR, etal., Thromb J. 2010 Sep 13;8:14. doi: 10.1186/1477-9560-8-14.
39. Impaired expression of inflammatory cytokines and chemokines at early stages of infection with Leishmania amazonensis. Ji J, etal., Infect Immun. 2003 Aug;71(8):4278-88.
40. Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis. Jiang Y, etal., J Neuroimmunol 1998 Jun 1;86(1):1-12.
41. Inhibition of MCP-1/CCR2 pathway ameliorates the development of diabetic nephropathy. Kanamori H, etal., Biochem Biophys Res Commun. 2007 Sep 7;360(4):772-7. Epub 2007 Jul 6.
42. Chemokine and chemokine receptor expression during experimental autoimmune uveoretinitis in mice. Keino H, etal., Graefes Arch Clin Exp Ophthalmol. 2003 Feb;241(2):111-5. Epub 2003 Jan 28.
43. Association between a genetic variation of CC chemokine receptor-2 and atopic asthma. Kim YK, etal., Allergy. 2007 Feb;62(2):208-9.
44. Force-dependent development of neuropathic central pain and time-related CCL2/CCR2 expression after graded spinal cord contusion injuries of the rat. Knerlich-Lukoschus F, etal., J Neurotrauma. 2008 May;25(5):427-48.
45. Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism. Lee I, etal., J Immunol. 2003 Dec 15;171(12):6929-35.
46. The expression of MCP-1 and CCR2 in induced rats periapical lesions. Liu L, etal., Arch Oral Biol. 2014 May;59(5):492-9. doi: 10.1016/j.archoralbio.2014.02.008. Epub 2014 Feb 22.
47. Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization. Lu P, etal., Cornea. 2009 Jun;28(5):562-9. doi: 10.1097/ICO.0b013e3181930bcd.
48. Important role of CCR2 in a murine model of coronary vasculitis. Martinez HG, etal., BMC Immunol. 2012 Oct 17;13:56. doi: 10.1186/1471-2172-13-56.
49. Exacerbation of established pulmonary fibrosis in a murine model by gammaherpesvirus. McMillan TR, etal., Am J Respir Crit Care Med. 2008 Apr 1;177(7):771-80. Epub 2008 Jan 10.
50. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Miller RE, etal., Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20602-7. doi: 10.1073/pnas.1209294110. Epub 2012 Nov 26.
51. Increased expression levels of monocyte CCR2 and monocyte chemoattractant protein-1 in patients with diabetes mellitus. Mine S, etal., Biochem Biophys Res Commun. 2006 Jun 9;344(3):780-5. Epub 2006 Apr 17.
52. CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Moore BB, etal., Am J Pathol. 2005 Mar;166(3):675-84.
53. 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. Na TY, etal., J Pathol. 2015 Apr;235(5):710-20. doi: 10.1002/path.4494. Epub 2015 Jan 5.
54. Chemokine receptor genotype is associated with diabetic nephropathy in Japanese with type 2 diabetes. Nakajima K, etal., Diabetes. 2002 Jan;51(1):238-42.
55. Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis. Nakamura H, etal., Int Arch Allergy Immunol. 2007;142(4):329-34. Epub 2006 Nov 28.
56. MCP-1/CCR2 signalling pathway regulates hyperoxia-induced acute lung injury via nitric oxide production. Okuma T, etal., Int J Exp Pathol. 2006 Dec;87(6):475-83.
57. Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age. Ortlepp JR, etal., J Mol Med. 2003 Jun;81(6):363-7. Epub 2003 Apr 29.
58. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Peters W, etal., Proc Natl Acad Sci U S A 2001 Jul 3;98(14):7958-63.
59. CC chemokine receptor (CCR)2 polymorphism in Czech patients with myocardial infarction. Petrkova J, etal., Immunol Lett. 2003 Jul 3;88(1):53-5.
60. Differential upregulation of chemokine receptors on CD56 NK cells and their transmigration to the site of infection in tuberculous pleurisy. Pokkali S, etal., FEMS Immunol Med Microbiol. 2009 Apr;55(3):352-60. Epub 2009 Jan 12.
61. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
62. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
63. The CCR2 promoter polymorphism T-960A, but not the serum MCP-1 level, is associated with endothelial function in prediabetic individuals. Rittig K, etal., Atherosclerosis. 2008 Jun;198(2):338-46. Epub 2007 Dec 21.
64. CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, b cell outgrowth, and sustained neutrophilic inflammation. Sato N, etal., J Exp Med. 2000 Jul 17;192(2):205-18.
65. CC chemokine receptor 2 is protective against noise-induced hair cell death: studies in CX3CR1(+/GFP) mice. Sautter NB, etal., J Assoc Res Otolaryngol. 2006 Dec;7(4):361-72. Epub 2006 Oct 31.
66. The suppression of bone marrow-derived microglia in the amygdala improves the anxiety-like behavior induced by chronic partial sciatic nerve ligation in mice. Sawada A, etal., Pain. 2014 Jun 4. pii: S0304-3959(14)00264-4. doi: 10.1016/j.pain.2014.05.031.
67. Post-reperfusion changes of monocyte function in coronary blood after extracorporeal circulation. Sbrana S, etal., Cytometry B Clin Cytom. 2005 May;65(1):14-21.
68. Blunt chest trauma induces mediator-dependent monocyte migration to the lung. Seitz DH, etal., Crit Care Med. 2010 Sep;38(9):1852-9.
69. CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. Sennlaub F, etal., EMBO Mol Med. 2013 Nov;5(11):1775-93. doi: 10.1002/emmm.201302692. Epub 2013 Oct 21.
70. Fms-like tyrosine kinase 3 ligand regulates migratory pattern and antigen uptake of lung dendritic cell subsets in a murine model of allergic airway inflammation. Shao Z, etal., J Immunol. 2009 Dec 1;183(11):7531-8. doi: 10.4049/jimmunol.0901341. Epub 2009 Nov 16.
71. Differential expression of chemokines and chemokine receptors in inflammatory periapical diseases. Silva TA, etal., Oral Microbiol Immunol. 2005 Oct;20(5):310-6.
72. Genetic variation at the CCR5/CCR2 gene cluster and risk of psoriasis and psoriatic arthritis. Soto-Sanchez J, etal., Cytokine. 2010 May;50(2):114-6. doi: 10.1016/j.cyto.2010.01.006. Epub 2010 Feb 12.
73. A common haplotype of the C-C chemokine receptor 2 gene and HLA-DRB1*0301 are independent genetic risk factors for Lofgren's syndrome. Spagnolo P, etal., J Intern Med. 2008 Nov;264(5):433-41. Epub 2008 May 29.
74. Chemokine receptor CCR2 and CCR5 polymorphisms in children with insulin-dependent diabetes mellitus. Szalai C, etal., Pediatr Res. 1999 Jul;46(1):82-4.
75. Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification. Valdes AM, etal., Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1924-8.
76. Proinflammatory gene expression at chronic periodontitis and peri-implantitis sites in patients with or without type 2 diabetes. Venza I, etal., J Periodontol. 2010 Jan;81(1):99-108. doi: 10.1902/jop.2009.090358.
77. Expression of CCR2 on monocytes and macrophages in chronically inflamed skin in atopic dermatitis and psoriasis. Vestergaard C, etal., Acta Derm Venereol. 2004;84(5):353-8.
78. Suppression and regression of choroidal neovascularization in mice by a novel CCR2 antagonist, INCB3344. Xie P, etal., PLoS One. 2011;6(12):e28933. doi: 10.1371/journal.pone.0028933. Epub 2011 Dec 19.
79. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
80. Role of monocyte chemoattractant protein-1 and its receptor,CCR-2, in the pathogenesis of bleomycin-induced scleroderma. Yamamoto T and Nishioka K, J Invest Dermatol. 2003 Sep;121(3):510-6.
81. Roles of CC chemokine receptors (CCRs) on lipopolysaccharide-induced acute lung injury. Yang D, etal., Respir Physiol Neurobiol. 2010 Mar 31;170(3):253-9. Epub 2010 Feb 10.
82. Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy. Yang SJ, etal., Diabetologia. 2009 May;52(5):972-81. doi: 10.1007/s00125-009-1309-8. Epub 2009 Mar 10.
83. [Interaction of polymorphisms of monocyte chemoattractant protein-1 receptor CCR2 gene 190A/G, nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox gene C242T and cigarette smoking increases the risk of nonalcoholic fatty liver disease]. Zhang C and Guo L, Wei Sheng Yan Jiu. 2015 Sep;44(5):730-7.
84. CCL2-CCR2 signaling promotes hepatic ischemia/reperfusion injury. Zhang J, etal., J Surg Res. 2016 May 15;202(2):352-62. doi: 10.1016/j.jss.2016.02.029. Epub 2016 Mar 3.
85. MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS). Zhang R, etal., J Neuroimmunol. 2006 Oct;179(1-2):87-93. Epub 2006 Jul 20.
86. Complementary DNA microarray analysis of chemokines and their receptors in allergic rhinitis. Zhang RX, etal., J Investig Allergol Clin Immunol. 2007;17(5):329-36.
87. Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain. Zhang ZJ, etal., J Neuroinflammation. 2012 Jul 9;9:136. doi: 10.1186/1742-2094-9-136.
88. Contribution of chemokine CCL2/CCR2 signaling in the dorsal root ganglion and spinal cord to the maintenance of neuropathic pain in a rat model of lumbar disc herniation. Zhu X, etal., J Pain. 2014 May;15(5):516-26. doi: 10.1016/j.jpain.2014.01.492. Epub 2014 Jan 23.
89. Combined association of CCR2-V64I and MCP-1-2518A/G polymorphisms with generalised aggressive periodontitis in Chinese. Zhu XL, etal., Chin J Dent Res. 2010;13(2):109-14.
Additional References at PubMed
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Genomics

Comparative Map Data
CCR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,354,111 - 46,360,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,353,864 - 46,360,940 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,395,602 - 46,402,431 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,370,364 - 46,377,432 (+)NCBINCBI36Build 36hg18NCBI36
Celera346,332,557 - 46,339,734 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,438,874 - 46,446,051 (+)NCBIHuRef
CHM1_1346,345,233 - 46,352,410 (+)NCBICHM1_1
T2T-CHM13v2.0346,369,948 - 46,376,777 (+)NCBIT2T-CHM13v2.0
Ccr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,901,954 - 123,913,594 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,901,987 - 123,913,594 (+)EnsemblGRCm39 Ensembl
GRCm389124,101,918 - 124,109,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,101,950 - 124,113,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv379124,016,922 - 124,023,879 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369123,950,982 - 123,957,349 (+)NCBIMGSCv36mm8
Celera9124,890,502 - 124,897,441 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
Ccr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,611,883 - 132,619,106 (+)NCBIGRCr8
mRatBN7.28123,734,465 - 123,742,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,734,430 - 123,742,100 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8129,328,887 - 129,330,008 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,528,007 - 127,529,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,345,931 - 125,347,052 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
RGSC_v3.48128,892,784 - 128,893,905 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,912,520 - 128,913,642 (+)NCBI
Celera8122,833,545 - 122,834,666 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ccr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542025,641,184 - 25,664,413 (-)NCBIChiLan1.0ChiLan1.0
CCR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,315,650 - 46,320,292 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,320,418 - 46,325,060 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,255,725 - 46,263,285 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,361,118 - 47,368,312 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,361,124 - 47,368,312 (+)Ensemblpanpan1.1panPan2
CCR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,305,344 - 42,313,258 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,307,580 - 42,308,698 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,220,658 - 42,229,191 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,787,203 - 42,795,751 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,787,205 - 42,793,246 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,028,417 - 42,036,962 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,429,835 - 42,438,385 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,710,738 - 42,719,282 (-)NCBIUU_Cfam_GSD_1.0
CCR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,369,122 - 29,376,343 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,368,735 - 29,374,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,532,565 - 32,538,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,795,192 - 7,801,242 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,798,646 - 7,799,728 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041159,351,063 - 159,358,108 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CCR2
31 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001123396.4(CCR2):c.190G>A (p.Val64Ile) single nucleotide variant CCR2-related disorder [RCV003982833]|Susceptibility to HIV infection [RCV000008756] Chr3:46357717 [GRCh38]
Chr3:46357717..46357718 [GRCh38]
Chr3:46399208 [GRCh37]
Chr3:46399208..46399209 [GRCh37]
Chr3:3p21.31
pathogenic|benign|protective
GRCh38/hg38 3p21.31-21.2(chr3:45879883-50749922)x4 copy number gain See cases [RCV000133650] Chr3:45879883..50749922 [GRCh38]
Chr3:45921375..50787353 [GRCh37]
Chr3:45896379..50762357 [NCBI36]
Chr3:3p21.31-21.2
pathogenic
GRCh37/hg19 3p22.2-21.31(chr3:37028313-49929220)x3 copy number gain See cases [RCV000240519] Chr3:37028313..49929220 [GRCh37]
Chr3:3p22.2-21.31
likely pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_001123396.4(CCR2):c.628G>A (p.Gly210Arg) single nucleotide variant not specified [RCV004304790] Chr3:46358155 [GRCh38]
Chr3:46399646 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001123396.4(CCR2):c.1043C>T (p.Thr348Met) single nucleotide variant Susceptibility to HIV infection [RCV003224395] Chr3:46358570 [GRCh38]
Chr3:46400061 [GRCh37]
Chr3:3p21.31
uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p21.31-21.1(chr3:45153770-53878616) copy number gain not provided [RCV000767704] Chr3:45153770..53878616 [GRCh37]
Chr3:3p21.31-21.1
pathogenic
NM_001123396.4(CCR2):c.*1179G>A single nucleotide variant Susceptibility to HIV infection [RCV003224394] Chr3:46359789 [GRCh38]
Chr3:46401280 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001123396.4(CCR2):c.189C>T (p.Val63=) single nucleotide variant not provided [RCV000937622] Chr3:46357716 [GRCh38]
Chr3:46399207 [GRCh37]
Chr3:3p21.31
likely benign
NM_001123396.4(CCR2):c.378C>T (p.Gly126=) single nucleotide variant not provided [RCV000909239] Chr3:46357905 [GRCh38]
Chr3:46399396 [GRCh37]
Chr3:3p21.31
likely benign
NM_001123396.4(CCR2):c.156G>T (p.Val52=) single nucleotide variant not provided [RCV000886510] Chr3:46357683 [GRCh38]
Chr3:46399174 [GRCh37]
Chr3:3p21.31
benign
NC_000003.11:g.(?_45435946)_(49137751_?)dup duplication Diffuse cerebral and cerebellar atrophy - intractable seizures - progressive microcephaly syndrome [RCV003116297] Chr3:45435946..49137751 [GRCh37]
Chr3:3p21.31
uncertain significance
GRCh37/hg19 3p21.31(chr3:44948482-49115809)x1 copy number loss not provided [RCV002279744] Chr3:44948482..49115809 [GRCh37]
Chr3:3p21.31
pathogenic
NM_001123396.4(CCR2):c.615G>A (p.Met205Ile) single nucleotide variant not specified [RCV004234808] Chr3:46358142 [GRCh38]
Chr3:46399633 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001123396.4(CCR2):c.781A>G (p.Ile261Val) single nucleotide variant not specified [RCV004098915] Chr3:46358308 [GRCh38]
Chr3:46399799 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001123396.4(CCR2):c.*1198A>G single nucleotide variant not specified [RCV004234774] Chr3:46359808 [GRCh38]
Chr3:46401299 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001123396.4(CCR2):c.142C>T (p.Leu48Phe) single nucleotide variant not specified [RCV004169750] Chr3:46357669 [GRCh38]
Chr3:46399160 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001123396.4(CCR2):c.655G>A (p.Val219Ile) single nucleotide variant not specified [RCV004132423] Chr3:46358182 [GRCh38]
Chr3:46399673 [GRCh37]
Chr3:3p21.31
likely benign
NM_001123396.4(CCR2):c.*1218G>A single nucleotide variant not specified [RCV004129434] Chr3:46359828 [GRCh38]
Chr3:46401319 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001123396.4(CCR2):c.397C>T (p.Leu133Phe) single nucleotide variant not specified [RCV004081716] Chr3:46357924 [GRCh38]
Chr3:46399415 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001123396.4(CCR2):c.72T>A (p.Phe24Leu) single nucleotide variant not specified [RCV004278059] Chr3:46357599 [GRCh38]
Chr3:46399090 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001123396.4(CCR2):c.75T>A (p.Asp25Glu) single nucleotide variant not specified [RCV004328323] Chr3:46357602 [GRCh38]
Chr3:46399093 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001123396.4(CCR2):c.648C>T (p.Leu216=) single nucleotide variant CCR2-related disorder [RCV003939372] Chr3:46358175 [GRCh38]
Chr3:46399666 [GRCh37]
Chr3:3p21.31
likely benign
NM_001123396.4(CCR2):c.780T>C (p.Asn260=) single nucleotide variant CCR2-related disorder [RCV003981977] Chr3:46358307 [GRCh38]
Chr3:46399798 [GRCh37]
Chr3:3p21.31
benign
NM_001123396.4(CCR2):c.1044G>A (p.Thr348=) single nucleotide variant CCR2-related disorder [RCV003984732] Chr3:46358571 [GRCh38]
Chr3:46400062 [GRCh37]
Chr3:3p21.31
benign
NM_001123396.4(CCR2):c.*1189G>A single nucleotide variant CCR2-related disorder [RCV003922135] Chr3:46359799 [GRCh38]
Chr3:46401290 [GRCh37]
Chr3:3p21.31
benign
NM_001123396.4(CCR2):c.182T>G (p.Met61Arg) single nucleotide variant Cystic disease of lung [RCV003984973] Chr3:46357709 [GRCh38]
Chr3:46399200 [GRCh37]
Chr3:3p21.31
pathogenic
NM_001123396.4(CCR2):c.887C>A (p.Thr296Asn) single nucleotide variant Cystic disease of lung [RCV003984974] Chr3:46358414 [GRCh38]
Chr3:46399905 [GRCh37]
Chr3:3p21.31
pathogenic
NM_001123396.4(CCR2):c.59_60insAC (p.Thr21fs) insertion Cystic disease of lung [RCV003984975] Chr3:46357586..46357587 [GRCh38]
Chr3:46399077..46399078 [GRCh37]
Chr3:3p21.31
pathogenic
NM_001123396.4(CCR2):c.356T>G (p.Leu119Arg) single nucleotide variant Cystic disease of lung [RCV003984976] Chr3:46357883 [GRCh38]
Chr3:46399374 [GRCh37]
Chr3:3p21.31
pathogenic
NM_001123396.4(CCR2):c.641_646del (p.Pro214_Leu215del) deletion Cystic disease of lung [RCV003984972] Chr3:46358164..46358169 [GRCh38]
Chr3:46399655..46399660 [GRCh37]
Chr3:3p21.31
pathogenic
NM_001123396.4(CCR2):c.849G>T (p.Leu283=) single nucleotide variant CCR2-related disorder [RCV003969360] Chr3:46358376 [GRCh38]
Chr3:46399867 [GRCh37]
Chr3:3p21.31
likely benign
NM_001123396.4(CCR2):c.470G>A (p.Gly157Glu) single nucleotide variant not specified [RCV004432964] Chr3:46357997 [GRCh38]
Chr3:46399488 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001123396.4(CCR2):c.*1243G>C single nucleotide variant not specified [RCV004432963] Chr3:46359853 [GRCh38]
Chr3:46401344 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001123396.4(CCR2):c.688C>T (p.Leu230Phe) single nucleotide variant not specified [RCV004432966] Chr3:46358215 [GRCh38]
Chr3:46399706 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001123396.4(CCR2):c.587G>A (p.Arg196Gln) single nucleotide variant not specified [RCV004432965] Chr3:46358114 [GRCh38]
Chr3:46399605 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001123396.4(CCR2):c.548A>G (p.Lys183Arg) single nucleotide variant not specified [RCV004604910] Chr3:46358075 [GRCh38]
Chr3:46399566 [GRCh37]
Chr3:3p21.31
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1311
Count of miRNA genes:638
Interacting mature miRNAs:700
Transcripts:ENST00000292301, ENST00000400888, ENST00000421659, ENST00000445132, ENST00000465202
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597610685GWAS1667545_Hmonocyte count QTL GWAS1667545 (human)7e-23monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)34635771746357718Human
1298487BFD1_HBody fluid distribution QTL 1 (human)3.94Body fluid distributionimpedance ratio33638071262380712Human
597084210GWAS1180284_Hmonocyte percentage of leukocytes QTL GWAS1180284 (human)8e-12monocyte percentage of leukocytesblood monocyte count to total leukocyte count ratio (CMO:0000374)34635827346358274Human
597232284GWAS1328358_Hblood protein measurement QTL GWAS1328358 (human)9e-138blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)34635771746357718Human
597609403GWAS1666263_Hmonocyte count QTL GWAS1666263 (human)7e-16monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)34635771746357718Human
406972711GWAS621687_Hmonocyte count QTL GWAS621687 (human)1e-11monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)34635771746357718Human
1298489RA4_HRheumatoid arthritis QTL 4 (human)0.0283Joint/bone inflammationrheumatoid arthritis33638071262380712Human
1643509BW293_HBody Weight QTL 293 (human)1.42Body weightBMI33638071262380712Human
597209896GWAS1305970_Hblood protein measurement QTL GWAS1305970 (human)2e-55blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)34635544746355448Human
597088263GWAS1184337_Hmonocyte count QTL GWAS1184337 (human)5e-10monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)34635827346358274Human
597121062GWAS1217136_Hmonocyte count QTL GWAS1217136 (human)7e-11monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)34635827346358274Human
597160899GWAS1256973_Hmonocyte count QTL GWAS1256973 (human)8e-22monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)34635771746357718Human
597609483GWAS1666343_Hmonocyte count QTL GWAS1666343 (human)6e-27monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)34635771746357718Human
597122560GWAS1218634_HCCL2 measurement QTL GWAS1218634 (human)7e-12CCL2 measurement34635771746357718Human
597324071GWAS1420145_HC-C motif chemokine 2 measurement QTL GWAS1420145 (human)6e-12C-C motif chemokine 2 measurement34635771746357718Human
2316061GLUCO194_HGlucose level QTL 194 (human)0.02Glucose level32338077449380774Human
2289308BW392_HBody weight QTL 392 (human)1.42Body weightBMI33638071262380712Human
597209894GWAS1305968_Hblood protein measurement QTL GWAS1305968 (human)1e-55blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)34635544746355448Human
597610016GWAS1666876_Hmonocyte count QTL GWAS1666876 (human)2e-38monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)34635771746357718Human

Markers in Region
SHGC-78976  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,399,915 - 46,400,263UniSTSGRCh37
Build 36346,374,919 - 46,375,267RGDNCBI36
Celera346,337,236 - 46,337,584RGD
Cytogenetic Map3p21.31UniSTS
HuRef346,443,553 - 46,443,901UniSTS
TNG Radiation Hybrid Map329204.0UniSTS
PMC228408P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,399,261 - 46,399,340UniSTSGRCh37
Build 36346,374,265 - 46,374,344RGDNCBI36
Celera346,336,582 - 46,336,661RGD
HuRef346,442,899 - 46,442,978UniSTS
D3S4500  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,398,988 - 46,399,658UniSTSGRCh37
Build 36346,373,992 - 46,374,662RGDNCBI36
Celera346,336,309 - 46,336,979RGD
Cytogenetic Map3p21.31UniSTS
HuRef346,442,626 - 46,443,296UniSTS
SHGC-76910  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,399,838 - 46,400,033UniSTSGRCh37
Build 36346,374,842 - 46,375,037RGDNCBI36
Celera346,337,159 - 46,337,354RGD
Cytogenetic Map3p21.31UniSTS
HuRef346,443,476 - 46,443,671UniSTS
TNG Radiation Hybrid Map329204.0UniSTS
GeneMap99-GB4 RH Map3151.95UniSTS
NCBI RH Map3458.7UniSTS
SHGC-76923  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,402,143 - 46,402,261UniSTSGRCh37
Build 36346,377,147 - 46,377,265RGDNCBI36
Celera346,339,464 - 46,339,582RGD
Cytogenetic Map3p21.31UniSTS
HuRef346,445,781 - 46,445,899UniSTS
TNG Radiation Hybrid Map329204.0UniSTS
GeneMap99-GB4 RH Map3155.98UniSTS
NCBI RH Map3473.3UniSTS
WI-9314  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,401,378 - 46,401,491UniSTSGRCh37
Build 36346,376,382 - 46,376,495RGDNCBI36
Celera346,338,699 - 46,338,812RGD
Cytogenetic Map3p21.31UniSTS
HuRef346,445,016 - 46,445,129UniSTS
Whitehead-YAC Contig Map3 UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2318 2740 2207 4139 1685 2115 2 598 1751 436 2005 6869 6219 12 3154 788 1603 1414 163

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_021428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001123041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001123396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011534069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC138069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF068265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF545480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV715904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX705062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC136396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ027284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX101672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D29984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA927445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC401093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC418358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU037782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU037783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X95583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000292301   ⟹   ENSP00000292301
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,353,744 - 46,360,921 (+)Ensembl
Ensembl Acc Id: ENST00000400888   ⟹   ENSP00000383681
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,357,489 - 46,360,928 (+)Ensembl
Ensembl Acc Id: ENST00000421659   ⟹   ENSP00000396736
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,354,126 - 46,357,892 (+)Ensembl
Ensembl Acc Id: ENST00000445132   ⟹   ENSP00000399285
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,354,111 - 46,360,940 (+)Ensembl
Ensembl Acc Id: ENST00000465202
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl346,353,864 - 46,358,688 (+)Ensembl
RefSeq Acc Id: NM_001123041   ⟹   NP_001116513
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38346,354,111 - 46,360,940 (+)NCBI
GRCh37346,395,235 - 46,402,413 (+)ENTREZGENE
HuRef346,438,874 - 46,446,051 (+)ENTREZGENE
CHM1_1346,345,233 - 46,352,410 (+)NCBI
T2T-CHM13v2.0346,369,948 - 46,376,777 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001123396   ⟹   NP_001116868
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38346,354,111 - 46,360,940 (+)NCBI
GRCh37346,395,235 - 46,402,413 (+)ENTREZGENE
HuRef346,438,874 - 46,446,051 (+)ENTREZGENE
CHM1_1346,345,233 - 46,350,865 (+)NCBI
T2T-CHM13v2.0346,369,948 - 46,376,777 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001116513 (Get FASTA)   NCBI Sequence Viewer  
  NP_001116868 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19119 (Get FASTA)   NCBI Sequence Viewer  
  AAA19120 (Get FASTA)   NCBI Sequence Viewer  
  AAB57791 (Get FASTA)   NCBI Sequence Viewer  
  AAB57792 (Get FASTA)   NCBI Sequence Viewer  
  AAC51636 (Get FASTA)   NCBI Sequence Viewer  
  AAC51637 (Get FASTA)   NCBI Sequence Viewer  
  AAH74751 (Get FASTA)   NCBI Sequence Viewer  
  AAH95540 (Get FASTA)   NCBI Sequence Viewer  
  AAI26453 (Get FASTA)   NCBI Sequence Viewer  
  AAI36397 (Get FASTA)   NCBI Sequence Viewer  
  AAN16400 (Get FASTA)   NCBI Sequence Viewer  
  ABW17216 (Get FASTA)   NCBI Sequence Viewer  
  ABW17217 (Get FASTA)   NCBI Sequence Viewer  
  AGC02842 (Get FASTA)   NCBI Sequence Viewer  
  AGC02843 (Get FASTA)   NCBI Sequence Viewer  
  AGC02844 (Get FASTA)   NCBI Sequence Viewer  
  AGC02845 (Get FASTA)   NCBI Sequence Viewer  
  AGC02846 (Get FASTA)   NCBI Sequence Viewer  
  AGC02847 (Get FASTA)   NCBI Sequence Viewer  
  AGC02848 (Get FASTA)   NCBI Sequence Viewer  
  AGC02849 (Get FASTA)   NCBI Sequence Viewer  
  AGC02850 (Get FASTA)   NCBI Sequence Viewer  
  AGC02851 (Get FASTA)   NCBI Sequence Viewer  
  BAA06253 (Get FASTA)   NCBI Sequence Viewer  
  BAF85374 (Get FASTA)   NCBI Sequence Viewer  
  BAF85609 (Get FASTA)   NCBI Sequence Viewer  
  CAA64835 (Get FASTA)   NCBI Sequence Viewer  
  CAD88094 (Get FASTA)   NCBI Sequence Viewer  
  EAW64760 (Get FASTA)   NCBI Sequence Viewer  
  EAW64761 (Get FASTA)   NCBI Sequence Viewer  
  EAW64762 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000383681
  ENSP00000383681.2
  ENSP00000396736.1
  ENSP00000399285
  ENSP00000399285.2
GenBank Protein P41597 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001116513   ⟸   NM_001123041
- Peptide Label: isoform A
- UniProtKB: Q4VBL2 (UniProtKB/Swiss-Prot),   P41597 (UniProtKB/Swiss-Prot),   O95950 (UniProtKB/Swiss-Prot),   B2RMT0 (UniProtKB/Swiss-Prot),   A0AVQ3 (UniProtKB/Swiss-Prot),   L7REX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001116868   ⟸   NM_001123396
- Peptide Label: isoform B
- UniProtKB: L7REX9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000292301   ⟸   ENST00000292301
Ensembl Acc Id: ENSP00000383681   ⟸   ENST00000400888
Ensembl Acc Id: ENSP00000399285   ⟸   ENST00000445132
Ensembl Acc Id: ENSP00000396736   ⟸   ENST00000421659
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41597-F1-model_v2 AlphaFold P41597 1-374 view protein structure

Promoters
RGD ID:6864188
Promoter ID:EPDNEW_H5259
Type:initiation region
Name:CCR2_1
Description:C-C motif chemokine receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38346,353,860 - 46,353,920EPDNEW
RGD ID:6800738
Promoter ID:HG_KWN:44761
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000344294,   OTTHUMT00000344295,   UC003CPM.2,   UC003CPN.2
Position:
Human AssemblyChrPosition (strand)Source
Build 36346,370,224 - 46,370,724 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1603 AgrOrtholog
COSMIC CCR2 COSMIC
Ensembl Genes ENSG00000121807 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000400888 ENTREZGENE
  ENST00000400888.2 UniProtKB/Swiss-Prot
  ENST00000421659.1 UniProtKB/TrEMBL
  ENST00000445132 ENTREZGENE
  ENST00000445132.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000121807 GTEx
HGNC ID HGNC:1603 ENTREZGENE
Human Proteome Map CCR2 Human Proteome Map
InterPro Chemokine_CCR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:729230 UniProtKB/Swiss-Prot
NCBI Gene CCR2 ENTREZGENE
OMIM 601267 OMIM
PANTHER C-C CHEMOKINE RECEPTOR TYPE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26167 PharmGKB
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHEMOKINER2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0AVQ3 ENTREZGENE
  B2RMT0 ENTREZGENE
  B4XH68_HUMAN UniProtKB/TrEMBL
  B4XH69_HUMAN UniProtKB/TrEMBL
  CCR2_HUMAN UniProtKB/Swiss-Prot
  E9PH76_HUMAN UniProtKB/TrEMBL
  L7RER4_HUMAN UniProtKB/TrEMBL
  L7REX9 ENTREZGENE, UniProtKB/TrEMBL
  O95950 ENTREZGENE
  P41597 ENTREZGENE
  Q4VBL2 ENTREZGENE
UniProt Secondary A0AVQ3 UniProtKB/Swiss-Prot
  B2RMT0 UniProtKB/Swiss-Prot
  O95950 UniProtKB/Swiss-Prot
  Q4VBL2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-21 CCR2  C-C motif chemokine receptor 2  CCR2  chemokine (C-C motif) receptor 2  Symbol and/or name change 5135510 APPROVED