MS4A15 (membrane spanning 4-domains A15) - Rat Genome Database

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Gene: MS4A15 (membrane spanning 4-domains A15) Homo sapiens
Analyze
Symbol: MS4A15
Name: membrane spanning 4-domains A15
RGD ID: 1603162
HGNC Page HGNC:28573
Description: Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FLJ34527; membrane-spanning 4-domains subfamily A member 15; membrane-spanning 4-domains, subfamily A, member 15; MGC35295
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,756,867 - 60,776,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,756,867 - 60,776,733 (+)EnsemblGRCh38hg38GRCh38
GRCh371160,524,340 - 60,544,206 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,280,916 - 60,300,780 (+)NCBINCBI36Build 36hg18NCBI36
Celera1157,888,546 - 57,908,417 (+)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1156,871,327 - 56,891,196 (+)NCBIHuRef
CHM1_11160,390,691 - 60,410,552 (+)NCBICHM1_1
T2T-CHM13v2.01160,708,024 - 60,727,897 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11181995   PMID:12477932   PMID:14702039   PMID:15489334   PMID:16554811   PMID:18976975   PMID:21873635   PMID:33961781   PMID:35151203  


Genomics

Comparative Map Data
MS4A15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,756,867 - 60,776,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,756,867 - 60,776,733 (+)EnsemblGRCh38hg38GRCh38
GRCh371160,524,340 - 60,544,206 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,280,916 - 60,300,780 (+)NCBINCBI36Build 36hg18NCBI36
Celera1157,888,546 - 57,908,417 (+)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1156,871,327 - 56,891,196 (+)NCBIHuRef
CHM1_11160,390,691 - 60,410,552 (+)NCBICHM1_1
T2T-CHM13v2.01160,708,024 - 60,727,897 (+)NCBIT2T-CHM13v2.0
Ms4a15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,955,667 - 10,970,614 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,955,671 - 10,970,614 (-)EnsemblGRCm39 Ensembl
GRCm381910,978,303 - 10,993,299 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,978,307 - 10,993,250 (-)EnsemblGRCm38mm10GRCm38
MGSCv371911,052,797 - 11,067,740 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361911,045,352 - 11,060,295 (-)NCBIMGSCv36mm8
Celera1911,669,311 - 11,684,741 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map197.47NCBI
Ms4a15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81217,053,199 - 217,066,693 (-)NCBIGRCr8
mRatBN7.21207,628,305 - 207,641,799 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1207,628,305 - 207,641,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,003,144 - 216,016,636 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,071,406 - 223,084,833 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,757,543 - 215,771,035 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01227,033,796 - 227,048,718 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1227,033,796 - 227,047,290 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01234,099,484 - 234,113,131 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41213,477,584 - 213,491,078 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1205,120,308 - 205,133,803 (-)NCBICelera
Cytogenetic Map1q43NCBI
Ms4a15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555115,485,001 - 5,502,748 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555115,485,001 - 5,502,548 (+)NCBIChiLan1.0ChiLan1.0
MS4A15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2961,928,415 - 61,948,376 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11162,972,458 - 62,992,363 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01156,022,378 - 56,042,262 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11159,463,341 - 59,483,412 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1159,463,321 - 59,483,412 (+)Ensemblpanpan1.1panPan2
MS4A15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11855,488,523 - 55,496,359 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1854,061,183 - 54,069,335 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01856,535,997 - 56,544,122 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11855,593,565 - 55,601,675 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01855,214,971 - 55,223,094 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01856,096,208 - 56,104,332 (-)NCBIUU_Cfam_GSD_1.0
Ms4a15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494712,002,989 - 12,009,770 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365812,117,387 - 2,130,743 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365812,116,823 - 2,123,592 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MS4A15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl210,960,498 - 10,969,359 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1210,959,559 - 10,969,433 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2210,434,022 - 10,449,148 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MS4A15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1113,061,545 - 13,073,392 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl113,061,584 - 13,073,280 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038110,422,419 - 110,434,426 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ms4a15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624926228,943 - 235,346 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624926225,576 - 236,243 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MS4A15
20 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q12.2(chr11:60526573-60628691)x1 copy number loss not provided [RCV000737539] Chr11:60526573..60628691 [GRCh37]
Chr11:11q12.2		 benign
GRCh37/hg19 11q12.2-12.3(chr11:60385382-62456278)x3 copy number gain not provided [RCV001006412] Chr11:60385382..62456278 [GRCh37]
Chr11:11q12.2-12.3		 uncertain significance
NM_001098835.2(MS4A15):c.700G>A (p.Ala234Thr) single nucleotide variant not specified [RCV004126018] Chr11:60775692 [GRCh38]
Chr11:60543165 [GRCh37]
Chr11:11q12.2		 uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh37/hg19 11q12.1-12.3(chr11:58935215-62177656)x3 copy number gain not provided [RCV000683362] Chr11:58935215..62177656 [GRCh37]
Chr11:11q12.1-12.3		 likely pathogenic
NM_001098835.2(MS4A15):c.321C>T (p.Gly107=) single nucleotide variant EBV-positive nodal T- and NK-cell lymphoma [RCV004557811] Chr11:60767628 [GRCh38]
Chr11:60535101 [GRCh37]
Chr11:11q12.2		 likely benign
NM_001098835.2(MS4A15):c.26G>A (p.Gly9Glu) single nucleotide variant not specified [RCV004316118] Chr11:60763759 [GRCh38]
Chr11:60531232 [GRCh37]
Chr11:11q12.2		 uncertain significance
NC_000011.9:g.(?_58916346)_(64972349_?)dup duplication Leukocyte adhesion deficiency 3 [RCV003113394]|not provided [RCV003113393] Chr11:58916346..64972349 [GRCh37]
Chr11:11q12.1-13.1		 uncertain significance|no classifications from unflagged records
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Familial temporal lobe epilepsy 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3		 uncertain significance
NM_001098835.2(MS4A15):c.449C>T (p.Ala150Val) single nucleotide variant not specified [RCV004235217] Chr11:60773435 [GRCh38]
Chr11:60540908 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.715G>A (p.Val239Ile) single nucleotide variant not specified [RCV004347080] Chr11:60775707 [GRCh38]
Chr11:60543180 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.91A>G (p.Thr31Ala) single nucleotide variant not specified [RCV004308484] Chr11:60763824 [GRCh38]
Chr11:60531297 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.206G>A (p.Gly69Glu) single nucleotide variant not specified [RCV004239932] Chr11:60763939 [GRCh38]
Chr11:60531412 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.365C>T (p.Ser122Phe) single nucleotide variant not specified [RCV004502942] Chr11:60771307 [GRCh38]
Chr11:60538780 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.290G>A (p.Arg97His) single nucleotide variant not specified [RCV004079659] Chr11:60767597 [GRCh38]
Chr11:60535070 [GRCh37]
Chr11:11q12.2		 uncertain significance
GRCh37/hg19 11q12.2-13.5(chr11:59923608-76272324)x3 copy number gain not provided [RCV003484842] Chr11:59923608..76272324 [GRCh37]
Chr11:11q12.2-13.5		 pathogenic
NM_001098835.2(MS4A15):c.484G>A (p.Gly162Ser) single nucleotide variant not specified [RCV004180938] Chr11:60773470 [GRCh38]
Chr11:60540943 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.7G>C (p.Ala3Pro) single nucleotide variant not specified [RCV004198990] Chr11:60763740 [GRCh38]
Chr11:60531213 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.686C>T (p.Ala229Val) single nucleotide variant not specified [RCV004345879] Chr11:60775678 [GRCh38]
Chr11:60543151 [GRCh37]
Chr11:11q12.2		 uncertain significance
GRCh37/hg19 11q12.2(chr11:60499486-61529578)x3 copy number gain not provided [RCV000848682] Chr11:60499486..61529578 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.56C>A (p.Ala19Asp) single nucleotide variant not specified [RCV004502970] Chr11:60763789 [GRCh38]
Chr11:60531262 [GRCh37]
Chr11:11q12.2		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_001098835.2(MS4A15):c.523G>A (p.Val175Met) single nucleotide variant not specified [RCV004631689] Chr11:60773861 [GRCh38]
Chr11:60541334 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.244G>C (p.Gly82Arg) single nucleotide variant not specified [RCV004631690] Chr11:60767551 [GRCh38]
Chr11:60535024 [GRCh37]
Chr11:11q12.2		 uncertain significance
GRCh37/hg19 11p11.2-q12.2(chr11:51581311-54891247)x3 copy number gain See cases [RCV002286338] Chr11:51581311..54891247 [GRCh37]
Chr11:11p11.2-q12.2		 pathogenic
NM_001098835.2(MS4A15):c.512G>C (p.Gly171Ala) single nucleotide variant not specified [RCV004161064] Chr11:60773850 [GRCh38]
Chr11:60541323 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.158G>A (p.Arg53Lys) single nucleotide variant not specified [RCV004265262] Chr11:60763891 [GRCh38]
Chr11:60531364 [GRCh37]
Chr11:11q12.2		 uncertain significance
GRCh37/hg19 11p11.12-q13.1(chr11:50398499-63924462)x3 copy number gain not specified [RCV003986918] Chr11:50398499..63924462 [GRCh37]
Chr11:11p11.12-q13.1		 likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_001098835.2(MS4A15):c.436A>G (p.Ser146Gly) single nucleotide variant not specified [RCV004502949] Chr11:60773422 [GRCh38]
Chr11:60540895 [GRCh37]
Chr11:11q12.2		 uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
GRCh37/hg19 11q12.1-13.3(chr11:56895955-69295402)x3 copy number gain not specified [RCV003986944] Chr11:56895955..69295402 [GRCh37]
Chr11:11q12.1-13.3		 likely pathogenic
NM_001098835.2(MS4A15):c.55G>A (p.Ala19Thr) single nucleotide variant not specified [RCV004189522] Chr11:60763788 [GRCh38]
Chr11:60531261 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.182G>T (p.Arg61Leu) single nucleotide variant not specified [RCV004344038] Chr11:60763915 [GRCh38]
Chr11:60531388 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.227C>T (p.Thr76Met) single nucleotide variant not specified [RCV004160386] Chr11:60767534 [GRCh38]
Chr11:60535007 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.329C>A (p.Pro110His) single nucleotide variant not provided [RCV004696327]|not specified [RCV004254136] Chr11:60767636 [GRCh38]
Chr11:60535109 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.443T>G (p.Met148Arg) single nucleotide variant not specified [RCV004296985] Chr11:60773429 [GRCh38]
Chr11:60540902 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.109C>T (p.Pro37Ser) single nucleotide variant not specified [RCV004082136] Chr11:60763842 [GRCh38]
Chr11:60531315 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.377C>T (p.Ala126Val) single nucleotide variant not specified [RCV004351980] Chr11:60771319 [GRCh38]
Chr11:60538792 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_001098835.2(MS4A15):c.680C>T (p.Pro227Leu) single nucleotide variant not specified [RCV004502978] Chr11:60775672 [GRCh38]
Chr11:60543145 [GRCh37]
Chr11:11q12.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3293
Count of miRNA genes:728
Interacting mature miRNAs:823
Transcripts:ENST00000337911, ENST00000405633, ENST00000429322, ENST00000528170
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407269109GWAS918085_Hsleep apnea measurement QTL GWAS918085 (human)5e-08sleep apnea measurement116077010560770106Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
389 1151 970 657 2608 626 1224 4 177 940 83 1015 2705 2340 25 1875 280 1097 996 100

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001098835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001278242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_152717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_103481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006718459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK091846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP004243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY584608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY584609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI818815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR747020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC359370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000337911   ⟹   ENSP00000338692
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,757,003 - 60,776,731 (+)Ensembl
Ensembl Acc Id: ENST00000405633   ⟹   ENSP00000386022
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,756,867 - 60,776,733 (+)Ensembl
Ensembl Acc Id: ENST00000429322   ⟹   ENSP00000413918
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,757,004 - 60,776,732 (+)Ensembl
Ensembl Acc Id: ENST00000528170   ⟹   ENSP00000434165
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,756,953 - 60,775,799 (+)Ensembl
RefSeq Acc Id: NM_001098835   ⟹   NP_001092305
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,756,867 - 60,776,733 (+)NCBI
GRCh371160,524,340 - 60,544,204 (+)RGD
Build 361160,280,916 - 60,300,780 (+)NCBI Archive
Celera1157,888,546 - 57,908,417 (+)RGD
HuRef1156,871,327 - 56,891,196 (+)RGD
CHM1_11160,390,691 - 60,410,552 (+)NCBI
T2T-CHM13v2.01160,708,024 - 60,727,897 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001278242   ⟹   NP_001265171
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,756,867 - 60,776,733 (+)NCBI
GRCh371160,524,340 - 60,544,204 (+)NCBI
HuRef1156,871,327 - 56,891,196 (+)NCBI
CHM1_11160,390,691 - 60,410,552 (+)NCBI
T2T-CHM13v2.01160,708,024 - 60,727,897 (+)NCBI
Sequence:
RefSeq Acc Id: NM_152717   ⟹   NP_689930
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,756,867 - 60,776,733 (+)NCBI
GRCh371160,524,340 - 60,544,204 (+)RGD
Build 361160,280,916 - 60,300,780 (+)NCBI Archive
Celera1157,888,546 - 57,908,417 (+)RGD
HuRef1156,871,327 - 56,891,196 (+)RGD
CHM1_11160,390,691 - 60,410,552 (+)NCBI
T2T-CHM13v2.01160,708,024 - 60,727,897 (+)NCBI
Sequence:
RefSeq Acc Id: NR_103481
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,756,867 - 60,776,733 (+)NCBI
GRCh371160,524,340 - 60,544,204 (+)NCBI
HuRef1156,871,327 - 56,891,196 (+)NCBI
CHM1_11160,390,691 - 60,410,552 (+)NCBI
T2T-CHM13v2.01160,708,024 - 60,727,897 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006718459   ⟹   XP_006718522
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,756,867 - 60,776,733 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011544812   ⟹   XP_011543114
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,756,867 - 60,776,733 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047426547   ⟹   XP_047282503
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,756,867 - 60,776,733 (+)NCBI
RefSeq Acc Id: XM_047426548   ⟹   XP_047282504
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,763,874 - 60,776,733 (+)NCBI
RefSeq Acc Id: XM_054367996   ⟹   XP_054223971
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01160,708,024 - 60,727,897 (+)NCBI
RefSeq Acc Id: XM_054367997   ⟹   XP_054223972
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01160,708,024 - 60,727,897 (+)NCBI
RefSeq Acc Id: XM_054367998   ⟹   XP_054223973
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01160,708,024 - 60,727,897 (+)NCBI
RefSeq Acc Id: XM_054367999   ⟹   XP_054223974
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01160,715,032 - 60,727,897 (+)NCBI
RefSeq Acc Id: NP_001092305   ⟸   NM_001098835
- Peptide Label: isoform 1
- UniProtKB: Q8N5U1 (UniProtKB/Swiss-Prot),   F2Z2J5 (UniProtKB/Swiss-Prot),   A9UJY7 (UniProtKB/Swiss-Prot),   A9UJY6 (UniProtKB/Swiss-Prot),   B4DTI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_689930   ⟸   NM_152717
- Peptide Label: isoform 2
- UniProtKB: Q8N5U1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265171   ⟸   NM_001278242
- Peptide Label: isoform 3
- UniProtKB: B4DTI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006718522   ⟸   XM_006718459
- Peptide Label: isoform X3
- UniProtKB: Q8N5U1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011543114   ⟸   XM_011544812
- Peptide Label: isoform X1
- UniProtKB: Q8N5U1 (UniProtKB/Swiss-Prot),   F2Z2J5 (UniProtKB/Swiss-Prot),   A9UJY7 (UniProtKB/Swiss-Prot),   A9UJY6 (UniProtKB/Swiss-Prot),   B4DTI9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000413918   ⟸   ENST00000429322
Ensembl Acc Id: ENSP00000338692   ⟸   ENST00000337911
Ensembl Acc Id: ENSP00000386022   ⟸   ENST00000405633
Ensembl Acc Id: ENSP00000434165   ⟸   ENST00000528170
RefSeq Acc Id: XP_047282503   ⟸   XM_047426547
- Peptide Label: isoform X2
- UniProtKB: B4DTI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047282504   ⟸   XM_047426548
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054223971   ⟸   XM_054367996
- Peptide Label: isoform X1
- UniProtKB: B4DTI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054223972   ⟸   XM_054367997
- Peptide Label: isoform X2
- UniProtKB: B4DTI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054223973   ⟸   XM_054367998
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054223974   ⟸   XM_054367999
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8N5U1-F1-model_v2 AlphaFold Q8N5U1 1-240 view protein structure

Promoters
RGD ID:6789127
Promoter ID:HG_KWN:13023
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:ENST00000405633
Position:
Human AssemblyChrPosition (strand)Source
Build 361160,287,471 - 60,287,972 (+)MPROMDB
RGD ID:7220485
Promoter ID:EPDNEW_H15988
Type:initiation region
Name:MS4A15_1
Description:membrane spanning 4-domains A15
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15989  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,756,950 - 60,757,010EPDNEW
RGD ID:7220487
Promoter ID:EPDNEW_H15989
Type:single initiation site
Name:MS4A15_2
Description:membrane spanning 4-domains A15
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15988  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,757,084 - 60,757,144EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:28573 AgrOrtholog
COSMIC MS4A15 COSMIC
Ensembl Genes ENSG00000166961 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000337911 ENTREZGENE
  ENST00000337911.8 UniProtKB/Swiss-Prot
  ENST00000405633 ENTREZGENE
  ENST00000405633.4 UniProtKB/Swiss-Prot
  ENST00000429322 ENTREZGENE
  ENST00000429322.6 UniProtKB/TrEMBL
  ENST00000528170 ENTREZGENE
  ENST00000528170.5 UniProtKB/Swiss-Prot
GTEx ENSG00000166961 GTEx
HGNC ID HGNC:28573 ENTREZGENE
Human Proteome Map MS4A15 Human Proteome Map
InterPro CD20-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MS4A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:219995 UniProtKB/Swiss-Prot
NCBI Gene MS4A15 ENTREZGENE
PANTHER MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam CD20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134959869 PharmGKB
UniProt A9UJY6 ENTREZGENE
  A9UJY7 ENTREZGENE
  B4DTI9 ENTREZGENE, UniProtKB/TrEMBL
  E7ET34_HUMAN UniProtKB/TrEMBL
  F2Z2J5 ENTREZGENE
  M4A15_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A9UJY6 UniProtKB/Swiss-Prot
  A9UJY7 UniProtKB/Swiss-Prot
  F2Z2J5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 MS4A15  membrane spanning 4-domains A15    membrane-spanning 4-domains subfamily A member 15  Symbol and/or name change 5135510 APPROVED
2016-01-19 MS4A15  membrane-spanning 4-domains subfamily A member 15    membrane-spanning 4-domains, subfamily A, member 15  Symbol and/or name change 5135510 APPROVED