ARHGAP35 (Rho GTPase activating protein 35) - Rat Genome Database

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Gene: ARHGAP35 (Rho GTPase activating protein 35) Homo sapiens
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Symbol: ARHGAP35
Name: Rho GTPase activating protein 35
RGD ID: 1603059
HGNC Page HGNC:4591
Description: Enables GTPase activator activity and phospholipid binding activity. Predicted to be involved in several processes, including axon development; establishment or maintenance of actin cytoskeleton polarity; and regulation of plasma membrane bounded cell projection organization. Predicted to act upstream of or within negative regulation of Rho protein signal transduction. Predicted to be located in ciliary basal body. Predicted to be active in cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: glucocorticoid receptor DNA binding factor 1; glucocorticoid receptor DNA-binding factor 1; glucocorticoid receptor repression factor 1; GRF-1; GRLF1; KIAA1722; MGC10745; P190-A; P190A; p190ARhoGAP; p190RhoGAP; rho GAP p190A; rho GTPase-activating protein 35
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,860,997 - 47,005,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1946,860,997 - 47,005,077 (+)Ensemblhg38GRCh38
GRCh371947,364,254 - 47,508,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,113,773 - 52,200,174 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1944,226,291 - 44,312,689 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,846,727 - 43,932,756 (+)NCBIHuRef
CHM1_11947,423,799 - 47,510,216 (+)NCBICHM1_1
T2T-CHM13v2.01949,686,835 - 49,830,977 (+)NCBIT2T-CHM13v2.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1894621   PMID:8189062   PMID:8419471   PMID:8702520   PMID:9034330   PMID:9535855   PMID:9548756   PMID:9819392   PMID:11054565   PMID:11214970   PMID:11309200   PMID:12168954  
PMID:12441060   PMID:12477932   PMID:14702039   PMID:15102857   PMID:15302935   PMID:15592455   PMID:16147992   PMID:16188938   PMID:16210701   PMID:16308318   PMID:16341674   PMID:16513268  
PMID:16751776   PMID:17081983   PMID:17562701   PMID:18282590   PMID:18567581   PMID:18642445   PMID:18829532   PMID:18922893   PMID:19086053   PMID:19293150   PMID:19393245   PMID:19435801  
PMID:19673492   PMID:20530197   PMID:20534586   PMID:20617170   PMID:20634891   PMID:20675588   PMID:21844884   PMID:21873635   PMID:22357615   PMID:22505611   PMID:22807448   PMID:22810586  
PMID:23178654   PMID:23552690   PMID:24043274   PMID:24403595   PMID:24465899   PMID:25025568   PMID:25136583   PMID:25185653   PMID:25359885   PMID:25416956   PMID:25798074   PMID:25921289  
PMID:26344197   PMID:28007963   PMID:28176259   PMID:28387812   PMID:28514442   PMID:28515276   PMID:28611215   PMID:29507755   PMID:29509190   PMID:29568061   PMID:29656322   PMID:29764989  
PMID:29934311   PMID:30015929   PMID:30232004   PMID:30397336   PMID:30659115   PMID:30890647   PMID:31332286   PMID:31452512   PMID:31462741   PMID:31519766   PMID:31623230   PMID:31871319  
PMID:32203420   PMID:32457342   PMID:32641858   PMID:32663194   PMID:33916271   PMID:33961781   PMID:34079125   PMID:35271311   PMID:35439318   PMID:35748872   PMID:35758029   PMID:35831314  
PMID:36178483   PMID:36215168   PMID:36232890   PMID:36257976   PMID:36450800   PMID:36516886   PMID:36543142   PMID:36634849   PMID:36779422   PMID:37507023   PMID:37827155   PMID:38280479  
PMID:38697112   PMID:38943005   PMID:39098523   PMID:39422127  


Genomics

Comparative Map Data
ARHGAP35
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,860,997 - 47,005,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1946,860,997 - 47,005,077 (+)Ensemblhg38GRCh38
GRCh371947,364,254 - 47,508,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,113,773 - 52,200,174 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1944,226,291 - 44,312,689 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,846,727 - 43,932,756 (+)NCBIHuRef
CHM1_11947,423,799 - 47,510,216 (+)NCBICHM1_1
T2T-CHM13v2.01949,686,835 - 49,830,977 (+)NCBIT2T-CHM13v2.0
Arhgap35
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,228,398 - 16,349,313 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,227,644 - 16,348,918 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38716,494,473 - 16,614,993 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,493,719 - 16,614,993 (-)Ensemblmm10GRCm38
MGSCv37717,079,822 - 17,200,342 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36715,653,561 - 15,773,515 (-)NCBIMGSCv36mm8
Celera713,691,036 - 13,812,194 (-)NCBICelera
Cytogenetic Map7A2NCBI
cM Map79.15NCBI
Arhgap35
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,330,566 - 86,447,414 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl186,330,566 - 86,447,414 (-)EnsemblGRCr8
mRatBN7.2177,202,436 - 77,319,298 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,202,436 - 77,319,298 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx182,576,527 - 82,693,394 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,140,568 - 91,257,426 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,331,623 - 84,448,478 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,456,409 - 78,573,374 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,456,409 - 78,573,374 (-)Ensemblrn6Rnor6.0
Rnor_5.0179,703,650 - 79,820,568 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4176,757,031 - 76,824,155 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera171,687,713 - 71,804,603 (-)NCBICelera
RGSC_v3.11628,093,164 - 28,259,729 (+)NCBI
Cytogenetic Map1q21NCBI
Arhgap35
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574915,325 - 984,744 (+)Ensembl
ChiLan1.0NW_004955574915,604 - 984,744 (+)NCBIChiLan1.0ChiLan1.0
ARHGAP35
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22053,006,784 - 53,151,982 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11954,878,676 - 55,023,271 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01943,850,692 - 43,994,487 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11952,435,379 - 52,521,104 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,435,379 - 52,521,104 (+)EnsemblpanPan2panpan1.1
ARHGAP35
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11108,952,836 - 109,034,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1108,952,562 - 109,034,337 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1108,432,475 - 108,561,300 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01109,473,916 - 109,607,035 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,476,089 - 109,607,038 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,144,987 - 109,284,705 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,789,454 - 108,918,490 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,657,989 - 109,786,942 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arhgap35
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934919,095,903 - 19,170,964 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936664713,984 - 789,344 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936664714,036 - 788,584 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP35
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,711,901 - 52,841,288 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1652,711,463 - 52,841,295 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2648,200,461 - 48,215,323 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP35
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,264,466 - 40,353,157 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl640,205,892 - 40,353,280 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607319,911,593 - 20,059,133 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap35
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,650,383 - 6,719,786 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248326,650,383 - 6,773,828 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in ARHGAP35
100 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.32-13.33(chr19:46658791-49050450)x3 copy number gain See cases [RCV000052913] Chr19:46658791..49050450 [GRCh38]
Chr19:47162048..49553707 [GRCh37]
Chr19:51853888..54245519 [NCBI36]
Chr19:19q13.32-13.33		 pathogenic
GRCh38/hg38 19q13.32-13.33(chr19:46458122-47683579)x1 copy number loss See cases [RCV000053976] Chr19:46458122..47683579 [GRCh38]
Chr19:46961379..48186836 [GRCh37]
Chr19:51653219..52878648 [NCBI36]
Chr19:19q13.32-13.33		 pathogenic
GRCh38/hg38 19q13.32-13.33(chr19:44971420-48257402)x3 copy number gain See cases [RCV000136578] Chr19:44971420..48257402 [GRCh38]
Chr19:45474677..48760659 [GRCh37]
Chr19:50166517..53452471 [NCBI36]
Chr19:19q13.32-13.33		 pathogenic
NM_004491.5(ARHGAP35):c.1959_1960delinsAA (p.Pro654Thr) indel Breast ductal adenocarcinoma [RCV000207060] Chr19:46920634..46920635 [GRCh38]
Chr19:47423891..47423892 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19q13.32(chr19:47228251-47867279)x3 copy number gain not provided [RCV000585171] Chr19:47228251..47867279 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19q13.32(chr19:46918881-47782258)x3 copy number gain See cases [RCV000446734] Chr19:46918881..47782258 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19q13.32(chr19:47450549-47880338)x3 copy number gain See cases [RCV000447405] Chr19:47450549..47880338 [GRCh37]
Chr19:19q13.32		 likely pathogenic
GRCh37/hg19 19q13.32-13.33(chr19:46404248-48488721)x1 copy number loss See cases [RCV000511362] Chr19:46404248..48488721 [GRCh37]
Chr19:19q13.32-13.33		 likely pathogenic
NM_004491.5(ARHGAP35):c.3700C>T (p.Arg1234Trp) single nucleotide variant not specified [RCV004320069] Chr19:46937282 [GRCh38]
Chr19:47440539 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.1751G>A (p.Arg584Gln) single nucleotide variant not specified [RCV004324173] Chr19:46920426 [GRCh38]
Chr19:47423683 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.1271G>A (p.Arg424Lys) single nucleotide variant not specified [RCV004327319] Chr19:46919946 [GRCh38]
Chr19:47423203 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
NM_004491.5(ARHGAP35):c.1034C>T (p.Pro345Leu) single nucleotide variant not specified [RCV004321373] Chr19:46919709 [GRCh38]
Chr19:47422966 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
NM_004491.5(ARHGAP35):c.1300del (p.Arg434fs) deletion not provided [RCV000660549] Chr19:46919974 [GRCh38]
Chr19:47423231 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
NM_004491.5(ARHGAP35):c.1743G>A (p.Pro581=) single nucleotide variant not provided [RCV000964071] Chr19:46920418 [GRCh38]
Chr19:47423675 [GRCh37]
Chr19:19q13.32		 benign
NM_004491.5(ARHGAP35):c.375T>C (p.Leu125=) single nucleotide variant not provided [RCV000954318] Chr19:46919050 [GRCh38]
Chr19:47422307 [GRCh37]
Chr19:19q13.32		 benign
NM_004491.5(ARHGAP35):c.3492G>T (p.Arg1164=) single nucleotide variant not provided [RCV000954319] Chr19:46922167 [GRCh38]
Chr19:47425424 [GRCh37]
Chr19:19q13.32		 benign
GRCh37/hg19 19q13.32-13.33(chr19:47036361-48525536) copy number gain not provided [RCV000767770] Chr19:47036361..48525536 [GRCh37]
Chr19:19q13.32-13.33		 pathogenic
GRCh37/hg19 19q13.32(chr19:47313394-47446351)x3 copy number gain not provided [RCV000847659] Chr19:47313394..47446351 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42		 pathogenic
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33		 pathogenic
NM_004491.5(ARHGAP35):c.2230C>T (p.Arg744Cys) single nucleotide variant not specified [RCV004292339] Chr19:46920905 [GRCh38]
Chr19:47424162 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19q13.32-13.33(chr19:47331662-48234260)x3 copy number gain not provided [RCV001007053] Chr19:47331662..48234260 [GRCh37]
Chr19:19q13.32-13.33		 uncertain significance
NM_004491.5(ARHGAP35):c.326G>A (p.Arg109Gln) single nucleotide variant not provided [RCV001280697] Chr19:46919001 [GRCh38]
Chr19:47422258 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.1600C>T (p.Gln534Ter) single nucleotide variant Neurodevelopmental disorder [RCV002273230] Chr19:46920275 [GRCh38]
Chr19:47423532 [GRCh37]
Chr19:19q13.32		 likely pathogenic
GRCh37/hg19 19q13.32(chr19:46918881-47782258) copy number gain not specified [RCV002052687] Chr19:46918881..47782258 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19q13.32-13.33(chr19:47028919-48185409) copy number gain Coffin-Siris syndrome 12 [RCV003232036] Chr19:47028919..48185409 [GRCh37]
Chr19:19q13.32-13.33		 likely pathogenic
NM_004491.5(ARHGAP35):c.1718T>C (p.Leu573Ser) single nucleotide variant not specified [RCV004299105] Chr19:46920393 [GRCh38]
Chr19:47423650 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4294T>C (p.Cys1432Arg) single nucleotide variant Anophthalmia [RCV002460355] Chr19:47000482 [GRCh38]
Chr19:47503739 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4235T>C (p.Met1412Thr) single nucleotide variant Martsolf syndrome 1 [RCV002305652] Chr19:47000423 [GRCh38]
Chr19:47503680 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.352A>T (p.Lys118Ter) single nucleotide variant Martsolf syndrome 1 [RCV002305669] Chr19:46919027 [GRCh38]
Chr19:47422284 [GRCh37]
Chr19:19q13.32		 likely pathogenic
NM_004491.5(ARHGAP35):c.516del (p.Asn173fs) deletion Martsolf syndrome 1 [RCV002305670] Chr19:46919190 [GRCh38]
Chr19:47422447 [GRCh37]
Chr19:19q13.32		 likely pathogenic
NM_004491.5(ARHGAP35):c.1849C>T (p.Arg617Ter) single nucleotide variant Bilateral microphthalmos [RCV002460354] Chr19:46920524 [GRCh38]
Chr19:47423781 [GRCh37]
Chr19:19q13.32		 pathogenic
NM_004491.5(ARHGAP35):c.4049G>A (p.Arg1350Gln) single nucleotide variant Martsolf syndrome 1 [RCV002305650] Chr19:46999316 [GRCh38]
Chr19:47502573 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4105C>G (p.His1369Asp) single nucleotide variant Martsolf syndrome 1 [RCV002305651] Chr19:46999372 [GRCh38]
Chr19:47502629 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4297C>G (p.Pro1433Ala) single nucleotide variant Martsolf syndrome 1 [RCV002305654] Chr19:47000485 [GRCh38]
Chr19:47503742 [GRCh37]
Chr19:19q13.32		 likely benign
NM_004491.5(ARHGAP35):c.4255C>T (p.Arg1419Cys) single nucleotide variant Martsolf syndrome 1 [RCV002305657] Chr19:47000443 [GRCh38]
Chr19:47503700 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4018G>A (p.Asp1340Asn) single nucleotide variant Martsolf syndrome 1 [RCV002305658] Chr19:46989657 [GRCh38]
Chr19:47492914 [GRCh37]
Chr19:19q13.32		 likely benign
NM_004491.5(ARHGAP35):c.4251del (p.Thr1418fs) deletion Unilateral microphthalmos [RCV002460352] Chr19:47000438 [GRCh38]
Chr19:47503695 [GRCh37]
Chr19:19q13.32		 pathogenic
NM_004491.5(ARHGAP35):c.4240G>A (p.Ala1414Thr) single nucleotide variant Martsolf syndrome 1 [RCV002305653] Chr19:47000428 [GRCh38]
Chr19:47503685 [GRCh37]
Chr19:19q13.32		 likely benign
NM_004491.5(ARHGAP35):c.3283_3286delinsT (p.Val1095_Lys1096delinsTer) indel Martsolf syndrome 1 [RCV002305656] Chr19:46921958..46921961 [GRCh38]
Chr19:47425215..47425218 [GRCh37]
Chr19:19q13.32		 likely pathogenic
NM_004491.5(ARHGAP35):c.325C>T (p.Arg109Ter) single nucleotide variant Martsolf syndrome 1 [RCV002305667] Chr19:46919000 [GRCh38]
Chr19:47422257 [GRCh37]
Chr19:19q13.32		 likely pathogenic
NM_004491.5(ARHGAP35):c.3850C>T (p.Arg1284Trp) single nucleotide variant Martsolf syndrome 1 [RCV002305672] Chr19:46988012 [GRCh38]
Chr19:47491269 [GRCh37]
Chr19:19q13.32		 likely pathogenic
NM_004491.5(ARHGAP35):c.3992C>T (p.Pro1331Leu) single nucleotide variant Martsolf syndrome 1 [RCV002305673] Chr19:46989631 [GRCh38]
Chr19:47492888 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2565C>A (p.Tyr855Ter) single nucleotide variant Martsolf syndrome 1 [RCV002305655] Chr19:46921240 [GRCh38]
Chr19:47424497 [GRCh37]
Chr19:19q13.32		 likely pathogenic
NM_004491.5(ARHGAP35):c.1800_1803del (p.Val601fs) deletion Martsolf syndrome 1 [RCV002305671] Chr19:46920473..46920476 [GRCh38]
Chr19:47423730..47423733 [GRCh37]
Chr19:19q13.32		 likely pathogenic
NM_004491.5(ARHGAP35):c.345del (p.Tyr116fs) deletion Martsolf syndrome 1 [RCV002305668] Chr19:46919018 [GRCh38]
Chr19:47422275 [GRCh37]
Chr19:19q13.32		 likely pathogenic
NM_004491.5(ARHGAP35):c.3569_3570del (p.Glu1190fs) microsatellite Martsolf syndrome 1 [RCV002305660] Chr19:46922242..46922243 [GRCh38]
Chr19:47425499..47425500 [GRCh37]
Chr19:19q13.32		 likely pathogenic
NM_004491.5(ARHGAP35):c.4444del (p.Gln1482fs) deletion Irido-corneo-trabecular dysgenesis [RCV002460353] Chr19:47000627 [GRCh38]
Chr19:47503884 [GRCh37]
Chr19:19q13.32		 pathogenic
NM_004491.5(ARHGAP35):c.1710T>G (p.Ile570Met) single nucleotide variant not specified [RCV004100958] Chr19:46920385 [GRCh38]
Chr19:47423642 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2974T>C (p.Ser992Pro) single nucleotide variant not specified [RCV004239062] Chr19:46921649 [GRCh38]
Chr19:47424906 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.866A>G (p.Asn289Ser) single nucleotide variant not specified [RCV004240387] Chr19:46919541 [GRCh38]
Chr19:47422798 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2828A>G (p.Glu943Gly) single nucleotide variant not specified [RCV004152910] Chr19:46921503 [GRCh38]
Chr19:47424760 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2905A>C (p.Asn969His) single nucleotide variant not specified [RCV004098564] Chr19:46921580 [GRCh38]
Chr19:47424837 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.1322A>G (p.Glu441Gly) single nucleotide variant not specified [RCV004085151] Chr19:46919997 [GRCh38]
Chr19:47423254 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4316G>A (p.Arg1439Gln) single nucleotide variant not specified [RCV004247173] Chr19:47000504 [GRCh38]
Chr19:47503761 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.3319G>A (p.Val1107Met) single nucleotide variant not specified [RCV004247221] Chr19:46921994 [GRCh38]
Chr19:47425251 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.416T>C (p.Leu139Pro) single nucleotide variant not specified [RCV004178554] Chr19:46919091 [GRCh38]
Chr19:47422348 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2066G>A (p.Arg689Gln) single nucleotide variant not specified [RCV004124672] Chr19:46920741 [GRCh38]
Chr19:47423998 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2476A>G (p.Ile826Val) single nucleotide variant not specified [RCV004146423] Chr19:46921151 [GRCh38]
Chr19:47424408 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2395A>C (p.Ile799Leu) single nucleotide variant not specified [RCV004112740] Chr19:46921070 [GRCh38]
Chr19:47424327 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2051C>G (p.Ser684Cys) single nucleotide variant not specified [RCV004093295] Chr19:46920726 [GRCh38]
Chr19:47423983 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.890G>A (p.Arg297Gln) single nucleotide variant not specified [RCV004246642] Chr19:46919565 [GRCh38]
Chr19:47422822 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.3022G>A (p.Asp1008Asn) single nucleotide variant not specified [RCV004218747] Chr19:46921697 [GRCh38]
Chr19:47424954 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.3406A>G (p.Ser1136Gly) single nucleotide variant not specified [RCV004167309] Chr19:46922081 [GRCh38]
Chr19:47425338 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.1378A>T (p.Met460Leu) single nucleotide variant not specified [RCV004099528] Chr19:46920053 [GRCh38]
Chr19:47423310 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.3049G>C (p.Glu1017Gln) single nucleotide variant not specified [RCV004166285] Chr19:46921724 [GRCh38]
Chr19:47424981 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4270A>G (p.Ile1424Val) single nucleotide variant not specified [RCV004095691] Chr19:47000458 [GRCh38]
Chr19:47503715 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.145G>A (p.Glu49Lys) single nucleotide variant not specified [RCV004265587] Chr19:46918820 [GRCh38]
Chr19:47422077 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2674G>A (p.Ala892Thr) single nucleotide variant not specified [RCV004252478] Chr19:46921349 [GRCh38]
Chr19:47424606 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2921G>A (p.Gly974Glu) single nucleotide variant not specified [RCV004287002] Chr19:46921596 [GRCh38]
Chr19:47424853 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2814dup (p.Lys939Ter) duplication Neurodevelopmental disorder [RCV003225665] Chr19:46921483..46921484 [GRCh38]
Chr19:47424740..47424741 [GRCh37]
Chr19:19q13.32		 pathogenic
NM_004491.5(ARHGAP35):c.4048C>T (p.Arg1350Trp) single nucleotide variant not specified [RCV004341168] Chr19:46999315 [GRCh38]
Chr19:47502572 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19q13.32(chr19:47185918-47435756)x3 copy number gain not specified [RCV003986114] Chr19:47185918..47435756 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2692A>G (p.Asn898Asp) single nucleotide variant not specified [RCV004422688] Chr19:46921367 [GRCh38]
Chr19:47424624 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4259C>G (p.Thr1420Ser) single nucleotide variant not specified [RCV004422692] Chr19:47000447 [GRCh38]
Chr19:47503704 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2171T>C (p.Ile724Thr) single nucleotide variant not specified [RCV004422684] Chr19:46920846 [GRCh38]
Chr19:47424103 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2965A>G (p.Ile989Val) single nucleotide variant not specified [RCV004422689] Chr19:46921640 [GRCh38]
Chr19:47424897 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.3718G>A (p.Ala1240Thr) single nucleotide variant not specified [RCV004422690] Chr19:46937300 [GRCh38]
Chr19:47440557 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4339G>A (p.Ala1447Thr) single nucleotide variant not specified [RCV004422693] Chr19:47000527 [GRCh38]
Chr19:47503784 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.860A>G (p.Asn287Ser) single nucleotide variant not specified [RCV004422695] Chr19:46919535 [GRCh38]
Chr19:47422792 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.1304C>T (p.Ala435Val) single nucleotide variant not specified [RCV004422681] Chr19:46919979 [GRCh38]
Chr19:47423236 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.1742C>T (p.Pro581Leu) single nucleotide variant not specified [RCV004422682] Chr19:46920417 [GRCh38]
Chr19:47423674 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2647A>G (p.Ile883Val) single nucleotide variant not specified [RCV004422686] Chr19:46921322 [GRCh38]
Chr19:47424579 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2035G>A (p.Glu679Lys) single nucleotide variant not specified [RCV004422683] Chr19:46920710 [GRCh38]
Chr19:47423967 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2237T>C (p.Ile746Thr) single nucleotide variant not specified [RCV004422685] Chr19:46920912 [GRCh38]
Chr19:47424169 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4123G>A (p.Val1375Ile) single nucleotide variant not specified [RCV004422691] Chr19:46999390 [GRCh38]
Chr19:47502647 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.979C>G (p.Arg327Gly) single nucleotide variant not specified [RCV004422696] Chr19:46919654 [GRCh38]
Chr19:47422911 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2671G>A (p.Gly891Ser) single nucleotide variant not specified [RCV004422687] Chr19:46921346 [GRCh38]
Chr19:47424603 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4363G>A (p.Val1455Met) single nucleotide variant not specified [RCV004422694] Chr19:47000551 [GRCh38]
Chr19:47503808 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.1238A>G (p.Glu413Gly) single nucleotide variant not specified [RCV004669417] Chr19:46919913 [GRCh38]
Chr19:47423170 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4439C>T (p.Thr1480Ile) single nucleotide variant not specified [RCV004669421] Chr19:47000627 [GRCh38]
Chr19:47503884 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.43A>C (p.Asn15His) single nucleotide variant not specified [RCV004665051] Chr19:46918718 [GRCh38]
Chr19:47421975 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2614G>A (p.Ala872Thr) single nucleotide variant ARHGAP35-related condition [RCV004732245] Chr19:46921289 [GRCh38]
Chr19:47424546 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.3116C>T (p.Pro1039Leu) single nucleotide variant ARHGAP35-related condition [RCV004759026] Chr19:46921791 [GRCh38]
Chr19:47425048 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.1958C>T (p.Thr653Met) single nucleotide variant not specified [RCV004848452] Chr19:46920633 [GRCh38]
Chr19:47423890 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.3176T>C (p.Leu1059Ser) single nucleotide variant not specified [RCV004848475] Chr19:46921851 [GRCh38]
Chr19:47425108 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.989A>G (p.His330Arg) single nucleotide variant not specified [RCV004848484] Chr19:46919664 [GRCh38]
Chr19:47422921 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2881T>G (p.Cys961Gly) single nucleotide variant not specified [RCV004848518] Chr19:46921556 [GRCh38]
Chr19:47424813 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.157G>A (p.Asp53Asn) single nucleotide variant not specified [RCV004848489] Chr19:46918832 [GRCh38]
Chr19:47422089 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.127G>A (p.Val43Met) single nucleotide variant not specified [RCV004848500] Chr19:46918802 [GRCh38]
Chr19:47422059 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2927C>T (p.Pro976Leu) single nucleotide variant not specified [RCV004848510] Chr19:46921602 [GRCh38]
Chr19:47424859 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.154T>G (p.Leu52Val) single nucleotide variant not specified [RCV005396049] Chr19:46918829 [GRCh38]
Chr19:47422086 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2075A>G (p.His692Arg) single nucleotide variant not specified [RCV005396040] Chr19:46920750 [GRCh38]
Chr19:47424007 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19q13.32-13.33(chr19:45531056-48174177)x3 copy number gain not provided [RCV001007051] Chr19:45531056..48174177 [GRCh37]
Chr19:19q13.32-13.33		 uncertain significance
NM_004491.5(ARHGAP35):c.4426T>A (p.Ser1476Thr) single nucleotide variant not specified [RCV004314533] Chr19:47000614 [GRCh38]
Chr19:47503871 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.3327T>G (p.His1109Gln) single nucleotide variant not specified [RCV004665043] Chr19:46922002 [GRCh38]
Chr19:47425259 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.970C>T (p.His324Tyr) single nucleotide variant not specified [RCV004848341] Chr19:46919645 [GRCh38]
Chr19:47422902 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2857A>G (p.Met953Val) single nucleotide variant not specified [RCV004848390] Chr19:46921532 [GRCh38]
Chr19:47424789 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.1738C>T (p.Arg580Trp) single nucleotide variant not specified [RCV004848430] Chr19:46920413 [GRCh38]
Chr19:47423670 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2320A>G (p.Ile774Val) single nucleotide variant not specified [RCV004848463] Chr19:46920995 [GRCh38]
Chr19:47424252 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4247C>T (p.Thr1416Ile) single nucleotide variant not specified [RCV004848420] Chr19:47000435 [GRCh38]
Chr19:47503692 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.1916C>G (p.Pro639Arg) single nucleotide variant not specified [RCV004848410] Chr19:46920591 [GRCh38]
Chr19:47423848 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2042G>A (p.Ser681Asn) single nucleotide variant not specified [RCV004848352] Chr19:46920717 [GRCh38]
Chr19:47423974 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4493C>T (p.Thr1498Met) single nucleotide variant not specified [RCV004848371] Chr19:47000681 [GRCh38]
Chr19:47503938 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.239G>T (p.Ser80Ile) single nucleotide variant not specified [RCV004848380] Chr19:46918914 [GRCh38]
Chr19:47422171 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2509G>A (p.Val837Ile) single nucleotide variant not specified [RCV004848441] Chr19:46921184 [GRCh38]
Chr19:47424441 [GRCh37]
Chr19:19q13.32		 likely benign
NM_004491.5(ARHGAP35):c.3040A>G (p.Met1014Val) single nucleotide variant not specified [RCV004848401] Chr19:46921715 [GRCh38]
Chr19:47424972 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.2333C>T (p.Ala778Val) single nucleotide variant not specified [RCV005396015] Chr19:46921008 [GRCh38]
Chr19:47424265 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.1739G>A (p.Arg580Gln) single nucleotide variant not specified [RCV005396028] Chr19:46920414 [GRCh38]
Chr19:47423671 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.4387A>C (p.Thr1463Pro) single nucleotide variant not specified [RCV005396021] Chr19:47000575 [GRCh38]
Chr19:47503832 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_004491.5(ARHGAP35):c.3836C>T (p.Thr1279Met) single nucleotide variant not specified [RCV005396030] Chr19:46987998 [GRCh38]
Chr19:47491255 [GRCh37]
Chr19:19q13.32		 uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:3464
Count of miRNA genes:1142
Interacting mature miRNAs:1477
Transcripts:ENST00000404338, ENST00000595822, ENST00000596593, ENST00000598548, ENST00000599284
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559110SCL22_HSerum cholesterol level QTL 22 (human)3.590.000241Lipid levelLDL cholesterol193190759457907594Human
406970483GWAS619459_Hresponse to cisplatin QTL GWAS619459 (human)0.000007response to cisplatin194698066546980666Human
597099124GWAS1195198_Hspondylosis QTL GWAS1195198 (human)0.00001spondylosis194688124246881243Human
597117732GWAS1213806_Hserum gamma-glutamyl transferase measurement QTL GWAS1213806 (human)0.000009blood gamma-glutamyltransferase amount (VT:0010607)serum gamma-glutamyltransferase activity level (CMO:0002241)194691172946911730Human
597309753GWAS1405827_Hcortical thickness QTL GWAS1405827 (human)5e-08cerebral cortex morphology trait (VT:0000788)194696051546960516Human
597136785GWAS1232859_Hneuroimaging measurement QTL GWAS1232859 (human)3e-12nervous system morphology trait (VT:0003632)194695621946956220Human
597099440GWAS1195514_Haspartate aminotransferase measurement QTL GWAS1195514 (human)2e-08blood aspartate transaminase amount (VT:0000203)blood aspartate aminotransferase activity level (CMO:0000580)194693221446932215Human
597396240GWAS1492314_Hcup-to-disc ratio measurement QTL GWAS1492314 (human)2e-08optic disc morphology trait (VT:0006215)194695205846952059Human
597083757GWAS1179831_Hwhite matter hyperintensity measurement QTL GWAS1179831 (human)0.000009brain morphology trait (VT:0002152)194697842546978426Human
1331657COPD9_HChronic obstructive pulmonary disease QTL 9 (human)1.94Chronic airflow obstructionpost-bronchodilator FEV1193102176057021760Human
597265988GWAS1362062_Heducational attainment QTL GWAS1362062 (human)3e-08educational attainment194697984846979849Human
596962506GWAS1082025_Hbrain measurement QTL GWAS1082025 (human)1e-11brain measurement194697741746977418Human

Markers in Region
D18S1154  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37183,892,030 - 3,892,305UniSTSGRCh37
GRCh371947,440,384 - 47,440,911UniSTSGRCh37
Build 36183,882,030 - 3,882,305RGDNCBI36
Celera1944,244,744 - 44,245,271UniSTS
Celera183,775,773 - 3,776,044RGD
Cytogenetic Map19q13.3UniSTS
HuRef1943,865,181 - 43,865,708UniSTS
HuRef183,856,188 - 3,856,459UniSTS
Marshfield Genetic Map188.3RGD
Marshfield Genetic Map188.3UniSTS
Genethon Genetic Map187.8UniSTS
TNG Radiation Hybrid Map181300.0UniSTS
deCODE Assembly Map1811.43UniSTS
Whitehead-YAC Contig Map18 UniSTS
D19S540  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371947,507,079 - 47,507,263UniSTSGRCh37
Build 361952,198,919 - 52,199,103RGDNCBI36
Celera1944,311,434 - 44,311,618RGD
Cytogenetic Map19q13.3UniSTS
HuRef1943,931,503 - 43,931,685UniSTS
Marshfield Genetic Map1970.14UniSTS
Marshfield Genetic Map1970.14RGD
RH15918  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371947,484,248 - 47,484,370UniSTSGRCh37
Build 361952,176,088 - 52,176,210RGDNCBI36
Celera1944,288,609 - 44,288,731RGD
Cytogenetic Map19q13.3UniSTS
HuRef1943,908,676 - 43,908,798UniSTS
GeneMap99-GB4 RH Map19255.29UniSTS
RH79947  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371947,507,307 - 47,507,501UniSTSGRCh37
Build 361952,199,147 - 52,199,341RGDNCBI36
Celera1944,311,662 - 44,311,856RGD
Cytogenetic Map19q13.3UniSTS
HuRef1943,931,729 - 43,931,923UniSTS
D19S851  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371947,465,674 - 47,465,814UniSTSGRCh37
Build 361952,157,514 - 52,157,654RGDNCBI36
Celera1944,270,035 - 44,270,175RGD
HuRef1943,890,853 - 43,890,993UniSTS
TNG Radiation Hybrid Map1917661.0UniSTS
Stanford-G3 RH Map192371.0UniSTS
NCBI RH Map19513.0UniSTS
RH68444  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371947,431,358 - 47,431,481UniSTSGRCh37
Build 361952,123,198 - 52,123,321RGDNCBI36
Celera1944,235,716 - 44,235,839RGD
Cytogenetic Map19q13.3UniSTS
HuRef1943,856,152 - 43,856,275UniSTS
GeneMap99-GB4 RH Map19264.72UniSTS
RH67855  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371947,504,442 - 47,504,614UniSTSGRCh37
Build 361952,196,282 - 52,196,454RGDNCBI36
Celera1944,308,797 - 44,308,969RGD
Cytogenetic Map19q13.3UniSTS
HuRef1943,928,866 - 43,929,038UniSTS
GeneMap99-GB4 RH Map19265.62UniSTS
NCBI RH Map19524.0UniSTS
STS-N25336  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371947,504,413 - 47,504,615UniSTSGRCh37
Build 361952,196,253 - 52,196,455RGDNCBI36
Celera1944,308,768 - 44,308,970RGD
Cytogenetic Map19q13.3UniSTS
HuRef1943,928,837 - 43,929,039UniSTS
GeneMap99-GB4 RH Map19264.83UniSTS
NCBI RH Map19516.7UniSTS
RH12331  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371947,484,193 - 47,484,327UniSTSGRCh37
Build 361952,176,033 - 52,176,167RGDNCBI36
Celera1944,288,554 - 44,288,688RGD
Cytogenetic Map19q13.3UniSTS
HuRef1943,908,621 - 43,908,755UniSTS
GeneMap99-GB4 RH Map1931.92UniSTS
WI-9140  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19q13.3UniSTS
GeneMap99-GB4 RH Map19255.29UniSTS
Whitehead-RH Map19342.0UniSTS
NCBI RH Map19541.0UniSTS
RH77962  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19q13.3UniSTS
GeneMap99-GB4 RH Map19266.47UniSTS
D19S851  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19q13.3UniSTS
TNG Radiation Hybrid Map1917661.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2432 2788 2245 4942 1723 2345 4 622 1948 464 2268 7281 6454 52 3708 847 1731 1612 171

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_047014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024451473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002958305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008485136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB051509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF159851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL831914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE871213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM855708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA429690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX163309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LS482328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M73077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000404338   ⟹   ENSP00000385720
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1946,918,676 - 47,005,066 (+)Ensembl
Ensembl Acc Id: ENST00000595822
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1946,937,320 - 47,001,425 (+)Ensembl
Ensembl Acc Id: ENST00000596593
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1946,989,584 - 46,997,750 (+)Ensembl
Ensembl Acc Id: ENST00000598548
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1946,999,085 - 46,999,815 (+)Ensembl
Ensembl Acc Id: ENST00000599284
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1946,999,098 - 47,000,949 (+)Ensembl
Ensembl Acc Id: ENST00000614079   ⟹   ENSP00000483730
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1946,918,676 - 47,004,307 (+)Ensembl
Ensembl Acc Id: ENST00000672722   ⟹   ENSP00000500409
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1946,860,997 - 47,005,077 (+)Ensembl
Ensembl Acc Id: ENST00000700035
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1946,920,783 - 46,952,263 (+)Ensembl
RefSeq Acc Id: NM_004491   ⟹   NP_004482
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,860,997 - 47,005,077 (+)NCBI
GRCh371947,421,824 - 47,508,334 (+)NCBI
Build 361952,113,773 - 52,200,174 (+)NCBI Archive
HuRef1943,846,727 - 43,932,756 (+)ENTREZGENE
CHM1_11947,423,799 - 47,510,216 (+)NCBI
T2T-CHM13v2.01949,686,835 - 49,830,977 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024451473   ⟹   XP_024307241
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,860,997 - 47,000,073 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054320752   ⟹   XP_054176727
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01949,686,835 - 49,825,970 (+)NCBI
RefSeq Acc Id: XR_002958305
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,860,997 - 46,999,374 (+)NCBI
Sequence:
RefSeq Acc Id: XR_008485136
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01949,686,835 - 49,825,271 (+)NCBI
RefSeq Acc Id: NP_004482   ⟸   NM_004491
- UniProtKB: Q14452 (UniProtKB/Swiss-Prot),   A7E2A4 (UniProtKB/Swiss-Prot),   Q9C0E1 (UniProtKB/Swiss-Prot),   Q9NRY4 (UniProtKB/Swiss-Prot),   A0A2X0SFV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024307241   ⟸   XM_024451473
- Peptide Label: isoform X1
- UniProtKB: A0A2X0SFV3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000483730   ⟸   ENST00000614079
Ensembl Acc Id: ENSP00000385720   ⟸   ENST00000404338
Ensembl Acc Id: ENSP00000500409   ⟸   ENST00000672722
RefSeq Acc Id: XP_054176727   ⟸   XM_054320752
- Peptide Label: isoform X1
- UniProtKB: A0A2X0SFV3 (UniProtKB/TrEMBL)
Protein Domains
FF   pG1 pseudoGTPase   pG2 pseudoGTPase   Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9NRY4-F1-model_v2 AlphaFold Q9NRY4 1-1499 view protein structure

Promoters
RGD ID:13204777
Promoter ID:EPDNEW_H26008
Type:initiation region
Name:ARHGAP35_2
Description:Rho GTPase activating protein 35
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26010  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,860,625 - 46,860,685EPDNEW
RGD ID:13204781
Promoter ID:EPDNEW_H26010
Type:initiation region
Name:ARHGAP35_1
Description:Rho GTPase activating protein 35
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26008  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,861,111 - 46,861,171EPDNEW
RGD ID:6795633
Promoter ID:HG_KWN:30366
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Jurkat
Transcripts:ENST00000317082,   ENST00000404338,   NM_004491
Position:
Human AssemblyChrPosition (strand)Source
Build 361952,115,816 - 52,116,316 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4591 AgrOrtholog
COSMIC ARHGAP35 COSMIC
Ensembl Genes ENSG00000160007 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000672722 ENTREZGENE
  ENST00000672722.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.440 UniProtKB/Swiss-Prot
  1.10.555.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
GTEx ENSG00000160007 GTEx
HGNC ID HGNC:4591 ENTREZGENE
Human Proteome Map ARHGAP35 Human Proteome Map
InterPro FF_domain UniProtKB/Swiss-Prot
  FF_domain_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  pG1 UniProtKB/Swiss-Prot
  Rho-GAP_domain UniProtKB/Swiss-Prot
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot
  RhoGAP-FF1 UniProtKB/Swiss-Prot
  RhoGAP_dom UniProtKB/Swiss-Prot
  RhoGAP_pG1_pG2 UniProtKB/Swiss-Prot
  RhoGAP_pG2 UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
KEGG Report hsa:2909 UniProtKB/Swiss-Prot
NCBI Gene 2909 ENTREZGENE
OMIM 605277 OMIM
PANTHER RHO GTPASE-ACTIVATING PROTEIN 190 UniProtKB/Swiss-Prot
  RHO GTPASE-ACTIVATING PROTEIN 35 UniProtKB/Swiss-Prot
Pfam FF_RHG35_4th UniProtKB/Swiss-Prot
  Ras UniProtKB/Swiss-Prot
  RhoGAP UniProtKB/Swiss-Prot
  RhoGAP-FF1 UniProtKB/Swiss-Prot
  RhoGAP_pG1_pG2 UniProtKB/Swiss-Prot
PharmGKB PA28988 PharmGKB
PROSITE PG1 UniProtKB/Swiss-Prot
  PG2 UniProtKB/Swiss-Prot
  PS51676 UniProtKB/Swiss-Prot
  RHOGAP UniProtKB/Swiss-Prot
SMART RhoGAP UniProtKB/Swiss-Prot
  SM00441 UniProtKB/Swiss-Prot
Superfamily-SCOP Rho_GAP UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF81698 UniProtKB/Swiss-Prot
UniProt A0A2X0SFV3 ENTREZGENE, UniProtKB/TrEMBL
  A7E2A4 ENTREZGENE
  Q14452 ENTREZGENE
  Q9C0E1 ENTREZGENE
  Q9NRY4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A7E2A4 UniProtKB/Swiss-Prot
  Q14452 UniProtKB/Swiss-Prot
  Q9C0E1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 ARHGAP35  Rho GTPase activating protein 35  GRLF1  glucocorticoid receptor DNA binding factor 1  Symbol and/or name change 5135510 APPROVED