PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1) - Rat Genome Database

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Gene: PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1) Homo sapiens
Analyze
Symbol: PREX1
Name: phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
RGD ID: 1603014
HGNC Page HGNC:32594
Description: Enables phospholipid binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of signaling. Predicted to act upstream of or within several processes, including neutrophil chemotaxis; positive regulation of GTPase activity; and positive regulation of substrate adhesion-dependent cell spreading. Located in cytosol. Biomarker of prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: KIAA1415; LOC105372648; P-REX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1; PIP3 dependent Rac exchange factor 1; ptdIns(3,4,5)-dependent Rac exchanger 1; uncharacterized LOC105372648
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382048,624,252 - 48,888,185 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2048,624,252 - 48,827,999 (-)EnsemblGRCh38hg38GRCh38
GRCh372047,240,790 - 47,444,536 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362046,674,200 - 46,877,827 (-)NCBINCBI36Build 36hg18NCBI36
Celera2043,945,979 - 44,149,646 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2043,990,060 - 44,195,320 (-)NCBIHuRef
CHM1_12047,145,458 - 47,349,091 (-)NCBICHM1_1
T2T-CHM13v2.02050,394,065 - 50,597,825 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-palmitoylglycerol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
alpha-Zearalanol  (ISO)
antirheumatic drug  (EXP)
aristolochic acid A  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
C60 fullerene  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
cerium trichloride  (EXP)
chloroprene  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
D-glucose  (EXP)
dexamethasone  (EXP)
Dibutyl phosphate  (EXP)
dieldrin  (ISO)
disodium selenite  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
Enterolactone  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
FR900359  (EXP)
genistein  (EXP)
gentamycin  (ISO)
glucose  (EXP)
glyphosate  (ISO)
indometacin  (EXP)
lanthanum trichloride  (EXP)
methapyrilene  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
microcystin-LR  (ISO)
nickel atom  (EXP)
nitrogen dioxide  (EXP)
O-methyleugenol  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
permethrin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
SB 431542  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
Soman  (ISO)
sotorasib  (EXP)
temozolomide  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trametinib  (EXP)
trichostatin A  (EXP)
triclosan  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IDA,IEA,TAS)
dendritic shaft  (IEA,ISO)
growth cone  (IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (IBA,IEA,TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. Qin J, etal., Oncogene. 2009 Apr 23;28(16):1853-63. Epub 2009 Mar 23.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
Additional References at PubMed
PMID:10718198   PMID:11230166   PMID:11549316   PMID:11756498   PMID:11780052   PMID:11955434   PMID:12123595   PMID:12168954   PMID:12376548   PMID:12477932   PMID:12787561   PMID:14702039  
PMID:15489334   PMID:15545267   PMID:16301320   PMID:17227822   PMID:17353931   PMID:17565979   PMID:17698854   PMID:17903302   PMID:18029348   PMID:18602983   PMID:18697831   PMID:19911011  
PMID:20018810   PMID:20036214   PMID:20074642   PMID:20379614   PMID:20650312   PMID:21042280   PMID:21172654   PMID:21339740   PMID:21441931   PMID:21636851   PMID:21873635   PMID:22207728  
PMID:22242915   PMID:22321011   PMID:22558309   PMID:23033535   PMID:23382862   PMID:23478800   PMID:23496005   PMID:23899556   PMID:25248717   PMID:25284585   PMID:26112412   PMID:26621702  
PMID:26792863   PMID:26797121   PMID:26923603   PMID:27025967   PMID:27150042   PMID:27351228   PMID:27358402   PMID:27481946   PMID:27788493   PMID:28051998   PMID:28162770   PMID:28694325  
PMID:28710285   PMID:29507755   PMID:29509190   PMID:30018141   PMID:30442662   PMID:30446620   PMID:30530493   PMID:31182584   PMID:31473760   PMID:31527615   PMID:31636389   PMID:31663027  
PMID:31871319   PMID:32203420   PMID:32661198   PMID:32785873   PMID:33061433   PMID:33412417   PMID:33961781   PMID:34624316   PMID:35575683   PMID:35748872   PMID:35831314   PMID:35864164  
PMID:35914814   PMID:36215168   PMID:36638890   PMID:37434402   PMID:37689310   PMID:37827155   PMID:38329813   PMID:39082940  


Genomics

Comparative Map Data
PREX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382048,624,252 - 48,888,185 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2048,624,252 - 48,827,999 (-)EnsemblGRCh38hg38GRCh38
GRCh372047,240,790 - 47,444,536 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362046,674,200 - 46,877,827 (-)NCBINCBI36Build 36hg18NCBI36
Celera2043,945,979 - 44,149,646 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2043,990,060 - 44,195,320 (-)NCBIHuRef
CHM1_12047,145,458 - 47,349,091 (-)NCBICHM1_1
T2T-CHM13v2.02050,394,065 - 50,597,825 (-)NCBIT2T-CHM13v2.0
Prex1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392166,408,265 - 166,555,752 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2166,408,262 - 166,555,752 (-)EnsemblGRCm39 Ensembl
GRCm382166,566,345 - 166,713,832 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2166,566,342 - 166,713,832 (-)EnsemblGRCm38mm10GRCm38
MGSCv372166,391,845 - 166,539,332 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,256,959 - 166,405,037 (-)NCBIMGSCv36mm8
Celera2172,502,260 - 172,653,067 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.09NCBI
Prex1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83175,724,939 - 175,875,764 (-)NCBIGRCr8
mRatBN7.23155,306,950 - 155,456,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,306,950 - 155,456,688 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,108,046 - 159,257,416 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03167,607,015 - 167,756,375 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,348,709 - 165,498,079 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,329,580 - 163,477,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,329,975 - 163,477,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03169,494,331 - 169,575,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43157,693,897 - 157,863,943 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13157,599,463 - 157,770,600 (-)NCBI
Celera3153,891,483 - 154,040,542 (-)NCBICelera
Cytogenetic Map3q42NCBI
Prex1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554459,229,793 - 9,398,662 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554459,229,775 - 9,401,277 (+)NCBIChiLan1.0ChiLan1.0
PREX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22154,369,425 - 54,573,462 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12054,362,530 - 54,566,568 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02044,965,850 - 45,169,891 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12046,034,724 - 46,157,984 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2046,033,937 - 46,226,500 (-)Ensemblpanpan1.1panPan2
PREX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12435,403,078 - 35,503,428 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2435,404,564 - 35,582,041 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2434,646,334 - 34,825,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02436,111,037 - 36,287,341 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2436,112,187 - 36,287,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12435,349,797 - 35,528,690 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02435,484,549 - 35,662,320 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02436,026,106 - 36,205,507 (-)NCBIUU_Cfam_GSD_1.0
Prex1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640189,903,846 - 189,990,356 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365145,368,629 - 5,444,003 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365145,291,473 - 5,443,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1750,354,775 - 50,550,637 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11750,352,273 - 50,550,402 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PREX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1215,152,001 - 15,354,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl215,152,096 - 15,354,544 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605063,656,144 - 63,859,525 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prex1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247906,453,066 - 6,637,597 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247906,453,085 - 6,622,179 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PREX1
151 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20q13.12-13.33(chr20:44787704-64277321)x3 copy number gain See cases [RCV000053035] Chr20:44787704..64277321 [GRCh38]
Chr20:43416345..62908674 [GRCh37]
Chr20:42849759..62379118 [NCBI36]
Chr20:20q13.12-13.33		 pathogenic
NM_020820.3(PREX1):c.1168G>A (p.Glu390Lys) single nucleotide variant Malignant melanoma [RCV000072674] Chr20:48690965 [GRCh38]
Chr20:47307503 [GRCh37]
Chr20:46740910 [NCBI36]
Chr20:20q13.13		 not provided
NM_020820.3(PREX1):c.816C>T (p.Leu272=) single nucleotide variant Malignant melanoma [RCV000072675] Chr20:48700854 [GRCh38]
Chr20:47317392 [GRCh37]
Chr20:46750799 [NCBI36]
Chr20:20q13.13		 not provided
NM_020820.3(PREX1):c.622-2145C>A single nucleotide variant Lung cancer [RCV000101631] Chr20:48710566 [GRCh38]
Chr20:47327104 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.3(PREX1):c.220-35281C>T single nucleotide variant Lung cancer [RCV000101632] Chr20:48783161 [GRCh38]
Chr20:47399698 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.3(PREX1):c.219+39529A>T single nucleotide variant Lung cancer [RCV000101633] Chr20:48788113 [GRCh38]
Chr20:47404650 [GRCh37]
Chr20:20q13.13		 uncertain significance
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33		 pathogenic
GRCh38/hg38 20q13.13(chr20:48756586-49532355)x3 copy number gain See cases [RCV000139593] Chr20:48756586..49532355 [GRCh38]
Chr20:47373123..48148892 [GRCh37]
Chr20:46806530..47582299 [NCBI36]
Chr20:20q13.13		 uncertain significance
GRCh37/hg19 20q13.13(chr20:46874875-47442163)x1 copy number loss not provided [RCV000487927] Chr20:46874875..47442163 [GRCh37]
Chr20:20q13.13		 uncertain significance
GRCh37/hg19 20q13.13(chr20:47427610-48085774)x3 copy number gain See cases [RCV000510231] Chr20:47427610..48085774 [GRCh37]
Chr20:20q13.13		 uncertain significance
GRCh37/hg19 20q13.13(chr20:46582570-47333968)x3 copy number gain See cases [RCV000510415] Chr20:46582570..47333968 [GRCh37]
Chr20:20q13.13		 uncertain significance
GRCh37/hg19 20q13.13(chr20:46856288-47737187)x3 copy number gain See cases [RCV000511637] Chr20:46856288..47737187 [GRCh37]
Chr20:20q13.13		 likely benign
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
NM_020820.4(PREX1):c.2130C>G (p.Ile710Met) single nucleotide variant not specified [RCV004322851] Chr20:48655369 [GRCh38]
Chr20:47271907 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.56A>G (p.His19Arg) single nucleotide variant not specified [RCV004307993] Chr20:48827805 [GRCh38]
Chr20:47444342 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.1532T>C (p.Met511Thr) single nucleotide variant not specified [RCV004309130] Chr20:48679658 [GRCh38]
Chr20:47296196 [GRCh37]
Chr20:20q13.13		 uncertain significance
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
Single allele duplication not provided [RCV000677941] Chr20:46962638..50647699 [GRCh37]
Chr20:20q13.13-13.2		 uncertain significance
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20q13.13(chr20:47177768-47262549)x3 copy number gain not provided [RCV000741246] Chr20:47177768..47262549 [GRCh37]
Chr20:20q13.13		 benign
GRCh37/hg19 20q13.13(chr20:47308798-47536334)x3 copy number gain not provided [RCV000741247] Chr20:47308798..47536334 [GRCh37]
Chr20:20q13.13		 benign
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
NM_020820.4(PREX1):c.3225C>T (p.Ile1075=) single nucleotide variant not provided [RCV000961213] Chr20:48649380 [GRCh38]
Chr20:47265918 [GRCh37]
Chr20:20q13.13		 benign
NM_020820.4(PREX1):c.2171G>A (p.Arg724His) single nucleotide variant not provided [RCV000882664] Chr20:48655328 [GRCh38]
Chr20:47271866 [GRCh37]
Chr20:20q13.13		 likely benign
NM_020820.4(PREX1):c.4851G>A (p.Thr1617=) single nucleotide variant not provided [RCV000949096] Chr20:48627879 [GRCh38]
Chr20:47244417 [GRCh37]
Chr20:20q13.13		 benign
NM_020820.4(PREX1):c.4456G>T (p.Ala1486Ser) single nucleotide variant not provided [RCV000883570] Chr20:48632347 [GRCh38]
Chr20:47248885 [GRCh37]
Chr20:20q13.13		 benign|likely benign
NM_020820.4(PREX1):c.2282A>G (p.Asn761Ser) single nucleotide variant PREX1-related disorder [RCV003936110]|not provided [RCV000971134] Chr20:48653425 [GRCh38]
Chr20:47269963 [GRCh37]
Chr20:20q13.13		 likely benign
NM_020820.4(PREX1):c.4368G>A (p.Glu1456=) single nucleotide variant not provided [RCV000959303] Chr20:48632539 [GRCh38]
Chr20:47249077 [GRCh37]
Chr20:20q13.13		 benign
NM_020820.4(PREX1):c.1698G>A (p.Ala566=) single nucleotide variant not provided [RCV000954192] Chr20:48666323 [GRCh38]
Chr20:47282861 [GRCh37]
Chr20:20q13.13		 benign
NM_020820.4(PREX1):c.1229C>T (p.Ala410Val) single nucleotide variant not specified [RCV004289238] Chr20:48688762 [GRCh38]
Chr20:47305300 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2496G>C (p.Arg832=) single nucleotide variant not provided [RCV000961214] Chr20:48651555 [GRCh38]
Chr20:47268093 [GRCh37]
Chr20:20q13.13		 benign
NM_020820.4(PREX1):c.4094G>T (p.Arg1365Leu) single nucleotide variant not specified [RCV004328406] Chr20:48636536 [GRCh38]
Chr20:47253074 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4676G>C (p.Ser1559Thr) single nucleotide variant not provided [RCV001720892] Chr20:48629539 [GRCh38]
Chr20:47246077 [GRCh37]
Chr20:20q13.13		 benign
NM_020820.4(PREX1):c.4626C>T (p.Leu1542=) single nucleotide variant not provided [RCV001621784] Chr20:48629589 [GRCh38]
Chr20:47246127 [GRCh37]
Chr20:20q13.13		 benign
NM_020820.4(PREX1):c.4044C>T (p.Tyr1348=) single nucleotide variant not provided [RCV000954524] Chr20:48636586 [GRCh38]
Chr20:47253124 [GRCh37]
Chr20:20q13.13		 benign|likely benign
NM_020820.4(PREX1):c.3972C>T (p.Asp1324=) single nucleotide variant not provided [RCV001172145] Chr20:48636658 [GRCh38]
Chr20:47253196 [GRCh37]
Chr20:20q13.13		 likely benign
NM_020820.4(PREX1):c.2275G>A (p.Val759Met) single nucleotide variant not specified [RCV004292804] Chr20:48653432 [GRCh38]
Chr20:47269970 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.1751G>T (p.Ser584Ile) single nucleotide variant not specified [RCV004325361] Chr20:48660049 [GRCh38]
Chr20:47276587 [GRCh37]
Chr20:20q13.13		 uncertain significance
GRCh37/hg19 20q13.12-13.13(chr20:42985044-48599046)x1 copy number loss Developmental and epileptic encephalopathy, 26 [RCV001801198] Chr20:42985044..48599046 [GRCh37]
Chr20:20q13.12-13.13		 pathogenic
GRCh37/hg19 20q13.13(chr20:46721299-47873110)x3 copy number gain not provided [RCV001829055] Chr20:46721299..47873110 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3352G>A (p.Ala1118Thr) single nucleotide variant not provided [RCV002034782] Chr20:48646011 [GRCh38]
Chr20:47262549 [GRCh37]
Chr20:20q13.13		 benign
NM_020820.4(PREX1):c.4850C>T (p.Thr1617Met) single nucleotide variant not specified [RCV004321249] Chr20:48627880 [GRCh38]
Chr20:47244418 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2788A>G (p.Ile930Val) single nucleotide variant not specified [RCV004313132] Chr20:48650923 [GRCh38]
Chr20:47267461 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2191G>A (p.Val731Ile) single nucleotide variant not specified [RCV004660149] Chr20:48655308 [GRCh38]
Chr20:47271846 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4817A>G (p.His1606Arg) single nucleotide variant not specified [RCV004660150] Chr20:48627913 [GRCh38]
Chr20:47244451 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3047C>T (p.Ser1016Leu) single nucleotide variant not specified [RCV004189926] Chr20:48649558 [GRCh38]
Chr20:47266096 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2620G>A (p.Val874Met) single nucleotide variant not specified [RCV004221715] Chr20:48651431 [GRCh38]
Chr20:47267969 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3148T>C (p.Phe1050Leu) single nucleotide variant not specified [RCV004134202] Chr20:48649457 [GRCh38]
Chr20:47265995 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4972G>A (p.Asp1658Asn) single nucleotide variant not specified [RCV004149615] Chr20:48625893 [GRCh38]
Chr20:47242431 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.91A>C (p.Ser31Arg) single nucleotide variant not specified [RCV004106831] Chr20:48827770 [GRCh38]
Chr20:47444307 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2620G>C (p.Val874Leu) single nucleotide variant not specified [RCV004238366] Chr20:48651431 [GRCh38]
Chr20:47267969 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3484G>A (p.Asp1162Asn) single nucleotide variant not specified [RCV004118535] Chr20:48645879 [GRCh38]
Chr20:47262417 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2169T>G (p.Ile723Met) single nucleotide variant not specified [RCV004090184] Chr20:48655330 [GRCh38]
Chr20:47271868 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3896A>C (p.Tyr1299Ser) single nucleotide variant not specified [RCV004215385] Chr20:48639774 [GRCh38]
Chr20:47256312 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2264A>G (p.Asn755Ser) single nucleotide variant not specified [RCV004193065] Chr20:48653443 [GRCh38]
Chr20:47269981 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2734G>A (p.Val912Met) single nucleotide variant not specified [RCV004144840] Chr20:48650977 [GRCh38]
Chr20:47267515 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2042T>G (p.Phe681Cys) single nucleotide variant not specified [RCV004239569] Chr20:48657121 [GRCh38]
Chr20:47273659 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.1222A>G (p.Met408Val) single nucleotide variant not specified [RCV004185129] Chr20:48688769 [GRCh38]
Chr20:47305307 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3184C>T (p.Arg1062Trp) single nucleotide variant not specified [RCV004111561] Chr20:48649421 [GRCh38]
Chr20:47265959 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4552C>G (p.Leu1518Val) single nucleotide variant not specified [RCV004167844] Chr20:48630769 [GRCh38]
Chr20:47247307 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.1874G>A (p.Arg625His) single nucleotide variant not specified [RCV004086945] Chr20:48659926 [GRCh38]
Chr20:47276464 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4706C>T (p.Ser1569Leu) single nucleotide variant not specified [RCV004173751] Chr20:48629509 [GRCh38]
Chr20:47246047 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2468C>A (p.Ala823Asp) single nucleotide variant not specified [RCV004090642] Chr20:48651583 [GRCh38]
Chr20:47268121 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4842G>T (p.Met1614Ile) single nucleotide variant not specified [RCV004104589] Chr20:48627888 [GRCh38]
Chr20:47244426 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2095C>T (p.Arg699Cys) single nucleotide variant not specified [RCV004191245] Chr20:48657068 [GRCh38]
Chr20:47273606 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3592A>T (p.Met1198Leu) single nucleotide variant not specified [RCV004120599] Chr20:48644418 [GRCh38]
Chr20:47260956 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3057G>T (p.Gln1019His) single nucleotide variant not specified [RCV004174075] Chr20:48649548 [GRCh38]
Chr20:47266086 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3131G>T (p.Gly1044Val) single nucleotide variant not specified [RCV004089433] Chr20:48649474 [GRCh38]
Chr20:47266012 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.456T>G (p.His152Gln) single nucleotide variant not specified [RCV004078083] Chr20:48734609 [GRCh38]
Chr20:47351146 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2543A>T (p.Asn848Ile) single nucleotide variant not specified [RCV004133763] Chr20:48651508 [GRCh38]
Chr20:47268046 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4126G>A (p.Val1376Ile) single nucleotide variant not specified [RCV004289789] Chr20:48636504 [GRCh38]
Chr20:47253042 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2387A>C (p.Gln796Pro) single nucleotide variant not specified [RCV004287156] Chr20:48652666 [GRCh38]
Chr20:47269204 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2170C>T (p.Arg724Cys) single nucleotide variant not specified [RCV004281144] Chr20:48655329 [GRCh38]
Chr20:47271867 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4559C>T (p.Thr1520Met) single nucleotide variant not specified [RCV004248950] Chr20:48630762 [GRCh38]
Chr20:47247300 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2326A>G (p.Ser776Gly) single nucleotide variant not specified [RCV004253691] Chr20:48653381 [GRCh38]
Chr20:47269919 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2656A>G (p.Ile886Val) single nucleotide variant not specified [RCV004256098] Chr20:48651055 [GRCh38]
Chr20:47267593 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2606T>C (p.Val869Ala) single nucleotide variant not specified [RCV004277410] Chr20:48651445 [GRCh38]
Chr20:47267983 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.802A>C (p.Ile268Leu) single nucleotide variant not specified [RCV004275825] Chr20:48700868 [GRCh38]
Chr20:47317406 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4666G>A (p.Ala1556Thr) single nucleotide variant not specified [RCV004250845] Chr20:48629549 [GRCh38]
Chr20:47246087 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.22G>A (p.Glu8Lys) single nucleotide variant not specified [RCV004262229] Chr20:48827839 [GRCh38]
Chr20:47444376 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4178G>A (p.Arg1393Gln) single nucleotide variant not specified [RCV004277219] Chr20:48634765 [GRCh38]
Chr20:47251303 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4000G>T (p.Ala1334Ser) single nucleotide variant not specified [RCV004316330] Chr20:48636630 [GRCh38]
Chr20:47253168 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.1721A>G (p.Asn574Ser) single nucleotide variant not specified [RCV004351656] Chr20:48666300 [GRCh38]
Chr20:47282838 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.801C>A (p.Asp267Glu) single nucleotide variant not specified [RCV004340262] Chr20:48700869 [GRCh38]
Chr20:47317407 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.1544T>C (p.Val515Ala) single nucleotide variant not specified [RCV004362088] Chr20:48679405 [GRCh38]
Chr20:47295943 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4568G>T (p.Ser1523Ile) single nucleotide variant not specified [RCV004347606] Chr20:48630753 [GRCh38]
Chr20:47247291 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4543C>T (p.Arg1515Trp) single nucleotide variant not specified [RCV004348097] Chr20:48630778 [GRCh38]
Chr20:47247316 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3039C>T (p.Asn1013=) single nucleotide variant not provided [RCV003440430] Chr20:48649566 [GRCh38]
Chr20:47266104 [GRCh37]
Chr20:20q13.13		 likely benign
NM_020820.4(PREX1):c.1635G>A (p.Gly545=) single nucleotide variant not provided [RCV003440431] Chr20:48676223 [GRCh38]
Chr20:47292761 [GRCh37]
Chr20:20q13.13		 likely benign
NM_020820.4(PREX1):c.1169A>T (p.Glu390Val) single nucleotide variant not specified [RCV004514928] Chr20:48690964 [GRCh38]
Chr20:47307502 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2179G>A (p.Ala727Thr) single nucleotide variant not specified [RCV004514932] Chr20:48655320 [GRCh38]
Chr20:47271858 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2704A>G (p.Arg902Gly) single nucleotide variant not specified [RCV004514934] Chr20:48651007 [GRCh38]
Chr20:47267545 [GRCh37]
Chr20:20q13.13		 likely benign
NM_020820.4(PREX1):c.3973G>A (p.Ala1325Thr) single nucleotide variant not specified [RCV004514944] Chr20:48636657 [GRCh38]
Chr20:47253195 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4679T>G (p.Val1560Gly) single nucleotide variant not specified [RCV004514945] Chr20:48629536 [GRCh38]
Chr20:47246074 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.62A>G (p.Asp21Gly) single nucleotide variant not specified [RCV004514947] Chr20:48827799 [GRCh38]
Chr20:47444336 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3509A>G (p.Tyr1170Cys) single nucleotide variant not specified [RCV004514941] Chr20:48645854 [GRCh38]
Chr20:47262392 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3836A>G (p.Gln1279Arg) single nucleotide variant PREX1-related disorder [RCV003904150] Chr20:48639834 [GRCh38]
Chr20:47256372 [GRCh37]
Chr20:20q13.13		 likely benign
NM_020820.4(PREX1):c.3187G>A (p.Gly1063Ser) single nucleotide variant not specified [RCV004514938] Chr20:48649418 [GRCh38]
Chr20:47265956 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3019C>G (p.Pro1007Ala) single nucleotide variant not specified [RCV004514936] Chr20:48650005 [GRCh38]
Chr20:47266543 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3349G>C (p.Asp1117His) single nucleotide variant not specified [RCV004514939] Chr20:48646014 [GRCh38]
Chr20:47262552 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.341T>C (p.Leu114Ser) single nucleotide variant not specified [RCV004514940] Chr20:48745098 [GRCh38]
Chr20:47361635 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.1820A>G (p.Lys607Arg) single nucleotide variant not specified [RCV004514930] Chr20:48659980 [GRCh38]
Chr20:47276518 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.1951G>A (p.Val651Ile) single nucleotide variant not specified [RCV004514931] Chr20:48658159 [GRCh38]
Chr20:47274697 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3763C>T (p.His1255Tyr) single nucleotide variant not specified [RCV004514942] Chr20:48642180 [GRCh38]
Chr20:47258718 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.632A>G (p.Lys211Arg) single nucleotide variant not specified [RCV004514948] Chr20:48708411 [GRCh38]
Chr20:47324949 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.346G>T (p.Ala116Ser) single nucleotide variant PREX1-related disorder [RCV003967029] Chr20:48745093 [GRCh38]
Chr20:47361630 [GRCh37]
Chr20:20q13.13		 likely benign
NM_020820.4(PREX1):c.3289G>A (p.Val1097Ile) single nucleotide variant PREX1-related disorder [RCV003974687] Chr20:48649316 [GRCh38]
Chr20:47265854 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2630G>A (p.Arg877His) single nucleotide variant PREX1-related disorder [RCV003904346] Chr20:48651421 [GRCh38]
Chr20:47267959 [GRCh37]
Chr20:20q13.13		 likely benign
NM_020820.4(PREX1):c.1071C>T (p.Asn357=) single nucleotide variant PREX1-related disorder [RCV003954902] Chr20:48691062 [GRCh38]
Chr20:47307600 [GRCh37]
Chr20:20q13.13		 likely benign
NM_020820.4(PREX1):c.119C>G (p.Ala40Gly) single nucleotide variant not specified [RCV004514929] Chr20:48827742 [GRCh38]
Chr20:47444279 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2366A>G (p.Tyr789Cys) single nucleotide variant not specified [RCV004514933] Chr20:48652687 [GRCh38]
Chr20:47269225 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3185G>C (p.Arg1062Pro) single nucleotide variant not specified [RCV004514937] Chr20:48649420 [GRCh38]
Chr20:47265958 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3829A>G (p.Ser1277Gly) single nucleotide variant not specified [RCV004514943] Chr20:48639841 [GRCh38]
Chr20:47256379 [GRCh37]
Chr20:20q13.13		 uncertain significance
NC_000020.10:g.(?_47340117)_(47538567_?)dup duplication not provided [RCV004579510] Chr20:47340117..47538567 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.436G>A (p.Glu146Lys) single nucleotide variant not specified [RCV004660151] Chr20:48734629 [GRCh38]
Chr20:47351166 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3954G>C (p.Glu1318Asp) single nucleotide variant not specified [RCV004660147] Chr20:48636676 [GRCh38]
Chr20:47253214 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.1165C>T (p.Arg389Cys) single nucleotide variant not specified [RCV004648593] Chr20:48690968 [GRCh38]
Chr20:47307506 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2641G>A (p.Gly881Ser) single nucleotide variant not specified [RCV004648594] Chr20:48651410 [GRCh38]
Chr20:47267948 [GRCh37]
Chr20:20q13.13		 likely benign
NM_020820.4(PREX1):c.1678A>G (p.Thr560Ala) single nucleotide variant not specified [RCV004648595] Chr20:48666343 [GRCh38]
Chr20:47282881 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4391A>G (p.His1464Arg) single nucleotide variant not specified [RCV004648596] Chr20:48632516 [GRCh38]
Chr20:47249054 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.3730G>A (p.Ala1244Thr) single nucleotide variant not specified [RCV004648597] Chr20:48642213 [GRCh38]
Chr20:47258751 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.4922C>T (p.Pro1641Leu) single nucleotide variant not specified [RCV004648598] Chr20:48627563 [GRCh38]
Chr20:47244101 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.1873C>T (p.Arg625Cys) single nucleotide variant not specified [RCV004660145] Chr20:48659927 [GRCh38]
Chr20:47276465 [GRCh37]
Chr20:20q13.13		 uncertain significance
NM_020820.4(PREX1):c.2111C>A (p.Thr704Lys) single nucleotide variant not specified [RCV004660148] Chr20:48657052 [GRCh38]
Chr20:47273590 [GRCh37]
Chr20:20q13.13		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3059
Count of miRNA genes:733
Interacting mature miRNAs:834
Transcripts:ENST00000371941, ENST00000396220, ENST00000482556, ENST00000496915
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406900064GWAS549040_Hblood pressure QTL GWAS549040 (human)0.000002blood pressure trait (VT:0000183)blood pressure measurement (CMO:0000003)204872652248726523Human
2292864PRSTS43_HProstate tumor susceptibility QTL 43 (human)0.620.05Prostate tumor susceptibility204730303964444167Human
407273602GWAS922578_Hintelligence QTL GWAS922578 (human)3e-11intelligence204888263348882634Human
406986442GWAS635418_Hintelligence QTL GWAS635418 (human)5e-10intelligence204880604048806041Human
596966620GWAS1086139_Hbody mass index QTL GWAS1086139 (human)1e-12body mass indexbody mass index (BMI) (CMO:0000105)204888158048881581Human
596952191GWAS1071710_Hhypertension QTL GWAS1071710 (human)6e-10hypertension204880417248804173Human
407305482GWAS954458_Hlymphocyte count QTL GWAS954458 (human)4e-13lymphocyte countblood lymphocyte count (CMO:0000031)204872692348726924Human
596965818GWAS1085337_Hcolorectal cancer QTL GWAS1085337 (human)3e-18colorectal cancer204872358048723581Human
407128916GWAS777892_Hnarcolepsy-cataplexy syndrome QTL GWAS777892 (human)0.000002narcolepsy-cataplexy syndrome204876327448763275Human
596968740GWAS1088259_Hsystolic blood pressure QTL GWAS1088259 (human)4e-16systolic blood pressuresystolic blood pressure (CMO:0000004)204879461248794613Human
407005683GWAS654659_Hmean corpuscular hemoglobin QTL GWAS654659 (human)4e-18mean corpuscular hemoglobinmean corpuscular hemoglobin (CMO:0000290)204882010948820110Human
1300007BP29_HBlood pressure QTL 29 (human)Blood pressurehypertension susceptibility203653600562536005Human
407305170GWAS954146_Hlymphocyte count QTL GWAS954146 (human)3e-14lymphocyte countblood lymphocyte count (CMO:0000031)204872320448723205Human
406905333GWAS554309_Hdiastolic blood pressure QTL GWAS554309 (human)1e-12diastolic blood pressurediastolic blood pressure (CMO:0000005)204879461248794613Human
596966497GWAS1086016_Hdiastolic blood pressure QTL GWAS1086016 (human)4e-18diastolic blood pressurediastolic blood pressure (CMO:0000005)204879461248794613Human
406999227GWAS648203_Hintelligence QTL GWAS648203 (human)3e-08intelligence204881697848816979Human
407000056GWAS649032_Hdiastolic blood pressure QTL GWAS649032 (human)2e-11diastolic blood pressurediastolic blood pressure (CMO:0000005)204869317848693179Human

Markers in Region
D20S176  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,313,460 - 47,313,632UniSTSGRCh37
Build 362046,746,867 - 46,747,039RGDNCBI36
Celera2044,018,683 - 44,018,855RGD
Cytogenetic Map20q13.13UniSTS
HuRef2044,063,505 - 44,063,671UniSTS
Marshfield Genetic Map2072.27RGD
Marshfield Genetic Map2072.27UniSTS
Genethon Genetic Map2071.3UniSTS
deCODE Assembly Map2075.75UniSTS
Whitehead-YAC Contig Map20 UniSTS
D20S866  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,363,395 - 47,363,591UniSTSGRCh37
Build 362046,796,802 - 46,796,998RGDNCBI36
Celera2044,068,634 - 44,068,810RGD
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map20q12-q13.1UniSTS
HuRef2044,113,359 - 44,113,549UniSTS
Marshfield Genetic Map2072.27UniSTS
Marshfield Genetic Map2072.27RGD
Genethon Genetic Map2071.3UniSTS
deCODE Assembly Map2075.75UniSTS
GeneMap99-GB4 RH Map20282.38UniSTS
A009C21  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,240,841 - 47,240,959UniSTSGRCh37
Build 362046,674,248 - 46,674,366RGDNCBI36
Celera2043,946,027 - 43,946,145RGD
Cytogenetic Map20q13.13UniSTS
HuRef2043,990,108 - 43,990,226UniSTS
GeneMap99-GB4 RH Map20269.78UniSTS
WI-13364  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,241,583 - 47,241,692UniSTSGRCh37
Build 362046,674,990 - 46,675,099RGDNCBI36
Celera2043,946,769 - 43,946,878RGD
Cytogenetic Map20q13.13UniSTS
HuRef2043,990,850 - 43,990,959UniSTS
GeneMap99-GB4 RH Map20272.78UniSTS
Whitehead-RH Map20312.3UniSTS
SHGC-3429  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,313,468 - 47,313,562UniSTSGRCh37
Build 362046,746,875 - 46,746,969RGDNCBI36
Celera2044,018,691 - 44,018,785RGD
Cytogenetic Map20q13.13UniSTS
HuRef2044,063,513 - 44,063,601UniSTS
TNG Radiation Hybrid Map2021990.0UniSTS
SHGC-148678  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,244,747 - 47,245,042UniSTSGRCh37
Build 362046,678,154 - 46,678,449RGDNCBI36
Celera2043,949,933 - 43,950,228RGD
Cytogenetic Map20q13.13UniSTS
HuRef2043,994,014 - 43,994,309UniSTS
TNG Radiation Hybrid Map2021956.0UniSTS
G20522  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,241,622 - 47,241,738UniSTSGRCh37
Build 362046,675,029 - 46,675,145RGDNCBI36
Celera2043,946,808 - 43,946,924RGD
Cytogenetic Map20q13.13UniSTS
HuRef2043,990,889 - 43,991,005UniSTS
A005U44  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,241,622 - 47,241,738UniSTSGRCh37
Build 362046,675,029 - 46,675,145RGDNCBI36
Celera2043,946,808 - 43,946,924RGD
Cytogenetic Map20q13.13UniSTS
HuRef2043,990,889 - 43,991,005UniSTS
GeneMap99-GB4 RH Map20269.78UniSTS
SHGC-153381  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,245,574 - 47,245,847UniSTSGRCh37
Build 362046,678,981 - 46,679,254RGDNCBI36
Celera2043,950,760 - 43,951,033RGD
Cytogenetic Map20q13.13UniSTS
HuRef2043,994,841 - 43,995,114UniSTS
TNG Radiation Hybrid Map2021956.0UniSTS
RH16260  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,279,564 - 47,279,739UniSTSGRCh37
Build 362046,712,971 - 46,713,146RGDNCBI36
Celera2043,984,783 - 43,984,958RGD
Cytogenetic Map20q13.13UniSTS
HuRef2044,029,615 - 44,029,790UniSTS
GeneMap99-GB4 RH Map20292.65UniSTS
Z94587  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,291,228 - 47,291,353UniSTSGRCh37
Build 362046,724,635 - 46,724,760RGDNCBI36
Celera2043,996,447 - 43,996,572RGD
Cytogenetic Map20q13.13UniSTS
HuRef2044,041,278 - 44,041,403UniSTS
Z94620  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,286,509 - 47,286,630UniSTSGRCh37
Build 362046,719,916 - 46,720,037RGDNCBI36
Celera2043,991,728 - 43,991,849RGD
Cytogenetic Map20q13.13UniSTS
HuRef2044,036,560 - 44,036,681UniSTS
RH47999  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,399,129 - 47,399,287UniSTSGRCh37
Build 362046,832,536 - 46,832,694RGDNCBI36
Celera2044,104,348 - 44,104,506RGD
Cytogenetic Map20q13.13UniSTS
HuRef2044,149,077 - 44,149,235UniSTS
GeneMap99-GB4 RH Map20269.78UniSTS
Z94459  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,382,147 - 47,382,319UniSTSGRCh37
Build 362046,815,554 - 46,815,726RGDNCBI36
Celera2044,087,367 - 44,087,539RGD
Cytogenetic Map20q13.13UniSTS
HuRef2044,132,106 - 44,132,278UniSTS
G32415  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372047,240,841 - 47,240,959UniSTSGRCh37
Celera2043,946,027 - 43,946,145UniSTS
Cytogenetic Map20q13.13UniSTS
HuRef2043,990,108 - 43,990,226UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2433 2788 2252 4974 1724 2333 6 623 1942 464 2270 7291 6463 53 3734 1 851 1744 1600 174 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_020820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011528934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047440331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047440332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047440333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047440334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054323770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054323771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054323772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB037836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ320261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL035106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL133342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL445192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF511314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LS482411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000371941   ⟹   ENSP00000361009
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2048,624,252 - 48,827,999 (-)Ensembl
Ensembl Acc Id: ENST00000482556   ⟹   ENSP00000434632
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2048,624,252 - 48,657,127 (-)Ensembl
Ensembl Acc Id: ENST00000496915
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2048,642,113 - 48,642,738 (-)Ensembl
Ensembl Acc Id: ENST00000620554   ⟹   ENSP00000481444
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2048,692,323 - 48,692,684 (-)Ensembl
RefSeq Acc Id: NM_020820   ⟹   NP_065871
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382048,624,252 - 48,827,999 (-)NCBI
GRCh372047,240,787 - 47,444,420 (-)NCBI
Build 362046,674,200 - 46,877,827 (-)NCBI Archive
HuRef2043,990,060 - 44,195,320 (-)ENTREZGENE
CHM1_12047,145,458 - 47,349,091 (-)NCBI
T2T-CHM13v2.02050,394,065 - 50,597,825 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011528934   ⟹   XP_011527236
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382048,624,252 - 48,691,035 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047440331   ⟹   XP_047296287
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382048,624,252 - 48,821,644 (-)NCBI
RefSeq Acc Id: XM_047440332   ⟹   XP_047296288
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382048,624,252 - 48,821,644 (-)NCBI
RefSeq Acc Id: XM_047440333   ⟹   XP_047296289
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382048,624,252 - 48,888,185 (-)NCBI
RefSeq Acc Id: XM_047440334   ⟹   XP_047296290
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382048,624,252 - 48,676,268 (-)NCBI
RefSeq Acc Id: XM_054323770   ⟹   XP_054179745
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02050,394,065 - 50,591,846 (-)NCBI
RefSeq Acc Id: XM_054323771   ⟹   XP_054179746
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02050,394,065 - 50,460,905 (-)NCBI
RefSeq Acc Id: XM_054323772   ⟹   XP_054179747
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02050,394,065 - 50,446,127 (-)NCBI
RefSeq Acc Id: NP_065871   ⟸   NM_020820
- UniProtKB: Q9P2D2 (UniProtKB/Swiss-Prot),   Q9H4Q6 (UniProtKB/Swiss-Prot),   Q9BX55 (UniProtKB/Swiss-Prot),   Q9BQH0 (UniProtKB/Swiss-Prot),   Q8TCU6 (UniProtKB/Swiss-Prot),   Q7Z2L9 (UniProtKB/Swiss-Prot),   Q69YL2 (UniProtKB/Swiss-Prot),   Q5JS96 (UniProtKB/Swiss-Prot),   Q5JS95 (UniProtKB/Swiss-Prot),   E1P5X9 (UniProtKB/Swiss-Prot),   Q9UGQ4 (UniProtKB/Swiss-Prot),   A0A2X0SFH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011527236   ⟸   XM_011528934
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSP00000481444   ⟸   ENST00000620554
Ensembl Acc Id: ENSP00000361009   ⟸   ENST00000371941
Ensembl Acc Id: ENSP00000434632   ⟸   ENST00000482556
RefSeq Acc Id: XP_047296289   ⟸   XM_047440333
- Peptide Label: isoform X1
- UniProtKB: A0A2X0SFH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047296288   ⟸   XM_047440332
- Peptide Label: isoform X1
- UniProtKB: A0A2X0SFH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047296287   ⟸   XM_047440331
- Peptide Label: isoform X1
- UniProtKB: A0A2X0SFH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047296290   ⟸   XM_047440334
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054179745   ⟸   XM_054323770
- Peptide Label: isoform X1
- UniProtKB: A0A2X0SFH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054179746   ⟸   XM_054323771
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054179747   ⟸   XM_054323772
- Peptide Label: isoform X3
Protein Domains
DEP   DH   PDZ   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8TCU6-F1-model_v2 AlphaFold Q8TCU6 1-1659 view protein structure

Promoters
RGD ID:6798964
Promoter ID:HG_KWN:39747
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   Lymphoblastoid
Transcripts:OTTHUMT00000079624,   UC002XTV.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362046,706,796 - 46,707,972 (-)MPROMDB
RGD ID:6798692
Promoter ID:HG_KWN:39748
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:ENST00000396223
Position:
Human AssemblyChrPosition (strand)Source
Build 362046,720,571 - 46,721,927 (-)MPROMDB
RGD ID:6798962
Promoter ID:HG_KWN:39750
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000396220,   OTTHUMT00000079623
Position:
Human AssemblyChrPosition (strand)Source
Build 362046,877,551 - 46,878,392 (-)MPROMDB
RGD ID:13207205
Promoter ID:EPDNEW_H27183
Type:initiation region
Name:PREX1_1
Description:phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchangefactor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27184  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382048,827,912 - 48,827,972EPDNEW
RGD ID:13207207
Promoter ID:EPDNEW_H27184
Type:single initiation site
Name:PREX1_2
Description:phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchangefactor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27183  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382048,888,185 - 48,888,245EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:32594 AgrOrtholog
COSMIC PREX1 COSMIC
Ensembl Genes ENSG00000124126 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000371941 ENTREZGENE
  ENST00000371941.4 UniProtKB/Swiss-Prot
  ENST00000482556.5 UniProtKB/TrEMBL
  ENST00000620554.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000124126 GTEx
HGNC ID HGNC:32594 ENTREZGENE
Human Proteome Map PREX1 Human Proteome Map
InterPro DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mTOR-Rac_regulators UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:57580 UniProtKB/Swiss-Prot
NCBI Gene 57580 ENTREZGENE
OMIM 606905 OMIM
PANTHER DEP DOMAIN PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA164725018 PharmGKB
PROSITE DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WY11_HUMAN UniProtKB/TrEMBL
  A0A2X0SFH1 ENTREZGENE, UniProtKB/TrEMBL
  E1P5X9 ENTREZGENE
  H0YDZ4_HUMAN UniProtKB/TrEMBL
  PREX1_HUMAN UniProtKB/Swiss-Prot
  Q5JS95 ENTREZGENE
  Q5JS96 ENTREZGENE
  Q69YL2 ENTREZGENE
  Q7Z2L9 ENTREZGENE
  Q8TCU6 ENTREZGENE
  Q9BQH0 ENTREZGENE
  Q9BX55 ENTREZGENE
  Q9H4Q6 ENTREZGENE
  Q9P2D2 ENTREZGENE
  Q9UGQ4 ENTREZGENE
UniProt Secondary E1P5X9 UniProtKB/Swiss-Prot
  Q5JS95 UniProtKB/Swiss-Prot
  Q5JS96 UniProtKB/Swiss-Prot
  Q69YL2 UniProtKB/Swiss-Prot
  Q7Z2L9 UniProtKB/Swiss-Prot
  Q9BQH0 UniProtKB/Swiss-Prot
  Q9BX55 UniProtKB/Swiss-Prot
  Q9H4Q6 UniProtKB/Swiss-Prot
  Q9P2D2 UniProtKB/Swiss-Prot
  Q9UGQ4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-14 PREX1  phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1  LOC105372648  uncharacterized LOC105372648  Data merged from RGD:38647969 737654 PROVISIONAL
2016-04-12 PREX1  phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1    phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1  Symbol and/or name change 5135510 APPROVED