Sod3<i><sup>m1Mcwi</sup></i> (superoxide dismutase 3; mutation 1, Medical College of Wisconsin) - Rat Genome Database

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Gene: Sod3m1Mcwi (superoxide dismutase 3; mutation 1, Medical College of Wisconsin) Rattus norvegicus
Symbol: Sod3m1Mcwi
Name: superoxide dismutase 3; mutation 1, Medical College of Wisconsin
RGD ID: 1599567
Description: mutation generated by ENU (N-ethyl-N-nitrourea); E124D mutation is generated from the codon change GAG/GAT
INVOLVED IN blood vessel diameter maintenance; ASSOCIATED WITH abnormal vasodilation; decreased superoxide dismutase level; decreased vasodilation; ASSOCIATED WITH Pulmonary Arterial Hypertension
Type: allele  of Sod3  
Previously known as: Sod3^[m1Mcwi]; Sod3m1Mcwi
Is Marker For: Strains:   SS-Sod3m1Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Cytogenetic Map14 RGD


References - curated
# Reference Title Reference Citation
1. Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase. Beyer AM, etal., Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H339-47. doi: 10.1152/ajpheart.00619.2012. Epub 2013 Dec 6.
2. Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3. Guo H, etal., Free Radic Biol Med. 2020 May 20;152:787-796. doi: 10.1016/j.freeradbiomed.2020.01.023. Epub 2020 Jan 21.
3. PhysGen Strains PhysGen strains
4. Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase. Xu D, etal., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5.


Related Rat Strains
The following Strains have been annotated to Sod3m1Mcwi



Nucleotide Sequences
RefSeq Transcripts NM_012880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Additional Information

RGD Curation Notes
Note Type Note Reference
gene_domains affected domain: Cu-Zn_Superoxide_Dismutase 629526