Sod3<i><sup>m1Mcwi</sup></i> (superoxide dismutase 3; mutation 1, Medical College of Wisconsin)

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Gene: Sod3^m1Mcwi (superoxide dismutase 3; mutation 1, Medical College of Wisconsin) Rattus norvegicus

Analyze

Symbol:

Sod3^m1Mcwi

Name:

superoxide dismutase 3; mutation 1, Medical College of Wisconsin

RGD ID:

1599567

Description:

mutation generated by ENU (N-ethyl-N-nitrourea); E124D mutation is generated from the codon change GAG/GAT
INVOLVED IN blood vessel diameter maintenance; ASSOCIATED WITH abnormal vasodilation; decreased superoxide dismutase level; decreased vasodilation; ASSOCIATED WITH Pulmonary Arterial Hypertension

Type:

allele of Sod3

Previously known as:

Sod3m1Mcwi

Is Marker For:

Strains: SS-Sod3^m1Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Cytogenetic Map	14		RGD

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Pulmonary Arterial Hypertension (IMP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood vessel diameter maintenance (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal vasodilation (IMP)

decreased superoxide dismutase level (IMP)

decreased vasodilation (IMP)

glomerulosclerosis (IMP)

heart left ventricle hypertrophy (IMP)

increased circulating creatinine level (IMP)

increased fluid intake (IMP)

increased food intake (IMP)

increased mean systemic arterial blood pressure (IMP)

increased systemic arterial diastolic blood pressure (IMP)

increased systemic arterial systolic blood pressure (IMP)

increased vasoconstriction (IMP)

increased vasodilation (IMP)

oxidative stress (IMP)

renal cast (IMP)

renal fibrosis (IMP)

renal glomerulus fibrosis (IMP)

renal interstitial fibrosis (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase.	Beyer AM, etal., Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H339-47. doi: 10.1152/ajpheart.00619.2012. Epub 2013 Dec 6.
2.	Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3.	Guo H, etal., Free Radic Biol Med. 2020 May 20;152:787-796. doi: 10.1016/j.freeradbiomed.2020.01.023. Epub 2020 Jan 21.
3.	PhysGen Strains	PhysGen strains
4.	Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase.	Xu D, etal., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5.

Genomics

Related Rat Strains

The following Strains have been annotated to Sod3^m1Mcwi

SS-Sod3^m1Mcwi

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012880	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Additional Information

RGD Curation Notes

Note Type	Note	Reference
gene_domains	affected domain: Cu-Zn_Superoxide_Dismutase	629526

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype