Alkbh7 (alkB homolog 7) - Rat Genome Database

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Gene: Alkbh7 (alkB homolog 7) Rattus norvegicus
Analyze
Symbol: Alkbh7
Name: alkB homolog 7
RGD ID: 1598126
Description: Predicted to be involved in several processes, including fatty acid metabolic process; regulation of lipid storage; and regulation of mitochondrial membrane permeability involved in programmed necrotic cell death. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human ALKBH7 (alkB homolog 7); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alkB, alkylation repair homolog 7; alkB, alkylation repair homolog 7 (E. coli); AlkB-like protein 7; alkylated DNA repair protein alkB homolog 7; alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial; LOC679944; similar to spermatogenesis associated 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,925,896 - 1,928,048 (+)NCBIGRCr8
mRatBN7.291,838,886 - 1,841,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,838,811 - 1,841,044 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,272,791 - 2,274,925 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,622,150 - 7,624,284 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,578,011 - 6,580,146 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,045,375 - 10,047,507 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,045,375 - 10,047,507 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,046,025 - 9,048,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,676,245 - 6,678,377 (-)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16174769   PMID:18614015   PMID:23572141   PMID:23666923  


Genomics

Comparative Map Data
Alkbh7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,925,896 - 1,928,048 (+)NCBIGRCr8
mRatBN7.291,838,886 - 1,841,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,838,811 - 1,841,044 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,272,791 - 2,274,925 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,622,150 - 7,624,284 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,578,011 - 6,580,146 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,045,375 - 10,047,507 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,045,375 - 10,047,507 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,046,025 - 9,048,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,676,245 - 6,678,377 (-)NCBICelera
Cytogenetic Map9q11NCBI
ALKBH7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,372,794 - 6,375,250 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,372,794 - 6,375,250 (+)EnsemblGRCh38hg38GRCh38
GRCh37196,372,805 - 6,375,261 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,323,444 - 6,326,040 (+)NCBINCBI36Build 36hg18NCBI36
Build 34196,323,443 - 6,326,040NCBI
Celera196,311,231 - 6,314,048 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,132,589 - 6,135,406 (+)NCBIHuRef
CHM1_1196,372,069 - 6,374,886 (+)NCBICHM1_1
T2T-CHM13v2.0196,361,696 - 6,364,152 (+)NCBIT2T-CHM13v2.0
Alkbh7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,304,339 - 57,306,340 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,304,339 - 57,306,322 (+)EnsemblGRCm39 Ensembl
GRCm381756,997,339 - 56,999,340 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,997,339 - 56,999,322 (+)EnsemblGRCm38mm10GRCm38
MGSCv371757,136,776 - 57,138,745 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,682,477 - 56,684,446 (+)NCBIMGSCv36mm8
Celera1761,345,279 - 61,347,248 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.61NCBI
Alkbh7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,220,994 - 3,223,551 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554953,220,994 - 3,222,675 (-)NCBIChiLan1.0ChiLan1.0
ALKBH7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,770,082 - 10,775,706 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,999,342 - 10,001,637 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,393,317 - 5,395,886 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,315,604 - 6,318,174 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,315,604 - 6,318,170 (+)Ensemblpanpan1.1panPan2
ALKBH7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,783,948 - 53,785,563 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,783,993 - 53,785,524 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,530,856 - 53,532,460 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,438,215 - 54,439,821 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,438,223 - 54,439,826 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,504,678 - 53,506,283 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,953,017 - 53,954,622 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,182,768 - 54,184,373 (-)NCBIUU_Cfam_GSD_1.0
Alkbh7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,100,011 - 214,101,677 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,732,526 - 3,737,219 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,733,103 - 3,734,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALKBH7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,698,529 - 72,703,736 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,702,077 - 72,703,924 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,215,582 - 73,218,234 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALKBH7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.165,988,610 - 5,991,194 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl65,988,371 - 5,991,136 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660812,032,188 - 2,034,764 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alkbh7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,507,657 - 3,509,314 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,507,657 - 3,509,314 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Alkbh7
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:106
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000072118
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat

Markers in Region
RH129643  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,840,583 - 1,840,772 (-)MAPPERmRatBN7.2
Rnor_6.0910,045,646 - 10,045,834NCBIRnor6.0
Rnor_5.099,046,296 - 9,046,484UniSTSRnor5.0
Celera96,676,516 - 6,676,704UniSTS
RH130001  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,837,474 - 1,837,671 (-)MAPPERmRatBN7.2
Rnor_6.0910,048,746 - 10,048,942NCBIRnor6.0
Rnor_5.099,049,396 - 9,049,592UniSTSRnor5.0
Celera96,679,616 - 6,679,812UniSTS
Cytogenetic Map9q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 23 14 16 14 1 3 72 35 41 11 1
Low 1 34 27 3 27 7 8 2 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000072118   ⟹   ENSRNOP00000065514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,838,910 - 1,841,044 (+)Ensembl
Rnor_6.0 Ensembl910,045,375 - 10,047,507 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097182   ⟹   ENSRNOP00000087380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,838,811 - 1,841,044 (+)Ensembl
RefSeq Acc Id: NM_001109384   ⟹   NP_001102854
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,925,916 - 1,928,048 (+)NCBI
mRatBN7.291,838,910 - 1,841,044 (+)NCBI
Rnor_6.0910,045,375 - 10,047,507 (-)NCBI
Rnor_5.099,046,025 - 9,048,175 (-)NCBI
Celera96,676,245 - 6,678,377 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084196   ⟹   XP_038940124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,925,896 - 1,927,794 (+)NCBI
mRatBN7.291,838,886 - 1,840,794 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102854 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940124 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83594 (Get FASTA)   NCBI Sequence Viewer  
  EDL83595 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065514
  ENSRNOP00000065514.1
  ENSRNOP00000087380
  ENSRNOP00000087380.1
GenBank Protein QST76990 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001102854   ⟸   NM_001109384
- UniProtKB: M0R7T2 (UniProtKB/TrEMBL),   A6KQT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065514   ⟸   ENSRNOT00000072118
RefSeq Acc Id: XP_038940124   ⟸   XM_039084196
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A7M8 (UniProtKB/TrEMBL),   A6KQT6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000087380   ⟸   ENSRNOT00000097182
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7T2-F1-model_v2 AlphaFold M0R7T2 1-221 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696444
Promoter ID:EPDNEW_R6969
Type:multiple initiation site
Name:Alkbh7_1
Description:alkB homolog 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,047,502 - 10,047,562EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598126 AgrOrtholog
BioCyc Gene G2FUF-28499 BioCyc
Ensembl Genes ENSRNOG00000047089 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072118 ENTREZGENE
  ENSRNOT00000072118.2 UniProtKB/TrEMBL
  ENSRNOT00000097182.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.590 UniProtKB/TrEMBL
InterPro AlkB-like UniProtKB/TrEMBL
  AlkB-like_sf UniProtKB/TrEMBL
  ALKBH7 UniProtKB/TrEMBL
KEGG Report rno:679944 UniProtKB/TrEMBL
NCBI Gene 679944 ENTREZGENE
PANTHER ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR21052 UniProtKB/TrEMBL
Pfam 2OG-FeII_Oxy_2 UniProtKB/TrEMBL
PhenoGen Alkbh7 PhenoGen
RatGTEx ENSRNOG00000047089 RatGTEx
Superfamily-SCOP Clavaminate synthase-like UniProtKB/TrEMBL
UniProt A0A8A1U9H3_RAT UniProtKB/TrEMBL
  A0A8I6A7M8 ENTREZGENE, UniProtKB/TrEMBL
  A6KQT6 ENTREZGENE, UniProtKB/TrEMBL
  A6KQT7 ENTREZGENE, UniProtKB/TrEMBL
  M0R7T2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-02 Alkbh7  alkB homolog 7  Alkbh7  alkB, alkylation repair homolog 7 (E. coli)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Alkbh7  alkB, alkylation repair homolog 7 (E. coli)  LOC681562  similar to spermatogenesis associated 11  Data merged from RGD:1594076 1643240 APPROVED
2008-03-05 Alkbh7  alkB, alkylation repair homolog 7 (E. coli)  LOC679944  similar to spermatogenesis associated 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC679944  similar to spermatogenesis associated 11      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC681562  similar to spermatogenesis associated 11      Symbol and Name status set to provisional 70820 PROVISIONAL