C14h2orf74 (similar to human chromosome 2 open reading frame 74) - Rat Genome Database

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Gene: C14h2orf74 (similar to human chromosome 2 open reading frame 74) Rattus norvegicus
Analyze
Symbol: C14h2orf74
Name: similar to human chromosome 2 open reading frame 74
RGD ID: 1597336
Description: Orthologous to human C2orf74 (chromosome 2 open reading frame 74); INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); arsenite(3-) (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC690352; LOC690352; uncharacterized protein C2orf74 homolog; uncharacterized protein LOC690352
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,694,721 - 101,697,842 (-)NCBIGRCr8
mRatBN7.21497,493,579 - 97,496,697 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1497,493,658 - 97,496,679 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14101,825,814 - 101,828,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014103,070,175 - 103,073,202 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01499,541,741 - 99,544,768 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014108,281,908 - 108,285,008 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14108,281,907 - 108,285,008 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014105,117,765 - 105,120,865 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414104,443,532 - 104,446,553 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1496,470,624 - 96,473,645 (-)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
C14h2orf74
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,694,721 - 101,697,842 (-)NCBIGRCr8
mRatBN7.21497,493,579 - 97,496,697 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1497,493,658 - 97,496,679 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14101,825,814 - 101,828,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014103,070,175 - 103,073,202 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01499,541,741 - 99,544,768 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014108,281,908 - 108,285,008 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14108,281,907 - 108,285,008 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014105,117,765 - 105,120,865 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414104,443,532 - 104,446,553 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1496,470,624 - 96,473,645 (-)NCBICelera
Cytogenetic Map14q22NCBI
C2orf74
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38261,145,116 - 61,164,828 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl261,145,068 - 61,164,828 (+)EnsemblGRCh38hg38GRCh38
GRCh37261,372,251 - 61,391,963 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36261,225,792 - 61,245,468 (+)NCBINCBI36Build 36hg18NCBI36
Celera261,215,846 - 61,236,014 (+)NCBICelera
Cytogenetic Map2p15NCBI
HuRef261,113,262 - 61,133,063 (+)NCBIHuRef
CHM1_1261,302,780 - 61,322,493 (+)NCBICHM1_1
T2T-CHM13v2.0261,150,976 - 61,170,676 (+)NCBIT2T-CHM13v2.0
1700093K21Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391123,466,203 - 23,471,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1123,466,203 - 23,471,155 (-)EnsemblGRCm39 Ensembl
GRCm381123,516,202 - 23,521,319 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1123,516,203 - 23,521,155 (-)EnsemblGRCm38mm10GRCm38
MGSCv371123,416,203 - 23,419,942 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361123,416,203 - 23,419,195 (-)NCBIMGSCv36mm8
Celera1125,643,964 - 25,647,707 (-)NCBICelera
Cytogenetic Map11A3.2NCBI
cM Map1114.32NCBI
CUNH2orf74
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542422,709,676 - 22,712,178 (-)NCBIChiLan1.0ChiLan1.0
C12H2orf74
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21265,212,265 - 65,232,116 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A65,216,227 - 65,236,067 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A61,236,580 - 61,256,389 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A62,377,116 - 62,395,225 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A62,392,633 - 62,395,225 (+)Ensemblpanpan1.1panPan2
C10H2orf74
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11061,199,711 - 61,231,862 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1061,229,922 - 61,231,834 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1061,089,577 - 61,121,728 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01062,208,401 - 62,240,704 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1062,238,753 - 62,240,667 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11061,911,317 - 61,943,472 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01062,195,570 - 62,228,168 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01062,491,291 - 62,523,461 (+)NCBIUU_Cfam_GSD_1.0
CUNH2orf74
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629221,913,425 - 21,917,216 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364916,654,380 - 6,657,560 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364916,654,389 - 6,657,560 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C3H2orf74
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl380,626,159 - 80,648,230 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1380,626,056 - 80,651,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2384,514,795 - 84,517,948 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CUNH2orf74
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11445,819,831 - 45,824,090 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1445,820,129 - 45,822,162 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604565,963,324 - 65,981,598 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH2orf74
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624833746,124 - 749,415 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624833746,419 - 748,845 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C14h2orf74
3 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 3 13 92 44 47 17 23 17 6 100 52 77 21 53 30

Sequence


Ensembl Acc Id: ENSRNOT00000078814   ⟹   ENSRNOP00000073410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl14108,281,907 - 108,284,619 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087501   ⟹   ENSRNOP00000071771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1497,493,658 - 97,496,679 (-)Ensembl
Rnor_6.0 Ensembl14108,281,987 - 108,285,008 (-)Ensembl
RefSeq Acc Id: NM_001419355   ⟹   NP_001406284
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814101,694,721 - 101,697,398 (-)NCBI
mRatBN7.21497,493,579 - 97,496,256 (-)NCBI
RefSeq Acc Id: XM_006251550   ⟹   XP_006251612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814101,694,754 - 101,697,842 (-)NCBI
mRatBN7.21497,493,579 - 97,496,697 (-)NCBI
Rnor_6.014108,281,908 - 108,284,969 (-)NCBI
Rnor_5.014105,117,765 - 105,120,865 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001406284 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251612 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97991 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071771.1
RefSeq Acc Id: XP_006251612   ⟸   XM_006251550
- Peptide Label: isoform X1
- UniProtKB: D3ZLU7 (UniProtKB/TrEMBL),   A6JQ74 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071771   ⟸   ENSRNOT00000087501
Ensembl Acc Id: ENSRNOP00000073410   ⟸   ENSRNOT00000078814
RefSeq Acc Id: NP_001406284   ⟸   NM_001419355
- UniProtKB: D3ZLU7 (UniProtKB/TrEMBL),   A6JQ74 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLU7-F1-model_v2 AlphaFold D3ZLU7 1-199 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699528
Promoter ID:EPDNEW_R10046
Type:multiple initiation site
Name:LOC690352_1
Description:hypothetical protein LOC690352
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.014108,284,585 - 108,284,645EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597336 AgrOrtholog
BioCyc Gene G2FUF-14770 BioCyc
Ensembl Genes ENSRNOG00000051590 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087501.2 UniProtKB/TrEMBL
InterPro DUF4642 UniProtKB/TrEMBL
NCBI Gene 690352 ENTREZGENE
PANTHER HYPOTHETICAL PROTEIN LOC690352 UniProtKB/TrEMBL
  PTHR37882 UniProtKB/TrEMBL
Pfam DUF4642 UniProtKB/TrEMBL
PhenoGen C14h2orf74 PhenoGen
RatGTEx ENSRNOG00000051590 RatGTEx
UniProt A6JQ74 ENTREZGENE, UniProtKB/TrEMBL
  D3ZLU7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-29 C14h2orf74  similar to human chromosome 2 open reading frame 74  LOC690352  hypothetical protein LOC690352  Name and Symbol changed 629549 APPROVED
2008-01-09 LOC690352  hypothetical protein LOC690352  LOC682682  hypothetical protein LOC682682  Data merged from RGD:1596611 1643240 APPROVED
2006-11-20 LOC690352  hypothetical protein LOC690352      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC682682  hypothetical protein LOC682682      Symbol and Name status set to provisional 70820 PROVISIONAL