Eid3 (EP300 interacting inhibitor of differentiation 3) - Rat Genome Database

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Gene: Eid3 (EP300 interacting inhibitor of differentiation 3) Rattus norvegicus
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Symbol: Eid3
Name: EP300 interacting inhibitor of differentiation 3
RGD ID: 1597206
Description: Predicted to be involved in DNA repair. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Orthologous to human EID3 (EP300 interacting inhibitor of differentiation 3); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E1A-like inhibitor of differentiation 3; EID-1-like inhibitor of differentiation 3; EID-3; EP300-interacting inhibitor of differentiation 3; MGC114449; non-SMC element 4 homolog B; non-structural maintenance of chromosomes element 4 homolog B; NS4EB; similar to E1A-like inhibitor of differentiation 3
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,747,645 - 22,748,967 (-)NCBIGRCr8
mRatBN7.2720,860,073 - 20,861,395 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx722,824,046 - 22,825,371 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0724,986,818 - 24,988,143 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0724,763,829 - 24,765,154 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0726,976,154 - 26,977,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0727,095,849 - 27,097,174 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4723,085,569 - 23,086,894 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera718,039,933 - 18,041,258 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
chromosome, telomeric region  (IEA)
cytoplasm  (IEA)
nucleolus  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IEA)
Smc5-Smc6 complex  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15970276   PMID:18086888  


Genomics

Comparative Map Data
Eid3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,747,645 - 22,748,967 (-)NCBIGRCr8
mRatBN7.2720,860,073 - 20,861,395 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx722,824,046 - 22,825,371 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0724,986,818 - 24,988,143 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0724,763,829 - 24,765,154 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0726,976,154 - 26,977,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0727,095,849 - 27,097,174 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4723,085,569 - 23,086,894 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera718,039,933 - 18,041,258 (-)NCBICelera
Cytogenetic Map7q13NCBI
EID3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812104,303,739 - 104,305,205 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12104,303,739 - 104,305,205 (+)EnsemblGRCh38hg38GRCh38
GRCh3712104,697,517 - 104,698,983 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612103,221,679 - 103,223,113 (+)NCBINCBI36Build 36hg18NCBI36
Celera12104,361,247 - 104,362,681 (+)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12101,757,788 - 101,759,261 (+)NCBIHuRef
CHM1_112104,663,356 - 104,664,829 (+)NCBICHM1_1
T2T-CHM13v2.012104,265,457 - 104,266,923 (+)NCBIT2T-CHM13v2.0
Eid3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391082,702,460 - 82,703,764 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1082,702,460 - 82,703,764 (+)EnsemblGRCm39 Ensembl
GRCm381082,866,626 - 82,867,930 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1082,866,626 - 82,867,930 (+)EnsemblGRCm38mm10GRCm38
MGSCv371082,329,371 - 82,330,675 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361082,296,457 - 82,297,726 (+)NCBIMGSCv36mm8
Celera1084,851,342 - 84,852,646 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1040.66NCBI
Eid3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540538,897,494 - 38,898,057 (+)NCBIChiLan1.0ChiLan1.0
EID3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11033,955,843 - 33,957,527 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1033,876,053 - 33,877,730 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01034,799,214 - 34,800,900 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11034,534,042 - 34,535,728 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01034,817,607 - 34,819,293 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01035,012,442 - 35,014,128 (-)NCBIUU_Cfam_GSD_1.0
Eid3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494517,220,912 - 17,223,142 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649210,232,335 - 10,233,438 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649210,232,140 - 10,233,557 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EID3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1580,221,334 - 80,234,567 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2583,725,886 - 83,727,438 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EID3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666037145,489,833 - 145,492,863 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eid3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247504,478,911 - 4,479,872 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247504,478,753 - 4,482,276 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eid3
6 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)72055570529891047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)71816950526029351Rat

Markers in Region
AW527618  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,860,129 - 20,860,375 (+)MAPPERmRatBN7.2
Rnor_6.0726,976,211 - 26,976,456NCBIRnor6.0
Rnor_5.0727,095,906 - 27,096,151UniSTSRnor5.0
RGSC_v3.4723,085,626 - 23,085,871UniSTSRGSC3.4
Celera718,039,990 - 18,040,235UniSTS
RH 3.4 Map7117.8UniSTS
Cytogenetic Map7q13UniSTS
AW527618  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,860,268 - 20,860,376 (+)MAPPERmRatBN7.2
Rnor_6.0726,976,350 - 26,976,457NCBIRnor6.0
Rnor_5.0727,096,045 - 27,096,152UniSTSRnor5.0
RGSC_v3.4723,085,765 - 23,085,872UniSTSRGSC3.4
Celera718,040,129 - 18,040,236UniSTS
RH 3.4 Map7117.8UniSTS
Cytogenetic Map7q13UniSTS


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: NM_001044304   ⟹   NP_001037769
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,747,645 - 22,748,967 (-)NCBI
mRatBN7.2720,860,073 - 20,861,395 (-)NCBI
Rnor_6.0726,976,154 - 26,977,479 (-)NCBI
Rnor_5.0727,095,849 - 27,097,174 (-)NCBI
RGSC_v3.4723,085,569 - 23,086,894 (-)RGD
Celera718,039,933 - 18,041,258 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001037769 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97404 (Get FASTA)   NCBI Sequence Viewer  
  EDM17074 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000109585
GenBank Protein Q4V8G2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001037769   ⟸   NM_001044304
- UniProtKB: Q4V8G2 (UniProtKB/Swiss-Prot),   A6IFH7 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Non-structural maintenance of chromosome element   Nse4/EID protein Nse3/MAGE-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8G2-F1-model_v2 AlphaFold Q4V8G2 1-387 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597206 AgrOrtholog
BioCyc Gene G2FUF-34569 BioCyc
Ensembl Genes ENSRNOG00000075657 ENTREZGENE
Ensembl Transcript ENSRNOT00000124484 ENTREZGENE
IMAGE_CLONE IMAGE:7453955 IMAGE-MGC_LOAD
InterPro Nse4/EID UniProtKB/Swiss-Prot
  Nse4_C UniProtKB/Swiss-Prot
  Nse4_Nse3-bd UniProtKB/Swiss-Prot
KEGG Report rno:691688 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114449 IMAGE-MGC_LOAD
NCBI Gene 691688 ENTREZGENE
PANTHER EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 3 UniProtKB/Swiss-Prot
  PTHR16140 UniProtKB/Swiss-Prot
Pfam Nse4-Nse3_bdg UniProtKB/Swiss-Prot
  Nse4_C UniProtKB/Swiss-Prot
PhenoGen Eid3 PhenoGen
RatGTEx ENSRNOG00000075657 RatGTEx
UniProt A6IFH7 ENTREZGENE, UniProtKB/TrEMBL
  EID3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-17 Eid3  EP300 interacting inhibitor of differentiation 3  LOC687496  similar to E1A-like inhibitor of differentiation 3  Data merged from RGD:1585310 1643240 APPROVED
2008-03-06 Eid3  EP300 interacting inhibitor of differentiation 3  MGC114449  similar to E1A-like inhibitor of differentiation 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 MGC114449  similar to E1A-like inhibitor of differentiation 3      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687496  similar to E1A-like inhibitor of differentiation 3      Symbol and Name status set to provisional 70820 PROVISIONAL