Idh2 (isocitrate dehydrogenase (NADP(+)) 2) - Rat Genome Database

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Gene: Idh2 (isocitrate dehydrogenase (NADP(+)) 2) Rattus norvegicus
Symbol: Idh2
Name: isocitrate dehydrogenase (NADP(+)) 2
RGD ID: 1597139
Description: Enables isocitrate dehydrogenase (NADP+) activity. Involved in several processes, including NADP biosynthetic process; negative regulation of glial cell proliferation; and negative regulation of matrix metallopeptidase secretion. Predicted to be located in cytosol and peroxisome. Predicted to be active in mitochondrion. Used to study status epilepticus. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2); PARTICIPATES IN citric acid cycle pathway; glutathione metabolic pathway; INTERACTS WITH (+)-schisandrin B; (R)-adrenaline; 17alpha-ethynylestradiol.
Type: protein-coding
Previously known as: ICD-M; IDH; IDP; isocitrate dehydrogenase (NADP(+)) 2, mitochondrial; isocitrate dehydrogenase 2 (NADP+), mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial; LOC361596; NADP(+)-specific ICDH; oxalosuccinate decarboxylase; similar to NADP+-specific isocitrate dehydrogenase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81143,447,925 - 143,467,248 (-)NCBIGRCr8
mRatBN7.21134,038,644 - 134,057,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,029,772 - 134,058,025 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1141,947,731 - 141,967,051 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,117,130 - 149,136,466 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,034,887 - 142,054,220 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,874,354 - 141,893,674 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,866,283 - 141,893,705 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,830,040 - 142,849,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,876,052 - 135,895,373 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1126,099,085 - 126,118,402 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
2-hydroxyglutaric aciduria  (ISO)
acute myeloid leukemia  (ISO)
acute myocardial infarction  (ISO)
acute promyelocytic leukemia  (ISO)
Animal Disease Models  (ISO)
Bloom syndrome  (ISO)
bone remodeling disease  (ISS)
Brain Neoplasms  (ISO)
Cardiomegaly  (ISO)
central nervous system disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
chondroma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Craniofacial Abnormalities  (ISO)
D-2-hydroxyglutaric aciduria  (ISO)
D-2-hydroxyglutaric aciduria 2  (ISO)
esophagus squamous cell carcinoma  (ISO)
genetic disease  (ISO)
Growth Disorders  (ISO)
head and neck squamous cell carcinoma  (ISO)
hemangioma  (ISO)
hepatocellular carcinoma  (ISO)
hepatocellular clear cell carcinoma  (ISO)
hereditary lymphedema  (ISO)
high grade glioma  (ISO)
hydronephrosis  (ISO)
hypertrophic cardiomyopathy  (ISO)
Immunoblastic Lymphadenopathy  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
kidney failure  (ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
Metabolic Syndrome  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Recurrence, Local  (ISO)
non-alcoholic fatty liver  (ISO)
oligodendroglioma  (ISO)
Ollier disease  (ISO)
osteoarthritis  (ISO)
osteochondrodysplasia  (ISO)
osteoporosis  (ISO)
Paraproteinemias  (ISO)
peripheral T-cell lymphoma  (ISO)
plasma cell neoplasm  (ISO)
status epilepticus  (IDA)
stomach cancer  (ISO)
teratoma  (ISO)
Vascular Malformations  (ISO)
Ventricular Dysfunction, Left  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(N(omega)-L-arginino)succinic acid  (ISO)
(R)-adrenaline  (EXP)
(R)-carnitine  (ISO)
(R)-pantothenic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2'-deoxycytosine 5'-monophosphate  (ISO)
2'-deoxyguanosine 5'-monophosphate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-bromohexadecanoic acid  (ISO)
2-hydroxyglutaric acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-dehydrocarnitine  (ISO)
3-methylcholanthrene  (ISO)
3-phosphoglyceric acid  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(trimethylammonio)butanoate  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
8-Epidiosbulbin E acetate  (ISO)
9H-xanthine  (EXP)
acetamide  (EXP)
aconitic acid  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-glucose 1-phosphate  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-fructofuranose 1,6-bisphosphate  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
creatinine  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cytidine  (ISO)
D-erythrose 4-phosphate  (ISO)
D-fructofuranose 1,6-bisphosphate  (ISO)
D-glyceric acid  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dihydroxyacetone phosphate  (ISO)
Diosbulbin B  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
GDP-alpha-D-glucose  (ISO)
glutathione  (ISO)
glyceric acid  (ISO)
glycerol 1-phosphate  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
guanine  (ISO)
Honokiol  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP,ISO)
indometacin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
keto-D-fructose 1,6-bisphosphate  (ISO)
L-alanine  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
malic acid  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylisothiazolinone  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methylnicotinamide  (ISO)
N-nitrosodiethylamine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nickel dichloride  (ISO)
O-acetyl-L-carnitine  (ISO)
O-butanoyl-L-carnitine  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prostaglandin A1  (ISO)
pyruvic acid  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 431542  (ISO)
sedoheptulose 1,7-bisphosphate  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sodium sulfide (anhydrous)  (EXP)
Soman  (EXP)
spermine  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
triazines  (ISO)
trilobatin  (EXP)
triptonide  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
UDP-N-acetyl-alpha-D-glucosamine  (ISO)
uridine  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vosaroxin  (ISO)
VX nerve agent  (EXP)
XL147  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
mitochondrion  (IBA,IEA,ISO)
peroxisome  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Difference in driver gene expression patterns between perihilar and peripheral intrahepatic cholangiocarcinoma in an experimental mouse model. Adachi T, etal., J Hepatobiliary Pancreat Sci. 2020 Aug;27(8):477-486. doi: 10.1002/jhbp.772. Epub 2020 Jul 13.
2. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Chen X, etal., Br J Cancer. 2020 Jul;123(1):126-136. doi: 10.1038/s41416-020-0852-4. Epub 2020 May 5.
3. Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer. Du C, etal., Gastric Cancer. 2015 Jul;18(3):516-25. doi: 10.1007/s10120-014-0409-4. Epub 2014 Aug 7.
4. Glioma-derived mutations in isocitrate dehydrogenase 2 beneficial to traditional chemotherapy. Fu Y, etal., Biochem Biophys Res Commun. 2011 Jul 1;410(2):218-23. doi: 10.1016/j.bbrc.2011.05.108. Epub 2011 May 27.
5. Mutations in isocitrate dehydrogenase 2 accelerate glioma cell migration via matrix metalloproteinase-2 and 9. Fu Y, etal., Biotechnol Lett. 2012 Mar;34(3):441-6. doi: 10.1007/s10529-011-0800-8. Epub 2011 Nov 22.
6. Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy. Gano LB, etal., Free Radic Biol Med. 2018 Aug 1;123:116-124. doi: 10.1016/j.freeradbiomed.2018.05.063. Epub 2018 May 17.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. IDH2 protects against nonalcoholic steatohepatitis by alleviating dyslipidemia regulated by oxidative stress. Gong F, etal., Biochem Biophys Res Commun. 2019 Jun 30;514(3):593-600. doi: 10.1016/j.bbrc.2019.04.069. Epub 2019 May 4.
9. Genetic variants in genes of tricarboxylic acid cycle key enzymes are associated with prognosis of patients with non-small cell lung cancer. Guo X, etal., Lung Cancer. 2015 Feb;87(2):162-8. doi: 10.1016/j.lungcan.2014.12.005. Epub 2014 Dec 18.
10. IDH2 deficiency increases the liver susceptibility to ischemia-reperfusion injury via increased mitochondrial oxidative injury. Han SJ, etal., Redox Biol. 2018 Apr;14:142-153. doi: 10.1016/j.redox.2017.09.003. Epub 2017 Sep 8.
11. Expression and mutagenesis of mammalian cytosolic NADP+-specific isocitrate dehydrogenase. Jennings GT, etal., Biochemistry. 1997 Nov 4;36(44):13743-7.
12. IDH2 deficiency exacerbates acetaminophen hepatotoxicity in mice via mitochondrial dysfunction-induced apoptosis. Kim H, etal., Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2333-2341. doi: 10.1016/j.bbadis.2019.05.012. Epub 2019 May 20.
13. Amelioration of late-onset hepatic steatosis in IDH2-deficient mice. Lee SJ, etal., Free Radic Res. 2017 Apr;51(4):368-374. doi: 10.1080/10715762.2017.1320554. Epub 2017 May 5.
14. A new functional IDH2 genetic variant is associated with the risk of lung cancer. Li J, etal., Mol Carcinog. 2017 Mar;56(3):1082-1087. doi: 10.1002/mc.22573. Epub 2016 Oct 24.
15. Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer. Li J, etal., Theranostics. 2018 Jul 16;8(15):4050-4061. doi: 10.7150/thno.21524. eCollection 2018.
16. IDH2 is a novel diagnostic and prognostic serum biomarker for non-small-cell lung cancer. Li JJ, etal., Mol Oncol. 2018 May;12(5):602-610. doi: 10.1002/1878-0261.12182. Epub 2018 Mar 25.
17. High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma. Liu WR, etal., J Exp Clin Cancer Res. 2014 Apr 10;33:32. doi: 10.1186/1756-9966-33-32.
18. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. Marcucci G, etal., J Clin Oncol. 2010 May 10;28(14):2348-55. doi: 10.1200/JCO.2009.27.3730. Epub 2010 Apr 5.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. IDH2 Deficiency Aggravates Fructose-Induced NAFLD by Modulating Hepatic Fatty Acid Metabolism and Activating Inflammatory Signaling in Female Mice. Pan JH, etal., Nutrients. 2018 May 27;10(6). pii: nu10060679. doi: 10.3390/nu10060679.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Comprehensive gene review and curation RGD comprehensive gene curation
26. A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model. Wang F, etal., J Inherit Metab Dis. 2016 Nov;39(6):807-820. doi: 10.1007/s10545-016-9960-y. Epub 2016 Jul 28.
27. Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Wang P, etal., Oncogene. 2013 Jun 20;32(25):3091-100. doi: 10.1038/onc.2012.315. Epub 2012 Jul 23.
28. Mutations in the isocitrate dehydrogenase 2 gene and IDH1 SNP 105C > T have a prognostic value in acute myeloid leukemia. Willander K, etal., Biomark Res. 2014 Oct 8;2:18. doi: 10.1186/2050-7771-2-18. eCollection 2014.
29. Genetic variations in IDH gene as prognosis predictors in TACE-treated hepatocellular carcinoma patients. Zhang H, etal., Med Oncol. 2014 Nov;31(11):278. doi: 10.1007/s12032-014-0278-z. Epub 2014 Oct 22.
Additional References at PubMed
PMID:7323947   PMID:8867815   PMID:12477932   PMID:12865426   PMID:14651853   PMID:15489334   PMID:18275837   PMID:18614015   PMID:18806796   PMID:20833797   PMID:22082260   PMID:22309944  
PMID:23226729   PMID:23533145   PMID:24296260   PMID:24625528   PMID:25931508   PMID:26316108   PMID:29476059   PMID:33450132  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81143,447,925 - 143,467,248 (-)NCBIGRCr8
mRatBN7.21134,038,644 - 134,057,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,029,772 - 134,058,025 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1141,947,731 - 141,967,051 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,117,130 - 149,136,466 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,034,887 - 142,054,220 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,874,354 - 141,893,674 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,866,283 - 141,893,705 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,830,040 - 142,849,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,876,052 - 135,895,373 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1126,099,085 - 126,118,402 (-)NCBICelera
Cytogenetic Map1q31NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381590,083,045 - 90,102,468 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,083,045 - 90,102,477 (-)EnsemblGRCh38hg38GRCh38
GRCh371590,626,277 - 90,645,700 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,428,214 - 88,446,712 (-)NCBINCBI36Build 36hg18NCBI36
Build 341588,428,217 - 88,446,712NCBI
Celera1567,031,136 - 67,049,657 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1566,738,326 - 66,745,989 (-)NCBIHuRef
CHM1_11590,468,783 - 90,487,283 (-)NCBICHM1_1
T2T-CHM13v2.01587,839,072 - 87,858,500 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39779,744,594 - 79,768,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,744,594 - 79,765,140 (-)EnsemblGRCm39 Ensembl
GRCm38780,094,845 - 80,118,608 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,094,846 - 80,115,392 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,239,732 - 87,260,236 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36779,968,359 - 79,988,834 (-)NCBIMGSCv36mm8
Celera777,493,303 - 77,513,823 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.43NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541615,197,366 - 15,223,363 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541615,197,611 - 15,212,919 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21679,630,229 - 79,649,755 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,330,550 - 83,349,140 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01568,771,050 - 68,790,523 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11587,972,883 - 87,991,270 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,972,889 - 87,991,276 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1353,070,462 - 53,077,566 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,070,695 - 53,087,496 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,708,523 - 55,724,976 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,486,432 - 53,502,992 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,486,432 - 53,503,494 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,006,922 - 53,023,434 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,217,752 - 53,234,294 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,558,279 - 53,574,816 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640130,470,218 - 130,488,711 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,845,792 - 15,864,341 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,845,777 - 15,864,341 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl755,651,609 - 55,675,554 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,654,298 - 55,675,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,539,333 - 60,549,480 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1298,633,429 - 8,650,744 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,633,715 - 8,650,657 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605938,130,227 - 38,147,558 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476817,094,655 - 17,111,397 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476817,094,649 - 17,111,333 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Idh2
99 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:209
Count of miRNA genes:157
Interacting mature miRNAs:169
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,038,739 - 134,038,943 (+)MAPPERmRatBN7.2
Rnor_6.01141,874,450 - 141,874,653NCBIRnor6.0
Rnor_5.01142,830,136 - 142,830,339UniSTSRnor5.0
RGSC_v3.41135,876,148 - 135,876,351UniSTSRGSC3.4
Celera1126,099,181 - 126,099,384UniSTS
Cytogenetic Map1q31UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,038,757 - 134,038,977 (+)MAPPERmRatBN7.2
Rnor_6.01141,874,468 - 141,874,687NCBIRnor6.0
Rnor_5.01142,830,154 - 142,830,373UniSTSRnor5.0
RGSC_v3.41135,876,166 - 135,876,385UniSTSRGSC3.4
Celera1126,099,199 - 126,099,418UniSTS
RH 3.4 Map11068.9UniSTS
Cytogenetic Map1q31UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 25
Medium 3 18 57 41 19 41 8 11 74 35 35 11 8
Low 6
Below cutoff


RefSeq Acc Id: ENSRNOT00000019059   ⟹   ENSRNOP00000019059
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,037,572 - 134,057,975 (-)Ensembl
Rnor_6.0 Ensembl1141,874,358 - 141,893,674 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085988   ⟹   ENSRNOP00000069080
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,029,772 - 134,058,025 (-)Ensembl
Rnor_6.0 Ensembl1141,866,283 - 141,893,705 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109065   ⟹   ENSRNOP00000080037
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,036,753 - 134,058,025 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114588   ⟹   ENSRNOP00000084214
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,038,962 - 134,058,025 (-)Ensembl
RefSeq Acc Id: NM_001014161   ⟹   NP_001014183
Rat AssemblyChrPosition (strand)Source
GRCr81143,447,925 - 143,467,248 (-)NCBI
mRatBN7.21134,038,644 - 134,057,969 (-)NCBI
Rnor_6.01141,874,354 - 141,893,674 (-)NCBI
Rnor_5.01142,830,040 - 142,849,360 (-)NCBI
RGSC_v3.41135,876,052 - 135,895,373 (-)RGD
Celera1126,099,085 - 126,118,402 (-)RGD
RefSeq Acc Id: NP_001014183   ⟸   NM_001014161
- Peptide Label: precursor
- UniProtKB: Q6DGF1 (UniProtKB/Swiss-Prot),   P56574 (UniProtKB/Swiss-Prot),   A6JC81 (UniProtKB/TrEMBL),   A0A0G2JUF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069080   ⟸   ENSRNOT00000085988
RefSeq Acc Id: ENSRNOP00000019059   ⟸   ENSRNOT00000019059
RefSeq Acc Id: ENSRNOP00000080037   ⟸   ENSRNOT00000109065
RefSeq Acc Id: ENSRNOP00000084214   ⟸   ENSRNOT00000114588
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56574-F1-model_v2 AlphaFold P56574 1-452 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690140
Promoter ID:EPDNEW_R661
Type:initiation region
Description:isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01141,893,687 - 141,893,747EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597139 AgrOrtholog
BioCyc Gene G2FUF-58763 BioCyc
Ensembl Genes ENSRNOG00000013949 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055008350 UniProtKB/Swiss-Prot
  ENSRNOG00060004276 UniProtKB/Swiss-Prot
  ENSRNOG00065030465 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019059 ENTREZGENE
  ENSRNOT00000019059.6 UniProtKB/TrEMBL
  ENSRNOT00000085988.2 UniProtKB/TrEMBL
  ENSRNOT00000109065.1 UniProtKB/TrEMBL
  ENSRNOT00000114588.1 UniProtKB/TrEMBL
  ENSRNOT00055014131 UniProtKB/Swiss-Prot
  ENSRNOT00060007158 UniProtKB/Swiss-Prot
  ENSRNOT00065052524 UniProtKB/Swiss-Prot
Gene3D-CATH Isopropylmalate Dehydrogenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IsoCit/isopropylmalate_DH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Isocitrate_DH_NADP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IsoPropMal-DH-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361596 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Iso_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Idh2 PhenoGen
RatGTEx ENSRNOG00000013949 RatGTEx
  ENSRNOG00055008350 RatGTEx
  ENSRNOG00060004276 RatGTEx
  ENSRNOG00065030465 RatGTEx
SMART Iso_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Isocitrate/Isopropylmalate dehydrogenase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q6DGF1 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Idh2  isocitrate dehydrogenase (NADP(+)) 2  Idh2  isocitrate dehydrogenase (NADP(+)) 2, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-04 Idh2  isocitrate dehydrogenase (NADP(+)) 2, mitochondrial  Idh2  isocitrate dehydrogenase 2 (NADP+), mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Idh2  isocitrate dehydrogenase 2 (NADP+), mitochondrial  LOC361596  similar to NADP+-specific isocitrate dehydrogenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC361596  similar to NADP+-specific isocitrate dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL