Iqsec2 (IQ motif and Sec7 domain ArfGEF 2) - Rat Genome Database

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Gene: Iqsec2 (IQ motif and Sec7 domain ArfGEF 2) Rattus norvegicus
Analyze
Symbol: Iqsec2
Name: IQ motif and Sec7 domain ArfGEF 2
RGD ID: 1596452
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Involved in modulation of chemical synaptic transmission; positive regulation of synapse assembly; and regulation of ARF protein signal transduction. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; photoreceptor ribbon synapse; and postsynaptic density. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2); INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IQ motif and Sec7 domain 2; IQ motif and SEC7 domain-containing protein 2; LOC685244; RGD1562109; similar to IQ motif and Sec7 domain 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X24,734,202 - 24,816,566 (+)NCBIGRCr8
mRatBN7.2X21,254,799 - 21,337,179 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX21,254,914 - 21,336,584 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX18,720,062 - 18,802,376 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X21,321,193 - 21,403,511 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X21,820,482 - 21,902,802 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X22,212,137 - 22,293,810 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX22,212,132 - 22,294,402 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X64,286,343 - 64,367,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X41,651,275 - 41,733,435 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX21,517,185 - 21,598,702 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression. Brown JC, etal., Nat Commun. 2016 Mar 24;7:11080. doi: 10.1038/ncomms11080.
2. Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation. Elagabani MN, etal., J Biol Chem. 2016 Apr 22;291(17):9105-18. doi: 10.1074/jbc.M115.691717. Epub 2016 Feb 16.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18164504   PMID:19811534   PMID:26793055  


Genomics

Comparative Map Data
Iqsec2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X24,734,202 - 24,816,566 (+)NCBIGRCr8
mRatBN7.2X21,254,799 - 21,337,179 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX21,254,914 - 21,336,584 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX18,720,062 - 18,802,376 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X21,321,193 - 21,403,511 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X21,820,482 - 21,902,802 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X22,212,137 - 22,293,810 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX22,212,132 - 22,294,402 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X64,286,343 - 64,367,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X41,651,275 - 41,733,435 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX21,517,185 - 21,598,702 (+)NCBICelera
Cytogenetic MapXq13NCBI
IQSEC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X53,225,813 - 53,321,350 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX53,225,828 - 53,321,350 (-)EnsemblGRCh38hg38GRCh38
GRCh37X53,262,058 - 53,350,548 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,278,783 - 53,327,521 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX57,091,294 - 57,179,759 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX50,327,195 - 50,414,951 (-)NCBIHuRef
CHM1_1X53,252,281 - 53,340,767 (-)NCBICHM1_1
T2T-CHM13v2.0X52,512,100 - 52,607,614 (-)NCBIT2T-CHM13v2.0
Iqsec2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X150,927,179 - 151,008,233 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX150,927,193 - 151,008,232 (+)EnsemblGRCm39 Ensembl
GRCm38X152,144,183 - 152,225,237 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX152,144,268 - 152,225,236 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X148,578,811 - 148,659,779 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X147,519,725 - 147,565,952 (+)NCBIMGSCv36mm8
MGSCv36X129,187,494 - 129,233,721 (+)NCBIMGSCv36mm8
CeleraX132,285,132 - 132,286,052 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Iqsec2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955475284,168 - 369,400 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955475285,977 - 369,380 (-)NCBIChiLan1.0ChiLan1.0
IQSEC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X54,625,041 - 54,720,577 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X54,628,648 - 54,724,175 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X45,447,977 - 45,535,836 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X53,557,847 - 53,604,744 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX53,557,563 - 53,644,737 (-)Ensemblpanpan1.1panPan2
IQSEC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X44,861,813 - 44,915,011 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX44,872,888 - 44,913,704 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX36,516,736 - 36,595,958 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X45,308,027 - 45,386,860 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX45,306,847 - 45,386,965 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X44,803,229 - 44,882,038 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X45,252,874 - 45,331,684 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X45,320,205 - 45,399,024 (-)NCBIUU_Cfam_GSD_1.0
Iqsec2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X37,871,074 - 37,963,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936751210,761 - 294,399 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936751210,800 - 294,358 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IQSEC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX46,011,388 - 46,094,817 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X46,011,386 - 46,094,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X51,511,372 - 51,566,645 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IQSEC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X49,363,569 - 49,452,872 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX49,364,909 - 49,387,050 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660863,317,401 - 3,407,594 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iqsec2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624909460,626 - 565,133 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624909462,724 - 564,989 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Iqsec2
201 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:110
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000038211, ENSRNOT00000050926, ENSRNOT00000059465
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000078210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX21,289,545 - 21,336,584 (+)Ensembl
Rnor_6.0 EnsemblX22,212,132 - 22,294,402 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX21,289,545 - 21,305,314 (+)Ensembl
Rnor_6.0 EnsemblX22,247,134 - 22,262,637 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079802   ⟹   ENSRNOP00000071222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX21,290,535 - 21,333,934 (+)Ensembl
Rnor_6.0 EnsemblX22,247,088 - 22,293,007 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX21,254,914 - 21,336,584 (+)Ensembl
Rnor_6.0 EnsemblX22,212,132 - 22,294,402 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX21,254,914 - 21,336,584 (+)Ensembl
Rnor_6.0 EnsemblX22,212,132 - 22,294,402 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086262   ⟹   ENSRNOP00000075320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX22,285,184 - 22,286,608 (+)Ensembl
RefSeq Acc Id: NM_001277386   ⟹   NP_001264315
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,768,957 - 24,816,566 (+)NCBI
mRatBN7.2X21,289,567 - 21,337,179 (+)NCBI
Rnor_6.0X22,247,189 - 22,293,810 (+)NCBI
Rnor_5.0X64,286,343 - 64,367,399 (-)NCBI
CeleraX21,551,851 - 21,598,702 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001277425   ⟹   NP_001264354
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,734,246 - 24,816,566 (+)NCBI
mRatBN7.2X21,254,849 - 21,337,179 (+)NCBI
Rnor_6.0X22,212,137 - 22,293,810 (+)NCBI
Rnor_5.0X64,286,343 - 64,367,399 (-)NCBI
CeleraX21,517,185 - 21,598,702 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039100078   ⟹   XP_038956006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,757,171 - 24,816,565 (+)NCBI
mRatBN7.2X21,278,301 - 21,337,179 (+)NCBI
RefSeq Acc Id: XM_063280304   ⟹   XP_063136374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,734,202 - 24,816,565 (+)NCBI
RefSeq Acc Id: XM_063280305   ⟹   XP_063136375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,757,176 - 24,816,565 (+)NCBI
RefSeq Acc Id: NP_001264354   ⟸   NM_001277425
- Peptide Label: isoform 1
- UniProtKB: A0A8I6GKX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264315   ⟸   NM_001277386
- Peptide Label: isoform 2
- UniProtKB: A0A0G2JZX5 (UniProtKB/TrEMBL),   A0A8I6APH1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071222   ⟸   ENSRNOT00000079802
Ensembl Acc Id: ENSRNOP00000075320   ⟸   ENSRNOT00000086262
RefSeq Acc Id: XP_038956006   ⟸   XM_039100078
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063136374   ⟸   XM_063280304
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y7S8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136375   ⟸   XM_063280305
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JZX5 (UniProtKB/TrEMBL)
Protein Domains
SEC7

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZX5-F1-model_v2 AlphaFold A0A0G2JZX5 1-949 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701771
Promoter ID:EPDNEW_R12295
Type:single initiation site
Name:Iqsec2_1
Description:IQ motif and Sec7 domain 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X22,247,126 - 22,247,186EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596452 AgrOrtholog
BioCyc Gene G2FUF-2717 BioCyc
Ensembl Genes ENSRNOG00000058975 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078210.2 UniProtKB/TrEMBL
  ENSRNOT00000078824.2 UniProtKB/TrEMBL
  ENSRNOT00000079802.2 UniProtKB/TrEMBL
  ENSRNOT00000080331.2 UniProtKB/TrEMBL
  ENSRNOT00000085263.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1000.11 UniProtKB/TrEMBL
  1.10.220.20 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro IQSEC_PH UniProtKB/TrEMBL
  PH/PTB_dom UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Sec7_alpha_orthog UniProtKB/TrEMBL
  Sec7_dom UniProtKB/TrEMBL
  Sec7_sf UniProtKB/TrEMBL
KEGG Report rno:685244 UniProtKB/TrEMBL
NCBI Gene 685244 ENTREZGENE
PANTHER GUANYL-NUCLEOTIDE EXCHANGE FACTOR UniProtKB/TrEMBL
  IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam IQ_SEC7_PH UniProtKB/TrEMBL
  Sec7 UniProtKB/TrEMBL
PhenoGen Iqsec2 PhenoGen
PROSITE PS50096 UniProtKB/TrEMBL
  SEC7 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058975 RatGTEx
SMART Sec7 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48425 UniProtKB/TrEMBL
UniProt A0A0G2JZX5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y7S8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APH1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APZ2_RAT UniProtKB/TrEMBL
  A0A8I6GKX8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-13 Iqsec2  IQ motif and Sec7 domain ArfGEF 2  Iqsec2  IQ motif and Sec7 domain 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-06-08 Iqsec2  IQ motif and Sec7 domain 2  LOC685244  similar to IQ motif and Sec7 domain 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC685244  similar to IQ motif and Sec7 domain 2  LOC683475  similar to IQ motif and Sec7 domain 2  Data merged from RGD:1586816 1643240 APPROVED
2006-11-20 LOC685244  similar to IQ motif and Sec7 domain 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683475  similar to IQ motif and Sec7 domain 2      Symbol and Name status set to provisional 70820 PROVISIONAL